CN113440569A - Jiuwei Xiao soft capsule formula and preparation method thereof - Google Patents

Jiuwei Xiao soft capsule formula and preparation method thereof Download PDF

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Publication number
CN113440569A
CN113440569A CN202110742366.6A CN202110742366A CN113440569A CN 113440569 A CN113440569 A CN 113440569A CN 202110742366 A CN202110742366 A CN 202110742366A CN 113440569 A CN113440569 A CN 113440569A
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China
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jiuwei
xiao
preparation
formulation
soft
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CN202110742366.6A
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Inventor
涂毛毛
王楠
腾之杰
林欣钥
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Beijing Yikangyuan Pharmaceutical Technology Co ltd
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Beijing Yikangyuan Pharmaceutical Technology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/58Reptiles
    • A61K35/586Turtles; Tortoises, e.g. terrapins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/062Ascomycota
    • A61K36/066Clavicipitaceae
    • A61K36/068Cordyceps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/89Cyperaceae (Sedge family)
    • A61K36/8905Cyperus (flatsedge)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention provides a formulation of Jiuwei Xiao soft capsule and a preparation method thereof, wherein the formulation comprises the following raw materials: 317g of red paeony root, 211g of bitter orange, 158g of Chinese angelica, 106g of roasted turtle shell, 317g of Szechuan lovage rhizome, 211g of nutgrass galingale rhizome, 5.28g of Chinese caterpillar fungus, 106g of safflower and 158g of peach kernel; the method comprises the following steps: drying and crushing carapax Trionycis preparata and Cordyceps, and sieving with 50-100 mesh sieve; decocting the rest seven materials in water for 2 times, 2 hr for the first time and 2 hr for the second time, mixing decoctions, filtering, concentrating the filtrate into soft extract, mixing with appropriate amount of starch, granulating, and making into capsule with 1000 granules. The Jiuwei Xiao soft capsule formula and the preparation method thereof provided by the invention are pure traditional Chinese medicine raw materials, can well treat female venereal disease, and achieve good radical treatment effect.

Description

Jiuwei Xiao soft capsule formula and preparation method thereof
Technical Field
The invention relates to a traditional Chinese medicine formula, in particular to a formula of Jiuwei Xiao soft capsules and a preparation method thereof.
Background
The traditional Chinese medicine is a medicine which is obtained by guiding collection, processing and preparation by the traditional Chinese medicine theory, explaining the action mechanism and guiding clinical application. The Chinese medicine is mainly prepared from natural medicines and processed products thereof, including plant medicines, animal medicines, mineral medicines and partial chemical and biological products. Because the traditional Chinese medicines are mostly prepared from plant medicines, there is a saying that the medicines are prepared from herbs. The existing female diseases are shown in a plurality of girls, and the female diseases can be mostly relieved for a period of time through western medicine treatment, but the effect is not obvious in a long term.
Disclosure of Invention
The invention aims to solve the problems in the background art, and provides a formulation of Jiuwei Xiao soft capsules and a preparation method thereof.
In order to solve the technical problems, the technical scheme provided by the invention is as follows:
a formulation of Jiuwei Xiao soft capsule comprises the following raw materials: 317g of red peony root, 211g of bitter orange, 158g of Chinese angelica, 106g of roasted turtle shell, 317g of Szechuan lovage rhizome, 211g of nutgrass galingale rhizome, 5.28g of Chinese caterpillar fungus, 106g of safflower and 158g of peach seed.
As an improvement, the red paeony root is the dried root of the common peony root.
As an improvement, the roasted turtle shell is a turtle shell which is not boiled at high temperature.
As an improvement, the peach kernels are fried peach kernels.
A preparation method of Jiuwei Xiao soft capsules comprises the following specific steps: drying and crushing carapax Trionycis preparata and Cordyceps, and sieving with 50-100 mesh sieve; decocting the rest seven materials in water for 2 times, 2 hr for the first time and 2 hr for the second time, mixing decoctions, filtering, concentrating the filtrate into soft extract, mixing with appropriate amount of starch, granulating, and making into capsule with 1000 granules.
The invention has the beneficial effects that:
red peony root: warm-toxicity, macula, blood heat, hematemesis and epistaxis: being bitter and cold with liver meridian and blood system entered property, it excels in clearing liver fire, purging stagnated heat in blood system and has the actions of cooling blood and stopping bleeding. Blood-shot eyes with swelling and pain, abscess, swelling and sores: being bitter and cold, it enters liver meridian to clear liver fire. Liver depression, hypochondriac pain, amenorrhea, dysmenorrhea, abdominal mass, traumatic injury: being bitter and cold, it enters liver meridian and blood system, and has the actions of activating blood, dissipating stasis and alleviating pain.
Fructus aurantii: the obstruction of the upper energizer qi, fullness and fullness in the chest and diaphragm and distending pain in the hypochondrium. Bitter orange, is the key herb for chest stuffiness due to qi stagnation, because it can descend, it excels in relieving chest stuffiness, alleviating diaphragma, moving qi and relieving stuffiness. Indigestion, abdominal fullness and pain, belching, vomiting and heavy diarrhea. Zhi Qiao excels at resolving food stagnation, purging stagnant qi and relieving distension. It is indicated for prolapse of anus and uterus due to collapse of qi. It is also indicated for intestinal wind and bleeding, rubella itching and abdominal pain during pregnancy.
Chinese angelica: tonify blood, activate blood, regulate menstruation, alleviate pain, moisten intestines to relieve constipation.
Roasting turtle shell: to nourish yin, clear heat, calm liver, stop wind, soften hardness and dissipate nodulation. For wind-heat syndrome due to internal heat and yin deficiency, manifested as wind-invasion of the lung, malaria, buoyi, amenorrhea and metrorrhagia, infantile convulsions and epilepsy.
Ligusticum wallichii: promote blood circulation and move qi, dispel wind and alleviate pain.
Rhizoma cyperi: it is mainly used for hypochondriac pain, abdominal pain, menoxenia, dysmenorrhea, breast distending pain, and abdominal pain due to stagnation of qi.
And (3) cordyceps sinensis: it is a good product for tonifying lung and kidney, and has the functions of tonifying kidney and lung, stopping bleeding and resolving phlegm, relieving cough and asthma, especially for relieving fatigue, cough and phlegm-blood.
Safflower: can be used for treating amenorrhea due to blood stagnation, dysmenorrhea, puerperal abdominal pain due to blood stasis, abdominal mass, thoracic obstruction, cardialgia, abdominal pain due to blood stasis, hypochondriac pain, traumatic injury, swelling and pain due to blood stasis, and macula due to blood stasis.
Peach kernel: promote blood circulation to remove blood stasis, moisten intestines to relieve constipation, relieve cough and relieve asthma.
Detailed Description
The invention is illustrated below by means of specific examples, without being restricted thereto.
Examples
A formulation of Jiuwei Xiao soft capsule comprises the following raw materials: 317g of red peony root, 211g of bitter orange, 158g of Chinese angelica, 106g of roasted turtle shell, 317g of Szechuan lovage rhizome, 211g of nutgrass galingale rhizome, 5.28g of Chinese caterpillar fungus, 106g of safflower and 158g of peach seed.
A preparation method of Jiuwei Xiao soft capsules comprises the following specific steps: drying and crushing carapax Trionycis preparata and Cordyceps, and sieving with 50-100 mesh sieve; decocting the rest seven materials in water for 2 times, 2 hr for the first time and 2 hr for the second time, mixing decoctions, filtering, concentrating the filtrate into soft extract, mixing with appropriate amount of starch, granulating, and making into capsule with 1000 granules.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims (5)

