CN113406981A - Circuit, method and device for controlling temperature of cell culture box and culture box - Google Patents
Circuit, method and device for controlling temperature of cell culture box and culture box Download PDFInfo
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- CN113406981A CN113406981A CN202110535782.9A CN202110535782A CN113406981A CN 113406981 A CN113406981 A CN 113406981A CN 202110535782 A CN202110535782 A CN 202110535782A CN 113406981 A CN113406981 A CN 113406981A
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- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D23/00—Control of temperature
- G05D23/19—Control of temperature characterised by the use of electric means
- G05D23/1927—Control of temperature characterised by the use of electric means using a plurality of sensors
- G05D23/193—Control of temperature characterised by the use of electric means using a plurality of sensors sensing the temperaure in different places in thermal relationship with one or more spaces
- G05D23/1931—Control of temperature characterised by the use of electric means using a plurality of sensors sensing the temperaure in different places in thermal relationship with one or more spaces to control the temperature of one space
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/25—Greenhouse technology, e.g. cooling systems therefor
Abstract
The application relates to the technical field of intelligent incubators and discloses a circuit, a method, a device and an incubator for controlling the temperature of a cell incubator. The method comprises the following steps: obtaining a current sampling voltage matched with the alternating voltage supplied by the cell incubator according to a current sampling voltage signal acquired by a sampling circuit; determining the current actual power supply voltage matched with the current sampling voltage according to the corresponding relation between the stored sampling voltage and the actual power supply voltage; and determining the current theoretical output power of the heating wires on each surface of the cell culture box according to the current actual power supply voltage, and controlling the operation of the corresponding heating wires according to the current theoretical output power. The accurate temperature control of the cell culture box is realized, the probability of condensation generated on the inner wall of the culture box is reduced, and the temperature stability of the culture box is improved.
Description
Technical Field
The present application relates to the field of intelligent incubator technology, for example, to circuits, methods, devices and incubators for temperature control of cell incubators.
Background
The cell culture box can also be called as a carbon dioxide culture box, and is a box body for controlling the temperature and the concentration of carbon dioxide, the temperature and the concentration are mainly controlled to be 37 ℃ plus or minus 0.1 and 5 percent plus or minus 0.1 respectively, and the humidity is more than 90 percent, so that the environment in a human body is simulated for cell culture. The incubator has extremely strict temperature control and is required to have no condensation phenomenon on the inner wall of the incubator body. Because the humidity in the box body is very high, the condensation phenomenon can be caused by slight fluctuation of temperature or uneven heat of the inner container wall.
At present, the temperature control of the carbon dioxide incubator is realized by controlling heating wires to heat, wherein the left side surface, the right side surface, the top part, the back part, the bottom part, the door body and the cabinet opening of the incubator body are all provided with heating wires with certain power, so that the heating wires are arranged on all surfaces, and the temperature can be controlled easily without generating condensation phenomenon. In the process of temperature control, if a certain surface is heated unevenly, in order to avoid the water vapor from condensing into dew, the power of the heating wire on the surface needs to be increased. However, the power distribution of each surface cannot be intelligentized at present, the fluctuation stability and the condensation-free phenomenon of the temperature are difficult to coexist, the critical value is often an empirical value, the temperature fluctuation is sacrificed to replace the condensation-free phenomenon of the inner wall most of the time, therefore, the temperature in the incubator is easy to fluctuate, the probability of generating the condensation is increased, and the temperature control stability is still required to be improved.
Disclosure of Invention
The following presents a simplified summary in order to provide a basic understanding of some aspects of the disclosed embodiments. This summary is not an extensive overview nor is intended to identify key/critical elements or to delineate the scope of such embodiments but rather as a prelude to the more detailed description that is presented later.
The embodiment of the disclosure provides a circuit, a method and a device for controlling the temperature of a cell culture box and the cell culture box, and aims to solve the technical problem that the temperature control stability of the cell culture box is not high.
In some embodiments, the circuit comprises: a transformer, a rectifying circuit, a filter circuit, and a series voltage divider circuit, wherein,
the alternating current voltage of the power supply of the cell culture box is converted into direct current voltage through the rectifier circuit after passing through the transformer;
and after being filtered by a filter circuit, the direct current voltage is input to two ends of the series voltage division circuit to obtain a sampling voltage on a first resistor in the series voltage division circuit, and is input into a device for controlling the temperature of the cell culture box.
