CN113425673A - Ointment, preparation method of ointment and convenient patch containing ointment - Google Patents

Ointment, preparation method of ointment and convenient patch containing ointment Download PDF

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CN113425673A
CN113425673A CN202110833020.7A CN202110833020A CN113425673A CN 113425673 A CN113425673 A CN 113425673A CN 202110833020 A CN202110833020 A CN 202110833020A CN 113425673 A CN113425673 A CN 113425673A
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parts
ointment
patient
years
treatment
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冯亮
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Foshan Jianxiang Hospital Co Ltd
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Foshan Jianxiang Hospital Co Ltd
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268—Asarum (wild ginger)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9062—Alpinia, e.g. red ginger or galangal
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K36/9064—Amomum, e.g. round cardamom
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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Abstract

The application relates to the field of traditional Chinese medicine ointment, in particular to ointment, a preparation method of the ointment and a convenient plaster containing the ointment. The ointment is prepared from the following raw materials in parts by weight: 38-48 parts of blumea red-foot, 15-25 parts of galangal, 9-15 parts of dried orange peel, 3-8 parts of amomum villosum, 4-6 parts of wrinkled gianthyssop, 3-5 parts of cinnamon, 5-10 parts of asarum, 4-8 parts of evodia rutaecarpa, 5-15 parts of eupatorium, 10-15 parts of murraya paniculata, 10-20 parts of Stephania delavayi and 8-20 parts of magnolia flower. The ointment claimed by the application has effects on rheumatism patients with different degrees, not only expands the application range of the ointment, but also shortens the curing time of the patients, and the patients can not relapse for two years.

Description

Ointment, preparation method of ointment and convenient patch containing ointment
Technical Field
The invention relates to the field of traditional Chinese medicine ointment, in particular to an ointment, a preparation method of the ointment and a convenient plaster containing the ointment.
Background
Rheumatism is a disease mainly affecting joints, bones, muscles, blood vessels and related soft tissues or connective tissues, and most of them are autoimmune diseases. The disease is usually more hidden and slower, the disease course is longer, and most of the diseases have hereditary tendency.
At present, the method for treating rheumatism comprises western medicine treatment, Chinese medicine treatment and the like. Western medicine treatment generally adopts antibiotics, aspirin and hormones to diminish inflammation, relieve pain and inhibit rheumatism activity, and can be relieved in a short time, but has large toxic and side effects. The traditional Chinese medicine treatment is generally divided into an oral medicine and an external medicine, and clinical verification shows that the oral administration method also has some toxic and side effects; topical applications provide only temporary relief of pain and are often prone to relapse within months.
Disclosure of Invention
In order to improve the treatment effect of the externally applied medicine for treating rheumatism, the application provides an ointment, a preparation method of the ointment and a convenient plaster containing the ointment.
In a first aspect, the application provides an ointment, which adopts the following technical scheme:
an ointment is prepared from the following raw materials in parts by weight:
38-48 parts of blumea balsamifera, 15-25 parts of galangal, 9-15 parts of dried orange peel, 3-8 parts of amomum villosum and agastache rugosus
4-6 parts of cinnamon, 3-5 parts of asarum, 5-10 parts of fructus evodiae, 4-8 parts of herba eupatorii, 10-15 parts of murraya paniculata, 10-20 parts of radix stephaniae tetrandrae and 8-20 parts of flos magnoliae.
When the ointment for treating rheumatism is prepared from the blumea balsamifera, the galangal, the dried orange peel, the amomum villosum, the agastache rugosus, the cinnamon, the asarum, the evodia rutaecarpa, the eupatorium fortunei, the murraya paniculata, the stephania sinica and the magnolia flower according to the proportion, the ointment can effectively exert the effects of eliminating dampness and relieving pain, so that the ointment can act on rheumatism patients with different degrees, the application range of the ointment is expanded, the cure time of the patients is shortened, and the relapse situation can not occur for two years.
Optionally, the ointment is prepared from the following raw materials in parts by weight:
40 parts of blumea balsamifera, 22 parts of galangal, 12 parts of dried orange peel, 3 parts of amomum villosum, 4 parts of wrinkled gianthyssop herb and cinnamon
3 parts of asarum, 10 parts of fructus evodiae, 5 parts of eupatorium, 15 parts of murraya paniculata, 15 parts of radix stephaniae tetrandrae and 10 parts of flos magnoliae.
When the ointment for treating rheumatism is prepared from the blumea balsamifera, the galangal, the dried orange peel, the amomum villosum, the agastache rugosus, the cinnamon, the asarum, the evodia rutaecarpa, the eupatorium fortunei, the murraya paniculata, the stephania sinica and the magnolia flower according to the proportion, the obtained ointment has a promoting effect on the treatment of patients with mild rheumatic arthritis, and is beneficial to shortening the recovery time of the patients with mild rheumatic arthritis.
Optionally, the ointment is prepared from the following raw materials in parts by weight:
45 parts of blumea balsamifera, 15 parts of galangal, 10 parts of dried orange peel, 8 parts of amomum villosum, 6 parts of wrinkled gianthyssop herb and cinnamon
5 parts of asarum, 5 parts of fructus evodiae, 10 parts of eupatorium, 10 parts of murraya paniculata, 10 parts of radix stephaniae tetrandrae and 15 parts of magnolia flower.
