CN113425783A - Oral spray for losing weight - Google Patents

Oral spray for losing weight Download PDF

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Publication number
CN113425783A
CN113425783A CN202110932941.9A CN202110932941A CN113425783A CN 113425783 A CN113425783 A CN 113425783A CN 202110932941 A CN202110932941 A CN 202110932941A CN 113425783 A CN113425783 A CN 113425783A
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Prior art keywords
parts
oral spray
distilled water
sample
weight
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CN202110932941.9A
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Chinese (zh)
Inventor
魏晶
吕博阳
郝瑞芳
岳萍
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Shenzhen Juyin Technology Co Ltd
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Shenzhen Juyin Technology Co Ltd
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Priority to CN202110932941.9A priority Critical patent/CN113425783A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
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    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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    • A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
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    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The invention belongs to the technical field of oral spray, in particular to an oral spray for losing weight, which comprises the following raw materials: 8-16 parts of oriental water melon, 8-16 parts of gamboge peel, 8-16 parts of Gymnema sylvestre, 5-15 parts of yellow capsicum, 5-10 parts of guarana, 4-10 parts of bean taro leaves, 4-10 parts of broussonetia papyrifera leaves, 4-7 parts of red raspberries, 4-7 parts of fructus piperis longi, 3-8 parts of Chinese pulsatilla flowers, 3-8 parts of grifola frondosa, 3-8 parts of cornflower and 1-3 parts of menthol. According to the invention, after the combination of the components of the fructus cucurbitae, the gamboge peel, the gymnema sylvestre, the yellow capsicum, the guarana, the taro leaf, the broussonetia papyrifera leaf, the raspberry, the long pepper, the Chinese pulsatilla flower, the grifola frondosa, the cornflower and the menthol is combined together to form the oral spray, not only can carbohydrates in various foods be inhibited from being converted into fat in vivo, the fat metabolism is improved, but also the carbohydrate metabolic balance is regulated, the absorption of saccharides in small intestines is inhibited, the blood sugar is stabilized, the hunger sensation is delayed, the daily essential energy of a body can be supplied and supplemented, the physical performance level is enhanced, and the effects of healthy weight losing are comprehensively realized from multiple angles.

Description

Oral spray for losing weight
Technical Field
The invention belongs to the technical field of oral sprays, and particularly relates to an oral spray for losing weight.
Background
Obesity is a phenomenon of excessive accumulation of adipose tissues in the body, and may be caused by heredity, improper food intake or other physiological reasons, and has gradually become an increasingly common social phenomenon, which not only changes the body shape of a human and reduces the activity, but also has negative effects on the cardiovascular system of the human body to cause various diseases. The realization of weight loss through manual intervention becomes a hot research problem, and currently, there are various weight loss methods, including aerobic exercise weight loss, drug weight loss, acupuncture, diarrhea weight loss, and the like. Many people who lose weight by exercise cannot insist on the ideal effect, the drug losing weight can generate many side effects, and most of the losing weight products on the market achieve the effect of losing weight by diarrhea, but the method for losing weight is very unfavorable for health, so that the development of the product which is beneficial to the body and has the function of losing weight is very necessary.
Disclosure of Invention
To solve the problems set forth in the background art described above. The invention provides an oral spray for losing weight, which has the characteristic of healthy weight loss.
In order to achieve the purpose, the invention provides the following technical scheme: an oral spray for losing weight comprises the following raw materials:
8-16 parts of jie melon
8-16 parts of gamboge peel
Gymnema sylvestre leaves 8-16 parts
5-15 parts of yellow capsicum frutescens
5-10 parts of guarana
4-10 parts of bean taro leaves
4-10 parts of broussonetia papyrifera leaves
4-7 parts of red raspberry
4-7 parts of long pepper
3-8 parts of Chinese pulsatilla flower
3-8 parts of grifola frondosa
Cornflower 3-8 parts
1-3 parts of menthol
The preparation method comprises the following steps:
the method comprises the following steps: weighing the samples respectively, drying in the shade, crushing, putting the materials into a triangular flask after crushing, adding distilled water while stirring, paving, and standing for a certain time to enable the solution to fully permeate into cell tissues;
step two: the fully infiltrated sample is put into a vacuum microwave device for rapid heating pretreatment, so that the water infiltrated into the cell tissue of the sample is vaporized, the cell tissue of the sample is fully destroyed, and a certain basis is laid for subsequent extraction;
step three: after the cell tissues of the sample are fully damaged, adding distilled water, and extracting for 1h in a constant-temperature water bath;
step four: filtering the extracting solution by a filtering device to obtain a sample solution;
step five: concentrating to 50ml with rotary evaporator under reduced pressure, and vacuum freeze drying for 24 hr to obtain dry powder;
step six: mixing the dry powder with distilled water according to a ratio of 1:2.5, heating to 50 ℃, stirring to be uniform, then carrying out high-pressure sterilization, and cooling at normal temperature after the sterilization is finished to obtain the weight-reducing mouth spray;
step seven: and carrying out sterile filling and mouth spraying.
