CN113384514A - 一种含有乳酸菌发酵提取物的儿童润肤剂及其制备方法 - Google Patents
一种含有乳酸菌发酵提取物的儿童润肤剂及其制备方法 Download PDFInfo
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- CN113384514A CN113384514A CN202110621073.2A CN202110621073A CN113384514A CN 113384514 A CN113384514 A CN 113384514A CN 202110621073 A CN202110621073 A CN 202110621073A CN 113384514 A CN113384514 A CN 113384514A
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Abstract
本发明提供一种含有乳酸菌发酵提取物的儿童润肤剂及其制备方法,该儿童润肤剂包括以下原料:牛油果树果脂、水解酵母蛋白、木糖醇、葡萄糖、羟苯基丙酰胺苯甲酸、椰子油、乳木果油、橄榄果油、角鲨烷、霍霍巴籽油、白油、鲸蜡硬脂醇、葡糖苷类、聚甘油类、维生素原B5、甘油、黄原胶、防腐剂、增稠剂、皮肤屏障修复剂、修复组合物和余量的水;所述皮肤屏障修复剂由神经酰胺、植物甾醇和脂肪酸组成。本发明制备儿童润肤剂,能够多方位呵护和滋润儿童的娇嫩肌肤,例如在晒后,有效降低皮肤红斑指数,提高皮肤含水量,修复受损肌肤。另外本品具有防水功能,满足多种情景下的儿童皮肤防护需求,多种修复成分可协同作用更好地修护儿童受损肌肤。
Description
技术领域
本发明涉及儿童润肤剂技术领域,特别涉及一种含有乳酸菌发酵提取物的儿童润肤剂及其制备方法。
背景技术
与成年人相比,儿童皮肤在结构和功能上都有巨大差别,包括:儿童皮肤薄嫩,皮肤角质层薄,缺少透明层;儿童皮肤含水量高,皮肤屏障功能较低,皮肤的失水量也较大;儿童皮肤的黑色素含量低,紫外线抵御能力差,易被紫外线辐射灼伤。儿童皮肤存在以上特点,所以儿童皮肤较成年人更易受损。而且儿童常常喜欢户外游玩,部分儿童尤其喜欢玩水,而夏季紫外线强烈,儿童皮肤娇嫩,尤其容易被晒伤。
例如为了避免儿童在外出时被烈日晒伤,一般给孩子准备遮阳帽或者太阳伞,并在外出前20-30分钟,在儿童裸露皮肤上涂抹防晒霜。另外出去户外长时间游玩时,每隔一个小时左右重新涂一遍防晒霜。但是在海边玩水时,或者体验水上项目时,常常会遇到浪大、风大,防晒霜效果易被破坏甚至失效,使得儿童容易出现晒伤等情况。因此急需一种儿童润肤剂,能够有效克服上述类似皮肤问题。
发明内容
鉴于此,本发明提出一种含有乳酸菌发酵提取物的儿童润肤剂及其制备方法,该儿童润肤剂不但皮肤受损后的修复效果佳,而且有防水作用,能更好满足儿童在多种情景下的皮肤保护需要。
本发明的技术方案是这样实现的:
一种含有乳酸菌发酵提取物的儿童润肤剂,包括以下质量百分比的原料:牛油果树果脂2~5%、水解酵母蛋白0.8~1.2%、木糖醇0.1~0.3%、葡萄糖0.1~0.2%、羟苯基丙酰胺苯甲酸0.6~0.8%、椰子油2~5%、乳木果油1~2%、橄榄果油0.5~2%、角鲨烷0.3~0.8%、霍霍巴籽油0.3~1.6%、白油4~7%、鲸蜡硬脂醇1-5%、葡糖苷类1~2.5%、聚甘油类0.5~3%、维生素原B5 0.6-1.3%、甘油5-8%、防腐剂0.1-0.5%、增稠剂0.2~2%、皮肤屏障修复剂1-5%、修复组合物2~5%和余量的水;所述皮肤屏障修复剂由神经酰胺、植物甾醇和脂肪酸组成;所述修复组合物由以下重量份的原料组成:乳酸菌发酵提取物0.15-0.25份、尿囊素4-6份、燕麦提取物0.2-0.4份、甘草酸2-3份和甘草酸盐类1.8-2.2份,优选地,所述修复组合物由以下重量份的原料组成:乳酸菌发酵提取物0.2份、尿囊素5份、燕麦提取物0.3份、甘草酸2.5份和甘草酸盐类2份。
进一步的,所述皮肤屏障修复剂由神经酰胺、植物甾醇和脂肪酸按照质量比3:1:1组成。
进一步的,所述葡糖苷类由木糖醇基葡糖苷、椰油基葡糖苷、鲸蜡硬脂基葡糖苷、花生醇葡糖苷按照质量比1.3:5:1:2组成;所述聚甘油类为由聚甘油-3甲基葡糖二硬脂酸酯、聚甘油-3蜂蜡酸酯、聚甘油-6聚蓖麻醇酸酯按照质量比2:3:5组成。
进一步的,所述增稠剂由以下重量份的原料组成:黄原胶1.5份、羟乙基纤维素2.5份、卡波姆1.0份、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物4份、丙烯酸(酯)类/C10-30烷醇丙烯酸酯交联聚合物9份和丙烯酰二甲基牛磺酸铵/VP共聚物6份组成。
进一步的,所述乳酸菌发酵提取物为乳酸菌胞外多糖。
进一步的,所述燕麦提取物由含燕麦葡聚糖质量百分比10%的燕麦提取物和含燕麦多酚质量百分比15%的燕麦提取物按照质量比3:2组成。
进一步的,所述甘草酸盐类为由甘草酸三钠和甘草酸二钾按照质量比3:7组成。
进一步的,所述儿童润肤剂还含有质量百分比为0.1-1%的大分子保湿剂,所述大分子保湿剂由透明质酸和海藻酸钠组成。
进一步的,所述大分子保湿剂由透明质酸和海藻酸钠按照质量比1:4组成。
本发明儿童润肤剂的制备方法,包括以下步骤:
(1)按上述质量百分比分别取牛油果树果脂、椰子油、乳木果油、橄榄果油、角鲨烷、霍霍巴籽油、白油、葡糖苷类、聚甘油类、鲸蜡硬脂醇,混合后,加热至70-80℃,制得A相;
(2)按上述质量百分比分别取木糖醇、葡萄糖、维生素原B5、甘油和增稠剂,混合后,加热至70-80℃,制得B相;将B相与A相混合后,于900-1500r/min条件下均质搅拌10-15分钟,制得混合相;
(3)将混合相降温至40-45℃,添加水解酵母蛋白、羟苯基丙酰胺苯甲酸、皮肤屏障修复剂、修复组合物和防腐剂,搅拌10-15分钟,制得润乳剂。
与现有技术相比,本发明的有益效果是:
(1)本发明以乳酸菌发酵提取物联合尿囊素、燕麦提取物、甘草酸和甘草酸盐类为修复组合物,搭配复配皮肤屏障修复剂,结合水解酵母蛋白、羟苯基丙酰胺苯甲酸,添加牛油果树果脂、椰子油、乳木果油、橄榄果油、角鲨烷、霍霍巴籽油、白油、葡糖苷类、聚甘油类、鲸蜡硬脂醇以及木糖醇、葡萄糖、维生素原B5等,制备儿童润肤剂,多方位呵护和滋润儿童的娇嫩肌肤,多种修复成分可协同作用更好地修护儿童受损肌肤,尤其能够有效降低晒后皮肤红斑指数,提高晒后皮肤含水量,能较好修复儿童受损肌肤,能够有效帮助儿童户外玩耍晒后修复,尤其夏季玩水后皮肤受损修复。