When the ointment for treating rheumatism is prepared from the blumea balsamifera, the galangal, the dried orange peel, the amomum villosum, the agastache rugosus, the cinnamon, the asarum, the evodia rutaecarpa, the eupatorium fortunei, the murraya paniculata, the stephania sinica and the magnolia flower according to the proportion, the obtained ointment has a promoting effect on the treatment of patients with mild rheumatic arthritis and patients with moderate rheumatic arthritis, and is beneficial to shortening of the healing time of the patients with mild rheumatic arthritis and the patients with moderate rheumatic arthritis.
Optionally, the ointment is prepared from the following raw materials in parts by weight:
40 parts of blumea balsamifera, 20 parts of galangal, 10 parts of dried orange peel, 5 parts of amomum villosum, 5 parts of wrinkled gianthyssop herb and cinnamon
5 parts of asarum, 5 parts of fructus evodiae, 5 parts of eupatorium, 10 parts of murraya paniculata, 10 parts of radix stephaniae tetrandrae and 10 parts of flos magnoliae.
When the ointment for treating rheumatism is prepared from the blumea balsamifera, the galangal, the dried orange peel, the amomum villosum, the agastache rugosus, the cinnamon, the asarum, the evodia rutaecarpa, the eupatorium fortunei, the murraya paniculata, the stephania sinica and the magnolia flower according to the proportion, the obtained ointment has a promoting effect on the treatment of patients with mild rheumatic arthritis, patients with moderate rheumatic arthritis and patients with severe rheumatic arthritis, and is beneficial to shortening of the recovery time of the patients with mild rheumatic arthritis, patients with moderate rheumatic arthritis and patients with severe rheumatic arthritis.
In a second aspect, the present application provides a method for preparing an ointment, comprising the steps of:
s1, crushing blumea balsamifera, galangal, dried orange peel, amomum villosum, agastache rugosus, cinnamon, asarum, evodia rutaecarpa, eupatorium, murraya paniculata, Stephania delavayi and magnolia flower pollen into 400 meshes in parts by weight to obtain traditional Chinese medicine powder;
s2, carrying out first CO treatment on the traditional Chinese medicine powder2Performing supercritical extraction to obtain extract A and residue A; wherein, CO for the first time2The entrainer used in the supercritical extraction is ethanol, the extraction pressure is 15-25MPa, the extraction temperature is 30-50 ℃, the separation pressure is 4-6MPa, the separation temperature is 20-30 ℃, and the extraction time is 2-3 h;
s3, drying the medicine residue A, and then carrying out secondary CO treatment on the dried medicine residue A2Performing supercritical extraction to obtain extract B and residue B; wherein, the second CO2The entrainer adopted in the supercritical extraction is ethyl acetate, the extraction pressure is 20-40MPa, the extraction temperature is 40-50 ℃, the separation pressure is 8-10MPa, the separation temperature is 30-40 ℃, and the extraction time is 1-2 h;
s4, adding glycerol into the medicine residue B, stirring to be pasty under the water bath heating state of 50-60 ℃, then adding sodium polyacrylate with the mass concentration of 1%, stirring uniformly, adding the extract A and the extract B, and continuing stirring uniformly to obtain an ointment; wherein the medicine residue B, glycerin, sodium polyacrylate with the mass concentration of 1%, and the weight ratio of the extract A to the extract B are (5-12): 25: (1-1.5): (1-1.5): (0.5-1.5).
The effective components in the traditional Chinese medicine powder are extracted twice, which is beneficial to extracting more components which play a role in improving the treatment of rheumatism; in addition, the medicine residue B, the glycerin, the sodium polyacrylate with the mass concentration of 1%, the extract A and the extract B are prepared into the ointment according to a certain proportion, so that the effect of the ointment can be fully exerted, and the treatment effect of the ointment is improved.
Optionally, the medicine residue B, glycerin, sodium polyacrylate with the mass concentration of 1%, and the weight ratio of the extract A to the extract B is 9: 25: 2: 1.25: 1.
when the medicine residue B, glycerin, sodium polyacrylate with the mass concentration of 1%, the extract A and the extract B are prepared into the ointment for treating rheumatism according to the mixture ratio, the obtained ointment can further shorten the treatment time of rheumatoid arthritis.
Optionally, the particle size range of the traditional Chinese medicine powder is 200-300 meshes.
When the particle size range of the traditional Chinese medicine powder is controlled to be 200-300 meshes, the effective components in the traditional Chinese medicine powder can be extracted, and the treatment effect of the ointment on the rheumatoid arthritis can be promoted.
In a third aspect, the application provides a convenient patch containing any one of the above ointments, which adopts the following technical scheme:
the utility model provides a convenient plaster, includes electric heater, electric heater's heating surface can be dismantled and is equipped with the installation piece, can dismantle on the installation piece and be equipped with any one of above-mentioned ointment.
The convenient plaster with the electric heater has the characteristic of long heating time, and is beneficial to accelerating the effective components in the plaster to enter a human body, thereby improving the treatment effect and the treatment efficiency of the plaster.
