CN113498860A - Abelmoschus manihot freeze-dried orally disintegrating tablet and preparation method thereof - Google Patents
Abelmoschus manihot freeze-dried orally disintegrating tablet and preparation method thereof Download PDFInfo
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- 235000001075 Abelmoschus manihot Nutrition 0.000 title claims abstract description 112
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses an abelmoschus manihot freeze-dried orally disintegrating tablet and a preparation method thereof, wherein the abelmoschus manihot freeze-dried orally disintegrating tablet comprises the following raw material components in parts by mass: 0.5-5 parts of gelatin, 5-10 parts of filling agent, 0.5-5 parts of abelmoschus manihot flower and 0.5-2 parts of flavoring agent. According to the technical scheme, the invention provides a sunflower flower abelmoschus flower product in the form of a tablet, the application range of the sunflower flower abelmoschus flower product is expanded, and the tablet is taken without water or chewing, is easy to eat by a user and has rich nutritional value; the mouth feel and the medicine taste of the freeze-dried abelmoschus manihot orally disintegrating tablet are better through the design of the addition amounts of gelatin, a filling agent, abelmoschus manihot powder and a flavoring agent.
Description
Technical Field
The invention relates to the technical field of health-care food, and in particular relates to an abelmoschus manihot freeze-dried orally disintegrating tablet and a preparation method thereof.
Background
The abelmoschus manihot is an annual herbaceous plant in okra of malvaceae, has rich contents of amino acid, total phenol, total flavone, selenium, iron and potassium elements in flowers, has stronger effects of resisting oxidation, aging and fatigue, enhancing immunity and the like, can be processed into powder and then directly eaten or used as a food additive, and has great development potential.
However, the currently marketed sunset abelmoschus flower products are generally in a relatively thick powder shape and have relatively poor mouthfeel when being directly taken; meanwhile, due to the characteristics that the abelmoschus manihot powder is not easy to dissolve in water and is sticky and conglobate after meeting water, if the abelmoschus manihot powder is taken with water, the abelmoschus manihot powder is very inconvenient to eat and has poor taste.
Disclosure of Invention
The invention mainly aims to provide an abelmoschus manihot freeze-dried orally disintegrating tablet and a preparation method thereof, and aims to provide the abelmoschus manihot freeze-dried orally disintegrating tablet which is rich in nutritional value and easy to eat.
In order to achieve the purpose, the invention provides an abelmoschus manihot freeze-dried orally disintegrating tablet which comprises the following raw material components in parts by mass:
0.5-5 parts of gelatin, 5-10 parts of filling agent, 0.5-5 parts of abelmoschus manihot and 0.5-2 parts of flavoring agent
Optionally, the filler comprises maltodextrin.
Optionally, the flavoring agent comprises steviol glycosides.
Further, the invention also provides a preparation method of the abelmoschus manihot freeze-dried orally disintegrating tablet, which comprises the following steps:
pulverizing flos Abelmoschi Manihot, and sieving to obtain flos Abelmoschi Manihot powder;
adding gelatin into pure water, heating and dissolving until the solution is clear and transparent to obtain a mixed solution;
cooling the mixed solution to room temperature, adding a filling agent, the abelmoschus manihot powder and a flavoring agent, and uniformly stirring to obtain a stock solution;
and (3) carrying out vacuum freeze drying on the stock solution to obtain the freeze-dried abelmoschus manihot orally disintegrating tablet.
Optionally, the step of pulverizing and sieving the abelmoschus manihot to obtain abelmoschus manihot powder comprises:
and the sieving is to sieve through a sieve of 100-150 meshes.
Optionally, the gelatin is added into pure water, and heated to be dissolved until the solution is clear and transparent, so as to obtain a mixed solution, wherein the step of:
the heating temperature is 50-70 ℃.
Optionally, the gelatin is added into pure water, and heated to be dissolved until the solution is clear and transparent, so as to obtain a mixed solution, wherein the step of:
the mass ratio of the gelatin to the pure water is (0.5-5): (80-94).