Preferably, in step one, the ratio of the material to the distilled water is 1: 3.
Preferably, in step two, the vacuum is 70 KPa.
Preferably, in the third step, the ratio of the material to the distilled water is 1:15, and the extraction temperature is 80 ℃.
Preferably, in the fifth step, the sterilization temperature is 120 ℃, the sterilization time is 25min, and the pressure is 0.2-0.3 MPa.
Compared with the prior art, the invention has the beneficial effects that:
according to the invention, the contents of tartronic in the jigua are beneficial to inhibiting carbohydrates in various foods from being converted into fat in vivo and decomposing fat in vivo, and the cellulose in the jigua can help intestinal tracts to discharge redundant waste garbage and reduce the absorption of cholesterol, so that the weight can be well controlled and the weight can be reduced, the garcinia cambogia pericarp contained in the garcinia cambogia peel is beneficial to inhibiting the carbohydrates from being converted or stored into fat, the gymnema sylvestre leaves can effectively clean sugar, the unique active ingredient, gymnemic acid is contained, the metabolic balance of sugar can be regulated, the absorption of the sugar in small intestines can be inhibited, the carbohydrates in the sugar and high-starch-content foods can be blocked and eliminated, the blood sugar can be stabilized, less insulin can be produced by the body after eating, the hunger feeling can be further delayed and the fat synthesis chance of capsicum can be reduced, and the body fat aggregation of the cherokee rose can be reduced, regulating blood lipid and energy metabolism, guarana can supply and supplement basic energy required by human body daily, enhance physical performance level and has the effect of reducing weight, taro leaves can reduce lipid deposition, broussonetia papyrifera leaves can improve fat metabolism, reduce fat and blood pressure, red raspberries and cornflower can decompose fat, long pepper, Chinese pulsatilla flower and gray tree flower all have the functions of regulating blood sugar, reducing weight, losing weight and improving immunity, menthol makes mouth feel of the mouth sprayer better, and can inhibit headache and inflammation of nose, pharynx and larynx, after the compositions are combined together to form mouth spray, the compositions can be synergistically complemented, not only can inhibit carbohydrates in various foods from being converted into fat in vivo and improve fat metabolism, but also can regulate carbohydrate metabolism balance, inhibit absorption of saccharides in small intestine, stabilize blood sugar, delay hunger sensation, and supply and supplement basic energy required by human body daily, enhancing physical ability level, and comprehensively realizing the effects of health and weight reduction from multiple angles.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The invention provides the following technical scheme: an oral spray for losing weight comprises the following raw materials:
8 portions of Jiejua
8 parts of gamboge peel
Gymnema sylvestre leaves 8 parts
5 parts of yellow capsicum frutescens
Guarana 5 parts
4 portions of bean taro leaves
4 portions of broussonetia papyrifera leaves
4 parts of red raspberry
4 parts of long pepper
3 parts of Chinese pulsatilla flower
3 portions of grifola frondosa
Cornflower 3 parts
Menthol 1 part
The preparation method comprises the following steps:
the method comprises the following steps: weighing the samples respectively, drying in the shade, crushing, putting the materials into a triangular flask after crushing, adding distilled water while stirring, paving, and standing for a certain time to enable the solution to fully permeate into cell tissues;
step two: the fully infiltrated sample is put into a vacuum microwave device for rapid heating pretreatment, so that the water infiltrated into the cell tissue of the sample is vaporized, the cell tissue of the sample is fully destroyed, and a certain basis is laid for subsequent extraction;
step three: after the cell tissues of the sample are fully damaged, adding distilled water, and extracting for 1h in a constant-temperature water bath;
step four: filtering the extracting solution by a filtering device to obtain a sample solution;
step five: concentrating to 50ml with rotary evaporator under reduced pressure, and vacuum freeze drying for 24 hr to obtain dry powder;
step six: mixing the dry powder with distilled water according to a ratio of 1:2.5, heating to 50 ℃, stirring to be uniform, then carrying out high-pressure sterilization, and cooling at normal temperature after the sterilization is finished to obtain the weight-reducing mouth spray;
step seven: and carrying out sterile filling and mouth spraying.