(2)而且,本发明儿童润肤剂具有较好的防水性,涂抹后遇水能够保持较好的修复效果,满足多种情景下的儿童皮肤防护需求,尤其能更好满足户外甚至海上玩水儿童肌肤需要。
(3)本发明添加一定量的特定大分子保湿剂,进一步提高其修复效果。
(4)另外,晒前涂抹本发明儿童润肤剂,也一定程度能够降低紫外线晒伤程度。
具体实施方式
为了更好理解本发明技术内容,下面提供具体实施例,对本发明做进一步的说明。
本发明实施例所用的实验方法如无特殊说明,均为常规方法。
本发明实施例所用的材料、试剂等,如无特殊说明,均可从商业途径得到。
实施例1-儿童润肤剂制备
1.1配方
按质量百分比计,由以下原料制得:牛油果树果脂3.5%、水解酵母蛋白1.0%、木糖醇0.2%、葡萄糖0.13%、羟苯基丙酰胺苯甲酸0.7%、椰子油3%、乳木果油1.5%、橄榄果油1.2%、角鲨烷05%、霍霍巴籽油0.7%、白油5%、鲸蜡硬脂醇3%、葡糖苷类1.2%、聚甘油类1.5%、维生素原B5 1.0%、甘油6.5%、防腐剂0.3%、增稠剂0.5%、皮肤屏障修复剂3%、修复组合物3.5%和余量的水;
上述修复组合物由以下重量份的原料组成:乳酸菌发酵提取物0.2份、尿囊素5份、燕麦提取物0.3份、甘草酸2.5份和甘草酸盐类2份,该乳酸菌发酵提取物为乳酸菌胞外多糖;所述燕麦提取物由含燕麦葡聚糖质量百分比10%的燕麦提取物和含燕麦多酚质量百分比15%的燕麦提取物按照质量比1:1组成;所述甘草酸盐类由甘草酸三钠和甘草酸二钾按照质量比1:1组成;
上述皮肤屏障修复剂由等量的神经酰胺、植物甾醇和脂肪酸组成;
上述葡糖苷类由等量的木糖醇基葡糖苷、椰油基葡糖苷、鲸蜡硬脂基葡糖苷、花生醇葡糖苷组成;
上述聚甘油类由等量的聚甘油-3甲基葡糖二硬脂酸酯、聚甘油-3蜂蜡酸酯、聚甘油-6聚蓖麻醇酸酯组成;
上述增稠剂由等量的黄原胶、羟乙基纤维素、卡波姆、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物、丙烯酸(酯)类/C10-30烷醇丙烯酸酯交联聚合物和丙烯酰二甲基牛磺酸铵/VP共聚物组成。
1.2制备
(1)按上述质量百分比分别取牛油果树果脂、椰子油、乳木果油、橄榄果油、角鲨烷、霍霍巴籽油、白油、葡糖苷类、聚甘油类、鲸蜡硬脂醇,混合后,加热至75℃,制得A相;
(2)按上述质量百分比分别取木糖醇、葡萄糖、维生素原B5、甘油和增稠剂,混合后,加热至75℃,制得B相;将B相与A相混合后,于1200r/min条件下均质搅拌12min,制得混合相;
(3)将混合相降温至43℃,添加水解酵母蛋白、羟苯基丙酰胺苯甲酸、皮肤屏障修复剂、修复组合物和防腐剂,搅拌12min,制得润乳剂。
实施例2
本实施例与实施例1主要区别在于:配方配比不同。具体地,按质量百分比计,由以下原料制得:牛油果树果脂5%、水解酵母蛋白0.8%、木糖醇0.3%、葡萄糖0.1%、羟苯基丙酰胺苯甲酸0.6%、椰子油2%、乳木果油2%、橄榄果油2%、角鲨烷0.8%、霍霍巴籽油1.6%、白油7%、鲸蜡硬脂醇1%、葡糖苷类2.5%、聚甘油类0.5%、维生素原B5 0.6%、甘油8%、防腐剂0.2%、增稠剂0.2%、皮肤屏障修复剂5%、修复组合物2%和余量的水;所述修复组合物由以下重量份的原料组成:乳酸菌发酵提取物0.15份、尿囊素6份、燕麦提取物0.4份、甘草酸2份和甘草酸盐类1.8份。
