CN113499364A - Preparation process of cortex magnoliae officinalis with ginger - Google Patents
Preparation process of cortex magnoliae officinalis with ginger Download PDFInfo
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Abstract
The application relates to the field of traditional Chinese medicine processing, and particularly discloses a preparation process of ginger-magnolia officinalis. The preparation process of the ginger magnolia officinalis comprises the following steps: s1, cleaning: selecting cortex Magnolia officinalis, removing impurities, scraping off coarse bark, and cleaning; s2, preparing fresh ginger decoction: slicing fresh ginger 10-15% of cortex Magnolia officinalis, placing into a non-woven bag, sealing, adding water 9-10 times of fresh ginger, and decocting for 2-3 hr to obtain fresh ginger decoction; s3, cooking: placing cortex Magnolia officinalis in fresh rhizoma Zingiberis recens decoction, and decocting until fresh rhizoma Zingiberis recens decoction is absorbed completely, wherein the fresh rhizoma Zingiberis recens decoction is 80-90% of cortex Magnolia officinalis by mass; s4, shredding and drying: cooling the decocted cortex Magnolia officinalis to room temperature, cutting into filaments, drying until the water content is less than or equal to 10%, sieving, and packaging. The preparation process of the ginger magnolia officinalis has the advantages that the prepared ginger magnolia officinalis is neat in sheet shape, not easy to break, high in finished product yield, time-saving and labor-saving, high in effective component content and frost yield, small in friability and long in quality guarantee period.
Description
Technical Field
The application relates to the technical field of traditional Chinese medicine processing, in particular to a preparation process of ginger-magnolia officinalis.
Background
The magnolia officinalis is dried, dry, root bark and branch bark of magnolia officinalis or magnolia biloba of Magnoliaceae, has the effects of drying dampness, diminishing inflammation, descending qi and eliminating fullness, is spicy when used as raw magnolia officinalis, has the side effect of 'thorn person throat and tongue', is less used clinically, and is considered by traditional Chinese medicine to be used clinically to reduce the stimulation to throat after being processed by ginger and enhance the effects of warming the middle-jiao and harmonizing the stomach, so the ginger product is commonly used clinically.
The processing technique of the magnolia officinalis processed by the ginger is different, and the method of ' removing the coarse skin, cutting into shreds, stirring with ginger juice, moistening until the ginger juice is absorbed completely, and parching to dry with slow fire ' in the ' Chinese pharmacopoeia of 2005 edition and ' national Chinese herbal medicine processing standard ' records.
In the prior art, a processing method of magnolia officinalis with ginger is disclosed in a Chinese invention patent document with application number of CN201610096047.1, and is characterized by comprising the following steps: (1) cleaning: weighing a certain weight of fresh magnolia officinalis, removing impurities, removing rough bark on the fresh bark, and cleaning; (2) de-enzyming: putting the cleaned cortex magnoliae officinalis into a steamer, heating in water bath, steaming with steam, turning over the cortex magnoliae officinalis from time to time in the steaming process to ensure that the cortex magnoliae officinalis is evenly steamed and cooked, and taking out after the cortex magnoliae officinalis is steamed to be soft; (3) sweating: pressing the mangnolia officinalis into a plate while the mangnolia officinalis is hot, wrapping the plate with a preservative film, sealing the plate, placing the plate in a wooden barrel, covering wet straws, sealing the plate to generate sweat, taking out the plate after the color of the plate is completely changed, cutting the plate into 2-3 mm filaments, and airing the filaments for later use; (4) preparing ginger juice: weighing a certain weight of ginger, cleaning, crushing, adding distilled water with the weight 1-2 times that of the ginger, squeezing to collect ginger juice, adding distilled water with the weight 2-3 times that of the ginger into ginger residues, squeezing again, filtering, and combining the two ginger juice for later use; (5) preparing ginger magnolia officinalis: adding prepared ginger juice into cortex Magnolia officinalis, stirring, moistening overnight, heating with slow fire, adding moistened cortex Magnolia officinalis, parching, heating with strong fire until the ginger juice is absorbed completely, parching until the surface of cortex Magnolia officinalis turns brown, taking out, pouring into a jar, sealing, standing overnight, taking out, and air drying.
In the related technology, the inventor thinks that the magnolia officinalis is steamed and de-enzymed, sweated while hot and moistened, and the ingredients are inevitably lost again, so that the quality of the magnolia officinalis is reduced, and unnecessary resource waste, energy waste and manpower and material waste are increased.
Disclosure of Invention
In order to improve the elution amount of the effective components of the magnolia officinalis and save manpower and material resources, the application provides a preparation process of the magnolia officinalis.
In a first aspect, the application provides a preparation process of magnolia officinalis, which adopts the following technical scheme:
a preparation process of magnolia officinalis with ginger comprises the following steps:
s1, cleaning: selecting cortex Magnolia officinalis, removing impurities, scraping off coarse bark, and cleaning;
s2, preparing fresh ginger decoction: slicing fresh ginger 10-15% of cortex Magnolia officinalis, placing into a non-woven bag, sealing, adding water 9-10 times of fresh ginger, and decocting for 2-3 hr to obtain fresh ginger decoction;
s3, cooking: placing cortex Magnolia officinalis in fresh rhizoma Zingiberis recens decoction, and decocting until fresh rhizoma Zingiberis recens decoction is absorbed completely, wherein the fresh rhizoma Zingiberis recens decoction is 80-90% of cortex Magnolia officinalis by mass;
s4, shredding and drying: cooling the decocted cortex Magnolia officinalis to room temperature, cutting into filaments, drying until the water content is less than or equal to 10%, sieving, and packaging.
By adopting the technical scheme, the mangnolia officinalis is directly boiled by using the fresh ginger decoction, so that the moistening steps are reduced, the resources such as manpower and material resources are saved, the problem that the effective components such as magnolol are lost after the medicinal materials are contacted with water for a long time is solved, the mangnolia officinalis fully absorbs the fresh ginger decoction, the mangnolia officinalis is cut after being uniformly softened, the residues are not easy to fall during cutting, the slicing is tidy, the loss of the raw materials is reduced, and the yield and the quality of the mangnolia officinalis product are improved.
Preferably, in the step S4, a solar drying room or oven is used for drying, the material spreading thickness is 3-5cm, and the drying temperature is less than or equal to 80 ℃.
By adopting the technical scheme, the solar drying room or the drying oven is adopted for drying, the drying temperature is less than or equal to 80 ℃, the drying efficiency is high, and the operation is easy.
Preferably, in the step S4, the cut thin threads of the cortex magnoliae officinalis are 4-8mm in size.
By adopting the technical scheme, the 4-8mm thin thread can increase the decoction rate of magnolol and honokiol in the water decoction of the magnolia officinalis, and the thin thread of the magnolia officinalis is neat in sheet shape and not easy to break, so that the yield is increased.