In some embodiments, the method comprises:
obtaining a current sampling voltage matched with an alternating voltage supplied by the cell incubator through the sampling circuit;
determining the current actual power supply voltage matched with the current sampling voltage according to the corresponding relation between the stored sampling voltage and the actual power supply voltage;
and determining the current theoretical output power of the heating wires on each surface of the cell culture box according to the current actual power supply voltage, and controlling the operation of the corresponding heating wires according to the current theoretical output power.
In some embodiments, the apparatus comprises:
the acquisition module is configured to obtain a current sampling voltage matched with an alternating voltage supplied by the cell incubator through the sampling circuit;
the determining module is configured to determine a current actual power supply voltage matched with the current sampling voltage according to the corresponding relation between the saved sampling voltage and the actual power supply voltage;
and the control module is configured to determine the current theoretical output power of the heating wires on each surface of the cell incubator according to the current actual power supply voltage, and control the operation of the corresponding heating wires according to the current theoretical output power.
In some embodiments, the apparatus for cell incubator temperature control comprises a processor and a memory storing program instructions, the processor being configured to, upon execution of the program instructions, perform the above-described method for cell incubator temperature control.
In some embodiments, the incubator comprises the above-described apparatus for temperature control of a cell incubator.
The circuit, the method, the device and the incubator for controlling the temperature of the cell incubator, provided by the embodiment of the disclosure, can realize the following technical effects:
the actual power supply voltage corresponding to the alternating voltage supplied by the cell incubator is obtained through the sampling circuit and corrected to be stable theoretical output power, so that the control parameters of the heating wires on each surface in the incubator are determined according to the stable theoretical output power, the start and stop of the heating wires are controlled, the temperature of each surface in the cell incubator is constant, the probability of condensation generated on the inner wall of the incubator is reduced, and the temperature stability of the incubator is improved.
The foregoing general description and the following description are exemplary and explanatory only and are not restrictive of the application.
Drawings
One or more embodiments are illustrated by way of example in the accompanying drawings, which correspond to the accompanying drawings and not in limitation thereof, in which elements having the same reference numeral designations are shown as like elements and not in limitation thereof, and wherein:
FIG. 1 is a schematic diagram of a sampling circuit for temperature control of a cell culture chamber according to an embodiment of the present disclosure;
FIG. 2 is a block diagram of a sampling circuit for temperature control of a cell culture chamber according to an embodiment of the present disclosure;
FIG. 3 is a schematic flow chart of a method for controlling the temperature of a cell culture chamber according to an embodiment of the present disclosure;
FIG. 4 is a schematic flow chart of a method for controlling the temperature of a cell culture chamber according to an embodiment of the present disclosure;
FIG. 5 is a schematic structural diagram of a temperature control device for a cell culture chamber according to an embodiment of the present disclosure;
FIG. 6 is a schematic structural diagram of a temperature control device for a cell culture chamber according to an embodiment of the present disclosure.
Detailed Description
So that the manner in which the features and elements of the disclosed embodiments can be understood in detail, a more particular description of the disclosed embodiments, briefly summarized above, may be had by reference to the embodiments, some of which are illustrated in the appended drawings. In the following description of the technology, for purposes of explanation, numerous details are set forth in order to provide a thorough understanding of the disclosed embodiments. However, one or more embodiments may be practiced without these details. In other instances, well-known structures and devices may be shown in simplified form in order to simplify the drawing.
The terms "first," "second," and the like in the description and in the claims, and the above-described drawings of embodiments of the present disclosure, are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It should be understood that the data so used may be interchanged under appropriate circumstances such that embodiments of the present disclosure described herein may be made. Furthermore, the terms "comprising" and "having," as well as any variations thereof, are intended to cover non-exclusive inclusions.
The term "plurality" means two or more unless otherwise specified.
In the embodiment of the present disclosure, the character "/" indicates that the preceding and following objects are in an or relationship. For example, A/B represents: a or B.
The term "and/or" is an associative relationship that describes objects, meaning that three relationships may exist. For example, a and/or B, represents: a or B, or A and B.
