CN113454084A - 醛糖还原酶抑制剂的盐及其制备方法和应用 - Google Patents

醛糖还原酶抑制剂的盐及其制备方法和应用 Download PDF

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CN113454084A
CN113454084A CN202080017461.3A CN202080017461A CN113454084A CN 113454084 A CN113454084 A CN 113454084A CN 202080017461 A CN202080017461 A CN 202080017461A CN 113454084 A CN113454084 A CN 113454084A
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compound
formula
treating
sodium
soil
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CN113454084B (zh
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杨占坤
杨汉煜
李鹏飞
刘晓鹏
周彩虹
王军玲
李春娜
刘喜宝
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CSPC Zhongqi Pharmaceutical Technology Shijiazhuang Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Organic Chemistry (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

本发明提供式A‑N所示的醛糖还原酶抑制剂的盐。该盐可以制备成晶型，相对于式A化合物的溶解度有显著改善，且吸湿性小能够稳定存在，因此相对于式A化合物或其他盐更易于成药。
Figure 989224DEST_PATH_IMAGE001
A‑N

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN202080017461.3A 2019-02-28 2020-02-28 醛糖还原酶抑制剂的盐及其制备方法和应用 Active CN113454084B (zh)

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CN201910152719X 2019-02-28
CN201910152719 2019-02-28
PCT/CN2020/077233 WO2020173495A1 (zh) 2019-02-28 2020-02-28 醛糖还原酶抑制剂的盐及其制备方法和应用

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EP (1) EP3932921A4 (zh)
JP (1) JP7457033B2 (zh)
KR (1) KR20210133997A (zh)
CN (1) CN113454084B (zh)
AU (1) AU2020229932B2 (zh)
CA (1) CA3131792C (zh)
WO (1) WO2020173495A1 (zh)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103052637A (zh) * 2010-07-16 2013-04-17 纽约市哥伦比亚大学理事会 醛糖还原酶抑制剂及其用途
CN105121414A (zh) * 2013-01-16 2015-12-02 纽约市哥伦比亚大学理事会 醛糖还原酶抑制剂和其用途
WO2019023648A1 (en) * 2017-07-28 2019-01-31 Applied Therapeutics Inc. COMPOSITIONS AND METHODS FOR TREATING GALACTOSEMIA

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009019A1 (en) * 1989-12-15 1991-06-27 Pfizer Inc. Substituted oxophthalazinyl acetic acids and analogs thereof
WO2014126885A1 (en) * 2013-02-13 2014-08-21 Mylari Banavara L Water soluble salts of aldose reductase inhibitors for treatment of diabetic complications

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103052637A (zh) * 2010-07-16 2013-04-17 纽约市哥伦比亚大学理事会 醛糖还原酶抑制剂及其用途
CN105121414A (zh) * 2013-01-16 2015-12-02 纽约市哥伦比亚大学理事会 醛糖还原酶抑制剂和其用途
WO2019023648A1 (en) * 2017-07-28 2019-01-31 Applied Therapeutics Inc. COMPOSITIONS AND METHODS FOR TREATING GALACTOSEMIA

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CA3131792A1 (en) 2020-09-03
AU2020229932B2 (en) 2023-09-21
KR20210133997A (ko) 2021-11-08
EP3932921A4 (en) 2022-11-23
CA3131792C (en) 2024-04-16
CN113454084B (zh) 2023-08-29
EP3932921A1 (en) 2022-01-05
WO2020173495A1 (zh) 2020-09-03
JP2022534636A (ja) 2022-08-03
US20220127273A1 (en) 2022-04-28
JP7457033B2 (ja) 2024-03-27
AU2020229932A1 (en) 2021-09-23

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