Preferably, in step S3, before decocting, kudzu root juice and agaricus blazei murill juice are added to the fresh ginger decoction, wherein the kudzu root juice is added in an amount of 20-30% by weight of the fresh ginger decoction, and the agaricus blazei murill juice is added in an amount of 10-20% by weight of the fresh ginger decoction.
By adopting the technical scheme, because the ginger magnolia bark has large brittleness and short plastic deformation area, the capacity of absorbing stress before damage is small, and the ginger magnolia bark is easy to damage in the processes of transportation, pharmacy grabbing, weighing and the like, the agaricus blazei murill juice and the kudzuvine root juice are added into the fresh ginger decoction, the kudzuvine root contains kudzuvine root fibers and dietary fibers, the agaricus blazei murill contains abundant dietary fibers, and the agaricus blazei murill juice and the kudzuvine root juice are mixed into the fresh ginger decoction and are absorbed by the magnolia bark during boiling, so that the toughness of the ginger magnolia bark is increased, and the friability is reduced.
The pueraria polysaccharide in the pueraria juice has a strong inhibition effect on bacillus subtilis, escherichia coli and the like, the agaricus blazei murill has a certain inhibition effect on bacteria and fungi, the bacteria are remarkably inhibited, especially staphylococcus aureus and escherichia coli, and mould is also strongly inhibited, and the pueraria juice and the agaricus blazei murill juice are used as natural preservatives, so that the shelf life of the magnolia officinalis with ginger can be prolonged; in addition, the kudzu root has the effects of clearing away heat and toxic materials, relieving spasm and easing pain, and the agaricus blazei contains agaricus blazei polysaccharide, so that the agaricus blazei has an anticancer effect and also has the effects of enhancing the immunity of a human body and the like, thereby improving the anti-inflammatory and analgesic effects of the magnolia officinalis.
Preferably, the kudzuvine root juice is prepared by the following method: taking cleaned, peeled, crushed and sieved kudzu root, adding water with the weight of 4-6 times of that of the kudzu root, soaking for 6-8h, grinding the kudzu root mixed solution by using a colloid mill, heating to 50-55 ℃, adding amylase with the amount of 0.2-0.8 wt% of the kudzu root, adjusting the pH value to 5.5-6.5, preserving heat, stirring for 0.5-1.5h, and filtering.
By adopting the technical scheme, the kudzuvine root contains a large amount of starch, amylase is used for hydrolyzing the starch in the kudzuvine root into maltose and glucose, and after drying, the effective components in the kudzuvine root form white cream on the surface of the magnolia officinalis, so that the cream yield is increased, and the anti-inflammatory and analgesic effects of the magnolia officinalis are improved.
Preferably, the amylase is alpha-amylase and beta-amylase, and the mass ratio of the alpha-amylase to the beta-amylase is 1: 1-1.5.
By adopting the technical scheme, two different amylases are used, so that the starch in the kudzuvine root juice is completely hydrolyzed, the polysaccharide content in the kudzuvine root is increased, and the frost yield of the surface of the ginger magnolia officinalis is improved.
Preferably, the agaricus blazei murill juice is prepared by the following method: cleaning Agaricus blazei Murill, cutting, adding 6-7 times of water, decocting at 80-90 deg.C for 30-40min, filtering, vacuum concentrating at 50-55 deg.C under 0.1-0.3MPa to obtain solid content of 40-50%, adding 50-60 wt% of Tremella polysaccharide, and mixing to obtain Agaricus blazei Murill juice.
Through adopting above-mentioned technical scheme, behind the agaricus blazei vacuum concentration, can increase dietary fiber's in the agaricus blazei, and do not influence the taste of agaricus blazei, and tremella polysaccharide has the film forming ability, after boiling, by the absorption inside the ginger magnolia officinalis, after drying, form the network of mutual cross-linking inside the ginger magnolia officinalis, increase toughness, simultaneously by the cladding on the ginger magnolia officinalis surface, increase the content of polysaccharide in the agaricus blazei juice, thereby make the agaricus blazei juice of cladding ginger magnolia officinalis surface have the frost effect, and the coating can reduce the friability of ginger magnolia officinalis at the tremella polysaccharide film on ginger magnolia officinalis surface, prevent the breakage, reduce the loss.
Preferably, in the step S4, before drying, a film-forming solution is uniformly sprayed on the magnolia officinalis filaments, the amount of the film-forming solution is 30-50% of the mass of the magnolia officinalis filaments, and the film-forming solution comprises the following components: 2-3 parts of corydalis tuber extract, 1-2 parts of gelatin, 2-3 parts of glycerol and 5-7 parts of water.
By adopting the technical scheme, the corydalis tuber can release high-viscosity substances such as volatile oil, sugar and the like, a cutin-shaped protective film is formed after drying, the toughness of the magnolia officinalis containing ginger can be improved, the gelatin is used as a strong protective colloid and has strong emulsifying power, the glycerol is used as a plasticizer and improves the toughness of the gelatin, and the corydalis tuber contains medium-grade glycoside substances such as saponin, anthraquinone glycoside and other compounds and has an obvious inhibiting effect on staphylococcus aureus, so that the antibacterial performance of the magnolia officinalis containing ginger is further enhanced, and the shelf life is prolonged.
Preferably, the film forming solution also comprises a water chestnut peel extract and a liquorice extract, wherein the using amount of the water chestnut peel extract is 0.8-1.2 parts by weight, and the using amount of the liquorice extract is 0.6-1 part by weight.
By adopting the technical scheme, the liquorice extract contains the triterpenoid and flavonoid mixture, has obvious bacteriostatic action on escherichia coli, staphylococcus aureus, bacillus subtilis, pseudomonas aeruginosa and the like, the chufa peel extract has inhibitory action on escherichia coli, staphylococcus aureus, aspergillus niger, penicillium and the like, and the liquorice extract and the chufa peel extract are added into the film forming solution, so that a protective film formed by the film forming solution on the surface of the magnolia officinalis can prevent the breeding of mold, reduce the adhesion among the magnolia officinalis, further improve the antibacterial effect of the magnolia officinalis and prolong the quality guarantee period of the magnolia officinalis.
Preferably, the preparation method of the deposition solution is as follows: mixing gelatin, glycerol and water, stirring, standing in 45-55 deg.C water bath for swelling for 20-30min, adding rhizoma corydalis extract, Glycyrrhrizae radix extract and corm Eleocharitis peel extract, homogenizing, and defoaming.
By adopting the technical scheme, the gelatin and the glycerol are dissolved in the water, and the gelatin is mixed with the plant extract and defoamed after being fully swelled, so that the protective film formed on the surface of the cortex magnoliae officinalis is compact, and the antibacterial property and the friability of the cortex magnoliae officinalis are obviously improved.
In summary, the present application has the following beneficial effects:
1. because the process of the application firstly uses the decoction of the fresh ginger to boil the magnolia officinalis, then cuts and dries the magnolia officinalis, the magnolia officinalis absorbing the decoction of the fresh ginger is fully softened, the fragments are few during cutting, the slices are neat, the yield is higher, and the stuffy moistening process is not adopted, so that the manpower and material resources are saved, the loss of magnolol and honokiol in the magnolia officinalis is reduced, and the content of total phenol in the magnolia officinalis is increased.