The cell culture box is called as the incubator for short, wherein the left side, the right side, the top, the back, the bottom, the door body and the cabinet opening of the box body are all provided with the additiveThe heating wires, that is, the heating wires with a certain resistance R are distributed on each surface in the incubator, the start and stop of the corresponding heating wires are controlled by modulating PWM (pulse width modulation) waves, and the power of the heating wires on each surface is required to be stable to realize the accurate temperature control of the incubator. However, the incubator is generally supplied by the mains, and the voltage of the power grid corresponding to the incubator often fluctuates according to P ═ U2The voltage U is changed, and the corresponding power P of the heating wire is also changed under the condition that the resistance R of the heating wire is constant, therefore, in the embodiment of the disclosure, the actual power supply voltage corresponding to the alternating voltage supplied by the cell incubator can be obtained through the sampling circuit, so that the power correction parameter value K can be obtained through the actual power supply voltage and the effective voltage of the alternating voltage supplied by the cell incubator, the actual output power on each surface of the cell incubator is corrected according to the power correction parameter value K, the theoretical output power of the heating wire is obtained, the corresponding duty ratio of the pulse width modulation PWM wave is determined according to the theoretical output power, the start and stop of the corresponding heating wire is controlled through the PWM wave of the determined parameter, the power of the corresponding heating wire is enabled to be relatively constant, namely, the temperature of each surface in the cell incubator is enabled to be constant, the probability of generating condensation on the inner wall of the incubator is reduced, and the temperature stability of the incubator is improved.
Therefore, in the process of temperature control of the incubator, the current sampling voltage matched with the alternating voltage supplied by the cell incubator needs to be obtained through the sampling circuit.
Fig. 1 is a schematic structural diagram of a sampling circuit for temperature control of a cell culture chamber according to an embodiment of the present disclosure. The sampling circuit includes: transformer 100, rectifier circuit 200, filter circuit 300, series voltage divider circuit 400.
The transformer 100 may be used to input ac voltage signals for powering the cell incubator and to convert high voltage signals from the utility grid to low voltage signals suitable for the device for temperature control of the cell incubator. For example: the high-voltage signal of about 220v can be converted into a low-voltage signal of about 24v, 12v or 5 v.
After the high-voltage signal of the utility power grid is converted by the transformer 100, the obtained low-voltage signal is still an alternating-current signal, and may be converted into a low-voltage direct-current voltage signal by the rectifier circuit 200. I.e. the ac voltage signal supplied by the cell incubator, passes through the transformer 100 and then through the rectifier circuit 200 to be converted into a dc voltage signal.
Of course, the converted dc voltage signal may be filtered by the filter circuit 300 and input to both ends of the serial voltage divider circuit 400, so that the divided voltage across the first resistor in the serial voltage divider circuit 400 is the sampling voltage signal, and is collected by the device for controlling the temperature of the cell incubator.
In some embodiments, the rectifier circuit 200 includes: the bridge rectifier circuit is composed of four diodes.
The series voltage divider circuit 400 divides the dc voltage signal, and thus includes at least two resistors connected in series, a first resistor and a second resistor. In some embodiments, the second resistor may be a variable resistor, i.e., the series voltage divider circuit 400 includes: the first resistor and the voltage regulator are connected in series. Since the voltage signal is transformed by the transformer and then the rectifying circuit into a dc voltage signal of 0-24v, and the device for controlling the temperature of the cell incubator can be a single chip or a digital programmable controller, the corresponding input voltage can be 0-5v or 0-12v, the serial voltage divider circuit 400 is required to divide the voltage, and the serial voltage divider circuit 400 includes: when the voltage regulator is used, the flexibility and the applicability of sampling voltage signals can be improved.
FIG. 2 is a block diagram of a sampling circuit for temperature control of a cell culture chamber according to an embodiment of the present disclosure. As shown in fig. 2, after the alternating voltage signal between the power supply alternating current electric fire zero line Lin-Nin of the cell culture box is reduced in voltage by the transformer VT1, the alternating voltage signal is rectified into a direct voltage signal by the action of the diode rectifier bridge D9-D10-D11-D12, the large-capacitance capacitor E5 is used for filtering, that is, the filter circuit includes: the capacitor E5 can filter the noise at 50Hz frequency, and the larger the capacitance value is according to the capacitance characteristic, the smaller the filtering frequency is.
