CN113519567A - Preparation method of disinfectant for medical instruments - Google Patents
Preparation method of disinfectant for medical instruments Download PDFInfo
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- CN113519567A CN113519567A CN202110967597.7A CN202110967597A CN113519567A CN 113519567 A CN113519567 A CN 113519567A CN 202110967597 A CN202110967597 A CN 202110967597A CN 113519567 A CN113519567 A CN 113519567A
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Abstract
The invention discloses a preparation method of a medical instrument disinfectant, which comprises the following components in parts by weight: 4-10 parts of 1-propoxy-2-propanol, 1.2-6 parts of glutamyl-N-alkyl propane diamine, 2-6 parts of chlorobromoisocyanuric acid, 3-9 parts of sodium metasilicate, 1.5-5 parts of polyoxyethylene lauryl ether, 8-15 parts of a self-made antibacterial agent and 90-150 parts of water.
Description
Technical Field
The invention belongs to the technical field of medical instrument cleaning agents, and particularly relates to a preparation method of a medical instrument disinfectant.
Background
For the disinfection and sterilization of medical instruments, the traditional chemical disinfection and sterilization agents such as glutaraldehyde, o-phthalaldehyde, peracetic acid and the like have long disinfection time, large smell and corrosiveness and are obviously limited in the using process. The glutaraldehyde disinfectant has drug resistance to mycobacterium bisecting, the o-phthalaldehyde disinfectant cannot achieve a sterilization effect when the using concentration is low, and the peracetic acid disinfectant has low stability and is corroded. Complexing chlorine: the process of combining molecules or ions with metal ions to form new stable ionic groups is called complexation, and generally refers to compounds containing complex chloride ions. The sterilization mechanism of the complex chlorine is as follows: HOCl molecules are continuously released into the solution and keep dynamic balance, the HOCl molecules are small and uncharged, can easily penetrate through cell membranes of microorganisms to enter the solution, nascent state [ O ] and [ Cl ] are released, the oxidation effect and the chlorination effect are strong, amino acids in the microorganisms can be decomposed, the amino acid chains are broken, and the proteins lose functions, so that the microorganisms can be rapidly killed.
Disclosure of Invention
The invention aims to provide a preparation method of a medical instrument disinfectant, which comprises the following components in parts by weight: 4-10 parts of 1-propoxy-2-propanol, 1.2-6 parts of glutamyl-N-alkyl propane diamine, 2-6 parts of chlorobromoisocyanuric acid, 3-9 parts of sodium metasilicate, 1.5-5 parts of polyoxyethylene lauryl ether, 8-15 parts of a self-made antibacterial agent and 90-150 parts of water.
Further, the self-made antibacterial agent is prepared by the following method:
1) cleaning liquorice, dandelion, radix bupleuri, pine needle, aloe, phellodendron, honeysuckle and folium artemisiae argyi, drying in the sun, then crushing, and screening with a 200-400-mesh screen for later use.
2) Adding the product obtained in the step 1) into pure water, cooking for 0.5-1 h at the cooking temperature of 90-100 ℃, filtering, and collecting filtrate.
3) Carrying out soxhlet extraction on the filter residue obtained in the step 2) by using an ethanol solution to obtain a soxhlet liquid, uniformly mixing the soxhlet liquid with the filtrate, and refrigerating for later use.
Furthermore, the self-made antibacterial agent comprises the following components in parts by weight: 10-15 parts of liquorice, 6-10 parts of dandelion, 7-12 parts of radix bupleuri, 6-10 parts of pine needles, 5-8 parts of aloe, 3-6 parts of golden cypress, 4-9 parts of honeysuckle and 5-10 parts of folium artemisiae argyi.
The preparation method comprises the following steps:
s1: weighing 1-propoxy-2-propanol, glutamyl-N-alkyl propane diamine, chlorobromoisocyanuric acid, sodium metasilicate, polyoxyethylene lauryl ether, a self-made antibacterial agent and water according to the proportion.
S2: uniformly mixing 1-propoxy-2-propanol, glutamyl-N-alkyl propane diamine, chlorobromoisocyanuric acid, sodium metasilicate, polyoxyethylene lauryl ether and water, heating to 60-70 ℃, and stirring for 2-4 hours.
S3: and adding the self-made antibacterial agent into a centrifugal tube, centrifuging, taking supernatant, adding the supernatant into the step S2, and continuously stirring for 0.5-1 h to obtain the disinfectant.
