CN113384514A - 一种含有乳酸菌发酵提取物的儿童润肤剂及其制备方法 - Google Patents
一种含有乳酸菌发酵提取物的儿童润肤剂及其制备方法 Download PDFInfo
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- CN113384514A CN113384514A CN202110621073.2A CN202110621073A CN113384514A CN 113384514 A CN113384514 A CN 113384514A CN 202110621073 A CN202110621073 A CN 202110621073A CN 113384514 A CN113384514 A CN 113384514A
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Abstract
本发明提供一种含有乳酸菌发酵提取物的儿童润肤剂及其制备方法，该儿童润肤剂包括以下原料：牛油果树果脂、水解酵母蛋白、木糖醇、葡萄糖、羟苯基丙酰胺苯甲酸、椰子油、乳木果油、橄榄果油、角鲨烷、霍霍巴籽油、白油、鲸蜡硬脂醇、葡糖苷类、聚甘油类、维生素原B5、甘油、黄原胶、防腐剂、增稠剂、皮肤屏障修复剂、修复组合物和余量的水；所述皮肤屏障修复剂由神经酰胺、植物甾醇和脂肪酸组成。本发明制备儿童润肤剂，能够多方位呵护和滋润儿童的娇嫩肌肤，例如在晒后，有效降低皮肤红斑指数，提高皮肤含水量，修复受损肌肤。另外本品具有防水功能，满足多种情景下的儿童皮肤防护需求，多种修复成分可协同作用更好地修护儿童受损肌肤。
Description
技术领域
本发明涉及儿童润肤剂技术领域，特别涉及一种含有乳酸菌发酵提取物的儿童润肤剂及其制备方法。
背景技术
与成年人相比，儿童皮肤在结构和功能上都有巨大差别，包括：儿童皮肤薄嫩，皮肤角质层薄，缺少透明层；儿童皮肤含水量高，皮肤屏障功能较低，皮肤的失水量也较大；儿童皮肤的黑色素含量低，紫外线抵御能力差，易被紫外线辐射灼伤。儿童皮肤存在以上特点，所以儿童皮肤较成年人更易受损。而且儿童常常喜欢户外游玩，部分儿童尤其喜欢玩水，而夏季紫外线强烈，儿童皮肤娇嫩，尤其容易被晒伤。
例如为了避免儿童在外出时被烈日晒伤，一般给孩子准备遮阳帽或者太阳伞，并在外出前20-30分钟，在儿童裸露皮肤上涂抹防晒霜。另外出去户外长时间游玩时，每隔一个小时左右重新涂一遍防晒霜。但是在海边玩水时，或者体验水上项目时，常常会遇到浪大、风大，防晒霜效果易被破坏甚至失效，使得儿童容易出现晒伤等情况。因此急需一种儿童润肤剂，能够有效克服上述类似皮肤问题。
发明内容
鉴于此，本发明提出一种含有乳酸菌发酵提取物的儿童润肤剂及其制备方法，该儿童润肤剂不但皮肤受损后的修复效果佳，而且有防水作用，能更好满足儿童在多种情景下的皮肤保护需要。
本发明的技术方案是这样实现的：