To sum up, the beneficial effects of this application include at least:
(1) when the ointment for treating rheumatism is prepared from the blumea balsamifera, the galangal, the dried orange peel, the amomum villosum, the agastache rugosus, the cinnamon, the asarum, the evodia rutaecarpa, the eupatorium fortunei, the murraya paniculata, the stephania sinica and the magnolia flower according to the proportion, the ointment can effectively exert the effects of eliminating dampness and relieving pain, so that the ointment has the effects on rheumatism patients with different degrees, the application range of the ointment is expanded, the cure time of the patients is shortened, and the relapse condition can not occur for two years;
(2) the effective components in the traditional Chinese medicine powder are extracted twice, which is beneficial to extracting more components which play a role in improving the treatment of rheumatism; in addition, the medicine residue B, the glycerin, the sodium polyacrylate with the mass concentration of 1%, the extract A and the extract B are prepared into the ointment according to a certain proportion, so that the effect of the ointment can be fully exerted, and the treatment effect of the ointment is improved.
(3) The convenient plaster with the electric heater has the characteristic of long heating time, and is beneficial to accelerating the effective components in the plaster to enter a human body, thereby improving the treatment effect and the treatment efficiency of the plaster.
Drawings
Fig. 1 is a schematic structural diagram of the convenient plaster of the present application.
Description of reference numerals:
1. an electric heater; 2. mounting blocks; 3. and (4) ointment.
Detailed Description
The present application will be further described with reference to examples and comparative examples.
TABLE 1 examples 1-5 raw Material compositions (kg) of the Chinese medicinal ointments
Raw materials Example 1 Example 2 Example 3 Example 4 Example 5
Folium Artemisiae Argyi for treating common cold 38 48 40 45 40
Galangal 15 25 22 15 20
Dried orange peel 9 15 12 10 10
Fructus amomi 3 8 3 8 5
Agastache rugosus 4 6 4 6 5
Cortex Cinnamomi 3 5 3 5 5
Herba asari 5 10 10 5 5
Evodia rutaecarpa 4 8 4 8 5
Herba Eupatorii 5 15 5 10 5
Root of common jasminorange 10 15 15 10 10
All right of money 10 20 15 10 10
Flos Magnoliae 8 20 10 15 10
Examples 1 to 5
The preparation method of the ointment comprises the following steps:
s1, weighing the traditional Chinese medicines of blumea balsamifera, galangal, dried orange peel, amomum villosum, agastache rugosus, cinnamon, asarum, evodia rutaecarpa, eupatorium fortunei, murraya paniculata, Stephania delavayi and magnolia flower according to the mixture ratio in the table 1 respectively, and then crushing the traditional Chinese medicines to 100-200 meshes to obtain traditional Chinese medicine powder;
s2, carrying out first CO treatment on the traditional Chinese medicine powder2Performing supercritical extraction to obtain extract A and residue A; wherein, CO for the first time2The entrainer adopted in the supercritical extraction is ethanol, the extraction pressure is 15MPa, the extraction temperature is 50 ℃, the separation pressure is 4MPa, the separation temperature is 30 ℃, and the extraction time is 3 hours;
s3, drying the medicine residue A, and then carrying out secondary CO treatment on the dried medicine residue A2Performing supercritical extraction to obtain extract B and residue B; wherein, the second CO2The entrainer adopted in the supercritical extraction is ethyl acetate, the extraction pressure is 20MPa, the extraction temperature is 50 ℃, the separation pressure is 8MPa, the separation temperature is 40 ℃, and the extraction time is 2 hours;
s4, adding glycerol into the medicine residue B, stirring to be pasty under the condition of heating in a water bath at 50 ℃, then adding sodium polyacrylate with the mass concentration of 1%, stirring uniformly, adding the extract A and the extract B, and continuing stirring uniformly to obtain an ointment;
wherein, the medicine residue B, glycerin, sodium polyacrylate with the mass concentration of 1%, and the weight ratio of the extract A to the extract B is 5: 25: 1: 0.5: 2.
example 6
An ointment which differs from example 5 in that:
s2, carrying out first CO treatment on the traditional Chinese medicine powder2Performing supercritical extraction to obtain extract A and residue A; wherein, CO for the first time2The entrainer adopted in the supercritical extraction is ethanol, the extraction pressure is 25MPa, the extraction temperature is 30 ℃, the separation pressure is 6MPa, the separation temperature is 20 ℃, and the extraction time is 2 hours;
s3, drying the medicine residue A, and then carrying out secondary CO treatment on the dried medicine residue A2Performing supercritical extraction to obtain extract B and residueB; wherein, the second CO2The entrainer adopted in the supercritical extraction is ethyl acetate, the extraction pressure is 40MPa, the extraction temperature is 40 ℃, the separation pressure is 10MPa, the separation temperature is 30 ℃, and the extraction time is 1 h.