The sliding rheostat VR1 (also called as a voltage regulator) is connected in parallel with the two resistors R112, and the two resistors can be regarded as a whole resistor, namely a second resistor which is connected in series with the first resistor R111 to form a series voltage division circuit, and voltage division at two ends of the R111 can be changed by changing the resistance of the VR1 according to a series voltage division principle. In this embodiment, the resistor R110 is used for limiting current, and the device for controlling the temperature of the cell incubator may be a single chip, so that the voltage sampled by the pin LN-OUT _ AD of the single chip may be the voltage across R111.
Therefore, through the sampling circuit, sampling voltage signals matched with alternating voltage supplied by the cell incubator can be collected to obtain corresponding sampling voltage, so that actual power supply voltage corresponding to the alternating voltage supplied by the cell incubator is obtained, then a power correction parameter value K can be obtained, so that theoretical output power of the heating wires on each surface of the cell incubator is determined, corresponding duty ratio of Pulse Width Modulation (PWM) waves is determined according to the theoretical output power, and the start and stop of the corresponding heating wires are controlled through the PWM waves with the determined parameters, so that the power of the corresponding heating wires is relatively constant, namely the temperature of each surface in the cell incubator is constant, the probability of condensation generated on the inner wall of the incubator is reduced, and the temperature stability of the incubator is improved.
FIG. 3 is a schematic flow chart of a method for controlling the temperature of a cell culture chamber according to an embodiment of the present disclosure. As shown in fig. 3, the process for temperature control of the cell incubator includes:
step 301: and obtaining the current sampling voltage matched with the alternating voltage supplied by the cell incubator according to the current sampling voltage signal acquired by the sampling circuit.
Through the sampling circuit, sampling voltage signals matched with alternating voltage supplied by the cell incubator can be acquired, and therefore corresponding sampling voltage is obtained. The sampling can be carried out in a timing or real-time manner, and the current sampling voltage signal and the current sampling voltage are obtained by sampling each time.
Step 302: and determining the current actual power supply voltage matched with the current sampling voltage according to the corresponding relation between the stored sampling voltage and the actual power supply voltage.
For the sampling circuit in the incubator, the correspondence between the sampling voltage and the actual power supply voltage may be preserved in advance. In some embodiments, the correspondence between the sampling circuit output voltage and the input voltage may be obtained and saved as the correspondence between the sampling voltage and the actual supply voltage. For example: through multiple times of experimental detection, multiple input voltages and corresponding output voltages of the sampling circuit are obtained, and the corresponding relation between the output voltage and the input voltage of the sampling circuit is obtained and stored as the corresponding relation between the sampling voltage and the actual power supply voltage. Or, a plurality of input voltages of the sampling circuit and corresponding output voltage samples thereof are obtained through network communication, experimental detection or numerical value input and the like, and then machine learning is carried out to obtain and store the corresponding relation between the sampling voltage and the actual power supply voltage.
Table 1 shows a corresponding relationship between a sampling voltage and an actual power supply voltage provided in an embodiment of the present disclosure.
TABLE 1
If the obtained current sampling voltage is consistent with the AD3 through the sampling circuit, then according to table 1, the current actual power supply voltage can be determined to be 47 v. If the current sampling voltage is consistent with AD177, the current actual supply voltage may be determined to be 221v according to table 1.
Step 303: and determining the current theoretical output power of the heating wires on each surface of the cell culture box according to the current actual power supply voltage, and controlling the operation of the corresponding heating wires according to the current theoretical output power.
In some embodiments, the incubator may be powered by the utility grid, and then the theoretical voltage corresponding to the utility grid may be an effective voltage of the ac voltage of the utility grid, that is, 220v, so that the theoretical output power for controlling the heating wire may be P0＝2202D is the duty ratio of PWM wave for controlling the heating wire at the moment, but the actually output power value is P1＝V1 2/R*D，V1For actual voltage values of the grid, i.e. current practiceThe supply voltage. To ensure accurate temperature control of the incubator, P is required0＝P1Then, a correction parameter value K is introduced to the actual output power P1Make a correction, i.e. 2202/R*D＝V1 2K is 2202/V1 2Obtaining the current theoretical output power P ═ P1*K。
Thus, determining the current theoretical output power of the heating wires on each side of the cell culture chamber from the current actual supply voltage comprises: obtaining a power correction parameter value according to the effective voltage of the alternating voltage supplied by the cell incubator and the current actual power supply voltage; and obtaining the current theoretical output power according to the current actual output power of the cell culture box and the power correction parameter value.