1. The formula of the Jiuwei Xiao soft capsule is characterized by comprising the following raw materials: 317g of red peony root, 211g of bitter orange, 158g of Chinese angelica, 106g of roasted turtle shell, 317g of Szechuan lovage rhizome, 211g of nutgrass galingale rhizome, 5.28g of Chinese caterpillar fungus, 106g of safflower and 158g of peach seed.
2. The formulation of the Jiuweixiao soft capsule according to claim 1, wherein the red peony root is a dried root of Chuan red peony root.
3. The formulation of the Jiuwei Xiao softgel as claimed in claim 1, wherein the carapax Trionycis preparata is carapax Trionycis not cooked at high temperature.
4. The formulation of the Jiuwei Xiao softgel as claimed in claim 1, wherein the peach kernel is a stir-fried peach kernel.
5. A preparation method of Jiuwei Xiao soft capsules is characterized by comprising the following specific steps: drying and crushing carapax Trionycis preparata and Cordyceps, and sieving with 50-100 mesh sieve; decocting the rest seven materials in water for 2 times, 2 hr for the first time and 2 hr for the second time, mixing decoctions, filtering, concentrating the filtrate into soft extract, mixing with appropriate amount of starch, granulating, and making into capsule with 1000 granules.
CN202110742366.6A 2021-07-01 2021-07-01 Jiuwei Xiao soft capsule formula and preparation method thereof Pending CN113440569A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110742366.6A CN113440569A (en) 2021-07-01 2021-07-01 Jiuwei Xiao soft capsule formula and preparation method thereof

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Application Number Priority Date Filing Date Title
CN202110742366.6A CN113440569A (en) 2021-07-01 2021-07-01 Jiuwei Xiao soft capsule formula and preparation method thereof

Publications (1)

Publication Number Publication Date
CN113440569A true CN113440569A (en) 2021-09-28

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CN202110742366.6A Pending CN113440569A (en) 2021-07-01 2021-07-01 Jiuwei Xiao soft capsule formula and preparation method thereof

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102078470A (en) * 2009-12-01 2011-06-01 邓晓莉 Traditional Chinese medicine composition for treating vital energy stagnation blood stasis type dysmenorrhea
CN102451330A (en) * 2010-10-29 2012-05-16 吴肖慧 Traditional Chinese medicine for treating infertility due to blood stasis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102078470A (en) * 2009-12-01 2011-06-01 邓晓莉 Traditional Chinese medicine composition for treating vital energy stagnation blood stasis type dysmenorrhea
CN102451330A (en) * 2010-10-29 2012-05-16 吴肖慧 Traditional Chinese medicine for treating infertility due to blood stasis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
杨锋等: "正交试验优选软肝灵胶囊的制粒工艺", 《中国医院用药评价与分析》 *
海蓉: "桃红四物汤治疗原发性痛经60例疗效观察", 《中国医学创新》 *

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