Optionally, the step of performing vacuum freeze-drying on the stock solution to obtain the freeze-dried orally disintegrating tablet of abelmoschus manihot comprises:
and (3) freezing the stock solution at-80 to-20 ℃ for 36 to 50 hours to enable the stock solution to form a solid intermediate, and drying the intermediate in a vacuum environment for 20 to 30 hours to obtain the freeze-dried orally disintegrating tablet of abelmoschus manihot.
In the technical scheme provided by the invention, the abelmoschus manihot freeze-dried orally disintegrating tablet comprises the following raw material components in parts by mass: the preparation method comprises the following steps of 0.5-5 parts of gelatin, 5-10 parts of filling agent, 0.5-5 parts of abelmoschus manihot flower and 0.5-2 parts of flavoring agent, and the abelmoschus manihot flower tablet is easy to eat and rich in nutritional value, and does not need water or chewing when taken.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other related drawings can be obtained according to the drawings without creative efforts.
Fig. 1 is a schematic flow diagram of an embodiment of a preparation method of a freeze-dried and orally disintegrating tablet of abelmoschus manihot according to the present invention.
The implementation, functional features and advantages of the objects of the present invention will be further explained with reference to the accompanying drawings.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
In addition, the meaning of "and/or" appearing throughout includes three juxtapositions, exemplified by "A and/or B" including either A or B or both A and B. In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The currently marketed sunset abelmoschus flower products are generally in a coarse powder shape and have poor mouthfeel when being directly taken; meanwhile, due to the characteristics that the abelmoschus manihot powder is not easy to dissolve in water and is sticky and conglobate after meeting water, if the abelmoschus manihot powder is taken with water, the abelmoschus manihot powder is very inconvenient to eat and has poor taste.
In view of the above, the invention provides an abelmoschus manihot freeze-dried orally disintegrating tablet, which comprises the following raw material components in parts by mass: 0.5-5 parts of gelatin, 5-10 parts of filling agent, 0.5-5 parts of abelmoschus manihot flower and 0.5-2 parts of flavoring agent.
Abelmoschus manihot flower is flower of Abelmoschus manihot of Malvaceae, contains abundant amino acids, total phenols, total flavonoids, iron and potassium elements, and has strong effects of resisting oxidation, aging, fatigue and immunity.
In this example, the flavoring agent is steviol glycoside. The taste of the abelmoschus manihot powder can be covered by adding stevioside, so that the taste of the abelmoschus manihot freeze-dried orally disintegrating tablet is improved, and the compliance of users is improved. In addition, the sweetness of the stevioside is 200-300 times that of the cane sugar, and the calorific value of the stevioside is only 1/300 of the cane sugar, so that the stevioside not only meets the requirement of common people on sweetness, but also is suitable for patients with diabetes and obesity to take, and better solves the problem of limited use of special people such as the patients with diabetes and obesity. It is apparent that the design of the present invention is not limited thereto, and the flavoring agent may further include any one or more of commonly used flavoring agents, such as orange flavor, peppermint oil, lemon, and the like.
The bulking agent is maltodextrin which can provide enough mechanical support for the freeze-dried orally disintegrating tablet of abelmoschus manihot, the appearance of the freeze-dried orally disintegrating tablet is improved, the phenomena of viscosity and easy moisture absorption of high-sugar-content materials in the freeze-drying process can be avoided, and the softening time of the freeze-dried orally disintegrating tablet product in the air is prolonged.
According to the technical scheme, the invention provides the sunflower flower abelmoschus flower product in the form of tablets, so that the application range of the sunflower flower abelmoschus flower product is widened, and the tablets are taken without water or chewing, are easy to eat by users and have rich nutritional value; meanwhile, the gelatin and the maltodextrin are water-soluble substances, so that the disintegration of the tablet can be accelerated; the abelmoschus manihot freeze-dried orally disintegrating tablet can improve the mouthfeel and is suitable for patients with diabetes and obesity to take; through the design of the addition amounts of gelatin, maltodextrin, abelmoschus manihot powder and stevioside, the abelmoschus manihot freeze-dried orally disintegrating tablet has better taste and medicinal taste.