2. In the application, the kudzu root juice and the agaricus blazei murill juice are preferably added into the fresh ginger decoction, because the kudzu root contains the kudzu root fiber, and the agaricus blazei murill is rich in the dietary fiber and absorbed by the officinal magnolia bark, the toughness of the ginger officinal magnolia bark can be enhanced, the friability of the ginger officinal magnolia bark can be reduced, the ginger officinal magnolia bark is not easy to break in the processes of storage, grabbing, weighing and the like, the kudzu root juice and the agaricus blazei murill juice have the effects of easing pain, resisting inflammation and sterilizing, the storage stability of the ginger officinal magnolia bark can be enhanced, the shelf life can be prolonged, the anti-inflammatory and analgesic effects of the ginger officinal magnolia bark can be further enhanced,
3. starch in the root of kudzu vine juice is decomposed into polysaccharide by using amylase when the root of kudzu vine juice is prepared, and tremella polysaccharide is added when the agaricus blazei juice is prepared, so that the root of kudzu vine juice and the agaricus blazei juice absorbed into the magnolia officinalis are rich in polysaccharide, and the polysaccharide permeates to the surface of the ginger magnolia officinalis to form white cream, the cream yield of the ginger magnolia officinalis is increased, and the analgesic and anti-inflammatory effects of the ginger magnolia officinalis are further enhanced.
4. According to the process, the membrane forming solution prepared from the corydalis tuber extract, the gelatin, the glycerol and the water is preferably sprayed on the surface of the magnolia officinalis filaments, the corydalis tuber extract and the gelatin can form a protective membrane on the surface of the magnolia officinalis filaments after gelatinization, so that the toughness of the magnolia officinalis can be increased, the antibacterial property of the magnolia officinalis can be improved, and the frost yield of the magnolia officinalis can be increased.
5. In the application, the liquorice extract and the water chestnut peel extract are preferably added into the film forming solution, have strong bactericidal effect, can prevent ginger magnolia officinalis from generating mould and the like, prolong the shelf life of the ginger magnolia officinalis, and can increase the toughness of the ginger magnolia officinalis, reduce the friability and reduce the loss.
Detailed Description
The sources of the raw materials in the following preparation examples are shown in table 1, but not limited thereto.
TABLE 1 sources of the respective raw materials in the preparation examples
| Name of raw materials | Manufacturer of the product | Model number | Specification of |
| Alpha-amylase | Sian Baiste Biotechnology Ltd | BH0735 | 4000u/g |
| Beta-amylase | Cangzhou midsummer enzyme biotechnology limited | FDY-2218 | 70 ten thousand u/g |
| Tremella polysaccharide | Shaanxi Zhou Biotechnology Co Ltd | LZ02-YEDT | Water solubility |
| Gelatin | Kaitan Biotechnology (Guangzhou) Ltd | 120LBB | Food grade |
| Rhizoma corydalis extract | Xian Bainiankang Biotechnology Co., Ltd | BNK001 | 10:1（%） |
| Glycyrrhiza extract | Xianfeida Biotechnology Ltd | FDBL-218 | 10:1（%） |
| Eleochairis Toberosa peel extract | Xianguohao Biotechnology Co Ltd | BJP-001 | 10:1（%） |
Preparation examples 1 to 5 of Kudzuvine root juice
Preparation example 1: 1000g of cleaned, peeled, crushed and sieved kudzu root is taken, water with the weight 4 times that of the kudzu root is added into the kudzu root for soaking for 6 hours, the kudzu root mixed solution is ground by a colloid mill, the clearance between a stator and a rotor of the colloid mill is 0.3um, and the flow rate of the colloid mill is 0.4 ton/h.
Preparation example 2: 1000g of cleaned, peeled, crushed and sieved kudzu root is taken, water with the weight being 4 times that of the kudzu root is added, the kudzu root is soaked for 6 hours, kudzu root mixed solution is ground by a colloid mill, the temperature is raised to 50 ℃, 2g of amylase is added, the pH value is adjusted to 5.5, the temperature is kept and the stirring is carried out for 0.5 hour, the filtration is carried out, the amylase is alpha-amylase and beta-amylase, the mass ratio of the alpha-amylase to the beta-amylase is 1:1, the gap between a stator and a rotor of the colloid mill is 0.3um, and the flow rate of the colloid mill is 0.4 ton/hour.
Preparation example 3: 1000g of cleaned, peeled, crushed and sieved kudzu root is taken, water with the weight 5 times that of the kudzu root is added, the kudzu root is soaked for 7 hours, kudzu root mixed solution is ground by a colloid mill, the temperature is raised to 55 ℃, 5g of amylase is added, the pH value is adjusted to 6, the temperature is kept and the stirring is carried out for 1 hour, the filtration is carried out, the amylase is alpha-amylase and beta-amylase, the mass ratio of the alpha-amylase to the beta-amylase is 1:1.3, the gap between a stator and a rotor of the colloid mill is 0.3um, and the flow rate of the colloid mill is 0.4 ton/hour.
Preparation example 4: 1000g of cleaned, peeled, crushed and sieved kudzu root is taken, water with the weight being 6 times that of the kudzu root is added, the kudzu root is soaked for 8 hours, kudzu root mixed solution is ground by a colloid mill, the temperature is raised to 55 ℃, 8g of amylase is added, the pH value is adjusted to 6.5, the temperature is kept and the stirring is carried out for 1.5 hours, the filtration is carried out, the amylase is alpha-amylase and beta-amylase, the mass ratio of the alpha-amylase to the beta-amylase is 1:1.5, the gap between a stator and a rotor of the colloid mill is 0.3um, and the flow rate of the colloid mill is 0.4 ton/hour.
Preparation example 5: the difference from preparation example 1 is that an equivalent amount of alpha-amylase was used instead of beta-amylase.
Preparation examples 6 to 9 of Agaricus blazei Murill juice
Preparation example 6: cleaning Agaricus blazei Murill 1000g, cutting, adding 6 times of water, decocting at 80 deg.C for 40min, filtering, vacuum concentrating at 0.1MPa and 50 deg.C, and concentrating to solid content of 40% to obtain Agaricus blazei Murill juice.
Preparation example 7: cleaning 1000g Agaricus blazei Murill, cutting, adding 6 times of water, decocting at 80 deg.C for 40min, filtering, vacuum concentrating at 0.1MPa and 50 deg.C until the solid content is 40%, adding 500g Tremella polysaccharide, and mixing to obtain Agaricus blazei Murill juice.
Preparation example 8: cleaning 1000g Agaricus blazei Murill, cutting, adding 6.5 times of water, decocting at 85 deg.C for 35min, filtering, vacuum concentrating at 0.2MPa and 55 deg.C until the solid content is 45%, and mixing with 550kg Tremella polysaccharide to obtain Agaricus blazei Murill juice.