一种含有乳酸菌发酵提取物的儿童润肤剂，包括以下质量百分比的原料：牛油果树果脂2～5％、水解酵母蛋白0.8～1.2％、木糖醇0.1～0.3％、葡萄糖0.1～0.2％、羟苯基丙酰胺苯甲酸0.6～0.8％、椰子油2～5％、乳木果油1～2％、橄榄果油0.5～2％、角鲨烷0.3～0.8％、霍霍巴籽油0.3～1.6％、白油4～7％、鲸蜡硬脂醇1-5％、葡糖苷类1～2.5％、聚甘油类0.5～3％、维生素原B5 0.6-1.3％、甘油5-8％、防腐剂0.1-0.5％、增稠剂0.2～2％、皮肤屏障修复剂1-5％、修复组合物2～5％和余量的水；所述皮肤屏障修复剂由神经酰胺、植物甾醇和脂肪酸组成；所述修复组合物由以下重量份的原料组成：乳酸菌发酵提取物0.15-0.25份、尿囊素4-6份、燕麦提取物0.2-0.4份、甘草酸2-3份和甘草酸盐类1.8-2.2份，优选地，所述修复组合物由以下重量份的原料组成：乳酸菌发酵提取物0.2份、尿囊素5份、燕麦提取物0.3份、甘草酸2.5份和甘草酸盐类2份。
进一步的，所述皮肤屏障修复剂由神经酰胺、植物甾醇和脂肪酸按照质量比3：1：1组成。
进一步的，所述葡糖苷类由木糖醇基葡糖苷、椰油基葡糖苷、鲸蜡硬脂基葡糖苷、花生醇葡糖苷按照质量比1.3：5：1：2组成；所述聚甘油类为由聚甘油-3甲基葡糖二硬脂酸酯、聚甘油-3蜂蜡酸酯、聚甘油-6聚蓖麻醇酸酯按照质量比2：3：5组成。
进一步的，所述增稠剂由以下重量份的原料组成：黄原胶1.5份、羟乙基纤维素2.5份、卡波姆1.0份、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物4份、丙烯酸(酯)类/C10-30烷醇丙烯酸酯交联聚合物9份和丙烯酰二甲基牛磺酸铵/VP共聚物6份组成。
进一步的，所述乳酸菌发酵提取物为乳酸菌胞外多糖。
进一步的，所述燕麦提取物由含燕麦葡聚糖质量百分比10％的燕麦提取物和含燕麦多酚质量百分比15％的燕麦提取物按照质量比3：2组成。
进一步的，所述甘草酸盐类为由甘草酸三钠和甘草酸二钾按照质量比3：7组成。
进一步的，所述儿童润肤剂还含有质量百分比为0.1-1％的大分子保湿剂，所述大分子保湿剂由透明质酸和海藻酸钠组成。
进一步的，所述大分子保湿剂由透明质酸和海藻酸钠按照质量比1：4组成。
本发明儿童润肤剂的制备方法，包括以下步骤：
(1)按上述质量百分比分别取牛油果树果脂、椰子油、乳木果油、橄榄果油、角鲨烷、霍霍巴籽油、白油、葡糖苷类、聚甘油类、鲸蜡硬脂醇，混合后，加热至70-80℃，制得A相；
(2)按上述质量百分比分别取木糖醇、葡萄糖、维生素原B5、甘油和增稠剂，混合后，加热至70-80℃，制得B相；将B相与A相混合后，于900-1500r/min条件下均质搅拌10-15分钟，制得混合相；
(3)将混合相降温至40-45℃，添加水解酵母蛋白、羟苯基丙酰胺苯甲酸、皮肤屏障修复剂、修复组合物和防腐剂，搅拌10-15分钟，制得润乳剂。
与现有技术相比，本发明的有益效果是：
(1)本发明以乳酸菌发酵提取物联合尿囊素、燕麦提取物、甘草酸和甘草酸盐类为修复组合物，搭配复配皮肤屏障修复剂，结合水解酵母蛋白、羟苯基丙酰胺苯甲酸，添加牛油果树果脂、椰子油、乳木果油、橄榄果油、角鲨烷、霍霍巴籽油、白油、葡糖苷类、聚甘油类、鲸蜡硬脂醇以及木糖醇、葡萄糖、维生素原B5等，制备儿童润肤剂，多方位呵护和滋润儿童的娇嫩肌肤，多种修复成分可协同作用更好地修护儿童受损肌肤，尤其能够有效降低晒后皮肤红斑指数，提高晒后皮肤含水量，能较好修复儿童受损肌肤，能够有效帮助儿童户外玩耍晒后修复，尤其夏季玩水后皮肤受损修复。