Example 7
The preparation method of the ointment comprises the following steps:
s1, weighing the traditional Chinese medicines of blumea balsamifera, galangal, dried orange peel, fructus amomi, agastache rugosus, cinnamon, asarum, evodia rutaecarpa, eupatorium, murraya jasminorage, radix stephaniae tetrandrae and magnolia flower according to the proportion of the embodiment 5 in the table 1 respectively, and then crushing the traditional Chinese medicines into 100-200-mesh powder to obtain traditional Chinese medicine powder;
s2, subjecting the Chinese medicine powder to CO treatment2Performing supercritical extraction to obtain extract A and residue A; wherein, CO2The entrainer adopted in the supercritical extraction is ethanol, the extraction pressure is 15MPa, the extraction temperature is 50 ℃, the separation pressure is 4MPa, the separation temperature is 30 ℃, and the extraction time is 3 hours;
s3, adding glycerol into the medicine residue A, stirring to be pasty under the condition of heating in a water bath at 50 ℃, then adding sodium polyacrylate with the mass concentration of 1%, stirring uniformly, adding the extract A, and continuing stirring uniformly to obtain an ointment;
wherein the weight ratio of the medicine residue A, the glycerin, the sodium polyacrylate with the mass concentration of 1% and the extract A is 5: 25: 1: 2.5.
example 8
S1, weighing the traditional Chinese medicines of blumea balsamifera, galangal, dried orange peel, fructus amomi, agastache rugosus, cinnamon, asarum, evodia rutaecarpa, eupatorium, murraya jasminorage, radix stephaniae tetrandrae and magnolia flower according to the proportion of the embodiment 5 in the table 1 respectively, and then crushing the traditional Chinese medicines into 100-200-mesh powder to obtain traditional Chinese medicine powder;
s2, subjecting the Chinese medicine powder to CO treatment2Performing supercritical extraction to obtain extract A and residue A; wherein, CO2The entrainer adopted in the supercritical extraction is ethyl acetate, the extraction pressure is 20MPa, the extraction temperature is 50 ℃, the separation pressure is 8MPa, the separation temperature is 40 ℃, and the extraction time is 2 hours;
s3, adding glycerol into the medicine residue A, stirring to be pasty under the condition of heating in a water bath at 50 ℃, then adding sodium polyacrylate with the mass concentration of 1%, stirring uniformly, adding the extract A, and continuing stirring uniformly to obtain an ointment;
wherein the weight ratio of the medicine residue A, the glycerin, the sodium polyacrylate with the mass concentration of 1% and the extract A is 5: 25: 1: 2.5.
example 9
An ointment which differs from example 5 in that:
s1, weighing the traditional Chinese medicines of blumea balsamifera, galangal, dried orange peel, amomum villosum, wrinkled gianthyssop, cinnamon, asarum, evodia rutaecarpa, eupatorium, murraya paniculata, Stephania delavayi and magnolia flower according to the mixture ratio in the table 1 respectively, and crushing the traditional Chinese medicines to 200-mesh and 300-mesh to obtain the traditional Chinese medicine powder.
Example 10
An ointment which differs from example 5 in that:
s1, weighing the traditional Chinese medicines of blumea balsamifera, galangal, dried orange peel, amomum villosum, wrinkled gianthyssop, cinnamon, asarum, evodia rutaecarpa, eupatorium, murraya paniculata, Stephania delavayi and magnolia flower according to the mixture ratio in the table 1 respectively, and then crushing the traditional Chinese medicines to 300-400 meshes to obtain the traditional Chinese medicine powder.
Example 11
An ointment which differs from example 9 in that:
s4, the Chinese medicine residue B, glycerin, sodium polyacrylate with the mass concentration of 1%, and the weight ratio of the extract A to the extract B is 5: 25: 1.5: 1.5: 1.5.
example 12
An ointment which differs from example 9 in that:
s4, the Chinese medicine residue B, glycerin, sodium polyacrylate with the mass concentration of 1%, and the weight ratio of the extract A to the extract B is 9: 25: 1: 1.25: 1.
example 13
An ointment which differs from example 9 in that:
s4, the Chinese medicine residue B, glycerin, sodium polyacrylate with the mass concentration of 1%, and the weight ratio of the extract A to the extract B is 12: 25: 1.25: 1: 0.5.
comparative example 1
An ointment which differs from example 5 in that:
10kg of blumea balsamifera, 20kg of galangal, 10kg of dried orange peel, 5kg of fructus amomi, 5kg of agastache rugosus, 5kg of cinnamon, 5kg of asarum, 5kg of fructus evodiae, 5kg of eupatorium, 40kg of murraya jasminorage, 10kg of stephania japonica and 10kg of magnolia flower.
Comparative example 2
An ointment which differs from example 5 in that:
20kg of blumea balsamifera, 10kg of galangal, 10kg of dried orange peel, 5kg of amomum villosum, 5kg of wrinkled gianthyssop, 5kg of cinnamon, 10kg of asarum, 5kg of evodia rutaecarpa, 5kg of eupatorium, 10kg of murraya paniculata, 40kg of stephania sinica and 5kg of magnolia flower.
Comparative example 3
An ointment which differs from example 5 in that:
50kg of blumea balsamifera, 10kg of galangal, 10kg of dried orange peel, 5kg of fructus amomi, 5kg of agastache rugosus, 5kg of cinnamon, 10kg of asarum, 10kg of fructus evodiae, 10kg of eupatorium, 5kg of murraya paniculata, 5kg of stephania sinica and 5kg of magnolia flower.
Application example
The utility model provides a convenient plaster, refers to fig. 1, including electric heater 1, electric heater's heating surface can be dismantled and be equipped with installation piece 2, can dismantle on the installation piece 2 and paste ointment 3. Wherein the thickness of the ointment 3 is 0.1-0.3 mm.