Preparation example 9: cleaning 1000g Agaricus blazei Murill, cutting, adding 7 times of water, decocting at 90 deg.C for 30min, filtering, vacuum concentrating at 0.3MPa and 55 deg.C until the solid content is 50%, and mixing with 600kg of Tremella polysaccharide to obtain Agaricus blazei Murill juice.
Preparation examples 10 to 15 of deposition solutions
Preparation example 10: mixing 2kg gelatin, 2kg glycerol and 5kg water, stirring, standing in 45 deg.C water bath for swelling for 30min, adding 2kg rhizoma corydalis extract, homogenizing and defoaming under the homogenizing pressure of 10MPa at 45 deg.C for 15min, and defoaming with ultrasonic at 45 deg.C and 40kHz for 10 min.
Preparation example 11: mixing 2.5kg gelatin, 2.5kg glycerol and 6kg water, stirring, standing in 50 deg.C water bath for swelling for 25min, adding 2.5kg rhizoma corydalis extract, homogenizing and defoaming at 50 deg.C and 50 MPa for 10min, and defoaming with ultrasonic at 50 deg.C and 45kHz for 15 min.
Preparation example 12: mixing 3kg gelatin, 3kg glycerol and 7kg water, stirring, standing in 55 deg.C water bath for swelling for 20min, adding 3kg rhizoma corydalis extract, homogenizing and defoaming at 55 deg.C under 25MPa for 13min, and defoaming with ultrasonic at 50 deg.C and 43kHz for 20 min.
Preparation example 13: the difference from preparation example 1 is that 0.6kg of licorice extract and 0.8kg of chufa peel extract were added together with the corydalis tuber extract before homogenization.
Preparation example 14: the difference from preparation example 1 is that 0.8kg of licorice extract and 1kg of chufa peel extract were added together with the corydalis tuber extract before homogenization.
Preparation example 15: the difference from preparation example 1 is that 1kg of licorice extract and 1.2kg of chufa peel extract were added together with the corydalis tuber extract before homogenization.
Examples
Example 1: a preparation process of magnolia officinalis with ginger comprises the following steps:
s1, cleaning: selecting cortex Magnolia officinalis, removing impurities, scraping off coarse bark, and cleaning;
s2, preparing fresh ginger decoction: weighing 10kg of fresh ginger, cutting into slices of 2mm, placing into a non-woven fabric bag, fastening and sealing the non-woven fabric bag, adding 100kg of water, and decocting for 2h to obtain fresh ginger decoction;
s3, cooking: placing 100kg of cortex Magnolia officinalis in fresh rhizoma Zingiberis recens decoction, and decocting until the fresh rhizoma Zingiberis recens decoction is absorbed completely, wherein the fresh rhizoma Zingiberis recens decoction has a mass of 80 kg;
s4, shredding and drying: cooling the decocted cortex Magnolia officinalis to room temperature, cutting into filaments with specification of 4mm, drying in solar drying room at 80 deg.C until water content is 9%, sieving, and packaging.
Example 2: a preparation process of magnolia officinalis with ginger comprises the following steps:
s1, cleaning: selecting cortex Magnolia officinalis, removing impurities, scraping off coarse bark, and cleaning;
s2, preparing fresh ginger decoction: weighing 15kg of fresh ginger, cutting into 4mm slices, placing into a non-woven fabric bag, fastening and sealing the non-woven fabric bag, adding 135kg of water, and decocting for 3h to obtain fresh ginger decoction;
s3, cooking: placing 100kg of cortex Magnolia officinalis in fresh rhizoma Zingiberis recens decoction, and decocting until the fresh rhizoma Zingiberis recens decoction is absorbed completely, wherein the fresh rhizoma Zingiberis recens decoction has a mass of 80 kg;
s4, shredding and drying: cooling the decocted cortex Magnolia officinalis to room temperature, cutting into filaments with a filament specification of 6mm, drying in oven at 70 deg.C until the water content is 10%, sieving, and packaging.
Example 3: a preparation process of magnolia officinalis with ginger comprises the following steps:
s1, cleaning: selecting cortex Magnolia officinalis, removing impurities, scraping off coarse bark, and cleaning;
s2, preparing fresh ginger decoction: weighing 13kg of fresh ginger, cutting into 3mm slices, placing into a non-woven fabric bag, fastening and sealing the non-woven fabric bag, adding 123.5kg of water, and decocting for 2h to obtain fresh ginger decoction;
s3, cooking: placing 100kg of cortex Magnolia officinalis in fresh rhizoma Zingiberis recens decoction, and decocting until the fresh rhizoma Zingiberis recens decoction is absorbed completely, wherein the fresh rhizoma Zingiberis recens decoction has a mass of 80 kg;
s4, shredding and drying: cooling the decocted cortex Magnolia officinalis to room temperature, cutting into filaments with specification of 8mm, drying in solar drying room at drying temperature of 75 deg.C and spreading thickness of 4mm, drying to water content of 8%, screening, and packaging.
Example 4: the preparation process of the ginger officinal magnolia, which is different from the embodiment 1, is characterized in that in the step S3, the mass of the fresh ginger decoction is 85 kg.
Example 5: the preparation process of the ginger-magnolia officinalis is different from the embodiment 1 in that in the step S3, the mass of the fresh ginger decoction is 90 kg.
Example 6: a preparation process of Magnolia officinalis with ginger, which is different from example 5, comprises the step of adding kudzu root juice and Agaricus blazei Murill juice into the decoction of fresh ginger before decocting in step S3, wherein the addition amount of kudzu root juice is 16kg, the use amount of Agaricus blazei Murill juice is 8kg, the kudzu root juice is prepared according to preparation example 1, and the Agaricus blazei Murill juice is prepared according to preparation example 6.
Example 7: a preparation process of Magnolia officinalis with ginger, as distinguished from example 5, comprises adding kudzu root juice and Agaricus blazei Murill juice 20kg, 12kg, in step S3, before decocting, wherein the kudzu root juice is prepared according to preparation 2, and the Agaricus blazei Murill juice is prepared according to preparation 6.
Example 8: a preparation process of Magnolia officinalis with ginger, as distinguished from example 5, comprises adding radix Puerariae juice and Agaricus blazei Murill juice to fresh ginger decoction in step S3, wherein radix Puerariae juice is added in an amount of 24kg, Agaricus blazei Murill juice is added in an amount of 16kg, radix Puerariae juice is prepared according to preparation example 3, and Agaricus blazei Murill juice is prepared according to preparation example 6.
Examples 9 to 13: a preparation process of cortex Magnolia officinalis with ginger is different from example 5 in the selection of radix Puerariae juice and Agaricus blazei Murr juice, and is shown in Table 2.