The on-off of the heating wire is controlled by the output PWM wave, the key parameter of the PWM comprises a duty ratio D, and the duty ratio is the proportion of the high level in one period to the period; the heater strip is opened when exporting the high level, and the heater strip is closed when the low level, consequently, according to present theoretical output, the operation of control correspondence heater strip includes: determining the current duty ratio of the pulse width modulation PWM wave according to the current theoretical output power; and determining the current PWM wave according to the current duty ratio, and outputting and controlling the start and stop of the corresponding heating wire.
Therefore, in the embodiment, the actual power supply voltage corresponding to the alternating voltage supplied by the cell incubator is obtained through the sampling circuit, so that the power correction parameter value K can be obtained through the actual power supply voltage and the effective voltage of the alternating voltage supplied by the cell incubator, the theoretical output power of the heating wires on each surface of the cell incubator is determined, the corresponding duty ratio of the pulse width modulation PWM wave is determined according to the theoretical output power, and the start and stop of the corresponding heating wires are controlled through the PWM wave of the determined parameter, so that the power of the corresponding heating wires is always matched with the theoretical output power, and therefore, the comparison is constant, namely, the temperature of each surface in the cell incubator is constant, the probability of condensation generated on the inner wall of the incubator is reduced, and the temperature stability of the incubator is improved.
The following operational procedures are integrated into specific embodiments to illustrate the temperature control process for cell culture chambers provided by embodiments of the present invention.
In this embodiment, the incubator is powered by the utility power grid, has a corresponding effective voltage of 220v, includes the sampling circuit shown in fig. 2, and stores the corresponding relationship between the sampling voltage and the actual power supply voltage shown in table 1.
FIG. 4 is a schematic flow chart of a method for controlling the temperature of a cell culture chamber according to an embodiment of the present disclosure. The process for cell incubator temperature control in conjunction with figure 4 includes:
step 401: and obtaining the current sampling voltage matched with the alternating voltage supplied by the cell incubator according to the current sampling voltage signal acquired by the sampling circuit.
The sampling can be carried out at regular time, and the current sampling voltage is correspondingly obtained after each sampling.
By means of the sampling circuit as shown in fig. 2, the current sampling voltage is obtained, which matches the ac voltage supplied by the cell incubator, such as AD170, AD176, etc.
Step 402: and determining the current actual power supply voltage matched with the current sampling voltage according to the corresponding relation between the stored sampling voltage and the actual power supply voltage.
According to the correspondence shown in table 1, it can be determined that the current actual power supply voltage corresponding to AD176 is 220v, and the current actual power supply voltage corresponding to AD210 is 254 v.
Step 403: and obtaining a power correction parameter value according to the effective voltage of the alternating voltage supplied by the cell culture box and the current actual power supply voltage.
In this embodiment, the effective voltage is 220v, and K is 2202/V1 2。
Step 404: and obtaining the current theoretical output power according to the current actual output power of the cell culture box and the power correction parameter value.
The current theoretical output power is P ═ P1*K，P1Is the current actual output power.
Step 405: and determining the current duty ratio of the pulse width modulation PWM wave according to the current theoretical output power.
Step 406: and determining the current PWM wave according to the current duty ratio, and outputting and controlling the start and stop of the corresponding heating wire.
Therefore, in the embodiment, the actual power supply voltage corresponding to the alternating voltage supplied by the cell incubator is obtained through the sampling circuit and is corrected to be the stable theoretical output power, so that the control parameter of the PWM wave for controlling the heating wire on each surface in the incubator is determined according to the stable theoretical output power, and the start and stop of the heating wire are further controlled, so that the power on each surface in the cell incubator is close to the theoretical output power and is in a constant state, the temperature of the incubator is constant, the probability of condensation generated on the inner wall of the incubator is reduced, and the temperature stability of the incubator is improved.
According to the above-described process for temperature control of a cell incubator, an apparatus for temperature control of a cell incubator can be constructed.
FIG. 5 is a schematic structural diagram of a temperature control device for a cell culture box according to an embodiment of the present disclosure. As shown in fig. 5, the temperature control device for a cell incubator comprises: an acquisition module 510, a determination module 520, and a control module 530.