Test 1
The ointment in each example and each proportion is used for treating patients suffering from mild rheumatoid arthritis (the disease age does not exceed 2 years, and the VAS pain score is less than 3 points), and the specific conditions of the patients are as follows:
patient 1:
mr. wang, age 32, suffered from rheumatoid arthritis for 1 year, had a VAS pain score of 2.53 points for the patient before treatment, and was treated by applying a convenient patch containing 0.2mm of the ointment of example 1 every day for 33 days, so that the pain of the patient disappeared and no recurrence occurred during two years of return visits.
Patient 2:
the plum female is 44 years old, suffers from rheumatic arthritis for 1.5 years, the VAS pain score of a patient before treatment is 2.69 minutes, and the pain of the patient disappears after 34 days of treatment by sticking a convenient plaster containing 0.2mm of the ointment of the embodiment 2, and the relapse phenomenon does not occur in two-year return visits.
Patient 3:
tan lady, 38 years old, suffered from rheumatoid arthritis for 1.5 years, had VAS pain rating of 2.78 points before treatment, and was pasted with a convenient paste containing 0.2mm of the ointment of embodiment 3 every day, after 29 days of treatment, the pain of the patient disappeared, and the disease was not relapsed during two-year return visits.
Patient 4:
for a grandchild, the age of 53 years old, the patient suffered from rheumatoid arthritis for 1.5 years, the VAS pain score of the patient before treatment was 2.83 minutes, and after 27 days of treatment, the pain of the patient disappeared after the patient was pasted with a convenient paste containing 0.2mm of the ointment of the embodiment 4, and the patient had no recurrence after two years of return visits.
Patient 5:
shen Mr. 53 years old, suffering from rheumatoid arthritis for 2 years, before treatment, the VAS pain score of the patient is 2.94 points, after a convenient plaster containing 0.2mm of the ointment 5 in the embodiment is pasted every day, the pain of the patient disappears after 25 days of treatment, and the patient does not have a relapse phenomenon after return visit within two years.
Patient 6:
the pain of the patients disappears after 24 days of treatment, and the patients have no recurrence phenomenon after revisitation within two years.
Patient 7:
xu women, 56 years old, suffered from rheumatoid arthritis for 1.5 years, had VAS pain rating of 2.67 minutes before treatment, and were treated by applying a convenient patch containing 0.2mm of the ointment of this example 7 every day for 42 days, the pain of the patients disappeared, and there was no recurrence after two-year return visits.
Patient 8:
the pain of the patients disappears after 45 days of treatment, and the patients have no recurrence phenomenon within two years of return visit.
Patient 9:
mr. gourmet, 35 years old, suffered from rheumatoid arthritis for 2 years, had a VAS pain score of 2.98 points for patients before treatment, and had no recurrence after 20 days of treatment since patients had no pain sensation after daily application of a convenient patch containing 0.2mm of the ointment of this example 9.
The patient 10:
mr. chen, age 46, suffered from rheumatoid arthritis for 1.5 years, had a VAS pain score of 2.86 points for the patient before treatment, and had pain disappeared after 24 days of treatment by applying a convenient patch containing 0.2mm of the ointment of this example 10, and there was no recurrence during two years of return visits.
Patient 11:
for a woman in the year of 60, suffering from rheumatoid arthritis for 2 years, the VAS pain score of the patient before treatment is 2.94 minutes, and the patient is pasted with a convenient paste containing 0.2mm of the ointment of the embodiment 11 every day, so that the pain of the patient disappears after 17 days of treatment, and the patient does not relapse after two-year return visits.
Patient 12:
mr. Li, age 46, suffered from rheumatoid arthritis for 2 years, had VAS pain rating of 2.98 points for patients before treatment, and had pain disappeared after 13 days of treatment by applying a convenient patch containing 0.2mm of the 12 embodiment ointment daily, and there was no recurrence within two years of return visits.
Patient 13:
mr. week, 51 years old, suffered from rheumatoid arthritis for 2 years, the VAS pain score of the patient before treatment was 2.96 minutes, and after 16 days of treatment, the pain of the patient disappeared and no recurrence occurred within two years of return visit by sticking a convenient patch containing 0.2mm of the ointment of this example 13 every day.
Patient 14:
the pain of the patients disappears after 72 days of treatment, and the patients do not relapse within two years of return visit.
Patient 15:
the female plum is 48 years old, suffered from rheumatic arthritis for 1.5 years, the VAS pain score of the patient before treatment is 2.81 points, and after the female plum is pasted with a convenient paste containing 0.2mm of the ointment in the comparative example 2 every day, the pain of the patient disappears after 78 days of treatment, and the female plum has no recurrence phenomenon after two years of return visits.
Patient 16:
mr. chen, age 39, suffered from rheumatoid arthritis for 2 years, had a VAS pain score of 2.93 points for the patient before treatment, and was treated 83 days later by applying a convenient patch containing 0.2mm of the ointment of comparative example 3, and the pain of the patient disappeared without recurrence within two years of return visits.
Test 2
The ointment in each example and each proportion is used for treating patients with moderate rheumatoid arthritis (the disease age is 3-5 years, and the VAS pain score is 4-6), and the specific conditions of the patients are as follows:
patient 1:
the pain of the patients disappears after 63 days of treatment, and the patients do not relapse within two years of return visit after the patients are treated by sticking a convenient plaster containing 0.2mm of the ointment of the embodiment 1 every day after the patients are treated by the VAS pain score of 4.62 for 43 years old with rheumatic arthritis.