TABLE 2 selection of preparation examples of Kudzuvine root juice and Agaricus blazei Murill juice in preparation examples 6-13
| Examples | Preparation example of Kudzuvine root juice | Preparation example of Agaricus blazei Murill juice |
| Example 6 | Preparation example 1 | Preparation example 6 |
| Example 7 | Preparation example 2 | Preparation example 6 |
| Example 8 | Preparation example 3 | Preparation example 6 |
| Example 9 | Preparation example 4 | Preparation example 6 |
| Example 10 | Preparation example 5 | Preparation example 6 |
| Example 11 | Preparation example 2 | Preparation example 7 |
| Example 12 | Preparation example 2 | Preparation example 8 |
| Example 13 | Preparation example 2 | Preparation example 9 |
Example 14: the preparation process of the magnolia officinalis, which is different from the embodiment 11, is that in the step S4, before the magnolia officinalis filaments are dried, the magnolia officinalis filaments are uniformly sprayed with a film-forming solution, the film-forming solution is prepared by the preparation example 10, and the spraying amount of the film-forming solution is 30% of the mass of the magnolia officinalis filaments.
Example 15: the preparation process of the magnolia officinalis, which is different from the embodiment 11, is that in the step S4, before the magnolia officinalis filaments are dried, the magnolia officinalis filaments are uniformly sprayed with a film-forming solution, the film-forming solution is prepared by the embodiment 11, and the spraying amount of the film-forming solution is 40% of the mass of the magnolia officinalis filaments.
Example 16: a process for preparing magnolia cortex, as distinguished from example 11, wherein in step S4, before the magnolia cortex filaments are dried, a film-forming solution is uniformly sprayed onto the magnolia cortex filaments, the film-forming solution is prepared by preparation example 12, and the spraying amount of the film-forming solution is 50% of the mass of the magnolia cortex filaments.
Example 17: a process for preparing magnolia cortex, as distinguished from example 11, wherein in step S4, before the magnolia cortex filaments are dried, a film-forming solution is uniformly sprayed onto the magnolia cortex filaments, the film-forming solution is prepared by preparation example 13, and the spraying amount of the film-forming solution is 30% of the mass of the magnolia cortex filaments.
Example 18: a process for preparing magnolia cortex, as distinguished from example 11, wherein in step S4, before the magnolia cortex filaments are dried, a film-forming solution is uniformly sprayed onto the magnolia cortex filaments, the film-forming solution is prepared according to preparation example 14, and the spraying amount of the film-forming solution is 30% of the mass of the magnolia cortex filaments.
Example 19: a process for preparing magnolia cortex, as distinguished from example 11, wherein in step S4, before the magnolia cortex filaments are dried, a film-forming solution is uniformly sprayed onto the magnolia cortex filaments, the film-forming solution is prepared by preparation example 15, and the spraying amount of the film-forming solution is 30% of the mass of the magnolia cortex filaments.
Comparative example
Comparative example 1: the preparation process of the magnolia officinalis with ginger is different from the example 1 in that the dosage of the fresh ginger in the step S2 is 5 percent of that of the magnolia officinalis.
Comparative example 2: the preparation process of the magnolia officinalis with ginger is different from the example 1 in that the dosage of the fresh ginger in the step S2 is 20% of that of the magnolia officinalis.
Comparative example 3: the preparation process of the magnolia officinalis with ginger is different from the embodiment 1 in that the mass of the fresh ginger decoction in the step S3 is 70% of the mass of the magnolia officinalis.
Comparative example 4: the preparation process of the magnolia officinalis with ginger is different from the embodiment 1 in that the mass ratio of the fresh ginger decoction to the magnolia officinalis in the step S3 is 1:1.
Comparative example 5: a preparation process of magnolia officinalis with ginger comprises the following steps:
s1, cleaning: selecting cortex Magnolia officinalis, removing impurities, scraping off coarse bark, and cleaning;
s2, moistening: soaking cortex Magnolia officinalis in water for softening, and cutting into 4mm filaments;
s3, drying: drying the fine magnolia officinalis filaments in an oven at 50 ℃ for 1.5 h;
s5, cooking: decocting 6kg fresh rhizoma Zingiberis recens with 10 times of water for 2 times (1 hr each time), mixing decoctions, filtering to obtain rhizoma Zingiberis recens decoction, adding 40L rhizoma Zingiberis recens decoction into 60kg cortex Magnolia officinalis, and decocting until the decoction is absorbed completely;
s6, drying: drying the shredded magnolia officinalis in an oven at 70 ℃, spreading to the thickness of 5mm, drying until the water content is 10%, screening and packaging.
Comparative example 6: a processing method of traditional Chinese medicine magnolia officinalis with ginger comprises the following specific process steps:
cleaning cortex Magnolia officinalis, scraping off coarse bark, cleaning, softening at room temperature, cutting into 1cm long shreds, drying in 60 deg.C oven for 1 hr to obtain cortex Magnolia officinalis raw product, and placing in container;
squeezing 50g of rhizoma Zingiberis recens into juice, adding water to obtain 200g of succus Zingiberis recens mixed solution, pouring into 500g of cortex Magnolia officinalis crude product, moistening for 60min until succus Zingiberis recens is fully absorbed by cortex Magnolia officinalis;
placing the ginger juice mangnolia officinalis in a microwave oven, carrying out microwave for 20min at the power of 550W, taking out, and cooling to obtain the traditional Chinese medicine processed ginger mangnolia officinalis product.
Comparative example 7: a processing technology of magnolia officinalis by ginger steaming comprises the following steps:
(1) preparing ginger juice, namely taking 1kg of ginger, cleaning and mashing the ginger, adding 500mL of water to squeeze the juice, adding a proper amount of 500mL of water into ginger residues, repeatedly squeezing once, and combining the juice to obtain the ginger juice.
(2) Preparing a ginger magnolia bark sample, namely taking 10kg of magnolia bark, removing impurities, scraping off rough bark, cleaning, moistening, shredding, and drying in a hot air circulating oven at 80 ℃ for later use;
(3) adding shredded cortex Magnolia officinalis into succus Zingiberis recens, stirring thoroughly, soaking for 1 hr;
(4) after 3 hours in a steam box, a part of the sample was taken out, dried in an oven at 80 ℃ and cooled.
Performance test
Firstly, detecting the content of magnolol and honokiol in cortex magnoliae officinalis, and recording the detection result in table 3.
Measuring by high performance liquid chromatography (China pharmacopoeia 2020 edition general rule 0512).
Chromatographic conditions and system applicability test: octadecylsilane chemically bonded silica is used as filler, methanol-water (78: 22) is used as mobile phase, the detection wavelength is 294nm, and the number of theoretical plates is not less than 3800 calculated according to magnolol peak.
Preparation of control solutions: precisely weighing appropriate amount of magnolol and honokiol reference substance, and adding methanol to obtain solutions containing magnolol 40 μ g and honokiol 24 μ g per 1mL respectively.
Preparation of a test solution: taking 0.2g of the product powder (passing through a third sieve), precisely weighing, placing in a conical flask with a plug, precisely adding 25mL of methanol, shaking uniformly, sealing the plug, soaking for 24 hours, filtering, precisely measuring 5mL of the subsequent filtrate, placing in a 25mL measuring flask, adding methanol to the scale, and shaking uniformly to obtain the product.