An acquisition module 510 configured to obtain, via the sampling circuit, a current sampled voltage that matches the ac voltage supplied by the cell incubator.
A determining module 520 configured to determine a current actual power supply voltage matching the current sampling voltage according to a correspondence between the saved sampling voltage and the actual power supply voltage.
A control module 530 configured to determine a current theoretical output power of the heating wires on each side of the cell incubator according to the current actual supply voltage, and to control the operation of the corresponding heating wires according to the current theoretical output power.
In some embodiments, further comprising:
and the storage module is configured to acquire the corresponding relation between the output voltage and the input voltage of the sampling circuit and store the corresponding relation as the corresponding relation between the sampling voltage and the actual power supply voltage.
In some embodiments, the control module 530 includes:
the correction determining unit is configured to obtain a power correction parameter value according to the effective voltage of the alternating voltage supplied by the cell incubator and the current actual power supply voltage;
and the power determining unit is configured to obtain the current theoretical output power according to the current actual output power of the cell incubator and the power correction parameter value.
In some embodiments, the control module 530 includes:
a duty ratio determination unit configured to determine a current duty ratio of the Pulse Width Modulation (PWM) wave according to a current theoretical output power;
and the output control unit is configured to determine the current PWM wave according to the current duty ratio and output and control the start and stop of the corresponding heating wire.
It can be seen that, in this embodiment, the device for controlling the temperature of the cell incubator can obtain the actual power supply voltage corresponding to the ac voltage supplied by the cell incubator through the sampling circuit, and correct the actual power supply voltage into the stable theoretical output power, thereby, according to the stable theoretical output power, determining the control parameters of the heating wires on each side of the incubator, and further controlling the start and stop of the heating wires, so that the temperature of each side of the cell incubator is constant, the probability of condensation generated on the inner wall of the incubator is reduced, and the temperature stability of the incubator is improved.
The disclosed embodiment provides a device for controlling temperature of a cell culture box, the structure of which is shown in fig. 6, comprising:
a processor (processor)1000 and a memory (memory)1001, and may further include a Communication Interface (Communication Interface)1002 and a bus 1003. The processor 1000, the communication interface 1002, and the memory 1001 may communicate with each other through the bus 1003. Communication interface 1002 may be used for the transfer of information. Processor 1000 may invoke logic instructions in memory 1001 to perform the method for cell incubator temperature control of the embodiments described above.
In addition, the logic instructions in the memory 1001 may be implemented in the form of software functional units and stored in a computer readable storage medium when the logic instructions are sold or used as independent products.
The memory 1001 is a computer readable storage medium and can be used for storing software programs, computer executable programs, such as program instructions/modules corresponding to the methods in the embodiments of the present disclosure. The processor 1000 executes functional applications and data processing, i.e. implements the method for cell incubator temperature control in the above-described method embodiments, by executing program instructions/modules stored in the memory 1001.
The memory 1001 may include a storage program area and a storage data area, wherein the storage program area may store an operating system, an application program required for at least one function; the storage data area may store data created according to the use of the terminal incubator, and the like. Further, the memory 1001 may include a high-speed random access memory and may also include a nonvolatile memory.
The disclosed embodiment provides a be used for cell culture case temperature control device, includes: a processor and a memory storing program instructions, the processor being configured to, upon execution of the program instructions, perform a method for cell incubator temperature control.
The embodiment of the disclosure provides an incubator, which comprises the temperature control device for the cell incubator.
Embodiments of the present disclosure provide a computer-readable storage medium storing computer-executable instructions configured to perform the above-described method for cell incubator temperature control.
The disclosed embodiments provide a computer program product comprising a computer program stored on a computer readable storage medium, the computer program comprising program instructions that, when executed by a computer, cause the computer to perform the above-described method for cell incubator temperature control.
The computer-readable storage medium described above may be a transitory computer-readable storage medium or a non-transitory computer-readable storage medium.
The technical solution of the embodiments of the present disclosure may be embodied in the form of a software product, which is stored in a storage medium and includes one or more instructions for enabling a computer incubator (which may be a personal computer, a server, or a network incubator, etc.) to execute all or part of the steps of the method of the embodiments of the present disclosure. And the aforementioned storage medium may be a non-transitory storage medium comprising: a U-disk, a removable hard disk, a Read-Only Memory (ROM), a Random Access Memory (RAM), a magnetic disk or an optical disk, and other various media capable of storing program codes, and may also be a transient storage medium.