实施例3
本实施例与实施例1主要区别在于:配方配比不同。具体地,按质量百分比计,由以下原料制得:牛油果树果脂2%、水解酵母蛋白1.2%、木糖醇0.1%、葡萄糖0.2%、羟苯基丙酰胺苯甲酸0.8%、椰子油5%、乳木果油1%、橄榄果油0.5%、角鲨烷0.8%、霍霍巴籽油0.3%、白油4%、鲸蜡硬脂醇5%、葡糖苷类1%、聚甘油类3%、维生素原B5 1.3%、甘油5%、防腐剂0.4%、增稠剂2%、皮肤屏障修复剂1%、修复组合物5%和余量的水;所述修复组合物由以下重量份的原料组成:乳酸菌发酵提取物0.25份、尿囊素4份、燕麦提取物0.2份、甘草酸3份和甘草酸盐类2.2份。
实施例4
本实施例与实施例1的区别在于,所述皮肤屏障修复剂由神经酰胺、植物甾醇和脂肪酸按照质量比3:1:1组成;
所述葡糖苷类由木糖醇基葡糖苷、椰油基葡糖苷、鲸蜡硬脂基葡糖苷、花生醇葡糖苷按照质量比1.3:5:1:2组成;
所述聚甘油类由聚甘油-3甲基葡糖二硬脂酸酯、聚甘油-3蜂蜡酸酯、聚甘油-6聚蓖麻醇酸酯按照质量比2:3:5组成;
所述增稠剂由以下重量份的原料组成:黄原胶1.5份、羟乙基纤维素2.5份、卡波姆1.0份、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物4份、丙烯酸(酯)类/C10-30烷醇丙烯酸酯交联聚合物9份和丙烯酰二甲基牛磺酸铵/VP共聚物6份组成;
所述燕麦提取物由含燕麦葡聚糖质量百分比10%的燕麦提取物和含燕麦多酚质量百分比15%的燕麦提取物按照质量比3:2组成;
所述甘草酸盐类为由甘草酸三钠和甘草酸二钾按照质量比3:7组成。
实施例5
本实施例与实施例1的区别在于:配方中还添加质量百分比为0.5%的大分子保湿剂,该大分子保湿剂由透明质酸和海藻酸钠按照质量比1:4组成。
(1)按上述质量百分比分别取牛油果树果脂、椰子油、乳木果油、橄榄果油、角鲨烷、霍霍巴籽油、白油、葡糖苷类、聚甘油类、鲸蜡硬脂醇,混合后,加热至75℃,制得A相;
(2)按上述质量百分比分别取木糖醇、葡萄糖、维生素原B5、甘油、大分子保湿剂和增稠剂,混合后,加热至75℃,制得B相;将B相与A相混合后,于1200r/min条件下均质搅拌12min,制得混合相;
(3)将混合相降温至43℃,添加水解酵母蛋白、羟苯基丙酰胺苯甲酸、皮肤屏障修复剂、修复组合物和防腐剂,搅拌12min,制得润乳剂。
对比例1
本对比例与实施例1的区别在于,牛油果树果脂1%、水解酵母蛋白1.5%、木糖醇0.5%、葡萄糖0.5%、羟苯基丙酰胺苯甲酸0.3%、椰子油1%、乳木果油0.5%、橄榄果油0.3%、角鲨烷1%、霍霍巴籽油1.8%、白油5%、鲸蜡硬脂醇0.5%、葡糖苷类0.5%、聚甘油类0.3%、维生素原B5 0.5%、甘油3%、防腐剂0.3%、增稠剂0.1%、皮肤屏障修复剂0.5%、修复组合物1%和余量的水。
对比例2
本对比例与实施例1的区别在于,所述皮肤屏障修复剂不含有植物甾醇和脂肪酸,为单一组分神经酰胺。
对比例3
本对比例与实施例1的区别在于,所述修复组合物由以下重量份的原料组成:乳酸菌发酵提取物0.05份、尿囊素1份、燕麦提取物0.6份、甘草酸4份和甘草酸盐类1份。
试验例1动物试验
1.1实验方法