The determination method comprises the following steps: precisely sucking 4 μ L of each of the two reference solutions and 3-5 μ L of the sample solution, injecting into a liquid chromatograph, and measuring.
TABLE 3 detection of magnolol and honokiol content in Magnolia cortex
| Sample (I) | Magnolol content/%) | Content of honokiol/%) | Magnolol, total amount of honokiol% |
| Example 1 | 1.82 | 1.56 | 3.38 |
| Example 2 | 1.95 | 1.62 | 3.47 |
| Example 3 | 1.86 | 1.66 | 3.52 |
| Example 4 | 1.98 | 1.8 | 3.78 |
| Example 5 | 1.94 | 1.68 | 3.62 |
| Example 6 | 1.98 | 1.67 | 3.65 |
| Example 7 | 1.97 | 1.79 | 3.76 |
| Example 8 | 1.99 | 1.7 | 3.69 |
| Example 9 | 1.91 | 1.79 | 3.70 |
| Example 10 | 1.89 | 1.72 | 3.61 |
| Example 11 | 1.89 | 1.75 | 3.64 |
| Example 12 | 1.88 | 1.67 | 3.65 |
| Example 13 | 1.97 | 1.76 | 3.73 |
| Example 14 | 1.89 | 1.77 | 3.66 |
| Example 15 | 1.86 | 1.79 | 3.65 |
| Example 16 | 1.99 | 1.72 | 3.71 |
| Example 17 | 1.86 | 1.78 | 3.64 |
| Example 18 | 1.86 | 1.79 | 3.65 |
| Example 19 | 1.96 | 1.72 | 3.68 |
| Comparative example 1 | 1.70 | 1.27 | 2.97 |
| Comparative example 2 | 1.88 | 1.43 | 3.31 |
| Comparative example 3 | 1.73 | 1.34 | 3.07 |
| Comparative example 4 | 1.89 | 1.45 | 3.34 |
| Comparative example 5 | 1.72 | 1.26 | 2.98 |
| Comparative example 6 | 1.70 | 1.21 | 2.91 |
| Comparative example 7 | 1.76 | 1.09 | 2.85 |
As can be seen from the data in Table 3, the sum of the contents of magnolol and honokiol in the ginger magnolia bark prepared by the method in the embodiments 1-3 of the application is 3.38-3.52%, while the use amount of the fresh ginger decoction in the embodiments 4-5 is increased, and the contents of magnolol and honokiol are increased.
The amounts of magnolol and honokiol used in examples 6-19 were not significantly changed from those used in examples 4-5.
The comparative examples 1 and 2 reduce and increase the amount of fresh ginger, respectively, compared to example 1, and the data in table 3 shows that the total phenolic content of the magnolia bark prepared in comparative examples 1 and 2 is lower.
Compared with example 1, comparative example 3 and comparative example 4 respectively reduce and increase the dosage of fresh ginger juice, and the magnolol and honokiol content of cortex Magnolia officinalis is reduced.
In comparative example 5, after moistening and slicing the magnolia officinalis, the magnolia officinalis is boiled, and the sum of the total amount of magnolol and honokiol in the prepared ginger magnolia officinalis is reduced.
In comparative example 6, the magnolia bark is moistened and softened, then cut into shreds, moistened by using ginger juice, and then dried by microwave, and the prepared ginger magnolia bark has larger loss of the sum of the contents of the effective components.
In comparative example 7, the magnolia bark is moistened, shredded and the ginger juice is moistened, so that the sum of the contents of magnolol and honokiol in the prepared ginger magnolia bark is reduced, and the loss of effective components is large.
Secondly, detecting the performance of the magnolia officinalis:
1. and (3) detecting yield after screening: the ginger magnolia bark was prepared according to the methods in examples and comparative examples, 2kg of ginger magnolia bark was selected, screened for 10min using a food-grade electromagnetic vibration screening machine with an amplitude of 0.5mm and a frequency of 3500 using a No. 4 mesh (250 ± 9.9 mesh), the mass of the ginger magnolia bark residue was weighed, the yield (%) = (2-residue mass)/2 × 100% was calculated according to the following formula, and the detection results were recorded in table 4.
2. And (3) detecting the friability: taking 10 ginger magnolia bark slices as a sample, using an FT-2000 friability detector, adjusting the rotating speed to (25 +/-1) r/min, detecting for 4min, namely the total number of times of rotation of the cylinder is 100 times, blowing off surface powder by using a blower, precisely weighing the detected ginger magnolia bark mass, calculating friability (%) = (the mass of the former 10 ginger magnolia bark to the mass of the latter 10 ginger magnolia bark to be detected)/the mass of the former 10 ginger magnolia bark to be 100% to be detected, and recording the detection result in a table 4.
3. And (3) frost yield detection: taking 10 ginger magnolia bark sample slices, placing the ginger magnolia bark sample slices in an environment with the temperature of 15 ℃ and the humidity of 50% for 5 days, detecting the percentage of the white cream on the surface of the ginger magnolia bark in the ginger magnolia bark surface, taking the percentage as the cream yield, and recording the detection result in the table 4.
4. Total number of colonies: the ginger magnolia bark product is placed in a constant temperature and humidity box with the temperature of 37 ℃ and the humidity of 75%, detection is carried out according to a microbial limit detection method in the version 2010 of Chinese pharmacopoeia after 3 months, and detection results are recorded in table 4.
TABLE 4 detection results of the Performance of Magnolia cortex with ginger
| Sample (I) | Screening yield (%) | Friability (%) | Percentage of frost formation (%) | Colony count (CFU/g) |
| Example 1 | 90.2 | 2.12 | 14.3 | 845 |
| Example 2 | 90.5 | 2.18 | 13.4 | 921 |
| Example 3 | 90.6 | 2.23 | 14.2 | 876 |
| Example 4 | 90.7 | 2.12 | 15.4 | 910 |
| Example 5 | 90.6 | 2.25 | 15.2 | 892 |
| Example 6 | 92.8 | 1.12 | 15.9 | 534 |
| Example 7 | 92.9 | 1.08 | 20.1 | 532 |
| Example 8 | 92.8 | 1.05 | 20.8 | 527 |
| Example 9 | 93.1 | 1.03 | 20.5 | 526 |
| Example 10 | 92.8 | 1.11 | 19.1 | 525 |
| Example 11 | 93.3 | 0.83 | 23.3 | 524 |
| Example 12 | 93.7 | 0.81 | 23.8 | 533 |
| Example 13 | 93.9 | 0.78 | 23.7 | 528 |
| Example 14 | 95.2 | 0.54 | 25.1 | 383 |
| Example 15 | 95.5 | 0.53 | 25.4 | 392 |
| Example 16 | 95.8 | 0.55 | 25.5 | 394 |
| Example 17 | 96.2 | 0.45 | 25.7 | 208 |
| Example 18 | 96.3 | 0.42 | 25.9 | 213 |
| Example 19 | 96.5 | 0.43 | 25.8 | 201 |
| Comparative example 1 | 90.2 | 2.13 | 13.2 | 946 |
| Comparative example 2 | 90.4 | 2.15 | 14.1 | 864 |
| Comparative example 3 | 88.6 | 2.24 | 13.8 | 975 |
| Comparative example 4 | 89.7 | 2.16 | 14.5 | 854 |
| Comparative example 5 | 86.5 | 2.21 | 14.3 | 946 |
| Comparative example 6 | 89.3 | 2.25 | 13.9 | 989 |
| Comparative example 7 | 87.1 | 2.16 | 13.2 | 965 |
As can be seen from the data in Table 4, the screening rate of the ginger-processed Magnolia officinalis prepared by the preparation method of examples 1-5 reaches above 90% after screening, which indicates that the ginger-processed Magnolia officinalis is not easily broken and has good sheet shape appearance after being sliced after being boiled with fresh ginger decoction; but the phenomenon of easy breaking still exists in the storage and transportation process, and the surface is not white and frosted enough.