Specifically, in the step one, the ratio of the material to the distilled water is 1: 3.
Specifically, in the second step, the degree of vacuum was 70 KPa.
Specifically, in the third step, the ratio of the materials to the distilled water is 1:15, and the extraction temperature is 80 ℃.
Specifically, in the fifth step, the sterilization temperature is 120 ℃, the sterilization time is 25min, and the pressure is 0.2-0.3 Mpa.
Example 2
The invention provides the following technical scheme: an oral spray for losing weight comprises the following raw materials:
12 portions of Jiejua
12 parts of gamboge peel
12 parts of leaves of Gymnema sylvestre
10 parts of yellow capsicum frutescens
Guarana 7 parts
7 parts of bean taro leaves
7 portions of broussonetia papyrifera leaves
5 parts of red raspberry
5 parts of long pepper
6 parts of Chinese pulsatilla flower
6 portions of grifola frondosa
Cornflower 6 parts
Menthol 2 parts
The preparation method comprises the following steps:
the method comprises the following steps: weighing the samples respectively, drying in the shade, crushing, putting the materials into a triangular flask after crushing, adding distilled water while stirring, paving, and standing for a certain time to enable the solution to fully permeate into cell tissues;
step two: the fully infiltrated sample is put into a vacuum microwave device for rapid heating pretreatment, so that the water infiltrated into the cell tissue of the sample is vaporized, the cell tissue of the sample is fully destroyed, and a certain basis is laid for subsequent extraction;
step three: after the cell tissues of the sample are fully damaged, adding distilled water, and extracting for 1h in a constant-temperature water bath;
step four: filtering the extracting solution by a filtering device to obtain a sample solution;
step five: concentrating to 50ml with rotary evaporator under reduced pressure, and vacuum freeze drying for 24 hr to obtain dry powder;
step six: mixing the dry powder with distilled water according to a ratio of 1:2.5, heating to 50 ℃, stirring to be uniform, then carrying out high-pressure sterilization, and cooling at normal temperature after the sterilization is finished to obtain the weight-reducing mouth spray;
step seven: and carrying out sterile filling and mouth spraying.
Specifically, in the step one, the ratio of the material to the distilled water is 1: 3.
Specifically, in the second step, the degree of vacuum was 70 KPa.
Specifically, in the third step, the ratio of the materials to the distilled water is 1:15, and the extraction temperature is 80 ℃.
Specifically, in the fifth step, the sterilization temperature is 120 ℃, the sterilization time is 25min, and the pressure is 0.2-0.3 Mpa.
Example 3
The invention provides the following technical scheme: an oral spray for losing weight comprises the following raw materials:
16 portions of Jiejua
16 portions of gamboge peel
Gymnema sylvestre leaves 16 parts
15 parts of yellow capsicum frutescens
10 portions of guarana
10 portions of bean taro leaves
10 portions of broussonetia papyrifera leaves
7 parts of red raspberry
7 parts of long pepper
8 parts of Chinese pulsatilla flower
8 portions of grifola frondosa
Cornflower 8 parts
Menthol 3 parts
The preparation method comprises the following steps:
the method comprises the following steps: weighing the samples respectively, drying in the shade, crushing, putting the materials into a triangular flask after crushing, adding distilled water while stirring, paving, and standing for a certain time to enable the solution to fully permeate into cell tissues;
step two: the fully infiltrated sample is put into a vacuum microwave device for rapid heating pretreatment, so that the water infiltrated into the cell tissue of the sample is vaporized, the cell tissue of the sample is fully destroyed, and a certain basis is laid for subsequent extraction;
step three: after the cell tissues of the sample are fully damaged, adding distilled water, and extracting for 1h in a constant-temperature water bath;
step four: filtering the extracting solution by a filtering device to obtain a sample solution;
step five: concentrating to 50ml with rotary evaporator under reduced pressure, and vacuum freeze drying for 24 hr to obtain dry powder;
step six: mixing the dry powder with distilled water according to a ratio of 1:2.5, heating to 50 ℃, stirring to be uniform, then carrying out high-pressure sterilization, and cooling at normal temperature after the sterilization is finished to obtain the weight-reducing mouth spray;
step seven: and carrying out sterile filling and mouth spraying.
Specifically, in the step one, the ratio of the material to the distilled water is 1: 3.
Specifically, in the second step, the degree of vacuum was 70 KPa.
