CN113425660A - Whitening composition for inhibiting tyrosinase activity by competitive and non-competitive combination - Google Patents
Whitening composition for inhibiting tyrosinase activity by competitive and non-competitive combination Download PDFInfo
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- CN113425660A CN113425660A CN202110915320.XA CN202110915320A CN113425660A CN 113425660 A CN113425660 A CN 113425660A CN 202110915320 A CN202110915320 A CN 202110915320A CN 113425660 A CN113425660 A CN 113425660A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The invention belongs to the technical field of cosmetics, and discloses a whitening composition for inhibiting tyrosinase activity by combining competitive and non-competitive methods, which comprises a solvent, an emulsifier, grease, a thickening agent, a humectant, an antioxidant, a preservative and the whitening composition, wherein the preparation method comprises the following steps: the method comprises the following steps of S1, mixing the emulsifier, the grease and the antioxidant, heating to 75-80 ℃ to obtain a first mixture for later use, S2, mixing the humectant and the thickener, heating to 75-80 ℃ to obtain a second mixture for later use, S3, adding the first mixture into the second mixture, homogenizing for 5 minutes, then stirring at a low speed in vacuum for 15 minutes, cooling to 40 ℃ after stirring is finished to obtain a third mixture, and S4, adding the rest raw materials into the third mixture, uniformly stirring, and taking out of a pot.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a whitening composition for inhibiting tyrosinase activity by combining competitive and non-competitive methods.
Background
People in modern society have fast pace of life and high pressure of life, and various problems often occur to the skin due to environmental influence, and the skin needs to be repaired by cosmetics. Statistically, about 50% or more of female responders consider the formation of facial freckles, chloasma, age spots as one of the major factors affecting appearance and confidence.
Currently, spot removing products in the cosmetic market are diversified, but most of the spot removing products contain various preservatives, ethanol, synthetic flavors and fragrances and other ingredients, and excessive non-functional ingredients cause additional damage to the skin, such as skin allergy and red swelling. In addition, most of the existing freckle removing and whitening products on the market mainly comprise chemical components, the whitening strategy is too single, certain effects can be achieved when the whitening products are used for a short time, but the skin can be endured and rebounded after the whitening products are used for a long time, and the effect is poor.
Disclosure of Invention
In order to solve the above problems of the prior art, the present invention aims to provide a whitening composition that inhibits tyrosinase activity in competitive and non-competitive combinations.
The technical scheme adopted by the invention is as follows: a whitening composition for inhibiting tyrosinase activity in competitive and non-competitive combination comprises a solvent, an emulsifier, grease, a thickening agent, a humectant, an antioxidant, a preservative and a whitening composition, and a preparation method of the preparation comprises the following steps: s1, mixing the emulsifier, the grease and the antioxidant, heating to 75-80 ℃ to obtain a first mixture for later use, S2, mixing the humectant and the thickener, heating to 75-80 ℃ to obtain a second mixture for later use, S3, adding the first mixture into the second mixture, homogenizing for 5 minutes, then stirring at low speed in vacuum for 15 minutes, cooling to 40 ℃ after stirring is finished to obtain a third mixture, and S4, adding the rest raw materials into the third mixture, uniformly stirring, and taking out of the third mixture.
Furthermore, the preparation comprises 21-92.15 parts of solvent, 2-4 parts of emulsifier, 5-40 parts of grease, 0.05-3 parts of thickener, 0.05-20 parts of humectant, 0.05-1 part of antioxidant, 0.2-1 part of preservative and 0.5-10 parts of whitening composition.
Further, the homogenizing speed in S3 is 2500-3000rpm, the rotating speed of low-speed vacuum stirring is 50-70rpm, the vacuum degree is-0.06 MPa to-0.08 MPa, and the cooling speed in S3 is 1 ℃/min.
Further, the solvent is pure water, and the emulsifier is glyceryl stearate, PEG-100 stearate, methyl glucose sesquistearate, PEG-20 methyl glucose sesquistearate, lanolin-polyether-25, potassium cetyl phosphate.
Further, the oil is olive oil, caprylic/capric triglyceride, cacao butter, polydimethylsiloxane, meadowfoam seed oil, shea butter, isopropyl myristate, hydrogenated polyisobutene.
Still further, the thickening agent includes xanthan gum, cetearyl alcohol, carbomer, sodium acrylate/sodium acryloyldimethyl taurate copolymer.
Still further, the moisturizer comprises glycerin, propylene glycol, butylene glycol, dipropylene glycol, glyceryl polyether-26, sodium hyaluronate, trehalose, allantoin, polyglutamic acid, and betaine.