Patient 2:
mr. wang, age 40, suffered from rheumatoid arthritis for 4 years, had a VAS pain score of 4.89 points for the patient before treatment, and had no recurrence after 64 days of treatment after the patient had pain disappeared by applying a convenient patch containing 0.2mm of the ointment of this example 2 daily.
Patient 3:
wen women, 45 years old, suffered from rheumatoid arthritis for 4 years, had VAS pain scores of 4.92 points before treatment, and were treated by applying a convenient patch containing 0.2mm of the ointment of this example 3 every day for 62 days, so that the pain of the patients disappeared and no recurrence occurred within two years of return visits.
Patient 4:
chua lady, 56 years old, suffered from rheumatoid arthritis for 4 years, had a VAS pain score of 4.97 minutes before treatment, and had a convenient plaster containing 0.2mm of the ointment of this example 4 applied every day, and after 56 days of treatment, the pain of the patient disappeared, and there was no recurrence during two years of return visits.
Patient 5:
mr. Li, 58 years old, suffered from rheumatoid arthritis for 5 years, had a VAS pain score of 5.22 points for patients before treatment, and had pain disappeared after 54 days of treatment by applying a convenient patch containing 0.2mm of the ointment of this example 5 every day, and there was no recurrence after two years of return visits.
Patient 6:
mr. summer, 43 years old, suffered from rheumatoid arthritis for 5 years, had a VAS pain score of 5.17 points for the patient before treatment, and was treated 53 days later by applying a convenient patch containing 0.2mm of the 6. sup. ointment of this example, the pain of the patient disappeared, and there was no recurrence during return visit for two years.
Patient 7:
mr. Yew, 59 years old, suffered from rheumatoid arthritis for 4 years, the VAS pain score of the patient before treatment was 4.84 minutes, and after 74 days of treatment, the pain of the patient disappeared and no recurrence occurred within two years of return visit by applying a convenient patch containing 0.2mm of the ointment of this example 7 every day.
Patient 8:
lu women, 50 years old, suffered from rheumatoid arthritis for 3 years, had VAS pain rating of 4.66 points before treatment, and were treated by applying a convenient patch containing 0.2mm of the ointment of this example 8 every day for 76 days, the pain of the patients disappeared, and there was no recurrence within two years of return visits.
Patient 9:
mr. week, age 58, suffered from rheumatoid arthritis for 5 years, with the VAS pain score of the patient before treatment being 5.32 points, and after 50 days of treatment, the pain of the patient disappeared and no recurrence occurred within two years of return visit by applying a convenient patch containing 0.2mm of the ointment of this example 9 daily.
The patient 10:
old women, 47 years old, suffered from rheumatoid arthritis for 4 years, had VAS pain scores of 4.90 points before treatment, and were pasted with a convenient paste containing 0.2mm of the ointment of this example 10 every day, after 54 days of treatment, the pain of the patients disappeared, and there was no recurrence within two years of return visits.
Patient 11:
mr. Zhang, 55 years old, suffered from rheumatoid arthritis for 5 years, the VAS pain score of the patient before treatment was 5.41 points, and after 45 days of treatment, the pain of the patient disappeared and no recurrence occurred within two years after the patient was treated by applying a convenient patch containing 0.2mm of the ointment of this example 11.
Patient 12:
mr. Dong, 45 years old, suffered from rheumatoid arthritis for 5 years, scored 5.48 points on VAS pain of patients before treatment, and stuck with a convenient paste containing 0.2mm of the 12-embodiment ointment every day, so that after 41 days of treatment, the pain of the patients disappears, and the patients do not relapse within two years of return visit.
Patient 13:
for a simple woman, 51 years old, suffering from rheumatoid arthritis for 5 years, the VAS pain score of a patient before treatment is 5.38 minutes, and after the patient is pasted with a convenient paste containing 0.2mm of the ointment 13 in the embodiment every day, the pain of the patient disappears after 46 days of treatment, and the patient does not have a relapse phenomenon after two-year return visits.
Patient 14:
peng Mr. meyensis, 60 years old, suffered from rheumatoid arthritis for 3 years, the VAS pain score of the patient before treatment is 4.53 minutes, and after 103 days of treatment, the pain of the patient disappears, and the patient returns to visit and recurs after 3 months by sticking a convenient plaster containing 0.2mm of the ointment of comparative example 1 every day.
Patient 15:
the pain of the patients is disappeared after 108 days of treatment, the patients return visit and relapse after 5 months after treatment by sticking a convenient plaster containing 0.2mm of the ointment of the comparative example 2 every day after the patients are cured for 4.90 minutes before the patients are cured by VAS pain.
Patient 16:
mr. Guo, age 49, suffered from rheumatoid arthritis for 5 years, with the VAS pain score of the patient before treatment of 5.18 points, after 116 days of treatment, the pain of the patient disappeared and was returned to visit, and after 4 months, the patient was returned by applying a convenient patch containing 0.2mm of the ointment of comparative example 3 every day.
