CN113521068A - 去势治疗相关症状的治疗 - Google Patents

去势治疗相关症状的治疗 Download PDF

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Publication number
CN113521068A
CN113521068A CN202110830219.4A CN202110830219A CN113521068A CN 113521068 A CN113521068 A CN 113521068A CN 202110830219 A CN202110830219 A CN 202110830219A CN 113521068 A CN113521068 A CN 113521068A
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China
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compound
day
dose
treatment
males
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Pending
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CN202110830219.4A
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English (en)
Chinese (zh)
Inventor
C·T·本森
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Ergen Pharmaceutical Co ltd
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Eli Lilly and Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Indole Compounds (AREA)
CN202110830219.4A 2014-09-11 2015-09-08 去势治疗相关症状的治疗 Pending CN113521068A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462049192P 2014-09-11 2014-09-11
US62/049192 2014-09-11
CN201580048887.4A CN106794178A (zh) 2014-09-11 2015-09-08 去势治疗相关症状的治疗

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201580048887.4A Division CN106794178A (zh) 2014-09-11 2015-09-08 去势治疗相关症状的治疗

Publications (1)

Publication Number Publication Date
CN113521068A true CN113521068A (zh) 2021-10-22

Family

ID=54151401

Family Applications (4)

Application Number Title Priority Date Filing Date
CN202110830219.4A Pending CN113521068A (zh) 2014-09-11 2015-09-08 去势治疗相关症状的治疗
CN201580048887.4A Pending CN106794178A (zh) 2014-09-11 2015-09-08 去势治疗相关症状的治疗
CN201810348598.1A Pending CN108440497A (zh) 2014-09-11 2015-09-08 去势治疗相关症状的治疗
CN202110871107.3A Pending CN113651797A (zh) 2014-09-11 2015-09-08 去势治疗相关症状的治疗

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN201580048887.4A Pending CN106794178A (zh) 2014-09-11 2015-09-08 去势治疗相关症状的治疗
CN201810348598.1A Pending CN108440497A (zh) 2014-09-11 2015-09-08 去势治疗相关症状的治疗
CN202110871107.3A Pending CN113651797A (zh) 2014-09-11 2015-09-08 去势治疗相关症状的治疗

Country Status (23)

Country Link
US (4) US10758515B2 (enExample)
EP (2) EP3191094B1 (enExample)
JP (4) JP6893171B2 (enExample)
KR (5) KR20210083370A (enExample)
CN (4) CN113521068A (enExample)
AP (1) AP2017009795A0 (enExample)
AU (2) AU2015315431C1 (enExample)
BR (2) BR112017002449B1 (enExample)
CA (2) CA2956514C (enExample)
EA (2) EA034553B1 (enExample)
ES (1) ES2779978T3 (enExample)
HK (1) HK1252811A1 (enExample)
IL (3) IL279209B2 (enExample)
JO (2) JOP20180072A1 (enExample)
MA (1) MA45416A (enExample)
MX (3) MX373322B (enExample)
MY (2) MY195767A (enExample)
NZ (1) NZ728612A (enExample)
SG (2) SG11201701630VA (enExample)
TW (1) TWI616201B (enExample)
UA (1) UA120099C2 (enExample)
WO (1) WO2016040234A1 (enExample)
ZA (1) ZA201802680B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20180072A1 (ar) * 2014-09-11 2019-01-30 Lilly Co Eli علاج الأعراض المرتبطة بالعلاج بالحرمان من الأندروجين
US20180185347A1 (en) * 2016-11-16 2018-07-05 Transition Therapeutics (Ireland 2) Limited Tetrahydrocyclopenta[b]indole compounds and phosphodiesterase inhibitors for the treatment of the signs and symptoms of bhp
US20230096602A1 (en) 2020-01-27 2023-03-30 Eirgen Pharma Ltd. Tetrahydrocyclopenta[b]indole compounds for treatment of renal disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101541749A (zh) * 2006-11-20 2009-09-23 伊莱利利公司 作为雄激素受体调节剂的四氢环戊二烯并[b]吲哚化合物