Still further, the antioxidant comprises tocopherol, rosemary leaf extract.
Still further, the preservative comprises 1, 2-pentanediol, p-hydroxyacetophenone, 1, 2-hexanediol, caprylyl hydroxamic acid, phenoxyethanol, glyceryl caprylate.
Still further, the whitening composition comprises millet seed extract, carnosine, rosa canina flower/leaf/stem extract, niacinamide, butylene glycol, water.
The invention has the beneficial effects that:
the whitening composition for inhibiting tyrosinase activity through competitive and non-competitive combination is characterized in that flavonoid components contained in a millet seed extract, such as quercetin, dihydroquercetin, myricetin, dihydromyricetin and the like, can well inhibit the tyrosinase activity in a mode of combining competitive inhibition and non-competitive inhibition; the rosa canina flower/leaf/stem extract is rich in polyphenol compounds, can non-competitively inhibit the activity of tyrosinase, can be combined with the active center of the tyrosinase to form a hydrogen bond, is accompanied with a hydrophobic structure, and realizes the effects of whitening and brightening skin.
Detailed Description
The present invention is further illustrated below with reference to specific examples.
Example 1:
the embodiment provides a whitening composition for inhibiting tyrosinase activity in a competitive and non-competitive combination manner, which comprises a solvent, an emulsifier, grease, a thickening agent, a humectant, an antioxidant, a preservative and a whitening composition, and the preparation method of the whitening composition comprises the following steps: s1, mixing the emulsifier, the grease and the antioxidant, heating to 75-80 ℃ to obtain a first mixture for later use, S2, mixing the humectant and the thickener, heating to 75-80 ℃ to obtain a second mixture for later use, S3, adding the first mixture into the second mixture, homogenizing for 5 minutes, then stirring at low speed in vacuum for 15 minutes, cooling to 40 ℃ after stirring is finished to obtain a third mixture, and S4, adding the rest raw materials into the third mixture, uniformly stirring, and taking out of the third mixture.
Specifically, the preparation comprises, by weight, 21-92.15 parts of a solvent, 2-4 parts of an emulsifier, 5-40 parts of grease, 0.05-3 parts of a thickener, 0.05-20 parts of a humectant, 0.05-1 part of an antioxidant, 0.2-1 part of a preservative, and 0.5-10 parts of a whitening composition.
Specifically, the homogenizing speed in S3 is 2500-3000rpm, the low-speed vacuum stirring speed is 50-70rpm, the vacuum degree is-0.06 MPa-0.08 MPa, and the cooling speed in S3 is 1 ℃/min.
Specifically, the solvent is pure water, the emulsifier is glycerol stearate, PEG-100 stearate, methyl glucose sesquistearate, PEG-20 methyl glucose sesquistearate, lanolin-25, potassium cetyl phosphate, the grease is olive oil, caprylic/capric triglyceride, cocoa butter, polydimethylsiloxane, meadowfoam seed oil, shea butter, isopropyl myristate, hydrogenated polyisobutene, the thickener comprises xanthan gum, cetyl stearyl alcohol, carbomer, sodium acrylate/sodium acryloyldimethyl taurate copolymer, the humectant comprises glycerol, propylene glycol, butylene glycol, dipropylene glycol, glyceryl polyether-26, sodium hyaluronate, trehalose, allantoin, polyglutamic acid, betaine, the antioxidant comprises tocopherol, rosemary leaf extract, the preservative comprises 1, 2-pentanediol, p-hydroxyacetophenone, 1, 2-hexanediol, caprylyl hydroxamic acid, phenoxyethanol, glyceryl caprylate, and the whitening composition comprises millet seed extract, carnosine, rosa canina flower/leaf/stem extract, niacinamide, butylene glycol, and water.
The present invention is not limited to the above-described alternative embodiments, and various other forms of products can be obtained by anyone in light of the present invention. The above detailed description should not be taken as limiting the scope of the invention, which is defined in the claims, and which the description is intended to be interpreted accordingly.
Claims (10)
1. A whitening composition that competitively and non-competitively binds to inhibit tyrosinase activity, characterized by: the whitening cream comprises a solvent, an emulsifier, grease, a thickening agent, a humectant, an antioxidant, a preservative and a whitening composition, and the preparation method of the whitening cream comprises the following steps:
s1, mixing the emulsifier, the grease and the antioxidant, and heating to 75-80 ℃ to obtain a first mixture for later use;
s2, mixing the humectant and the thickener, and heating to 75-80 ℃ to obtain a second mixture for later use;
s3, adding the first mixture into the second mixture, homogenizing for 5 minutes, then stirring at low speed in vacuum for 15 minutes, and cooling to 40 ℃ after stirring to obtain a third mixture;
and S4, adding the rest raw materials into the third mixture, uniformly stirring, and taking out of the pot.
