CN113396222A - 腺相关病毒(aav)生产细胞系和相关方法 - Google Patents

腺相关病毒(aav)生产细胞系和相关方法 Download PDF

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Publication number
CN113396222A
CN113396222A CN201980090045.3A CN201980090045A CN113396222A CN 113396222 A CN113396222 A CN 113396222A CN 201980090045 A CN201980090045 A CN 201980090045A CN 113396222 A CN113396222 A CN 113396222A
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gene
promoter
mammalian cell
derepressed
nucleic acid
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顾炳南
C·M·冈瑟
A·塞思
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Lonza Walkersville Inc
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Lonza Walkersville Inc
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CN201980090045.3A 2018-12-21 2019-12-18 腺相关病毒(aav)生产细胞系和相关方法 Pending CN113396222A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862783589P 2018-12-21 2018-12-21
US62/783,589 2018-12-21
US201962866092P 2019-06-25 2019-06-25
US62/866,092 2019-06-25
PCT/US2019/067156 WO2020132059A1 (en) 2018-12-21 2019-12-18 Adeno-associated virus (aav) producer cell line and related methods

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CN113396222A true CN113396222A (zh) 2021-09-14

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US (2) US11739347B2 (https=)
EP (1) EP3891290A4 (https=)
JP (2) JP7650800B2 (https=)
KR (1) KR20210108423A (https=)
CN (1) CN113396222A (https=)
IL (1) IL284219A (https=)
SG (1) SG11202106217TA (https=)
WO (1) WO2020132059A1 (https=)

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EP4189077A1 (en) * 2020-07-30 2023-06-07 Shape Therapeutics Inc. Stable cell lines for inducible production of raav virions
EP4229205B1 (en) * 2020-10-15 2025-05-14 F. Hoffmann-La Roche AG Nucleic acid constructs for va rna transcription
CN112501209B (zh) * 2020-12-07 2024-02-13 和元生物技术（上海）股份有限公司 外源基因可控表达的腺相关病毒包装方法
CN116829725A (zh) * 2021-02-12 2023-09-29 富士胶片株式会社 用于产生腺相关病毒的试剂盒及其利用
EP4322975A4 (en) * 2021-04-14 2025-03-26 Capsida, Inc. PLASMIDS AND PROCESSES FOR PRODUCING ADENO-ASSOCIATED VIRUSES
EP4410971A4 (en) * 2021-09-30 2025-06-04 FUJIFILM Corporation METHOD FOR PRODUCING AN ADENO-ASSOCIATED VIRUS, CELLS AND EXPRESSION VECTOR
AU2022373653A1 (en) * 2021-10-18 2024-05-02 Regeneron Pharmaceuticals, Inc. Eukaryotic cells comprising adenovirus-associated virus polynucleotides
EP4473123A4 (en) * 2022-02-01 2026-03-11 Shape Therapeutics Inc STABLE CELL LINES FOR INDUCIBLE VAAR VIRION PRODUCTION
EP4491717A4 (en) 2022-03-08 2025-11-12 Fujifilm Corp PRODUCING CELL, PRODUCTION METHOD FOR PRODUCING PRODUCING CELLS AND PRODUCTION METHOD FOR ADENE-ASSOCIATED VIRUS
CN120092093A (zh) * 2022-08-25 2025-06-03 富士胶片株式会社 靶病毒的制造方法及培养组合物
EP4624584A1 (en) * 2022-12-27 2025-10-01 Synplogen Co., Ltd. Helper gene control
US12410436B2 (en) * 2023-10-31 2025-09-09 Lonza Houston, Inc. Adeno-associated virus (AAV) producer cell lines
WO2025122676A1 (en) * 2023-12-05 2025-06-12 Shape Therapeutics Inc. Systems and methods for raav production using a biphasic culture
WO2025168663A1 (en) 2024-02-09 2025-08-14 F. Hoffmann-La Roche Ag Method for producing recombinant adeno-associated viral particles
WO2025252480A1 (en) 2024-06-07 2025-12-11 F. Hoffmann-La Roche Ag Method for purifying plasmid dna
CN118460545B (zh) * 2024-07-08 2025-02-11 凌意(杭州)生物科技有限公司 一种诱导型表达Rep多肽的表达框
US20260022401A1 (en) 2024-07-22 2026-01-22 Hoffmann-La Roche Inc. Novel AAV rep ORFs and Rep polypeptides
WO2026037757A1 (en) 2024-08-13 2026-02-19 F. Hoffmann-La Roche Ag Modified aav particles
WO2026044087A1 (en) * 2024-08-21 2026-02-26 Shape Therapeutics Inc. Increased cellular stability for aav production

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JP7650800B2 (ja) 2025-03-25
US11739347B2 (en) 2023-08-29
EP3891290A1 (en) 2021-10-13
KR20210108423A (ko) 2021-09-02
JP2022516004A (ja) 2022-02-24
US20240018545A1 (en) 2024-01-18
IL284219A (en) 2021-08-31
WO2020132059A1 (en) 2020-06-25
EP3891290A4 (en) 2022-11-02
US12529074B2 (en) 2026-01-20
SG11202106217TA (en) 2021-07-29
US20200199627A1 (en) 2020-06-25
JP2025102801A (ja) 2025-07-08

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