CN113444584A - 固体酶清洗剂及其制备方法 - Google Patents
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Abstract
本发明属于医疗器械用助剂技术领域，具体涉及一种固体酶清洗剂及其制备方法。所述的固体酶清洗剂，由以下重量百分含量的原料组成：固体生物酶25‑35％，固体表面活性剂50‑60％，固体缓蚀剂5‑10％，造粒助剂1‑5％。本发明所述的固体酶清洗剂方便储运，手工清洗和机洗通用，原材料安全环保，易于降解；本发明同时提供了简单易行的制备方法。
Description
技术领域
本发明属于医疗器械用助剂技术领域，具体涉及一种固体酶清洗剂及其制备方法。
背景技术
随着医院消毒供应中心整体供应理念的推行，CSSD的规范性越来越强，医疗器械的清洗质量越来越受到重视。器械的清洗质量是器械消毒灭菌成功的前提条件。在实际临床使用中，医疗器械表面的常见污染物(如血液、体液、分泌物等)可通过多酶清洗剂清洗干净。
目前，医用使用的多酶清洗剂均为液体型清洗剂，液体型清洗剂具有扩散迅速均匀的优势，但普遍存在酶活性不稳定和加注量比较大的缺点，储运和使用成本高的问题。
基于以上情况，研发一种用于医疗器械的固体酶清洗剂，具有酶活性稳定，储运成本低使用方便的优势。
发明内容
本发明要解决的技术问题是：克服现有技术的不足，提供一种固体酶清洗剂，其原材料环保易得，对医疗器械常见污染物去除效果好，方便储运；本发明同时提供了简单易行的制备方法。
本发明所述的固体酶清洗剂，由以下重量百分含量的原料组成：
优选的，所述的固体酶清洗剂，由以下重量百分含量的原料组成：
优选的，所述的固体酶清洗剂，由以下重量百分含量的原料组成：
优选的，固体生物酶为固体蛋白酶、固体脂肪酶、固体淀粉酶或固体纤维素酶中的两种或多种。
优选的，固体表面活性剂为改性聚羧盐、脂肪醇聚氧乙烯醚或脂肪酸甲酯乙氧基化物中的一种或多种。
优选的，固体缓蚀剂为多元羧酸盐或苯并三氮唑中的一种或两种。
优选的，造粒助剂为丙二醇、丙三醇或酒精的一种或多种。
本发明所述的固体酶清洗剂的制备方法，将固体表面活性剂和固体缓蚀剂进行粉碎混匀，然后添加造粒助剂进行造粒和抛丸，干燥后获得粒径为0.5-1mm颗粒混合物，向颗粒混合物中加入固体生物酶混合40-80min后，即得固体酶清洗剂。
本发明所述的固体酶清洗剂的使用方法如下：供应室的清洗槽中放入常规用量的清洗用水，然后按照产品说明的比例加入固体酶清洗剂，轻微的搅拌混匀溶解后即可放入污染的器械进行浸泡手工清洗。同时固体酶清洗剂也可配套专门的注入设备自动加注到全自动清洗消毒器中，自动运行程序即可，操作方便运行简单。
与现有技术相比，本发明具有以下有益效果：
(1)所述的固体酶清洗剂，所使用原料环保，无刺激，对环境友好，易于降解。
(2)所述的固体酶清洗剂，方便储运，溶解迅速，酶活力稳定。
(3)所述的固体酶清洗剂，操作简便，供应室手工清洗和机洗均可使用。
(4)所述的固体酶清洗剂，用于去除器械表面的蛋白质、脂肪、淀粉等有机污染物，具有降低微生物负载量和去污的良好效果。
(5)本发明同时提供了简单易行的固体酶清洗剂的制备方法。
具体实施方式
下面结合实施例对本发明作进一步的说明，但其并不限制本发明的实施。
实施例1
所述的固体酶清洗剂，其各组分的质量百分组成为：
其中固体生物酶为蛋白酶(20％)、脂肪酶(5％)、淀粉酶(3％)和纤维素酶(2％)，固体表面活性剂为改性羧酸盐(35％)、脂肪醇聚氧乙烯醚(20％)，固体缓蚀剂为多元羧酸盐(7％)、苯并三氮唑(3％)，造粒助剂为丙二醇(5％)。
将固体表面活性剂和固体缓蚀剂进行粉碎混匀，然后加入助剂进行造粒和抛丸，烘干后获得直径为0.5-1mm大小的颗粒。最后将固体的生物酶按照蛋白酶、脂肪酶、淀粉酶、纤维素酶的顺序依次按照规定比例加入并充分混匀60min，即可制的固体酶清洗剂。
实施例2
所述的固体酶清洗剂，其各组分的质量百分组成为：