2. The competitive and non-competitive binding tyrosinase activity inhibiting whitening composition according to claim 1, characterized by: the preparation comprises the following components of 21-92.15 parts of solvent, 2-4 parts of emulsifier, 5-40 parts of grease, 0.05-3 parts of thickener, 0.05-20 parts of humectant, 0.05-1 part of antioxidant, 0.2-1 part of preservative and 0.5-10 parts of whitening composition.
3. The competitive and non-competitive binding tyrosinase activity inhibiting whitening composition according to claim 1, characterized by: the homogenizing speed in the S3 is 2500-3000rpm, the low-speed vacuum stirring speed is 50-70rpm, the vacuum degree is-0.06 MPa-0.08 MPa, and the cooling speed in the S3 is 1 ℃/min.
4. The competitive and non-competitive binding tyrosinase activity inhibiting whitening composition according to claim 2, characterized by: the solvent is pure water, and the emulsifier is glyceryl stearate, PEG-100 stearate, methyl glucose sesquistearate, PEG-20 methyl glucose sesquistearate, lanolin alcohol polyether-25, and potassium cetyl phosphate.
5. The competitive and non-competitive binding tyrosinase activity inhibiting whitening composition according to claim 2, characterized by: the oil is selected from olive oil, caprylic/capric triglyceride, cacao butter, polydimethylsiloxane, meadowfoam seed oil, shea butter, isopropyl myristate, and hydrogenated polyisobutene.
6. The competitive and non-competitive binding tyrosinase activity inhibiting whitening composition according to claim 2, characterized by: the thickening agent comprises xanthan gum, cetearyl alcohol, carbomer, and sodium acrylate/sodium acryloyldimethyl taurate copolymer.
7. The competitive and non-competitive binding tyrosinase activity inhibiting whitening composition according to claim 2, characterized by: the humectant comprises glycerol, propylene glycol, butanediol, dipropylene glycol, glyceryl polyether-26, sodium hyaluronate, trehalose, allantoin, polyglutamic acid, and betaine.
8. The competitive and non-competitive binding tyrosinase activity inhibiting whitening composition according to claim 2, characterized by: the antioxidant comprises tocopherol and rosemary leaf extract.
9. The competitive and non-competitive binding tyrosinase activity inhibiting whitening composition according to claim 2, characterized by: the preservative comprises 1, 2-pentanediol, p-hydroxyacetophenone, 1, 2-hexanediol, caprylyl hydroxamic acid, phenoxyethanol and glyceryl caprylate.
10. The competitive and non-competitive binding tyrosinase activity inhibiting whitening composition according to claim 2, characterized by: the whitening composition comprises millet seed extract, carnosine, rosa canina flower/leaf/stem extract, niacinamide, butylene glycol, and water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110915320.XA CN113425660A (en) | 2021-08-10 | 2021-08-10 | Whitening composition for inhibiting tyrosinase activity by competitive and non-competitive combination |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110915320.XA CN113425660A (en) | 2021-08-10 | 2021-08-10 | Whitening composition for inhibiting tyrosinase activity by competitive and non-competitive combination |
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| Publication Number | Publication Date |
|---|---|
| CN113425660A true CN113425660A (en) | 2021-09-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110915320.XA Withdrawn CN113425660A (en) | 2021-08-10 | 2021-08-10 | Whitening composition for inhibiting tyrosinase activity by competitive and non-competitive combination |
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| CN (1) | CN113425660A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116751257A (en) * | 2023-08-14 | 2023-09-15 | 江苏华肌生物科技有限公司 | Rosa polypeptide and application thereof in skin whitening and moisturizing medicines or cosmetics |
-
2021
- 2021-08-10 CN CN202110915320.XA patent/CN113425660A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116751257A (en) * | 2023-08-14 | 2023-09-15 | 江苏华肌生物科技有限公司 | Rosa polypeptide and application thereof in skin whitening and moisturizing medicines or cosmetics |
| CN116751257B (en) * | 2023-08-14 | 2023-10-20 | 江苏华肌生物科技有限公司 | Rosa polypeptide and application thereof in skin whitening and moisturizing medicines or cosmetics |
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| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20210924 |
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| WW01 | Invention patent application withdrawn after publication |