In example 6, the pueraria root juice and the agaricus blazei murill juice are added into the fresh ginger decoction, so that the screening yield of the ginger magnolia bark is increased, the friability is increased, and the number of bacterial colonies is small, which indicates that the pueraria root juice and the agaricus blazei murill juice can increase the toughness of the finished ginger magnolia bark, so that the finished ginger magnolia bark is not easy to damage and the loss of the product is reduced during transportation and storage, and after an acceleration test, the total number of bacterial colonies is small, so that the storage stability of the ginger magnolia bark can be increased, and the shelf life of the ginger magnolia bark can be prolonged.
The difference between examples 7-9 and example 5 is that the pueraria lobata juice prepared in preparation examples 2-4 is used, and the data in table 4 show that the screening yield, friability and total number of colonies are not much different from those in example 6, but the frost yield is obviously increased, which indicates that the white frost on the surface of cortex magnoliae officinalis can be increased and the frost yield can be increased by performing enzymolysis on the pueraria lobata juice by using alpha-amylase and beta-amylase.
Example 10 is different from example 5 in that the pueraria lobata juice prepared in preparation example 5, in which alpha-amylase is used in its entirety, has a reduced blooming rate of the magnolia officinalis prepared in example 10 compared to examples 7 to 9.
Examples 11 to 13 in comparison with example 7, the agaricus blazei murrill juices prepared in preparation examples 7 to 9 were respectively used, and in comparison with the agaricus blazei murrill juice prepared in preparation example 6, tremella polysaccharides were added to the agaricus blazei murrill juices prepared in preparation examples 7 to 9, and ginger magnolia officinalis prepared in examples 11 to 13 was increased in screening yield, decreased in friability and increased in frost yield in comparison with example 7, but the total number of colonies was not changed much after the acceleration test.
Examples 14-16 in comparison with example 11, the deposition solutions prepared in preparation examples 10-12 were sprayed on the thin threads of Magnolia officinalis, and the data in Table 4 show that the Magnolia officinalis prepared in examples 14-16 has increased screening yield, decreased friability, and decreased total number of colonies, indicating that the deposition solution can reduce the friability of Magnolia officinalis, prevent it from breaking, improve its antibacterial properties, and prolong its storage period.
Examples 17 to 19 As compared with example 11, when the deposition solutions prepared in preparation examples 13 to 15 were spray-coated on the thin threads of Magnolia officinalis, the yield of Magnolia officinalis screened was increased, the friability was decreased, the number of colonies was decreased, the antibacterial property was increased, the friability was decreased, and the shelf life was extended, as compared with example 11, examples 17 to 19.
As can be seen from the test results in Table 4, the use amount of fresh ginger in comparative examples 1-3 has little influence on the screening yield, friability and the like of the ginger magnolia bark; in the comparative example 3, when the amount of the fresh ginger decoction is less, the mangnolia officinalis cannot be softened completely, and crumbs are easily generated during cutting; in the comparative example 4, the fresh ginger decoction is large in dosage, the fresh ginger decoction is easy to remain, and the mangnolia officinalis absorbs more fresh ginger decoction, is softer and is easy to generate crumbs during cutting.
In comparative example 5, after moistening and slicing cortex magnoliae officinalis, and then boiling, the yield of the prepared ginger cortex magnoliae officinalis is reduced after screening, which indicates that fragments are easy to generate after moistening and slicing.
In comparative example 6, the magnolia officinalis was moistened and softened and then shredded, moistened with ginger juice, and then microwave-dried, and the screened yield of the prepared magnolia officinalis was decreased, which indicates that the magnolia officinalis was cut into many pieces and irregular slices after moistened and softened.
In comparative example 7, the Magnolia officinalis was moistened, shredded and the ginger juice was moistened, and the screened Magnolia officinalis produced had a lower yield, indicating that the shredded Magnolia officinalis was brittle and easily broken.
Thirdly, anti-inflammatory analgesic effect: the detection is carried out by using a xylene induced mouse ear swelling test: selecting Kunming mice, selecting male, randomly dividing into 23 groups, each group containing 10 mice, namely example 1-19 groups, comparative example 1-3 groups and blank control group, performing intragastric administration once a day, performing intragastric administration with 0.4mL distilled water in the blank control group, the other groups are respectively given 0.4mL of the corresponding liquid medicine of each group, the concentration of the liquid medicine is adjusted according to the weight of the mouse, each kilogram of the mouse corresponds to 8g of the cortex magnoliae officinalis, after 7 days of administration, after 30 minutes of the last gavage, 20. mu.L of xylene-induced inflammation was applied to the right ear, 1 hour later, each group of mice was sacrificed, round ear pieces were punched out at the same positions of the left and right ears by a punch having a diameter of 8mm, weighed by an analytical balance, the difference in the left and right ear weights was used as the swelling degree, and the swelling inhibition ratio (%) = (average swelling degree of blank control group-average swelling degree of test group)/average swelling degree of blank control group × 100% was calculated, and the detection results were recorded in table 4.
TABLE 5 detection of anti-inflammatory and analgesic effects of Magnolia cortex
| Examples | Swelling degree (g) | Swelling inhibition ratio (%) | Examples | Swelling degree (g) | Swelling inhibition ratio (%) |
| Example 1 | 5.55 | 52.2 | Example 15 | 3.67 | 68.4 |
| Example 2 | 5.67 | 51.2 | Example 16 | 3.76 | 67.6 |
| Example 3 | 5.59 | 51.9 | Example 17 | 3.45 | 70.3 |
| Example 4 | 5.73 | 50.7 | Example 18 | 3.36 | 71.1 |
| Example 5 | 5.69 | 51.0 | Example 19 | 3.42 | 70.6 |
| Example 6 | 4.25 | 63.4 | Comparative example 1 | 6.15 | 47.1 |
| Example 7 | 4.21 | 63.8 | Comparative example 2 | 5.92 | 49.1 |
| Example 8 | 4.23 | 63.6 | Comparative example 3 | 6.84 | 41.1 |
| Example 9 | 4.25 | 63.4 | Comparative example 4 | 5.88 | 49.4 |
| Example 10 | 4.22 | 63.7 | Comparative example 1 | 6.54 | 43.7 |
| Example 11 | 4.25 | 63.4 | Comparative example 2 | 7.12 | 38.7 |
| Example 12 | 4.21 | 63.8 | Comparative example 3 | 6.81 | 41.4 |
| Example 13 | 4.23 | 63.6 | Control group | 11.62 | 0 |
| Example 14 | 3.85 | 66.9 | / | / | / |
As can be seen from the data in Table 5, the mouse auricle swelling caused by the gingered magnolia bark p-xylene prepared by the methods in examples 1-5 has obvious effect and high anti-inflammatory and analgesic effects, which indicates that the preparation method of the gingered magnolia bark in the application has an enhancement effect on the efficiency of the gingered magnolia bark.