The above description and drawings sufficiently illustrate embodiments of the disclosure to enable those skilled in the art to practice them. Other embodiments may incorporate structural, logical, electrical, process, and other changes. The examples merely typify possible variations. Individual components and functions are optional unless explicitly required, and the sequence of operations may vary. Portions and features of some embodiments may be included in or substituted for those of others. The scope of the disclosed embodiments includes the full ambit of the claims, as well as all available equivalents of the claims. As used in this application, although the terms "first," "second," etc. may be used in this application to describe various elements, these elements should not be limited by these terms. These terms are only used to distinguish one element from another. For example, a first element could be termed a second element, and, similarly, a second element could be termed a first element, unless the meaning of the description changes, so long as all occurrences of the "first element" are renamed consistently and all occurrences of the "second element" are renamed consistently. The first and second elements are both elements, but may not be the same element. Furthermore, the words used in the specification are words of description only and are not intended to limit the claims. As used in the description of the embodiments and the claims, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. Similarly, the term "and/or" as used in this application is meant to encompass any and all possible combinations of one or more of the associated listed. Furthermore, the terms "comprises" and/or "comprising," when used in this application, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof. Without further limitation, an element defined by the phrase "comprising an …" does not exclude the presence of other like elements in a process, method, or incubator comprising the element. In this document, each embodiment may be described with emphasis on differences from other embodiments, and the same and similar parts between the respective embodiments may be referred to each other. For methods, products, etc. of the embodiment disclosures, reference may be made to the description of the method section for relevance if it corresponds to the method section of the embodiment disclosure.
Those of skill in the art would appreciate that the various illustrative elements and algorithm steps described in connection with the embodiments disclosed herein may be implemented as electronic hardware or combinations of computer software and electronic hardware. Whether such functionality is implemented as hardware or software may depend upon the particular application and design constraints imposed on the solution. Skilled artisans may implement the described functionality in varying ways for each particular application, but such implementation decisions should not be interpreted as causing a departure from the scope of the disclosed embodiments. It can be clearly understood by the skilled person that, for convenience and brevity of description, the specific working processes of the system, the apparatus and the unit described above may refer to the corresponding processes in the foregoing method embodiments, and are not described herein again.
In the embodiments disclosed herein, the disclosed methods, products (including but not limited to devices, incubators, etc.) may be implemented in other ways. For example, the above-described apparatus embodiments are merely illustrative, and for example, the division of the units may be merely a logical division, and in actual implementation, there may be another division, for example, multiple units or components may be combined or integrated into another system, or some features may be omitted, or not executed. In addition, the shown or discussed mutual coupling or direct coupling or communication connection may be an indirect coupling or communication connection through some interfaces, devices or units, and may be in an electrical, mechanical or other form. The units described as separate parts may or may not be physically separate, and parts displayed as units may or may not be physical units, may be located in one place, or may be distributed on a plurality of network units. Some or all of the units can be selected according to actual needs to implement the present embodiment. In addition, functional units in the embodiments of the present disclosure may be integrated into one processing unit, or each unit may exist alone physically, or two or more units are integrated into one unit.
The flowchart and block diagrams in the figures illustrate the architecture, functionality, and operation of possible implementations of systems, methods and computer program products according to embodiments of the present disclosure. In this regard, each block in the flowchart or block diagrams may represent a module, segment, or portion of code, which comprises one or more executable instructions for implementing the specified logical function(s). In some alternative implementations, the functions noted in the block may occur out of the order noted in the figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality involved. In the description corresponding to the flowcharts and block diagrams in the figures, operations or steps corresponding to different blocks may also occur in different orders than disclosed in the description, and sometimes there is no specific order between the different operations or steps. For example, two sequential operations or steps may in fact be executed substantially concurrently, or they may sometimes be executed in the reverse order, depending upon the functionality involved. Each block of the block diagrams and/or flowchart illustrations, and combinations of blocks in the block diagrams and/or flowchart illustrations, can be implemented by special purpose hardware-based systems that perform the specified functions or acts, or combinations of special purpose hardware and computer instructions.