The currently developed sunset abelmoschus flower products have problems in the process, for example, hot air drying or microwave drying is generally adopted for drying the products, and the factors can influence the activity of phenolic substances and enzymes in the sunset abelmoschus flower, damage the structure and the function of the sunset abelmoschus flower and cause the reduction of the nutritional value of the sunset abelmoschus flower. Therefore, the present invention further provides a preparation method of the freeze-dried abelmoschus manihot orally disintegrating tablet, and fig. 1 is a schematic flow diagram of an embodiment of the preparation method of the freeze-dried abelmoschus manihot orally disintegrating tablet provided by the present invention.
Referring to fig. 1, in an embodiment, a preparation method of the lyophilized abelmoschus manihot orally disintegrating tablet includes the following steps:
step S10, drying the Abelmoschus manihot, crushing and sieving to obtain Abelmoschus manihot powder.
In order to better retain the nutritional ingredients in the flower of abelmoschus manihot, the flower of abelmoschus manihot is preferably dried in a natural air drying manner. It is understood that dried flower of abelmoschus manihot can also be purchased directly from the market, and then pulverized and sieved.
In an embodiment, the step of sieving after crushing is to sieve through a sieve of 100-150 meshes, that is, the crushed abelmoschus manihot can be sieved through a sieve of eight meshes, so that the particle size of the sieved abelmoschus manihot powder is 0.1-0.15 mm, and the prepared lyophilized abelmoschus manihot orally disintegrating tablet is fine in taste.
And step S20, adding gelatin into pure water, heating and dissolving until the solution is clear and transparent, and obtaining a mixed solution.
In order to make the prepared lyophilized abelmoschus manihot orally disintegrating tablet have good medicinal taste and mouthfeel, the gelatin is used as a binder, and the mass ratio of the gelatin to pure water is (0.5-5): (80-94), that is, it may be 0.5:80, 0.5:94, 1:85, 2:90, 3:92, 3.5:93, 4:94, 5:94, or the like. The heating and dissolving temperature is not limited in the invention, and the gelatin can be uniformly dispersed in pure water, and in the embodiment, the heating temperature is 50-70 ℃ in consideration of the cost and the time required for dissolving.
It should be understood that the present invention is not limited to the sequence of step S10 and step S20, and step S10 may be performed before step S20, or may be performed simultaneously.
And step S30, cooling the mixed solution to room temperature, adding a filling agent, the abelmoschus manihot powder and a flavoring agent, and uniformly stirring to obtain a stock solution.
In one embodiment, the mass ratio of the gelatin to the filler to the abelmoschus manihot powder to the flavoring agent is (0.5-5): (5-10): (0.5-5): (0.5 to 2), that is, it may be 0.5:5:0.5:0.5, 1:5:2.5:1, 1:6:2:1, 2:6:3:0.5, 3:10:5:1, 5:6:2:1, etc., preferably 1:5:2.5: 1.
And step S40, carrying out vacuum freeze drying on the stock solution to obtain the freeze-dried abelmoschus manihot orally disintegrating tablet.
In an embodiment, step S40 specifically includes: and (3) freezing the stock solution at-80 to-20 ℃ for 36 to 50 hours to enable the stock solution to form a solid intermediate, and drying the intermediate in a vacuum environment for 20 to 30 hours to obtain the freeze-dried orally disintegrating tablet of abelmoschus manihot. By selecting vacuum freeze drying technology and optimizing the freeze drying temperature and time, the active ingredients in the abelmoschus manihot can be effectively protected from being damaged, and the drug effect function of the abelmoschus manihot is retained to a greater extent.
In addition, the vacuum freeze-drying forms loose porous structures in the tablets, which facilitates the rapid penetration of moisture into the interior of the tablets, thereby facilitating the disintegration thereof in the oral cavity. Furthermore, the gelatin and the maltodextrin are both water-soluble substances, so that the disintegration of the tablet can be accelerated, and the disintegration time of the prepared tablet in the oral cavity is proper by designing the addition amount of the gelatin and the maltodextrin and the vacuum freeze-drying condition.