In example 6, the kudzuvine root juice and the agaricus blazei murill juice are added into the fresh ginger decoction, compared with example 1, the swelling degree is remarkably reduced, and the swelling inhibition rate is remarkably increased, which shows that the analgesic and anti-inflammatory effects of the magnolia officinalis are further improved by adding the kudzuvine root juice and the agaricus blazei murill juice.
In contrast, in examples 7 to 10, the ginger-magnolia bark prepared in preparation examples 2 to 5 was used, and compared to example 6, the anti-inflammatory and analgesic effects of the ginger-magnolia bark were not significantly improved.
In examples 11 to 13, the agaricus blazei murill juice prepared in preparation examples 7 to 9 was used, and the anti-inflammatory and analgesic effects of magnolia cortex, ginger processed, were not much different from those of example 6.
Examples 14-16 compared to example 11, when the deposition solution was further applied to Magnolia officinalis, swelling of auricle of mice decreased, swelling inhibition rate increased, and anti-inflammatory and analgesic effects of Magnolia officinalis increased.
Examples 17 to 19 As compared with example 11, when the deposition solutions prepared in preparation examples 13 to 15 were sprayed on Magnolia officinalis of Zingiber officinale, respectively, the swelling degree of auricles of mice was decreased, the swelling inhibition rate was increased, and the anti-inflammatory and analgesic effects were enhanced as compared with example 14.
With reference to table 3, the magnolol and honokiol contents of magnolia officinalis in comparative examples 1-4 are reduced compared to example 1, the inhibitory effect on swelling of mouse pinna is reduced, and the anti-inflammatory analgesic effect is inferior to that of example 1.
The magnolol and honokiol contents of the cortex magnoliae officinalis in comparative examples 5-7 are reduced compared with that in example 1, and the data in table 5 show that the swelling degree is higher and the swelling inhibition rate is increased in comparative examples 5-7 compared with that in example 1, which indicates that the cortex magnoliae officinalis prepared by the method in comparative examples 5-7 has a lower anti-inflammatory and analgesic effect than the cortex magnoliae officinalis prepared in example 1.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (10)
1. The preparation process of the magnolia officinalis with ginger is characterized by comprising the following steps:
s1, cleaning: selecting cortex Magnolia officinalis, removing impurities, scraping off coarse bark, and cleaning;
s2, preparing fresh ginger decoction: slicing fresh ginger 10-15% of cortex Magnolia officinalis, placing into a non-woven bag, sealing, adding water 9-10 times of fresh ginger, and decocting for 2-3 hr to obtain fresh ginger decoction;
s3, cooking: placing cortex Magnolia officinalis in fresh rhizoma Zingiberis recens decoction, and decocting until fresh rhizoma Zingiberis recens decoction is absorbed completely, wherein the fresh rhizoma Zingiberis recens decoction is 80-90% of cortex Magnolia officinalis by mass;
s4, shredding and drying: cooling the decocted cortex Magnolia officinalis to room temperature, cutting into filaments, drying until the water content is less than or equal to 10%, sieving, and packaging.
2. The preparation process of cortex magnoliae officinalis with ginger according to claim 1, wherein in the step S4, a solar drying room or oven is adopted during drying, the spreading thickness of the material is 3-5cm, and the drying temperature is less than or equal to 80 ℃.
3. The process for preparing magnolia cortex as claimed in claim 1, wherein in step S4, the cut ginger magnolia cortex has a filament size of 4-8 mm.
4. The preparation process of magnolia cortex as claimed in claim 1, wherein, in step S3, before decocting, pueraria root juice and agaricus blazei murill juice are added to the decoction of fresh ginger, wherein the amount of pueraria root juice is 20-30% wt of the decoction of fresh ginger, and the amount of agaricus blazei murill juice is 10-20% wt of the decoction of fresh ginger.
5. The preparation process of cortex magnoliae officinalis as claimed in claim 4, wherein the radix puerariae juice is prepared by the following method: taking cleaned, peeled, crushed and sieved kudzu root, adding water with the weight of 4-6 times of that of the kudzu root, soaking for 6-8h, grinding the kudzu root mixed solution by using a colloid mill, heating to 50-55 ℃, adding amylase with the amount of 0.2-0.8 wt% of the kudzu root, adjusting the pH value to 5.5-6.5, preserving heat, stirring for 0.5-1.5h, and filtering.
6. The preparation process of cortex magnoliae officinalis as claimed in claim 5, wherein the amylase is alpha-amylase and beta-amylase, and the mass ratio of the alpha-amylase to the beta-amylase is 1: 1-1.5.
7. The preparation process of magnolia cortex as claimed in claim 4, wherein the agaricus blazei juice is prepared by the following method: cleaning Agaricus blazei Murill, cutting, adding 6-7 times of water, decocting at 80-90 deg.C for 30-40min, filtering, vacuum concentrating at 50-55 deg.C under 0.1-0.3MPa to obtain solid content of 40-50%, adding 50-60 wt% of Tremella polysaccharide, and mixing to obtain Agaricus blazei Murill juice.
8. The preparation process of cortex zingiberis officinalis according to claim 1, wherein in the step S4, before drying, a film forming solution is uniformly sprayed on the cortex zingiberis officinalis filaments, the amount of the film forming solution is 30-50% of the mass of the cortex zingiberis officinalis filaments, and the film forming solution comprises the following components: 2-3 parts of corydalis tuber extract, 1-2 parts of gelatin, 2-3 parts of glycerol and 5-7 parts of water.
9. The process for preparing magnolia cortex as claimed in claim 8, wherein the filming solution further comprises chufa peel extract and licorice extract, the chufa peel extract is used in an amount of 0.8 to 1.2 parts by weight, and the licorice extract is used in an amount of 0.6 to 1 part by weight.
10. The preparation process of cortex magnoliae officinalis according to claim 9, wherein the preparation method of the film-forming solution comprises the following steps: mixing gelatin, glycerol and water, stirring, standing in 45-55 deg.C water bath for swelling for 20-30min, adding rhizoma corydalis extract, Glycyrrhrizae radix extract and corm Eleocharitis peel extract, homogenizing, and defoaming.
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