随机抽取昆明种小鼠110只,以脱毛膏脱去小鼠背部(2cm×2cm)毛发。脱毛后的皮肤用清水洗净,24h后随机分为9组,每组10只,分别为正常组(生理盐水)、阴性对照组(生理盐水)、阳性对照组(市售chicco智高儿童晒伤修复霜)、研究组1-8(实施例1-5、对比例1-3),分别编号标记。除正常组,将各组处理好的小鼠放18w紫外灯10cm处照射30min,观察各小鼠背部皮肤受损程度。阳性对照组小鼠背部每日涂抹晒伤修复霜2mg/cm2,研究组1-8小鼠背部每日涂抹儿童润肤剂2mg/cm2,正常组、阴性对照组涂抹等量生理盐水。3d后取分别切取小鼠1cm×1cm的创面皮肤组织,用于病理切片的制作。观察紫外线晒伤修复后小鼠血管数目。
1.2实验结果
实验结果表明,本发明实施例1-5儿童润肤剂能够促进晒伤皮肤血管新生,结果如表1。本发明实施例1-5儿童润肤剂能够促进晒伤小鼠内源性血管内皮生长因子(VEGF)表达,具有良好的晒后修复效果。
表1对紫外线晒伤小鼠血管数目影响
与阴性对照组比较,**P≤0.01,*P<0.05
同时,将实施例1-5的润肤剂分别进行动物皮肤刺激试验、皮肤致敏试验、体外细胞毒性试验,结果显示实施例1-5的润肤剂安全无毒。
试验例2临床试验
收集80名健康儿童,男女各40名,年龄为10-12岁,随机分4组,每组20名,分别为试验组1-3、对照组。统一服装,露出双臂,于2020年7月于海南省海口市假日海滩玩耍日晒2h后,分别测试皮肤红斑指数、皮肤含水量。晒后各组均匀涂抹对应儿童润肤剂,其中试验组1涂抹实施例1的儿童润肤剂,试验组2-3涂抹实施例4的儿童润肤剂,对照组涂抹市售chicco智高儿童晒伤修复霜,其中试验组3涂抹实施例1的儿童润肤剂后海水安全区继续玩耍30分钟(保持双臂浸入海水)。涂抹后间隔8h再重复涂抹一次。涂抹1h后测试皮肤红斑指数,24h后测试皮肤红斑指数、皮肤含水量,并统计修复后皮肤红斑指数降低百分比、皮肤含水量增加百分比。结果见表2。
修复1h后皮肤红斑指数降低百分比(%)=(晒后修复前皮肤红斑指数-晒后修复后皮肤红斑指数)/晒后修复前皮肤红斑指数*100%。
修复24h后皮肤含水量增加百分比(%)=(晒后修复后皮肤含水量-晒后修复前皮肤含水量)/晒后修复前皮肤含水量*100%。
表2晒后修复情况
上述结果表明,相比对照组市售超,试验组1-3显著降低晒后皮肤红斑指数,提高晒后皮肤含水量。即本发明制备儿童润肤剂能够有效降低晒后皮肤红斑指数,提高晒后皮肤含水量,能较好修复肌肤。而且试验组3与试验组2相比,两者没有显著性差异,表明本发明儿童润肤剂具有较好的防水性,涂抹后遇水能够保持较好的修复防护效果。
以上所述仅为本发明的较佳实施例而已,并不用以限制本发明,凡在本发明的精神和原则之内,所做的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (10)
1.一种含有乳酸菌发酵提取物的儿童润肤剂,其特征在于,包括以下质量百分比的原料:牛油果树果脂2~5%、水解酵母蛋白0.8~1.2%、木糖醇0.1~0.3%、葡萄糖0.1~0.2%、羟苯基丙酰胺苯甲酸0.6~0.8%、椰子油2~5%、乳木果油1~2%、橄榄果油0.5~2%、角鲨烷0.3~0.8%、霍霍巴籽油0.3~1.6%、白油4~7%、鲸蜡硬脂醇1-5%、葡糖苷类1~2.5%、聚甘油类0.5~3%、维生素原B5 0.6-1.3%、甘油5-8%、防腐剂0.1-0.5%、增稠剂0.2~2%、皮肤屏障修复剂1-5%、修复组合物2~5%和余量的水;