Test 3
The ointment in each example and each proportion is used for treating patients with severe rheumatoid arthritis (the disease age is more than 5 years, and the VAS pain score is 8-10), and the specific conditions of the patients are as follows:
patient 1:
mr. forest, 54 years old, suffered from rheumatoid arthritis for 8 years, scored 8.66 points for VAS pain of patients before treatment, and stuck with a convenient plaster containing 0.2mm of the ointment of the embodiment 1 every day, so that after 102 days of treatment, the pain of the patients disappears, and no relapse occurs in return visits within two years.
Patient 2:
for women, 62 years old, suffering from rheumatoid arthritis for 9 years, the VAS pain score of a patient before treatment is 8.90 minutes, and after 104 days of treatment, the pain of the patient disappears and no recurrence occurs in return visit within two years after the patient is pasted with a convenient paste containing 0.2mm of the ointment of the embodiment 2 every day.
Patient 3:
mr. Sun, 56 years old, suffered from rheumatoid arthritis for 9 years, the VAS pain score of the patient before treatment was 9.01 points, and after 102 days of treatment, the pain of the patient disappeared after the patient was treated by applying a convenient patch containing 0.2mm of the ointment of the embodiment 3 every day, and no recurrence occurred within two years of return visits.
Patient 4:
for a lady with leaves and age 62, the patient suffered from rheumatoid arthritis for 9 years, the VAS pain score of the patient before treatment was 9.06 points, and after the patient was pasted with a convenient paste containing 0.2mm of the ointment of the embodiment 4 every day, the pain of the patient disappeared after treatment for 103 days, and the patient had no recurrence after return visit within two years.
Patient 5:
mr. old, 58 years old, suffered from rheumatoid arthritis for 10 years, had a VAS pain score of 9.32 points for the patient before treatment, and was pasted with a convenient patch containing 0.2mm of the ointment of example 5 every day, after 90 days of treatment, the pain of the patient disappeared, and there was no recurrence within two years of return visits.
Patient 6:
the patients with rheumatoid arthritis suffered from the rheumatoid arthritis for 10 years in 62 years old in the week are 9.28 points in VAS pain score before treatment, and after the patients are pasted with a convenient paste containing 0.2mm of the ointment 6 in the embodiment every day for 92 days, the pain of the patients disappears, and the patients do not relapse after return visit within two years.
Patient 7:
mr. Li, 49 years old, suffered from rheumatoid arthritis for 9 years, had VAS pain rating of 8.84 points for the patient before treatment, and after 116 days of treatment, the pain of the patient disappeared and no recurrence occurred within two years after treatment by applying a convenient patch containing 0.2mm of the ointment of this example 7 every day.
Patient 8:
old women, 52 years old, suffered from rheumatoid arthritis for 8 years, had VAS pain scores of 8.68 points before treatment, and were pasted with a convenient paste containing 0.2mm of the ointment of this example 8 every day, after 113 days of treatment, the pain of the patients disappeared, and there was no recurrence within two years of return visits.
Patient 9:
mr. Song, 61 years old, suffered from rheumatoid arthritis for 10 years, scored 9.42 points for VAS pain of patients before treatment, and stuck with a convenient patch containing 0.2mm of the ointment 9 of the embodiment every day, after 83 days of treatment, the pain of patients disappeared, and no recurrence occurred within two years of return visits.
The patient 10:
mr. Cheng, 52 years old, suffered from rheumatoid arthritis for 9 years, had VAS pain rating of 9.03 points for patients before treatment, and had pain disappeared after 89 days of treatment by applying a convenient patch containing 0.2mm of the ointment of this example 10 every day, and there was no recurrence after two years of return visits.
Patient 11:
blue women, 62 years old, suffered from rheumatoid arthritis for 10 years, had VAS pain scores of 9.48 points before treatment, and had pain disappeared after 79 days of treatment by applying a convenient patch containing 0.2mm of the ointment of this example 11 every day, and there was no recurrence after two years of return visits.
Patient 12:
zhengmr, age 68, suffering from rheumatoid arthritis for 10 years, VAS pain of the patient before treatment is scored as 9.50 minutes, and after the patient is pasted with a convenient paste containing 0.2mm of the ointment 12 in the embodiment every day, the pain of the patient disappears after 74 days of treatment, and the patient does not have a relapse phenomenon after return visit within two years.
Patient 13:
liao women, 58 years old, suffered from rheumatic arthritis for 10 years, had VAS pain score of 9.46 points before treatment, and had pain disappeared after 78 days of treatment by applying a convenient patch containing 0.2mm of the ointment of this example 13 every day, and there was no recurrence after two years of return visits.
Patient 14:
mr. wang, 55 years old, suffered from rheumatoid arthritis for 8 years, had a VAS pain score of 8.69 points for patients before treatment, and had a VAS pain score of 4.53 points for patients after 120 days of treatment by daily application of a convenient patch containing 0.2mm of the ointment of comparative example 1.
Patient 15:
mr. Li, 56 years old, suffered from rheumatoid arthritis for 9 years, had a VAS pain score of 8.93 for the patient before treatment, and had a VAS pain score of 3.98 for 120 days after treatment by applying a convenient patch containing 0.2mm of the ointment of comparative example 2 daily.
Patient 16:
mr. Guen, 61 years old, suffered from rheumatoid arthritis for 10 years, had a VAS pain score of 9.28 points for patients before treatment, and had a VAS pain score of 5.02 points after 120 days of treatment by daily application of a convenient patch containing 0.2mm of the ointment of comparative example 3.
