CN113507962A - Mt1-mmp特异性的双环肽配体 - Google Patents

Mt1-mmp特异性的双环肽配体 Download PDF

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Publication number
CN113507962A
CN113507962A CN201980090137.1A CN201980090137A CN113507962A CN 113507962 A CN113507962 A CN 113507962A CN 201980090137 A CN201980090137 A CN 201980090137A CN 113507962 A CN113507962 A CN 113507962A
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cys
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Pending
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CN201980090137.1A
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English (en)
Chinese (zh)
Inventor
L·陈
E·理查兹
R·拉尼
G·马德
C·斯泰斯
D·托伊费尔
E·沃克
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BicycleTx Ltd
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BicycleTx Ltd
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Priority claimed from GBGB1820286.1A external-priority patent/GB201820286D0/en
Priority claimed from GBGB1906534.1A external-priority patent/GB201906534D0/en
Application filed by BicycleTx Ltd filed Critical BicycleTx Ltd
Publication of CN113507962A publication Critical patent/CN113507962A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201980090137.1A 2018-12-13 2019-12-13 Mt1-mmp特异性的双环肽配体 Pending CN113507962A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1820286.1 2018-12-13
GBGB1820286.1A GB201820286D0 (en) 2018-12-13 2018-12-13 Bicyclic peptide ligands specific for mt1-mmp
GBGB1906534.1A GB201906534D0 (en) 2019-05-09 2019-05-09 Bicycle peptide ligands specific for MT1-MMP
GB1906534.1 2019-05-09
PCT/GB2019/053540 WO2020120984A1 (en) 2018-12-13 2019-12-13 Bicyclic peptide ligands specific for mt1-mmp

Publications (1)

Publication Number Publication Date
CN113507962A true CN113507962A (zh) 2021-10-15

Family

ID=68988066

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980090137.1A Pending CN113507962A (zh) 2018-12-13 2019-12-13 Mt1-mmp特异性的双环肽配体

Country Status (12)

Country Link
US (1) US20220024982A1 (https=)
EP (1) EP3894010A1 (https=)
JP (2) JP2022513806A (https=)
KR (1) KR20210123295A (https=)
CN (1) CN113507962A (https=)
AU (2) AU2019398516B2 (https=)
BR (1) BR112021011340A2 (https=)
CA (1) CA3122669A1 (https=)
IL (2) IL326448A (https=)
MX (1) MX2021006991A (https=)
SG (1) SG11202106081YA (https=)
WO (1) WO2020120984A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023088236A1 (zh) * 2021-11-16 2023-05-25 海思科医药集团股份有限公司 Mt1-mmp的双环肽配体及其缀合物

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107148425B (zh) 2014-10-29 2021-08-03 拜斯科阿迪有限公司 对mt1-mmp特异性的双环肽配体
WO2018115203A1 (en) 2016-12-23 2018-06-28 Bicyclerd Limited Peptide derivatives having novel linkage structures
EP3645549A1 (en) 2017-06-26 2020-05-06 BicycleRD Limited Bicyclic peptide ligands with detectable moieties and uses thereof
JP7670481B2 (ja) 2017-08-04 2025-04-30 バイスクルテクス・リミテッド Ｃｄ１３７に対して特異的な二環式ペプチドリガンド
TWI825046B (zh) 2017-12-19 2023-12-11 英商拜西可泰克斯有限公司 Epha2特用之雙環胜肽配位基
CN111902429A (zh) 2018-02-23 2020-11-06 拜斯科技术开发有限公司 多聚体双环肽配体
IL279489B2 (en) 2018-06-22 2025-10-01 Bicycletx Ltd Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate
GB201820288D0 (en) * 2018-12-13 2019-01-30 Bicycle Tx Ltd Bicycle peptide ligaands specific for MT1-MMP
GB201820325D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for psma
GB201820295D0 (en) * 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for MT1-MMP
WO2020128527A1 (en) 2018-12-21 2020-06-25 Bicyclerd Limited Bicyclic peptide ligands specific for pd-l1
US12492224B2 (en) 2018-12-21 2025-12-09 Bicycletx Limited Bicyclic peptide ligands specific for PD-L1
GB201900529D0 (en) 2019-01-15 2019-03-06 Bicycletx Ltd Bicyclic peptide ligands specific for CD38
TWI860386B (zh) 2019-07-30 2024-11-01 英商拜西可泰克斯有限公司 異質雙環肽複合物
AU2021322934A1 (en) 2020-08-03 2023-03-30 Bicycletx Limited Peptide-based linkers
AU2022206577A1 (en) * 2021-01-08 2023-08-24 Bicycletx Limited Heterotandem bicyclic peptide complexes
MX2024003876A (es) * 2021-09-29 2024-04-19 Conjustar Zhuhai Biologics Co Ltd Conjugado farmaco-polipeptido triciclico y sus aplicaciones.

