CN113384679A - 一种用于治疗肺部出血的中药组合物 - Google Patents
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Abstract
本发明公开了一种用于治疗肺部出血的中药组合物，包括以下重量份的中药原料：干姜10～20份、葶苈子25～35份、八仙草10～20份、野毛蛋10～20份、八爪金龙15～25份、八果10～20份、巴戟天10～20份、白背叶15～25份、红枣15～25份、白活麻5～15份、葫芦藤10～20份、白石英15～25份.本发明的中药组合物本发明可有效预防和治疗肺部出血、瘀血、潮红、黑肺病、肺坏死等常见的肺部综合症；安全无毒副作用，使用方便，见效快。
Description
技术领域
本发明涉及兽药技术领域，具体涉及一种用于治疗肺部出血的中药组合物。
背景技术
家禽的肺部呈鲜红色，无哺乳动物支气管树的结构；家禽的肺部体积不大，不分叶，紧贴胸腔背侧。肺内各级支气管与易于扩张的气囊相同。家禽的肺部疾病较多，例如肺炎、支气管炎、呼吸道疾病、心包积水综合症等。针对这类肺部疾病，治疗的药物较多，其中不乏中药制剂。但针对肺部出血、瘀血、潮红、黑肺病、肺坏死等肺部综合症的中药组合物较少见到。所以需要一种用于治疗肺部出血的中药组合物，能够有效治疗肺部出血等肺部综合症。
发明内容
针对上述现有技术，本发明的目的是提供一种用于治疗肺部出血的中药组合物，可有效预防和治疗肺部出血、瘀血、潮红、黑肺病、肺坏死等常见的肝脏综合症。
为实现上述目的，本发明采用如下技术方案：
本发明的第一方面，提供一种用于治疗肺部出血的中药组合物，包括以下重量份的中药原料：
干姜10～20份、葶苈子25～35份、八仙草10～20份、野毛蛋10～20份、八爪金龙15～25份、八果10～20份、巴戟天10～20份、白背叶15～25份、红枣15～25份、白活麻5～15份、葫芦藤10～20份、白石英15～25份。
优选的，包括以下重量份的中药原料：
干姜15份、葶苈子30份、八仙草15份、野毛蛋15份、八爪金龙20份、八果15份、巴戟天15份、白背叶20份、红枣20份、白活麻10份、葫芦藤15份、白石英20份。
中药的配伍讲究相须、相使、相畏、相杀、相恶、相反，由于不同的中药之间存在不同的配伍关系，因此在使用两味以上中药时，必须有所选择，充分发挥药物之间相须相使的配伍关系，使产品的临床效果得到显著提高。本发明的防治家禽感冒的中药组合物中，各原料组分是一个有机的整体，缺一不可。发明人在研发过程中发现，减少上述组合物中的任何一种原料组分，或以具有相似药性的原料药对本发明中药组合物的原料组分进行替换，则中药组合物整体的作用效果显著降低；在本发明的中药组合物的基础上再增加其他的原料组分，中药组合物的整体效果并未有明显的改善，甚至有中药组合物的整体效果降低的情况出现。
本发明的第二方面，提供上述中药组合物在制备治疗家禽肺部出血药剂中的应用。
本发明的第三方面，提供一种用于治疗肺部出血的中药制剂，以上述中药组合物为有效成分。
优选的，所述中药制剂中有效成分的质量百分含量为10-100％。
优选的，所述中药制剂还包括医药学上可接受的辅料。
优选的，所述中药制剂的剂型包括口服液、浸膏散剂或颗粒剂。
优选的，所述口服液由以下方法制备：
将上述中药组合物按配比混合，加入10-12质量倍的水煎煮1小时，煎煮三次，过滤，合并滤液，即得口服液。
优选的，所述浸膏散剂由以下方法制备：
将上述中药组合物按配比混合，加入10-12质量倍的水煎煮1小时，煎煮三次，过滤，合并滤液，浓缩喷雾干燥，粉碎，即得浸膏散剂。
优选的，浓缩至相对密度为1.35±0.2(50-55℃)。
优选的，所述颗粒剂由以下方法制备：
将上述中药组合物按配比混合，加入10-12质量倍的水煎煮1小时，煎煮三次，过滤，合并滤液，浓缩，加辅料，制成颗粒，干燥，整粒，即得颗粒剂。
本发明中，各药材具有以下功效：
干姜：温中散寒，回阳通脉，温肺化饮。
葶苈子：泻肺降气，祛痰平喘，利水消肿，泄热逐邪。