It can be understood that, in practical operation, the stock solution is generally dispensed into a freeze-drying mold, and then the freeze-drying mold is placed in a low-temperature environment for freezing and then vacuum drying, wherein the freeze-drying mold is made of food-grade silica gel.
The technical solutions of the present invention are further described in detail below with reference to specific examples and drawings, it should be understood that the following examples are merely illustrative of the present invention and are not intended to limit the present invention.
Example 1
The abelmoschus manihot freeze-dried orally disintegrating tablet comprises the following raw material components in parts by mass: 1 part of gelatin, 5 parts of maltodextrin, 2.5 parts of flower of abelmoschus manihot and 1 part of stevioside.
Example 2
The abelmoschus manihot freeze-dried orally disintegrating tablet comprises the following raw material components in parts by mass: 0.5 parts of gelatin, 6 parts of maltodextrin, 5 parts of flower of abelmoschus manihot and 0.5 parts of stevioside.
Example 3
The abelmoschus manihot freeze-dried orally disintegrating tablet comprises the following raw material components in parts by mass: 5 parts of gelatin, 10 parts of maltodextrin, 0.5 part of flower of abelmoschus manihot and 2 parts of stevioside.
Example 4
The abelmoschus manihot freeze-dried orally disintegrating tablet comprises the following raw material components in parts by mass: 2 parts of gelatin, 6 parts of maltodextrin, 3 parts of flower of abelmoschus manihot and 2 parts of stevioside.
Example 5
(1) The raw material components of the abelmoschus manihot freeze-dried orally disintegrating tablet are the same as those in example 1.
(2) Drying Abelmoschus manihot, pulverizing, and sieving with 110 mesh sieve to obtain Abelmoschus manihot powder.
(3) Adding gelatin into pure water, heating to 60 ℃ to dissolve the gelatin until the solution is clear and transparent, and obtaining a mixed solution, wherein the mass ratio of the gelatin to the pure water is 2: 82.
(4) And cooling the mixed solution to room temperature, adding maltodextrin, abelmoschus manihot powder and stevioside, and uniformly stirring to obtain a stock solution.
(5) And (3) subpackaging the stock solution into a silica gel mold, freezing the silica gel mold at-50 ℃ for 36h to enable the stock solution to form a solid intermediate, and drying the intermediate in a vacuum environment for 24h to obtain the freeze-dried orally disintegrating tablet of abelmoschus manihot.
Example 6
(1) The raw material components of the abelmoschus manihot freeze-dried orally disintegrating tablet are the same as those in the example 2.
(2) Drying Abelmoschus manihot, pulverizing, and sieving with 100 mesh sieve to obtain Abelmoschus manihot powder.
(3) Adding gelatin into pure water, heating to 50 ℃ to dissolve the gelatin until the solution is clear and transparent, and obtaining a mixed solution, wherein the mass ratio of the gelatin to the pure water is 0.5: 85.
(4) And cooling the mixed solution to room temperature, adding maltodextrin, abelmoschus manihot powder and stevioside, and uniformly stirring to obtain a stock solution.
(5) And (3) subpackaging the stock solution into a silica gel mold, freezing the silica gel mold at-20 ℃ for 48h to enable the stock solution to form a solid intermediate, and drying the intermediate in a vacuum environment for 20h to obtain the freeze-dried orally disintegrating tablet of abelmoschus manihot.
Example 7
(1) The raw material components of the abelmoschus manihot freeze-dried orally disintegrating tablet are the same as those in example 3.
(2) Drying Abelmoschus manihot, pulverizing, and sieving with 150 mesh sieve to obtain Abelmoschus manihot powder.
(3) Adding gelatin into pure water, heating to 65 ℃ to dissolve the gelatin until the solution is clear and transparent, and obtaining a mixed solution, wherein the mass ratio of the gelatin to the pure water is 1: 80.
(4) And cooling the mixed solution to room temperature, adding maltodextrin, abelmoschus manihot powder and stevioside, and uniformly stirring to obtain a stock solution.