Further, the centrifugation speed is 10000-15000 r/min, and the centrifugation time is 10-16 min.
Further, the polyoxyethylene lauryl ether is selected from polyoxyethylene lauryl ether-7 (AEO-7).
Compared with the prior art, the invention has the following beneficial effects:
the prepared medical instrument disinfectant has the advantages of obvious disinfection and sterilization, wide sterilization variety, quick response, no irritation, low preparation cost, no corrosivity and no toxicity, and is suitable for disinfecting most of clinical medical instruments. In addition, according to the preparation method of the medical instrument disinfectant, the self-made antibacterial agent is added, the efficiency of extracting beneficial substances in the raw materials is improved, the ultrafiltration membrane is used for filtering the disinfectant to prevent fine impurities from attaching to the medical instrument when the medical instrument is cleaned by the impurities in the disinfectant, and the residual color on the disinfectant is prevented from influencing the disinfection of the medical instrument by decoloring the disinfectant.
Detailed Description
The following embodiments of the present invention are described in detail, and the embodiments are implemented on the premise of the technical solution of the present invention, and a detailed implementation manner and a specific operation process are given, it should be noted that, for those skilled in the art, a plurality of modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Example 1
The preparation method of the disinfectant for the medical instruments comprises the following components in parts by weight: 4 parts of 1-propoxy-2-propanol, 1.2 parts of glutamyl-N-alkyl propane diamine, 2 parts of chlorobromoisocyanuric acid, 3 parts of sodium metasilicate, 1.5 parts of polyoxyethylene lauryl ether, 8 parts of a self-made antibacterial agent and 90 parts of water.
The self-made antibacterial agent is prepared by the following method:
1) cleaning 10 parts of liquorice, 6 parts of dandelion, 7 parts of radix bupleuri, 6 parts of pine needle, 5 parts of aloe, 3 parts of phellodendron, 4 parts of honeysuckle and 5 parts of folium artemisiae argyi, drying in the sun, then crushing, and drying in the sun through a 200-mesh net for later use.
2) Adding the product obtained in the step 1) into pure water, cooking for 0.5h at the cooking temperature of 90 ℃, filtering, and collecting filtrate.
3) Carrying out soxhlet extraction on the filter residue obtained in the step 2) by using an ethanol solution to obtain a soxhlet liquid, uniformly mixing the soxhlet liquid with the filtrate, and refrigerating for later use.
The preparation method comprises the following steps:
s1: weighing 1-propoxy-2-propanol, glutamyl-N-alkyl propane diamine, chlorobromoisocyanuric acid, sodium metasilicate, polyoxyethylene lauryl ether, a self-made antibacterial agent and water according to the proportion.
S2: uniformly mixing 1-propoxy-2-propanol, glutamyl-N-alkyl propane diamine, chlorobromoisocyanuric acid, sodium metasilicate, polyoxyethylene lauryl ether and water, heating to 60 ℃, and stirring for 2 hours.
S3: and adding the self-made antibacterial agent into a centrifuge tube, centrifuging, taking supernatant, adding the supernatant into the step S2, and continuously stirring for 0.5h to obtain the disinfectant.
Wherein the centrifugation rate is 10000r/min, and the centrifugation time is 10 min; the polyoxyethylene lauryl ether is selected from polyoxyethylene lauryl ether-7 (AEO-7).
Example 2
The preparation method of the disinfectant for the medical instruments comprises the following components in parts by weight: 10 parts of 1-propoxy-2-propanol, 6 parts of glutamyl-N-alkyl propane diamine, 6 parts of chlorobromoisocyanuric acid, 9 parts of sodium metasilicate, 5 parts of polyoxyethylene lauryl ether, 15 parts of a self-made antibacterial agent and 150 parts of water.
The self-made antibacterial agent is prepared by the following method:
1) washing 15 parts of liquorice, 10 parts of dandelion, 12 parts of radix bupleuri, 10 parts of pine needle, 8 parts of aloe, 6 parts of phellodendron, 9 parts of honeysuckle and 10 parts of folium artemisiae argyi, drying in the sun, crushing, and drying in the sun by using a 400-mesh screen for later use.
2) Adding the product obtained in the step 1) into pure water, cooking for 1h at the cooking temperature of 100 ℃, filtering and collecting filtrate.