(2)而且，本发明儿童润肤剂具有较好的防水性，涂抹后遇水能够保持较好的修复效果，满足多种情景下的儿童皮肤防护需求，尤其能更好满足户外甚至海上玩水儿童肌肤需要。
(3)本发明添加一定量的特定大分子保湿剂，进一步提高其修复效果。
(4)另外，晒前涂抹本发明儿童润肤剂，也一定程度能够降低紫外线晒伤程度。
具体实施方式
为了更好理解本发明技术内容，下面提供具体实施例，对本发明做进一步的说明。
本发明实施例所用的实验方法如无特殊说明，均为常规方法。
本发明实施例所用的材料、试剂等，如无特殊说明，均可从商业途径得到。
实施例1-儿童润肤剂制备
1.1配方
按质量百分比计，由以下原料制得：牛油果树果脂3.5％、水解酵母蛋白1.0％、木糖醇0.2％、葡萄糖0.13％、羟苯基丙酰胺苯甲酸0.7％、椰子油3％、乳木果油1.5％、橄榄果油1.2％、角鲨烷05％、霍霍巴籽油0.7％、白油5％、鲸蜡硬脂醇3％、葡糖苷类1.2％、聚甘油类1.5％、维生素原B5 1.0％、甘油6.5％、防腐剂0.3％、增稠剂0.5％、皮肤屏障修复剂3％、修复组合物3.5％和余量的水；
上述修复组合物由以下重量份的原料组成：乳酸菌发酵提取物0.2份、尿囊素5份、燕麦提取物0.3份、甘草酸2.5份和甘草酸盐类2份，该乳酸菌发酵提取物为乳酸菌胞外多糖；所述燕麦提取物由含燕麦葡聚糖质量百分比10％的燕麦提取物和含燕麦多酚质量百分比15％的燕麦提取物按照质量比1：1组成；所述甘草酸盐类由甘草酸三钠和甘草酸二钾按照质量比1：1组成；
上述皮肤屏障修复剂由等量的神经酰胺、植物甾醇和脂肪酸组成；
上述葡糖苷类由等量的木糖醇基葡糖苷、椰油基葡糖苷、鲸蜡硬脂基葡糖苷、花生醇葡糖苷组成；
上述聚甘油类由等量的聚甘油-3甲基葡糖二硬脂酸酯、聚甘油-3蜂蜡酸酯、聚甘油-6聚蓖麻醇酸酯组成；
上述增稠剂由等量的黄原胶、羟乙基纤维素、卡波姆、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物、丙烯酸(酯)类/C10-30烷醇丙烯酸酯交联聚合物和丙烯酰二甲基牛磺酸铵/VP共聚物组成。
1.2制备
(1)按上述质量百分比分别取牛油果树果脂、椰子油、乳木果油、橄榄果油、角鲨烷、霍霍巴籽油、白油、葡糖苷类、聚甘油类、鲸蜡硬脂醇，混合后，加热至75℃，制得A相；
(2)按上述质量百分比分别取木糖醇、葡萄糖、维生素原B5、甘油和增稠剂，混合后，加热至75℃，制得B相；将B相与A相混合后，于1200r/min条件下均质搅拌12min，制得混合相；
(3)将混合相降温至43℃，添加水解酵母蛋白、羟苯基丙酰胺苯甲酸、皮肤屏障修复剂、修复组合物和防腐剂，搅拌12min，制得润乳剂。
实施例2