(5) And (3) subpackaging the stock solution into a silica gel mold, freezing the silica gel mold at-80 ℃ for 24h to enable the stock solution to form a solid intermediate, and drying the intermediate in a vacuum environment for 26h to obtain the freeze-dried orally disintegrating tablet of abelmoschus manihot.
Example 8
(1) The raw material components of the abelmoschus manihot freeze-dried orally disintegrating tablet are the same as those in example 4.
(2) Drying Abelmoschus manihot, pulverizing, and sieving with 120 mesh sieve to obtain Abelmoschus manihot powder.
(3) Adding gelatin into pure water, heating to 70 ℃ to dissolve the gelatin until the solution is clear and transparent, and obtaining a mixed solution, wherein the mass ratio of the gelatin to the pure water is 5: 94.
(4) And cooling the mixed solution to room temperature, adding maltodextrin, abelmoschus manihot powder and stevioside, and uniformly stirring to obtain a stock solution, wherein the mass ratio of gelatin to maltodextrin to abelmoschus manihot powder to stevioside in the mixed solution is 2:6:3: 2.
(5) And (3) subpackaging the stock solution into a silica gel mold, freezing the silica gel mold at-50 ℃ for 32h to enable the stock solution to form a solid intermediate, and drying the intermediate in a vacuum environment for 30h to obtain the freeze-dried orally disintegrating tablet of abelmoschus manihot.
Comparative example 1
The procedure was the same as in example 1 except that the mass ratio of gelatin to pure water was changed to 0.2: 82.
Comparative example 2
The procedure of example 1 was repeated except that the vacuum freeze-drying of the stock solution was changed to hot air drying at 40 to 60 ℃.
Comparative example 3
The procedure was the same as in example 1 except that the raw material components (by mass) of the lyophilized abelmoschus manihot orally disintegrating tablet were modified to 0.1 part of gelatin, 5 parts of maltodextrin, 2 parts of okra flower, and 2 parts of stevioside.
Comparative example 4
The procedure was the same as in example 1 except that the raw material components (by mass) of the lyophilized abelmoschus manihot orally disintegrating tablet were modified to 0.5 parts of gelatin, 5 parts of maltodextrin, 2 parts of okra flower, and 3 parts of stevioside.
The examples and the prepared lyophilized oral disintegrating tablets of abelmoschus manihot were evaluated for satisfaction according to the satisfaction rating table shown in table 1 below.
TABLE 1 satisfaction score criteria
According to the satisfaction rating table shown in table 1, 50 volunteers of different sexes and ages were selected to score the lyophilized oral disintegrating tablets of abelmoschus manihot prepared in the examples and comparative examples, and the scoring results are shown in table 2.
TABLE 2 satisfaction score results
As can be seen from table 2, the total satisfaction score is 20, and the scores of the freeze-dried abelmoschus manihot orally disintegrating tablets prepared in the examples are all above 18, which indicates that the freeze-dried abelmoschus manihot orally disintegrating tablets provided by the invention have good taste, proper disintegration time and are easy to eat by users, while the scores of the freeze-dried abelmoschus manihot orally disintegrating tablets prepared in the comparative examples are low, which indicates that the gelatin, abelmoschus manihot powder, stevioside and maltodextrin provided by the invention are proper in addition amount, and the preparation steps and the working parameters are reasonable in setting.
The above is only a preferred embodiment of the present invention, and it is not intended to limit the scope of the invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention shall be included in the scope of the present invention.
Claims (8)
1. The freeze-dried orally disintegrating tablet of abelmoschus manihot is characterized by comprising the following raw material components in parts by mass:
0.5-5 parts of gelatin, 5-10 parts of filling agent, 0.5-5 parts of abelmoschus manihot flower and 0.5-2 parts of flavoring agent.
2. The lyophilized orally disintegrating tablet of abelmoschus manihot of claim 1, wherein said bulking agent comprises maltodextrin.
3. The lyophilized orally disintegrating tablet of abelmoschus manihot of claim 1, wherein said flavoring agent comprises steviol glycosides.
