CN113473986B - 用于治疗皮肤疾病萘啶酮苯胺化合物 - Google Patents

用于治疗皮肤疾病萘啶酮苯胺化合物 Download PDF

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Publication number
CN113473986B
CN113473986B CN201980089587.9A CN201980089587A CN113473986B CN 113473986 B CN113473986 B CN 113473986B CN 201980089587 A CN201980089587 A CN 201980089587A CN 113473986 B CN113473986 B CN 113473986B
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alkyl
compounds
acid
compound
disease
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CN113473986A (zh
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J·金凯德
M·邓克顿
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Enfreixon Treatment Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201980089587.9A 2018-11-20 2019-11-20 用于治疗皮肤疾病萘啶酮苯胺化合物 Active CN113473986B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862769866P 2018-11-20 2018-11-20
US62/769,866 2018-11-20
PCT/US2019/000070 WO2020106308A1 (en) 2018-11-20 2019-11-20 Naphthyridinone-aniline compounds for treatment of dermal disorders

Publications (2)

Publication Number Publication Date
CN113473986A CN113473986A (zh) 2021-10-01
CN113473986B true CN113473986B (zh) 2024-10-11

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US (1) US12378240B2 (enExample)
EP (1) EP3883567B8 (enExample)
JP (1) JP7393808B2 (enExample)
CN (1) CN113473986B (enExample)
AU (1) AU2019384646B2 (enExample)
CA (1) CA3120337A1 (enExample)
MA (1) MA55144A (enExample)
WO (1) WO2020106308A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020106305A1 (en) 2018-11-20 2020-05-28 Nflection Therapeutics, Inc. Thienyl-aniline compounds for treatment of dermal disorders
EP3883552B1 (en) 2018-11-20 2025-04-09 NFlection Therapeutics, Inc. Cyanoaryl-aniline compounds for treatment of dermal disorders
CN113473986B (zh) 2018-11-20 2024-10-11 恩福莱克逊治疗有限公司 用于治疗皮肤疾病萘啶酮苯胺化合物
AU2022210443A1 (en) * 2021-01-21 2023-09-07 Nflection Therapeutics, Inc. Processes for preparing pyrrolopyridine-aniline compounds
JP7897341B2 (ja) * 2022-05-30 2026-07-29 賽諾哈勃薬業（成都）有限公司 色素沈着を改善する製品を製造するためのテトラヒドロナフチリジン誘導体の使用

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CN113473986A (zh) 2021-10-01
JP7393808B2 (ja) 2023-12-07
JP2022510587A (ja) 2022-01-27
WO2020106308A1 (en) 2020-05-28
EP3883567A1 (en) 2021-09-29
EP3883567B1 (en) 2025-05-28
AU2019384646A1 (en) 2021-06-17
CA3120337A1 (en) 2020-05-28
US20220144819A1 (en) 2022-05-12
EP3883567A4 (en) 2022-07-27
US12378240B2 (en) 2025-08-05
EP3883567B8 (en) 2025-07-02
AU2019384646B2 (en) 2025-09-18
MA55144A (fr) 2021-09-29

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