其中固体生物酶为蛋白酶(15％)、脂肪酶(5％)、淀粉酶(3％)和纤维素酶(2％)，固体表面活性剂为改性羧酸盐(35％)、脂肪酸甲酯乙氧基化物(25％)，固体缓蚀剂为多元羧酸盐(7％)、苯并三氮唑(3％)，造粒助剂为丙三醇(5％)。
将固体表面活性剂和固体缓蚀剂进行粉碎混匀，然后加入助剂进行造粒和抛丸，烘干后获得直径为0.5-1mm大小的颗粒。最后将固体的生物酶按照蛋白酶、脂肪酶、淀粉酶、纤维素酶的顺序依次按照规定比例加入并充分混匀60min，即可制的固体酶清洗剂。
实施例3
所述的固体酶清洗剂，其各组分的质量百分组成为：
其中固体生物酶为蛋白酶(25％)、脂肪酶(5％)、淀粉酶(3％)和纤维素酶(2％)，固体表面活性剂为改性羧酸盐(25％)、脂肪酸甲酯乙氧基化物(25％)，固体缓蚀剂为多元羧酸盐(8％)、苯并三氮唑(3％)，造粒助剂为酒精(4％)。
将固体表面活性剂和固体缓蚀剂进行粉碎混匀，然后加入助剂进行造粒和抛丸，烘干后获得直径为0.5-1mm大小的颗粒。最后将固体的生物酶按照蛋白酶、脂肪酶、淀粉酶、纤维素酶的顺序依次按照规定比例加入并充分混匀60min，即可制的固体酶清洗剂。
实施例4
所述的固体酶清洗剂，其各组分的质量百分组成为：
其中固体生物酶为蛋白酶(15％)、脂肪酶(5％)、淀粉酶(3％)和纤维素酶(2％)，固体表面活性剂为改性羧酸盐(60％)，固体缓蚀剂为多元羧酸盐(8％)、苯并三氮唑(2％)，助剂为酒精(5％)。
将固体表面活性剂和固体缓蚀剂进行粉碎混匀，然后加入助剂进行造粒和抛丸，烘干后获得直径为0.5-1mm大小的颗粒。最后将固体的生物酶按照蛋白酶、脂肪酶、淀粉酶、纤维素酶的顺序依次按照规定比例加入并充分混匀60min，即可制的固体酶清洗剂。
实施例5
所述的固体酶清洗剂，其各组分的质量百分组成为：
其中固体生物酶为蛋白酶(20％)、脂肪酶(5％)、淀粉酶(5％)，固体表面活性剂为改性羧酸盐(55％)，固体缓蚀剂为多元羧酸盐(8％)、苯并三氮唑(2％)，助剂为丙三醇(5％)。
将固体表面活性剂和固体缓蚀剂进行粉碎混匀，然后加入助剂进行造粒和抛丸，烘干后获得直径为0.5-1mm大小的颗粒。最后将固体的生物酶按照蛋白酶、脂肪酶、淀粉酶的顺序依次按照规定比例加入并充分混匀60min，即可制的固体酶清洗剂。
当然，上述内容仅为本发明的较佳实施例，不能被认为用于限定对本发明的实施例范围。本发明也并不仅限于上述举例，本技术领域的普通技术人员在本发明的实质范围内所做出的均等变化与改进等，均应归属于本发明的专利涵盖范围内。
Claims (10)
1.一种固体酶清洗剂，其特征在于：由以下重量百分含量的原料组成：
2.根据权利要求1所述的固体酶清洗剂，其特征在于：由以下重量百分含量的原料组成：
3.根据权利要求1所述的固体酶清洗剂，其特征在于：由以下重量百分含量的原料组成：
4.根据权利要求1所述的固体酶清洗剂，其特征在于：固体生物酶为固体蛋白酶、固体脂肪酶、固体淀粉酶或固体纤维素酶中的两种或多种。
5.根据权利要求1所述的固体酶清洗剂，其特征在于：固体表面活性剂为改性聚羧盐、脂肪醇聚氧乙烯醚或脂肪酸甲酯乙氧基化物中的一种或多种。
6.根据权利要求1所述的固体酶清洗剂，其特征在于：固体缓蚀剂为多元羧酸盐或苯并三氮唑中的一种或两种。
7.根据权利要求1所述的固体酶清洗剂，其特征在于：造粒助剂为丙二醇、丙三醇或酒精的一种或多种。
8.一种权利要求1-7任一所述的固体酶清洗剂的制备方法，其特征在于：将固体表面活性剂和固体缓蚀剂进行粉碎混匀，然后添加造粒助剂进行造粒和抛丸，干燥后获得颗粒混合物，向颗粒混合物中加入固体生物酶混合均匀后，即得固体酶清洗剂。
9.根据权利要求8所述的固体酶清洗剂的制备方法，其特征在于：颗粒混合物的粒径为0.5-1mm。
10.根据权利要求8所述的固体酶清洗剂的制备方法，其特征在于：向颗粒混合物中加入固体生物酶混合的时间为40-80min。
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