Therefore, when the ointment for treating rheumatism is prepared from the blumea balsamifera, the galangal, the dried orange peel, the amomum villosum, the agastache rugosus, the cinnamon, the asarum, the evodia rutaecarpa, the eupatorium fortunei, the murraya paniculata, the stephania sinica and the magnolia flower according to the proportion of the ointment, the ointment can effectively play the effects of eliminating dampness and relieving pain, so that the ointment can play a role in treating rheumatism patients with different degrees, the application range of the ointment is expanded, the cure time of the patients is shortened, and the relapse situation of the patients can not occur for two years.

Claims (8)

1. An ointment which is characterized in that: the ointment is prepared from the following raw materials in parts by weight:
38-48 parts of blumea red-foot, 15-25 parts of galangal, 9-15 parts of dried orange peel, 3-8 parts of amomum villosum, 4-6 parts of wrinkled gianthyssop, 3-5 parts of cinnamon, 5-10 parts of asarum, 4-8 parts of evodia rutaecarpa, 5-15 parts of eupatorium, 10-15 parts of murraya paniculata, 10-20 parts of Stephania delavayi and 8-20 parts of magnolia flower.
2. An ointment according to claim 1, characterized in that: the ointment is prepared from the following raw materials in parts by weight:
40 parts of blumea red-foot, 22 parts of galangal, 12 parts of dried orange peel, 3 parts of amomum villosum, 4 parts of wrinkled gianthyssop herb, 3 parts of cinnamon, 10 parts of asarum, 4 parts of evodia rutaecarpa, 5 parts of eupatorium, 15 parts of murraya paniculata, 15 parts of stephania sinica and 10 parts of magnolia flower.
3. An ointment according to claim 1, characterized in that: the ointment is prepared from the following raw materials in parts by weight:
45 parts of blumea red-foot, 15 parts of galangal, 10 parts of dried orange peel, 8 parts of amomum villosum, 6 parts of wrinkled gianthyssop, 5 parts of cinnamon, 5 parts of asarum, 8 parts of evodia rutaecarpa, 10 parts of eupatorium, 10 parts of murraya paniculata, 10 parts of stephania sinica and 15 parts of magnolia flower.
4. An ointment according to claim 1, characterized in that: the ointment is prepared from the following raw materials in parts by weight:
40 parts of blumea red-foot, 20 parts of galangal, 10 parts of dried orange peel, 5 parts of amomum villosum, 5 parts of wrinkled gianthyssop, 5 parts of cinnamon, 5 parts of asarum, 5 parts of evodia rutaecarpa, 5 parts of eupatorium, 10 parts of murraya paniculata, 10 parts of stephania sinica and 10 parts of magnolia flower.
5. A method of preparing an ointment according to any one of claims 1 to 4, characterized in that: the method comprises the following steps:
s1, crushing blumea balsamifera, galangal, dried orange peel, amomum villosum, agastache rugosus, cinnamon, asarum, evodia rutaecarpa, eupatorium, murraya paniculata, Stephania delavayi and magnolia flower pollen into 400 meshes in parts by weight to obtain traditional Chinese medicine powder;
s2, carrying out first CO treatment on the traditional Chinese medicine powder2Performing supercritical extraction to obtain extract A and residue A; wherein, CO for the first time2The entrainer used in the supercritical extraction is ethanol, the extraction pressure is 15-25MPa, the extraction temperature is 30-50 ℃, the separation pressure is 4-6MPa, the separation temperature is 20-30 ℃, and the extraction time is 2-3 h;
s3, drying the medicine residue A, and then carrying out secondary CO treatment on the dried medicine residue A2Performing supercritical extraction to obtain extract B and residue B; wherein, the second CO2The entrainer adopted in the supercritical extraction is ethyl acetate, the extraction pressure is 20-40MPa, the extraction temperature is 40-50 ℃, the separation pressure is 8-10MPa, the separation temperature is 30-40 ℃, and the extraction time is 1-2 h;
s4, adding glycerol into the medicine residue B, stirring to be pasty under the water bath heating state of 50-60 ℃, then adding sodium polyacrylate with the mass concentration of 1%, stirring uniformly, adding the extract A and the extract B, and continuing stirring uniformly to obtain an ointment; wherein the medicine residue B, glycerin, sodium polyacrylate with the mass concentration of 1%, and the weight ratio of the extract A to the extract B are (5-12): 25: (1-1.5): (1-1.5): (0.5-1.5).
6. The method for preparing an ointment according to claim 5, which is characterized in that: the medicine residue B, glycerin, sodium polyacrylate with the mass concentration of 1%, and the weight ratio of the extract A to the extract B is 9: 25: 2: 1.25: 1.
7. the method for preparing an ointment according to claim 5, which is characterized in that: the particle size range of the traditional Chinese medicine powder is 200-300 meshes.
8. A convenient patch containing an ointment according to any one of claims 1 to 4, which is characterized in that: the ointment patch comprises an electric heater, wherein a heating surface of the electric heater is detachably provided with a mounting block, and the mounting block is detachably provided with the ointment patch as claimed in any one of claims 1 to 4.
CN202110833020.7A 2021-07-22 2021-07-22 Ointment, preparation method of ointment and convenient patch containing ointment Pending CN113425673A (en)

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Application publication date: 20210924