4. A method for preparing the lyophilized orally disintegrating tablet of abelmoschus manihot according to any one of claims 1 to 3, comprising the steps of:
drying Abelmoschus manihot, pulverizing, and sieving to obtain Abelmoschus manihot powder;
adding gelatin into pure water, heating and dissolving until the solution is clear and transparent to obtain a mixed solution;
cooling the mixed solution to room temperature, adding a filling agent, the abelmoschus manihot powder and a flavoring agent, and uniformly stirring to obtain a stock solution;
and (3) carrying out vacuum freeze drying on the stock solution to obtain the freeze-dried abelmoschus manihot orally disintegrating tablet.
5. The method for preparing the lyophilized Abelmoschus manihot orally disintegrating tablet of claim 4, wherein the step of drying Abelmoschus manihot, pulverizing and sieving to obtain Abelmoschus manihot powder comprises:
and the sieving is to sieve through a sieve of 100-150 meshes.
6. The method for preparing the lyophilized orally disintegrating tablet of abelmoschus manihot according to claim 4, wherein the step of adding gelatin into pure water, heating to dissolve until the solution is clear and transparent to obtain a mixed solution comprises:
the heating temperature is 50-70 ℃.
7. The method for preparing the lyophilized orally disintegrating tablet of abelmoschus manihot according to claim 4, wherein the step of adding gelatin into pure water, heating to dissolve until the solution is clear and transparent to obtain a mixed solution comprises:
the mass ratio of the gelatin to the pure water is (0.5-5): (80-94).
8. The method for preparing the lyophilized abelmoschus manihot orally disintegrating tablet of claim 4, wherein the step of vacuum freeze-drying the stock solution to obtain the lyophilized abelmoschus manihot orally disintegrating tablet comprises:
and (3) freezing the stock solution at-80 to-20 ℃ for 36 to 50 hours to enable the stock solution to form a solid intermediate, and drying the intermediate in a vacuum environment for 20 to 30 hours to obtain the freeze-dried orally disintegrating tablet of abelmoschus manihot.
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008136636A1 (en) * | 2007-05-08 | 2008-11-13 | Industry-Academic Cooperation Foundation Chosun University | Composition for fast disintegrating tablet containing herbal extract and its preparation method |
CN104352836A (en) * | 2014-10-15 | 2015-02-18 | 焦作市七月花生物科技有限公司 | Compound effervescent tablet containing abelmoschus manihot plant extract and having weight losing function |
CN107198080A (en) * | 2016-03-18 | 2017-09-26 | 陈夫 | A kind of medicinal and edible plant extract effervescent tablet and preparation method thereof |
CN107375358A (en) * | 2017-07-18 | 2017-11-24 | 江苏苏轩堂药业有限公司 | The direct oral traditional Chinese medicine medicine materical crude slice of Sunset Abelmoschus Root pollen |
-
2021
- 2021-06-28 CN CN202110722934.6A patent/CN113498860A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008136636A1 (en) * | 2007-05-08 | 2008-11-13 | Industry-Academic Cooperation Foundation Chosun University | Composition for fast disintegrating tablet containing herbal extract and its preparation method |
CN104352836A (en) * | 2014-10-15 | 2015-02-18 | 焦作市七月花生物科技有限公司 | Compound effervescent tablet containing abelmoschus manihot plant extract and having weight losing function |
CN107198080A (en) * | 2016-03-18 | 2017-09-26 | 陈夫 | A kind of medicinal and edible plant extract effervescent tablet and preparation method thereof |
CN107375358A (en) * | 2017-07-18 | 2017-11-24 | 江苏苏轩堂药业有限公司 | The direct oral traditional Chinese medicine medicine materical crude slice of Sunset Abelmoschus Root pollen |
Non-Patent Citations (3)
Title |
---|
王鑫 等: "红景天冻干口腔崩解片的制备", 临床医药文献电子杂志 * |
罗仁琪 等: "响应面优化黄蜀葵咀嚼片配方", 武汉轻工业大学学报 * |
闫淇雨 等: "黄蜀葵泡腾片制备工艺的研究", 食品研究与开发 * |
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