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MXPA05007536A (es) * 2003-01-13 2005-10-20 Gtx Inc Sintesis a gran escala de moduladores de receptor de androgeno selectivos.
US20110237664A1 (en) * 2004-06-07 2011-09-29 Dalton James T Selective androgen receptor modulators for treating diabetes
US9889110B2 (en) * 2004-06-07 2018-02-13 University Of Tennessee Research Foundation Selective androgen receptor modulator for treating hormone-related conditions
JP2009538873A (ja) 2006-05-31 2009-11-12 グラクソ グループ リミテッド 新規複素環化合物
MX2009000714A (es) * 2006-07-19 2009-07-27 Osurf Moduladores de receptor de androgeno selectivos, analogos y derivados de los mismos.
US7443672B2 (en) 2006-10-03 2008-10-28 Fu Zhun Precision Industry (Shen Zhen) Co., Ltd. Video graphics array (VGA) card assembly
TW200918521A (en) * 2007-08-31 2009-05-01 Astrazeneca Ab Heterocyclic amides and methods of use thereof
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MX2010006972A (es) * 2007-12-21 2010-08-26 Ligand Pharm Inc Moduladores selectivos de receptores de andrógenos (sarm) y usos de los mismos.
BRPI0912394A2 (pt) * 2008-05-16 2016-07-26 Lilly Co Eli moduladores do receptor de androgênio à base de tetra-hidrociclopenta[b]indol
US8003689B2 (en) * 2008-06-20 2011-08-23 Gtx, Inc. Metabolites of selective androgen receptor modulators and methods of use thereof
AR078862A1 (es) * 2009-11-13 2011-12-07 Lilly Co Eli Ester isopropilico del acido ((s)-7-ciano-4-((2r,3s)-3-hidroxitetrahidrofuran-2-ilmetil)-1,2,3,4-tetrahidro-ciclopenta(b)indol-2-il)carbamico, composiciones farmaceuticas que lo comprenden y su uso en terapia
CN102234287B (zh) * 2010-04-26 2015-08-05 上海阳帆医药科技有限公司 硝基咪唑类化合物、其制备方法和用途
JP2012149054A (ja) * 2010-12-27 2012-08-09 Dainippon Sumitomo Pharma Co Ltd Ｎ−置換−環状アミノ誘導体からなる医薬
LT2915804T (lt) * 2012-10-31 2019-06-10 Fujifilm Toyama Chemical Co., Ltd. Nauji amino dariniai arba jo druskos kaip tnf alfa inhibitoriai
JP6469692B2 (ja) * 2013-12-09 2019-02-13 ユーシービー バイオファルマ エスピーアールエル Ｔｎｆ活性のモジュレーターとしてのイミダゾピリジン誘導体
JOP20180072A1 (ar) * 2014-09-11 2019-01-30 Lilly Co Eli علاج الأعراض المرتبطة بالعلاج بالحرمان من الأندروجين

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
CN101541749A (zh) * 2006-11-20 2009-09-23 伊莱利利公司 作为雄激素受体调节剂的四氢环戊二烯并[b]吲哚化合物

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AP2017009795A0 (en) 2017-03-31
AU2015315431A1 (en) 2017-03-09
KR102024493B1 (ko) 2019-09-23
US10799478B2 (en) 2020-10-13
KR20220132669A (ko) 2022-09-30
KR102619415B1 (ko) 2024-01-02
IL258651A (en) 2018-06-28
US10758515B2 (en) 2020-09-01
JP2019089795A (ja) 2019-06-13
IL250291B (en) 2020-09-30
US20200390744A1 (en) 2020-12-17
US20240148694A1 (en) 2024-05-09
KR20210083370A (ko) 2021-07-06
WO2016040234A1 (en) 2016-03-17
BR112017002449A2 (pt) 2017-12-05
US20170172992A1 (en) 2017-06-22
EP3191094B1 (en) 2020-02-19
JP6893171B2 (ja) 2021-06-23
HK1252811A1 (en) 2019-06-06
JOP20180072A1 (ar) 2019-01-30
AU2015315431B2 (en) 2018-03-08
CN113651797A (zh) 2021-11-16
EA201891008A2 (ru) 2018-09-28
AU2015315431C1 (en) 2018-08-02
EP3191094A1 (en) 2017-07-19
JP2017527584A (ja) 2017-09-21
KR20190015628A (ko) 2019-02-13
CA3067289A1 (en) 2016-03-17
JP7349480B2 (ja) 2023-09-22
EA034553B1 (ru) 2020-02-19
MA45416A (fr) 2019-04-24
IL279209B2 (en) 2023-02-01
EA201790220A1 (ru) 2017-07-31
AU2018202714B2 (en) 2019-06-20
BR122018007412B1 (pt) 2022-08-23
BR112017002449B1 (pt) 2022-08-09
IL279209A (en) 2021-01-31
EA201891008A3 (ru) 2019-03-29
IL258651B (en) 2021-02-28
CA3067289C (en) 2023-04-04
CN108440497A (zh) 2018-08-24
MY195767A (en) 2023-02-10
MX2017003140A (es) 2017-05-23
ES2779978T3 (es) 2020-08-21
MX391447B (es) 2025-03-21
MX2021014120A (es) 2022-01-04
JP6938550B2 (ja) 2021-09-22
SG10201809673RA (en) 2018-12-28
IL250291A0 (en) 2017-03-30
TW201618782A (zh) 2016-06-01
JO3609B1 (ar) 2020-08-27
JP2023145479A (ja) 2023-10-11
JP2022000432A (ja) 2022-01-04
US20190111039A1 (en) 2019-04-18
CN106794178A (zh) 2017-05-31
TWI616201B (zh) 2018-03-01
CA2956514C (en) 2023-04-18
AU2018202714A1 (en) 2018-05-17
MX373322B (es) 2020-05-21
MY198753A (en) 2023-09-23
ZA201802680B (en) 2020-08-26
SG11201701630VA (en) 2017-03-30
KR20170040338A (ko) 2017-04-12
IL279209B (en) 2022-10-01
EA033606B1 (ru) 2019-11-08
UA120099C2 (uk) 2019-10-10
CA2956514A1 (en) 2016-03-17
NZ728612A (en) 2018-03-23
EP3375444A1 (en) 2018-09-19
KR20180041268A (ko) 2018-04-23

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