Claims (10)
1. A sampling circuit for temperature control of a cell culture chamber, comprising: a transformer, a rectifying circuit, a filter circuit, and a series voltage divider circuit, wherein,
the alternating current voltage signal of the power supply of the cell culture box passes through the transformer and then is converted into a direct current voltage signal through the rectifying circuit;
and after being filtered by a filter circuit, the direct current voltage signal is input to two ends of the series voltage division circuit to obtain a sampling voltage signal on a first resistor in the series voltage division circuit, and is input into a device for controlling the temperature of the cell culture box.
2. The sampling circuit of claim 1, wherein the rectification circuit comprises:
the bridge rectifier circuit is composed of four diodes.
3. The sampling circuit of claim 1 or 2, wherein the series voltage divider circuit comprises:
the first resistor and the voltage regulator are connected in series.
4. A method for temperature control of a cell incubator, the cell incubator comprising a sampling circuit according to any one of claims 1-3, the method comprising:
obtaining a current sampling voltage matched with the alternating voltage supplied by the cell incubator according to the current sampling voltage signal acquired by the sampling circuit;
determining the current actual power supply voltage matched with the current sampling voltage according to the corresponding relation between the stored sampling voltage and the actual power supply voltage;
and determining the current theoretical output power of the heating wires on each surface of the cell culture box according to the current actual power supply voltage, and controlling the operation of the corresponding heating wires according to the current theoretical output power.
5. The method of claim 4, wherein said obtaining a current sample voltage matching an AC voltage supplied to said cell incubator comprises:
and acquiring the corresponding relation between the output voltage and the input voltage of the sampling circuit, and storing the corresponding relation as the corresponding relation between the sampling voltage and the actual power supply voltage.
6. The method according to claim 4, wherein said determining a current theoretical output power of the heating wires on each side of the cell incubator based on the current actual supply voltage comprises:
obtaining a power correction parameter value according to the effective voltage of the alternating voltage supplied by the cell incubator and the current actual power supply voltage;
and obtaining the current theoretical output power according to the current actual output power of the cell culture box and the power correction parameter value.
7. The method according to claim 6, wherein said controlling the operation of the corresponding heating wire according to said current theoretical output power comprises:
determining the current duty ratio of the pulse width modulation PWM wave according to the current theoretical output power;
and determining the current PWM wave according to the current duty ratio, and outputting and controlling the start and stop of the corresponding heating wire.
8. An apparatus for temperature control of a cell incubator, the cell incubator comprising a sampling circuit according to any one of claims 1-3, the apparatus comprising:
the acquisition module is configured to obtain a current sampling voltage matched with an alternating voltage supplied by the cell incubator through the sampling circuit;
the determining module is configured to determine a current actual power supply voltage matched with the current sampling voltage according to the corresponding relation between the saved sampling voltage and the actual power supply voltage;
and the control module is configured to determine the current theoretical output power of the heating wires on each surface of the cell incubator according to the current actual power supply voltage, and control the operation of the corresponding heating wires according to the current theoretical output power.
9. An apparatus for cell incubator temperature control, the apparatus comprising a processor and a memory storing program instructions, wherein the processor is configured to, when executing the program instructions, perform a method for cell incubator temperature control as claimed in any one of claims 4 to 7.
10. A cell culture chamber, comprising: the apparatus for temperature control of a cell culture chamber according to claim 8 or 9.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110535782.9A CN113406981B (en) | 2021-05-17 | 2021-05-17 | Circuit, method and device for controlling temperature of cell incubator and incubator |
| PCT/CN2022/073014 WO2022242215A1 (en) | 2021-05-17 | 2022-01-20 | Circuit, method and apparatus for temperature control of cell incubator, and incubator |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110535782.9A CN113406981B (en) | 2021-05-17 | 2021-05-17 | Circuit, method and device for controlling temperature of cell incubator and incubator |
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| CN202110535782.9A Active CN113406981B (en) | 2021-05-17 | 2021-05-17 | Circuit, method and device for controlling temperature of cell incubator and incubator |
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| WO (1) | WO2022242215A1 (en) |
Cited By (1)
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| WO2022242215A1 (en) * | 2021-05-17 | 2022-11-24 | 青岛海尔生物医疗科技有限公司 | Circuit, method and apparatus for temperature control of cell incubator, and incubator |
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| Publication number | Publication date |
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| CN113406981B (en) | 2023-06-16 |
| WO2022242215A1 (en) | 2022-11-24 |
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