Citations (6)

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Publication number Priority date Publication date Assignee Title
CN102405060A (zh) * 2009-02-04 2012-04-04 医疗研究局 多特异性肽
WO2013142229A1 (en) * 2012-03-19 2013-09-26 President And Fellows Of Harvard College Designing novel peptides for inducing fibronectin matrix assembly
WO2016067035A1 (en) * 2014-10-29 2016-05-06 Bicycle Therapeutics Limited Bicyclic peptide ligands specific for mt1-mmp
GB201713560D0 (en) * 2017-08-23 2017-10-04 Bicycle Therapeutics Ltd Peptide ligands for binding to Mt1-Mmp
WO2018127699A1 (en) * 2017-01-06 2018-07-12 Bicyclerd Limited Compounds for treating cancer
US20180311300A1 (en) * 2017-04-27 2018-11-01 Bicycletx Limited Bicyclic peptide ligands and uses thereof

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EP1452868A2 (en) 2003-02-27 2004-09-01 Pepscan Systems B.V. Method for selecting a candidate drug compound
WO2006078161A1 (en) 2005-01-24 2006-07-27 Pepscan Systems B.V. Binding compounds, immunogenic compounds and peptidomimetics
EP2653545A1 (en) 2008-02-05 2013-10-23 Bicycle Therapeutics Limited Methods and compositions
GB201306623D0 (en) * 2013-04-11 2013-05-29 Bicycle Therapeutics Ltd Modulation of structured polypeptide specificity
GB201600911D0 (en) * 2016-01-18 2016-03-02 Bicycle Therapeutics Ltd Stabilized peptide derivatives
GB201607827D0 (en) * 2016-05-04 2016-06-15 Bicycle Therapeutics Ltd Bicyclic peptide-toxin conjugates specific for MT1-MMP
US20190389907A1 (en) * 2016-12-23 2019-12-26 Bicycletx Limited Peptide ligands for binding to mt1-mmp

Patent Citations (8)

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Publication number Priority date Publication date Assignee Title
CN102405060A (zh) * 2009-02-04 2012-04-04 医疗研究局 多特异性肽
WO2013142229A1 (en) * 2012-03-19 2013-09-26 President And Fellows Of Harvard College Designing novel peptides for inducing fibronectin matrix assembly
WO2016067035A1 (en) * 2014-10-29 2016-05-06 Bicycle Therapeutics Limited Bicyclic peptide ligands specific for mt1-mmp
CN107148425A (zh) * 2014-10-29 2017-09-08 拜斯科医疗有限公司 对mt1‑mmp特异性的双环肽配体
WO2018127699A1 (en) * 2017-01-06 2018-07-12 Bicyclerd Limited Compounds for treating cancer
US20180200378A1 (en) * 2017-01-06 2018-07-19 Bicycle Therapeutics Limited Compounds for treating cancer
US20180311300A1 (en) * 2017-04-27 2018-11-01 Bicycletx Limited Bicyclic peptide ligands and uses thereof
GB201713560D0 (en) * 2017-08-23 2017-10-04 Bicycle Therapeutics Ltd Peptide ligands for binding to Mt1-Mmp

Non-Patent Citations (2)

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ENKHZAYA DAVAA等: "MT1-MMP Responsive Doxorubicin Conjugated Poly(lactic-co-glycolic Acid)/Poly(styrene-alt-maleic Anhydride) Core/Shell Microparticles for Intrahepatic Arterial Chemotherapy of Hepatic Cancer", ACS APPL MATER INTERFACES, vol. 9, no. 1, 22 November 2016 (2016-11-22), pages 71 - 79 *
胡晓慧, 阮长耿: "MT1-MMP在肿瘤血管新生中的作用", 国外医学.生理.病理科学与临床分册, vol. 24, no. 04, 30 August 2004 (2004-08-30), pages 311 - 312 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023088236A1 (zh) * 2021-11-16 2023-05-25 海思科医药集团股份有限公司 Mt1-mmp的双环肽配体及其缀合物

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Publication number Publication date
AU2019398516B2 (en) 2025-09-04
IL283873B1 (en) 2026-03-01
IL326448A (en) 2026-04-01
WO2020120984A1 (en) 2020-06-18
US20220024982A1 (en) 2022-01-27
KR20210123295A (ko) 2021-10-13
MX2021006991A (es) 2021-10-13
JP2024119862A (ja) 2024-09-03
CA3122669A1 (en) 2020-06-18
JP2022513806A (ja) 2022-02-09
BR112021011340A2 (pt) 2021-09-08
AU2019398516A1 (en) 2021-08-05
EP3894010A1 (en) 2021-10-20
SG11202106081YA (en) 2021-07-29
IL283873A (en) 2021-07-29
AU2025271131A1 (en) 2025-12-18

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