所述皮肤屏障修复剂由神经酰胺、植物甾醇和脂肪酸组成;
所述修复组合物由以下重量份的原料组成:乳酸菌发酵提取物0.15-0.25份、尿囊素4-6份、燕麦提取物0.2-0.4份、甘草酸2-3份和甘草酸盐类1.8-2.2份。
2.根据权利要求1所述的含有乳酸菌发酵提取物的儿童润肤剂,其特征在于,所述皮肤屏障修复剂由神经酰胺、植物甾醇和脂肪酸按照质量比3:1:1组成。
3.根据权利要求1或2所述的含有乳酸菌发酵提取物的儿童润肤剂,其特征在于,所述修复组合物由以下重量份的原料组成:乳酸菌发酵提取物0.2份、尿囊素5份、燕麦提取物0.3份、甘草酸2.5份和甘草酸盐类2份。
4.根据权利要求1所述的含有乳酸菌发酵提取物的儿童润肤剂,其特征在于,所述葡糖苷类由木糖醇基葡糖苷、椰油基葡糖苷、鲸蜡硬脂基葡糖苷、花生醇葡糖苷按照质量比1.3:5:1:2组成;所述聚甘油类为由聚甘油-3甲基葡糖二硬脂酸酯、聚甘油-3蜂蜡酸酯、聚甘油-6聚蓖麻醇酸酯按照质量比2:3:5组成。
5.根据权利要求1所述的含有乳酸菌发酵提取物的儿童润肤剂,其特征在于,所述增稠剂由以下重量份的原料组成:黄原胶1.5份、羟乙基纤维素2.5份、卡波姆1.0份、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物4份、丙烯酸(酯)类/C10-30烷醇丙烯酸酯交联聚合物9份和丙烯酰二甲基牛磺酸铵/VP共聚物6份组成。
6.根据权利要求1所述的含有乳酸菌发酵提取物的儿童润肤剂,其特征在于,所述乳酸菌发酵提取物为乳酸菌胞外多糖。
7.根据权利要求1所述的含有乳酸菌发酵提取物的儿童润肤剂,其特征在于,所述燕麦提取物由含燕麦葡聚糖质量百分比10%的燕麦提取物和含燕麦多酚质量百分比15%的燕麦提取物按照质量比3:2组成。
8.根据权利要求1所述的含有乳酸菌发酵提取物的儿童润肤剂,其特征在于,所述甘草酸盐类由甘草酸三钠和甘草酸二钾按照质量比3:7组成。
9.根据权利要求1所述的含有乳酸菌发酵提取物的儿童润肤剂,其特征在于,所述儿童润肤剂还含有质量百分比为0.1-1%的大分子保湿剂,所述大分子保湿剂由透明质酸和海藻酸钠按照质量比1:4组成。
10.根据权利要求1-9任一项所述的含有乳酸菌发酵提取物的儿童润肤剂的制备方法,其特征在于,包括以下步骤:
(1)按上述质量百分比分别取牛油果树果脂、椰子油、乳木果油、橄榄果油、角鲨烷、霍霍巴籽油、白油、葡糖苷类、聚甘油类、鲸蜡硬脂醇,混合后,加热至70-80℃,制得A相;
(2)按上述质量百分比分别取木糖醇、葡萄糖、维生素原B5、甘油和增稠剂,混合后,加热至70-80℃,制得B相;将B相与A相混合后,于900-1500r/min条件下均质搅拌10-15分钟,制得混合相;
(3)将混合相降温至40-45℃,添加水解酵母蛋白、羟苯基丙酰胺苯甲酸、皮肤屏障修复剂、修复组合物和防腐剂,搅拌10-15分钟,制得润乳剂。
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