Specifically, in the third step, the ratio of the materials to the distilled water is 1:15, and the extraction temperature is 80 ℃.
Specifically, in the fifth step, the sterilization temperature is 120 ℃, the sterilization time is 25min, and the pressure is 0.2-0.3 Mpa.
The composition prepared in example 1 and comparative example 1 (selected from conventional weight-reducing mouth spray) were subjected to trial test for efficacy.
Test objects: all experimental groups are 5 volunteers, the age is 25-44 years, all volunteers use the oral spray every day, and the using method comprises the following steps: the cap was removed and the nozzle was placed 1 cm away from the mouth and pressed against the mouth two times a day, 3 times a day, each time about 10 minutes before a meal, for 2 months of continuous use.
As a result: the results are shown in Table 1.
Table 1:
Figure BDA0003211706120000081
the curative effect standard is as follows: according to the standard of obesity curative effect in the guideline of clinical research on new drugs, 2 months is determined as 1 course of treatment, the weight loss is more than 5kg after 1 course of treatment, and the skin fold thickness is close to normal and is significant; weight loss > 3kg, effective with skin fold thickness approaching the upper normal limit; the non-weight loss patients were not effective.
Typical cases are as follows:
case 1: the weight of the plum female is 145 jin, the height is 160cm, the plum female is 29 years old, the plum female has strong appetite, is not eaten by pickles, has large food intake and is weak, the weight of the plum female is reduced by 6 kg after 2 months of treatment by using the medicine, and the appetite is reduced, the food intake is reduced and the spirit is improved after the plum female is used by using the spray every time.
Case 2: the weight of the young is reduced by 5.5 kg after 2 months of treatment by using the medicine provided by the invention, the appetite is reduced, the food intake is reduced, the appropriate exercise is combined, the physical strength is improved, and the habit of sleepiness is improved.
In conclusion, the data analysis shows that the weight-reducing effect of the example 1 is significantly better than that of the comparative example, which shows that the weight-reducing oral spray of the invention has better weight-reducing effect and safety.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (5)

1. An oral spray for weight loss, which is characterized in that: the mouth spray for losing weight comprises the following raw materials:
8-16 parts of jie melon
8-16 parts of gamboge peel
Gymnema sylvestre leaves 8-16 parts
5-15 parts of yellow capsicum frutescens
5-10 parts of guarana
4-10 parts of bean taro leaves
4-10 parts of broussonetia papyrifera leaves
4-7 parts of red raspberry
4-7 parts of long pepper
3-8 parts of Chinese pulsatilla flower
3-8 parts of grifola frondosa
Cornflower 3-8 parts
1-3 parts of menthol
The preparation method comprises the following steps:
the method comprises the following steps: weighing the samples respectively, drying in the shade, crushing, putting the materials into a triangular flask after crushing, adding distilled water while stirring, paving, and standing for a certain time to enable the solution to fully permeate into cell tissues;
step two: the fully infiltrated sample is put into a vacuum microwave device for rapid heating pretreatment, so that the water infiltrated into the cell tissue of the sample is vaporized, the cell tissue of the sample is fully destroyed, and a certain basis is laid for subsequent extraction;
step three: after the cell tissues of the sample are fully damaged, adding distilled water, and extracting for 1h in a constant-temperature water bath;
step four: filtering the extracting solution by a filtering device to obtain a sample solution;
step five: concentrating to 50ml with rotary evaporator under reduced pressure, and vacuum freeze drying for 24 hr to obtain dry powder;
step six: mixing the dry powder with distilled water according to a ratio of 1:2.5, heating to 50 ℃, stirring to be uniform, then carrying out high-pressure sterilization, and cooling at normal temperature after the sterilization is finished to obtain the weight-reducing mouth spray;
step seven: and carrying out sterile filling and mouth spraying.
2. The oral spray for slimming of claim 1, wherein: in step one, the ratio of the material to distilled water is 1: 3.
3. The oral spray for slimming of claim 1, wherein: in step two, the vacuum was 70 KPa.
4. The oral spray for slimming of claim 1, wherein: in the third step, the ratio of the materials to distilled water is 1:15, and the extraction temperature is 80 ℃.
5. The oral spray for slimming of claim 1, wherein: in the fifth step, the sterilization temperature is 120 ℃, the sterilization time is 25min, and the pressure is 0.2-0.3 Mpa.
CN202110932941.9A 2021-08-13 2021-08-13 Oral spray for losing weight Pending CN113425783A (en)

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Application publication date: 20210924