八仙草：为景天科植物，又名景天三七、、活血丹、见血散、土三七等。清热消炎，祛风湿，散瘀血。
野毛蛋：学名为八月札，舒肝理气，活血止痛，除烦利尿。治肝胃气痛，胃热食呆，烦渴，亦白痢疾，腰痛，胁痛，疝气，窟经，子宫下坠。
八爪金龙：性凉味辛、苦，具有清利咽喉，祛痰利湿，散瘀消肿之功效。
八果：温阳散寒，理气止痛。
巴戟天：补肾阳，强筋骨，祛风湿。
白背叶：消炎止血。
红枣：补脾和胃，益气生津，调营卫，解药毒。
白活麻：祛风除湿。
葫芦藤：又称作“白毛藤”，祛风通络；散瘀止痛。
白石英：温肺肾，安心神，利小便。
本发明采用葶苈子为君药，干姜为臣药，两药相合既可抵御外邪又能防邪复入；以八仙草、野毛蛋、八爪金龙、八果、巴戟天和白背叶清瘀、消痰共为佐药，红枣、白活麻、葫芦藤、白石英皆为使药。全方紧扣病机，上述原料药针对肺部出血、瘀血、潮红、黑肺病、肺坏死等常见的肺部综合症的发病病因，合理配伍，协同增效，具有很好的预防和治疗肺部综合征的功效。
本发明的有益效果：
(1)本发明可有效预防和治疗肺部出血、瘀血、潮红、黑肺病、肺坏死等常见的肺部综合症。
(2)本发明的中药组合物无毒副作用，使用方便，见效快。
具体实施方式
应该指出，以下详细说明都是例示性的，旨在对本申请提供进一步的说明。除非另有指明，本文使用的所有技术和科学术语具有与本申请所属技术领域的普通技术人员通常理解的相同含义。
为了使得本领域技术人员能够更加清楚地了解本申请的技术方案，以下将结合具体的实施例详细说明本申请的技术方案。
本发明实施例中所用的试验材料均为本领域常规的试验材料，均可通过商业渠道购买得到。
实施例1
将干姜15g、葶苈子30g、八仙草15g、野毛蛋15g、八爪金龙20g、八果15g、巴戟天15g、白背叶20g、红枣20g、白活麻10g、葫芦藤15g、白石英20g按配比混合，加入2100g水煎煮1小时，煎煮三次，过滤，合并滤液，即得口服液。
实施例2
将干姜10g、葶苈子35g、八仙草10g、野毛蛋20g、八爪金龙15g、八果20g、巴戟天10g、白背叶25g、红枣15g、白活麻15g、葫芦藤10g、白石英25g按配比混合，加入2310g水煎煮1小时，煎煮三次，过滤，合并滤液，即得口服液。
实施例3
将干姜20g、葶苈子25g、八仙草20g、野毛蛋10g、八爪金龙25g、八果10g、巴戟天20g、白背叶15g、红枣25g、白活麻5g、葫芦藤20g、白石英15g按配比混合，加入2520g水煎煮1小时，煎煮三次，过滤，合并滤液，即得口服液。
试验例1
地点：泰山脚下某养肉鸡养殖场；
品种：白羽肉鸡
该场饲养20～25日龄白羽肉鸡8000只。发病鸡大约有250～300只，出现呼吸道症状，甩鼻、咳嗽、呼噜；张嘴伸脖子怪叫；乍毛、畏寒；采食量下降。对病死鸡解剖后发现：支气管出现黄色栓塞，肺部出血或瘀血，严重的出现肺坏死。将发病鸡分成5组，每组50只，每组单独隔离。第一组作为空白组，饲喂正常日粮；第二组作为对照组，饲喂正常日粮+口服替米考星可溶性粉(10％)(每天一次，，按照0.5g兑水1L)；第三组为实施例1组，饲喂正常日粮+口服实施例1制备的口服液(每天一次，按照2mL兑水1L)；第四组为实施例2组，饲喂正常日粮+口服实施例2制备的口服液(每天一次，按照2mL兑水1L)；第五组为实施例3组，饲喂正常日粮+口服实施例3制备的口服液(每天一次，按照2mL兑水1L)；其他日常管理均相同。连续饲喂7天后，每天观察试验鸡病症、精神、发病等情况，记录各组每日死淘量，每组抽取5只活鸡解剖观察肺部情况；所得结果见表1。
表1
由表1可以看出，服用本发明的中药制剂后，白羽肉鸡的肺部出血、支气管栓塞均得到明显改善，疗效快速。
试验例2
地点：肥城某养鸭子养殖场；
品种：樱桃谷鸭
该场饲养25～35日龄樱桃谷鸭6000只。发病鸭子大约有2000只，每天死亡100～200只左右。发病鸭子出现精神委顿，呼吸急促、腹式呼吸，单侧性眼睛流泪；头颈震颤、摇头晃脑、站立不稳。对刚发病的鸭子解剖后发现：肺脏潮红。发病5日后对病鸭进行解剖发现：两侧肺黑紫。诊断为黑肺病。