3) Carrying out soxhlet extraction on the filter residue obtained in the step 2) by using an ethanol solution to obtain a soxhlet liquid, uniformly mixing the soxhlet liquid with the filtrate, and refrigerating for later use.
The preparation method comprises the following steps:
s1: weighing 1-propoxy-2-propanol, glutamyl-N-alkyl propane diamine, chlorobromoisocyanuric acid, sodium metasilicate, polyoxyethylene lauryl ether, a self-made antibacterial agent and water according to the proportion.
S2: uniformly mixing 1-propoxy-2-propanol, glutamyl-N-alkyl propane diamine, chlorobromoisocyanuric acid, sodium metasilicate, polyoxyethylene lauryl ether and water, heating to 70 ℃, and stirring for 4 hours.
S3: and adding the self-made antibacterial agent into a centrifugal tube, centrifuging, taking supernatant, adding the supernatant into the step S2, and continuously stirring for 1h to obtain the disinfectant.
Wherein the centrifugation speed is 15000r/min, and the centrifugation time is 16 min; the polyoxyethylene lauryl ether is selected from polyoxyethylene lauryl ether-7 (AEO-7).
Example 3
The preparation method of the disinfectant for the medical instruments comprises the following components in parts by weight: 6 parts of 1-propoxy-2-propanol, 3 parts of glutamyl-N-alkyl propane diamine, 4 parts of chlorobromoisocyanuric acid, 5 parts of sodium metasilicate, 3 parts of polyoxyethylene lauryl ether, 10 parts of a self-made antibacterial agent and 110 parts of water.
The self-made antibacterial agent is prepared by the following method:
1) cleaning 12 parts of liquorice, 8 parts of dandelion, 9 parts of radix bupleuri, 8 parts of pine needle, 6 parts of aloe, 4 parts of phellodendron, 6 parts of honeysuckle and 7 parts of folium artemisiae argyi, drying in the sun, then crushing, and drying in the sun through a 300-mesh net for later use.
2) Adding the product obtained in the step 1) into pure water, cooking for 0.7h at the cooking temperature of 95 ℃, filtering, and collecting filtrate.
3) Carrying out soxhlet extraction on the filter residue obtained in the step 2) by using an ethanol solution to obtain a soxhlet liquid, uniformly mixing the soxhlet liquid with the filtrate, and refrigerating for later use.
The preparation method comprises the following steps:
s1: weighing 1-propoxy-2-propanol, glutamyl-N-alkyl propane diamine, chlorobromoisocyanuric acid, sodium metasilicate, polyoxyethylene lauryl ether, a self-made antibacterial agent and water according to the proportion.
S2: uniformly mixing 1-propoxy-2-propanol, glutamyl-N-alkyl propane diamine, chlorobromoisocyanuric acid, sodium metasilicate, polyoxyethylene lauryl ether and water, heating to 65 ℃, and stirring for 3 hours.
S3: and adding the self-made antibacterial agent into a centrifuge tube, centrifuging, taking supernatant, adding the supernatant into the step S2, and continuously stirring for 0.7h to obtain the disinfectant.
Wherein the centrifugation rate is 12000r/min, and the centrifugation time is 12 min; the polyoxyethylene lauryl ether is selected from polyoxyethylene lauryl ether-7 (AEO-7).
Example 4
The preparation method of the disinfectant for the medical instruments comprises the following components in parts by weight: 9 parts of 1-propoxy-2-propanol, 5 parts of glutamyl-N-alkyl propane diamine, 5 parts of chlorobromoisocyanuric acid, 8 parts of sodium metasilicate, 4 parts of polyoxyethylene lauryl ether, 13 parts of a self-made antibacterial agent and 140 parts of water.
The self-made antibacterial agent is prepared by the following method:
1) washing 14 parts of liquorice, 9 parts of dandelion, 11 parts of radix bupleuri, 9 parts of pine needle, 7 parts of aloe, 3-6 parts of phellodendron, 8 parts of honeysuckle and 9 parts of folium artemisiae argyi, drying in the sun, crushing, and drying in the sun through a 350-mesh net for later use.
2) Adding the product obtained in the step 1) into pure water, cooking for 0.8h at the cooking temperature of 98 ℃, filtering and collecting filtrate.
3) Carrying out soxhlet extraction on the filter residue obtained in the step 2) by using an ethanol solution to obtain a soxhlet liquid, uniformly mixing the soxhlet liquid with the filtrate, and refrigerating for later use.