本实施例与实施例1主要区别在于：配方配比不同。具体地，按质量百分比计，由以下原料制得：牛油果树果脂5％、水解酵母蛋白0.8％、木糖醇0.3％、葡萄糖0.1％、羟苯基丙酰胺苯甲酸0.6％、椰子油2％、乳木果油2％、橄榄果油2％、角鲨烷0.8％、霍霍巴籽油1.6％、白油7％、鲸蜡硬脂醇1％、葡糖苷类2.5％、聚甘油类0.5％、维生素原B5 0.6％、甘油8％、防腐剂0.2％、增稠剂0.2％、皮肤屏障修复剂5％、修复组合物2％和余量的水；所述修复组合物由以下重量份的原料组成：乳酸菌发酵提取物0.15份、尿囊素6份、燕麦提取物0.4份、甘草酸2份和甘草酸盐类1.8份。
实施例3
本实施例与实施例1主要区别在于：配方配比不同。具体地，按质量百分比计，由以下原料制得：牛油果树果脂2％、水解酵母蛋白1.2％、木糖醇0.1％、葡萄糖0.2％、羟苯基丙酰胺苯甲酸0.8％、椰子油5％、乳木果油1％、橄榄果油0.5％、角鲨烷0.8％、霍霍巴籽油0.3％、白油4％、鲸蜡硬脂醇5％、葡糖苷类1％、聚甘油类3％、维生素原B5 1.3％、甘油5％、防腐剂0.4％、增稠剂2％、皮肤屏障修复剂1％、修复组合物5％和余量的水；所述修复组合物由以下重量份的原料组成：乳酸菌发酵提取物0.25份、尿囊素4份、燕麦提取物0.2份、甘草酸3份和甘草酸盐类2.2份。
实施例4
本实施例与实施例1的区别在于，所述皮肤屏障修复剂由神经酰胺、植物甾醇和脂肪酸按照质量比3：1：1组成；
所述葡糖苷类由木糖醇基葡糖苷、椰油基葡糖苷、鲸蜡硬脂基葡糖苷、花生醇葡糖苷按照质量比1.3：5：1：2组成；
所述聚甘油类由聚甘油-3甲基葡糖二硬脂酸酯、聚甘油-3蜂蜡酸酯、聚甘油-6聚蓖麻醇酸酯按照质量比2：3：5组成；
所述增稠剂由以下重量份的原料组成：黄原胶1.5份、羟乙基纤维素2.5份、卡波姆1.0份、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物4份、丙烯酸(酯)类/C10-30烷醇丙烯酸酯交联聚合物9份和丙烯酰二甲基牛磺酸铵/VP共聚物6份组成；
所述燕麦提取物由含燕麦葡聚糖质量百分比10％的燕麦提取物和含燕麦多酚质量百分比15％的燕麦提取物按照质量比3：2组成；
所述甘草酸盐类为由甘草酸三钠和甘草酸二钾按照质量比3：7组成。
实施例5
本实施例与实施例1的区别在于：配方中还添加质量百分比为0.5％的大分子保湿剂，该大分子保湿剂由透明质酸和海藻酸钠按照质量比1：4组成。
(1)按上述质量百分比分别取牛油果树果脂、椰子油、乳木果油、橄榄果油、角鲨烷、霍霍巴籽油、白油、葡糖苷类、聚甘油类、鲸蜡硬脂醇，混合后，加热至75℃，制得A相；
(2)按上述质量百分比分别取木糖醇、葡萄糖、维生素原B5、甘油、大分子保湿剂和增稠剂，混合后，加热至75℃，制得B相；将B相与A相混合后，于1200r/min条件下均质搅拌12min，制得混合相；
(3)将混合相降温至43℃，添加水解酵母蛋白、羟苯基丙酰胺苯甲酸、皮肤屏障修复剂、修复组合物和防腐剂，搅拌12min，制得润乳剂。
对比例1
本对比例与实施例1的区别在于，牛油果树果脂1％、水解酵母蛋白1.5％、木糖醇0.5％、葡萄糖0.5％、羟苯基丙酰胺苯甲酸0.3％、椰子油1％、乳木果油0.5％、橄榄果油0.3％、角鲨烷1％、霍霍巴籽油1.8％、白油5％、鲸蜡硬脂醇0.5％、葡糖苷类0.5％、聚甘油类0.3％、维生素原B5 0.5％、甘油3％、防腐剂0.3％、增稠剂0.1％、皮肤屏障修复剂0.5％、修复组合物1％和余量的水。