将发病鸭分成5组，每组200只，每组单独隔离。第一组作为空白组，饲喂正常日粮；第二组作为对照组，饲喂正常日粮+口服麻杏石甘口服液(每天一次，按照2mL兑水1L)；第三组为实施例1组，饲喂正常日粮+口服实施例1制备的口服液(每天一次，按照2mL兑水1L)；第四组为实施例2组，饲喂正常日粮+口服实施例2制备的口服液(每天一次，按照2mL兑水1L)；第五组为实施例3组，饲喂正常日粮+口服实施例3制备的口服液(每天一次，按照2mL兑水1L)；其他日常管理均相同。连续饲喂10天后，每天观察试验鸭子病症、精神、发病等情况，记录各组每日死淘量，每组抽取5只活鸭解剖观察肺部情况；所得结果见表2。
表2
由表1～2可以看出，家禽在服用本发明制备的中药制剂后，其存活率均高于空白组和对照组。表1中，发病白羽肉鸡在服用本发明的中药制剂后，肺部出血、瘀血基本得到改善。其存活率也高于对照组。表2中，发病樱桃谷鸭在服用本发明的中药制剂后，两侧肺均恢复正常，呼吸急促、站立不稳等症状得到明显改善，其存活率高于对照组。
说明本发明的中药组合物无毒副作用，使用方便，能够有效治疗家禽的各类肺病综合症。
以上所述仅为本申请的优选实施例而已，并不用于限制本申请，对于本领域的技术人员来说，本申请可以有各种更改和变化。凡在本申请的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本申请的保护范围之内。
Claims (10)
1.一种用于治疗肺部出血的中药组合物，其特征在于：包括以下重量份的中药原料：
干姜10～20份、葶苈子25～35份、八仙草10～20份、野毛蛋10～20份、八爪金龙15～25份、八果10～20份、巴戟天10～20份、白背叶15～25份、红枣15～25份、白活麻5～15份、葫芦藤10～20份、白石英15～25份。
2.根据权利要求1所述的中药组合物，其特征在于：包括以下重量份的中药原料：
干姜15份、葶苈子30份、八仙草15份、野毛蛋15份、八爪金龙20份、八果15份、巴戟天15份、白背叶20份、红枣20份、白活麻10份、葫芦藤15份、白石英20份。
3.权利要求1或2所述的中药组合物在制备治疗家禽肺部出血药剂中的应用。
4.一种用于治疗肺部出血的中药制剂，其特征在于：以权利要求1或2所述的中药组合物为有效成分。
5.据权利要求4所述的中药制剂，其特征在于：所述中药制剂中有效成分的质量百分含量为10-100％。
6.根据权利要求4所述的中药制剂，其特征在于：所述中药制剂还包括医药学上可接受的辅料。
7.根据权利要求4所述的中药制剂，其特征在于：所述中药制剂的剂型包括口服液、浸膏散剂或颗粒剂。
8.根据权利要求7所述的中药制剂，其特征在于：所述口服液由以下方法制备：
将权利要求1或2所述的中药组合物按配比混合，加入10-12质量倍的水煎煮1小时，煎煮三次，过滤，合并滤液，即得口服液。
9.根据权利要求7所述的中药制剂，其特征在于：所述浸膏散剂由以下方法制备：
将权利要求1或2所述的中药组合物按配比混合，加入10-12质量倍的水煎煮1小时，煎煮三次，过滤，合并滤液，浓缩喷雾干燥，粉碎，即得浸膏散剂。
10.根据权利要求7所述的中药制剂，其特征在于：所述颗粒剂由以下方法制备：
将权利要求1或2所述的中药组合物按配比混合，加入10-12质量倍的水煎煮1小时，煎煮三次，过滤，合并滤液，浓缩，加辅料，制成颗粒，干燥，整粒，即得颗粒剂。
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| CN102920988A (zh) * | 2012-11-23 | 2013-02-13 | 李梅华 | 一种治疗结核病的中药组合物及其制备方法 |
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| CN102920988A (zh) * | 2012-11-23 | 2013-02-13 | 李梅华 | 一种治疗结核病的中药组合物及其制备方法 |
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