The preparation method comprises the following steps:
s1: weighing 1-propoxy-2-propanol, glutamyl-N-alkyl propane diamine, chlorobromoisocyanuric acid, sodium metasilicate, polyoxyethylene lauryl ether, a self-made antibacterial agent and water according to the proportion.
S2: uniformly mixing 1-propoxy-2-propanol, glutamyl-N-alkyl propane diamine, chlorobromoisocyanuric acid, sodium metasilicate, polyoxyethylene lauryl ether and water, heating to 60-70 ℃, and stirring for 2-4 hours.
S3: and adding the self-made antibacterial agent into a centrifugal tube, centrifuging, taking supernatant, adding the supernatant into the step S2, and continuously stirring for 0.5-1 h to obtain the disinfectant.
Wherein the centrifugation rate is 14000r/min, and the centrifugation time is 15 min; the polyoxyethylene lauryl ether is selected from polyoxyethylene lauryl ether-7 (AEO-7).
The disinfectant prepared in examples 1 to 4 was used to test the disinfection effect on the skin disinfection surface according to the method of the 2002 edition "disinfection technical Specification" of Ministry of health, the disinfectant was used to act on Escherichia coli and Staphylococcus aureus for 2 minutes, and Candida albicans and Aspergillus niger for 10 minutes, and the disinfectant was placed in a constant temperature oven at 54 ℃ for 15 days to observe the change of the disinfection effect, the results are shown in Table 1,
table 1. test results:
as can be seen from Table 1, the disinfecting solutions prepared in examples 1 to 4 have broad-spectrum antibacterial and disinfecting effects, and at the same time, have excellent antibacterial effects.
Claims (4)
1. The preparation method of the disinfectant for the medical instruments is characterized by comprising the following components in parts by weight: 4-10 parts of 1-propoxy-2-propanol, 1.2-6 parts of glutamyl-N-alkyl propane diamine, 2-6 parts of chlorobromoisocyanuric acid, 3-9 parts of sodium metasilicate, 1.5-5 parts of polyoxyethylene lauryl ether, 8-15 parts of a self-made antibacterial agent and 90-150 parts of water;
the self-made antibacterial agent is prepared by the following method:
1) cleaning liquorice, dandelion, radix bupleuri, pine needle, aloe, phellodendron, honeysuckle and folium artemisiae argyi, drying in the sun, then crushing, and screening with a 200-400-mesh screen for later use;
2) adding the product obtained in the step 1) into pure water, cooking for 0.5-1 h at the cooking temperature of 90-100 ℃, filtering, and collecting filtrate;
3) carrying out soxhlet extraction on the filter residue obtained in the step 2) by using an ethanol solution to obtain a soxhlet liquid, uniformly mixing the soxhlet liquid with the filtrate, and refrigerating for later use;
the preparation method comprises the following steps:
s1: weighing 1-propoxy-2-propanol, glutamyl-N-alkyl propane diamine, chlorobromoisocyanuric acid, sodium metasilicate, polyoxyethylene lauryl ether, a self-made antibacterial agent and water according to the proportion;
s2: uniformly mixing 1-propoxy-2-propanol, glutamyl-N-alkyl propane diamine, chlorobromoisocyanuric acid, sodium metasilicate, polyoxyethylene lauryl ether and water, heating to 60-70 ℃, and stirring for 2-4 hours;
s3: and adding the self-made antibacterial agent into a centrifugal tube, centrifuging, taking supernatant, adding the supernatant into the step S2, and continuously stirring for 0.5-1 h to obtain the disinfectant.
2. The preparation method of the disinfectant for medical instruments according to claim 1, wherein the self-made antibacterial agent comprises the following components in parts by weight: 10-15 parts of liquorice, 6-10 parts of dandelion, 7-12 parts of radix bupleuri, 6-10 parts of pine needles, 5-8 parts of aloe, 3-6 parts of golden cypress, 4-9 parts of honeysuckle and 5-10 parts of folium artemisiae argyi.
3. The method of claim 1, wherein the centrifugation rate is 10000-15000 r/min, and the centrifugation time is 10-16 min.
4. The method as claimed in claim 1, wherein the polyoxyethylene lauryl ether is selected from polyoxyethylene lauryl ether-7 (AEO-7).
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