对比例2
本对比例与实施例1的区别在于，所述皮肤屏障修复剂不含有植物甾醇和脂肪酸，为单一组分神经酰胺。
对比例3
本对比例与实施例1的区别在于，所述修复组合物由以下重量份的原料组成：乳酸菌发酵提取物0.05份、尿囊素1份、燕麦提取物0.6份、甘草酸4份和甘草酸盐类1份。
试验例1动物试验
1.1实验方法
随机抽取昆明种小鼠110只，以脱毛膏脱去小鼠背部(2cm×2cm)毛发。脱毛后的皮肤用清水洗净，24h后随机分为9组，每组10只，分别为正常组(生理盐水)、阴性对照组(生理盐水)、阳性对照组(市售chicco智高儿童晒伤修复霜)、研究组1-8(实施例1-5、对比例1-3)，分别编号标记。除正常组，将各组处理好的小鼠放18w紫外灯10cm处照射30min，观察各小鼠背部皮肤受损程度。阳性对照组小鼠背部每日涂抹晒伤修复霜2mg/cm2，研究组1-8小鼠背部每日涂抹儿童润肤剂2mg/cm2，正常组、阴性对照组涂抹等量生理盐水。3d后取分别切取小鼠1cm×1cm的创面皮肤组织，用于病理切片的制作。观察紫外线晒伤修复后小鼠血管数目。
1.2实验结果
实验结果表明，本发明实施例1-5儿童润肤剂能够促进晒伤皮肤血管新生，结果如表1。本发明实施例1-5儿童润肤剂能够促进晒伤小鼠内源性血管内皮生长因子(VEGF)表达，具有良好的晒后修复效果。
表1对紫外线晒伤小鼠血管数目影响
与阴性对照组比较，**P≤0.01，*P＜0.05
同时，将实施例1-5的润肤剂分别进行动物皮肤刺激试验、皮肤致敏试验、体外细胞毒性试验，结果显示实施例1-5的润肤剂安全无毒。
试验例2临床试验
收集80名健康儿童，男女各40名，年龄为10-12岁，随机分4组，每组20名，分别为试验组1-3、对照组。统一服装，露出双臂，于2020年7月于海南省海口市假日海滩玩耍日晒2h后，分别测试皮肤红斑指数、皮肤含水量。晒后各组均匀涂抹对应儿童润肤剂，其中试验组1涂抹实施例1的儿童润肤剂，试验组2-3涂抹实施例4的儿童润肤剂，对照组涂抹市售chicco智高儿童晒伤修复霜，其中试验组3涂抹实施例1的儿童润肤剂后海水安全区继续玩耍30分钟(保持双臂浸入海水)。涂抹后间隔8h再重复涂抹一次。涂抹1h后测试皮肤红斑指数，24h后测试皮肤红斑指数、皮肤含水量，并统计修复后皮肤红斑指数降低百分比、皮肤含水量增加百分比。结果见表2。
修复1h后皮肤红斑指数降低百分比(％)＝(晒后修复前皮肤红斑指数-晒后修复后皮肤红斑指数)/晒后修复前皮肤红斑指数*100％。
修复24h后皮肤含水量增加百分比(％)＝(晒后修复后皮肤含水量-晒后修复前皮肤含水量)/晒后修复前皮肤含水量*100％。
表2晒后修复情况
上述结果表明，相比对照组市售超，试验组1-3显著降低晒后皮肤红斑指数，提高晒后皮肤含水量。即本发明制备儿童润肤剂能够有效降低晒后皮肤红斑指数，提高晒后皮肤含水量，能较好修复肌肤。而且试验组3与试验组2相比，两者没有显著性差异，表明本发明儿童润肤剂具有较好的防水性，涂抹后遇水能够保持较好的修复防护效果。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内，所做的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
Claims (10)
1.一种含有乳酸菌发酵提取物的儿童润肤剂，其特征在于，包括以下质量百分比的原料：牛油果树果脂2～5％、水解酵母蛋白0.8～1.2％、木糖醇0.1～0.3％、葡萄糖0.1～0.2％、羟苯基丙酰胺苯甲酸0.6～0.8％、椰子油2～5％、乳木果油1～2％、橄榄果油0.5～2％、角鲨烷0.3～0.8％、霍霍巴籽油0.3～1.6％、白油4～7％、鲸蜡硬脂醇1-5％、葡糖苷类1～2.5％、聚甘油类0.5～3％、维生素原B5 0.6-1.3％、甘油5-8％、防腐剂0.1-0.5％、增稠剂0.2～2％、皮肤屏障修复剂1-5％、修复组合物2～5％和余量的水；
所述皮肤屏障修复剂由神经酰胺、植物甾醇和脂肪酸组成；
所述修复组合物由以下重量份的原料组成：乳酸菌发酵提取物0.15-0.25份、尿囊素4-6份、燕麦提取物0.2-0.4份、甘草酸2-3份和甘草酸盐类1.8-2.2份。
2.根据权利要求1所述的含有乳酸菌发酵提取物的儿童润肤剂，其特征在于，所述皮肤屏障修复剂由神经酰胺、植物甾醇和脂肪酸按照质量比3：1：1组成。
3.根据权利要求1或2所述的含有乳酸菌发酵提取物的儿童润肤剂，其特征在于，所述修复组合物由以下重量份的原料组成：乳酸菌发酵提取物0.2份、尿囊素5份、燕麦提取物0.3份、甘草酸2.5份和甘草酸盐类2份。
4.根据权利要求1所述的含有乳酸菌发酵提取物的儿童润肤剂，其特征在于，所述葡糖苷类由木糖醇基葡糖苷、椰油基葡糖苷、鲸蜡硬脂基葡糖苷、花生醇葡糖苷按照质量比1.3：5：1：2组成；所述聚甘油类为由聚甘油-3甲基葡糖二硬脂酸酯、聚甘油-3蜂蜡酸酯、聚甘油-6聚蓖麻醇酸酯按照质量比2：3：5组成。
5.根据权利要求1所述的含有乳酸菌发酵提取物的儿童润肤剂，其特征在于，所述增稠剂由以下重量份的原料组成：黄原胶1.5份、羟乙基纤维素2.5份、卡波姆1.0份、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物4份、丙烯酸(酯)类/C10-30烷醇丙烯酸酯交联聚合物9份和丙烯酰二甲基牛磺酸铵/VP共聚物6份组成。
6.根据权利要求1所述的含有乳酸菌发酵提取物的儿童润肤剂，其特征在于，所述乳酸菌发酵提取物为乳酸菌胞外多糖。
7.根据权利要求1所述的含有乳酸菌发酵提取物的儿童润肤剂，其特征在于，所述燕麦提取物由含燕麦葡聚糖质量百分比10％的燕麦提取物和含燕麦多酚质量百分比15％的燕麦提取物按照质量比3：2组成。
8.根据权利要求1所述的含有乳酸菌发酵提取物的儿童润肤剂，其特征在于，所述甘草酸盐类由甘草酸三钠和甘草酸二钾按照质量比3：7组成。
9.根据权利要求1所述的含有乳酸菌发酵提取物的儿童润肤剂，其特征在于，所述儿童润肤剂还含有质量百分比为0.1-1％的大分子保湿剂，所述大分子保湿剂由透明质酸和海藻酸钠按照质量比1：4组成。
10.根据权利要求1-9任一项所述的含有乳酸菌发酵提取物的儿童润肤剂的制备方法，其特征在于，包括以下步骤：
(1)按上述质量百分比分别取牛油果树果脂、椰子油、乳木果油、橄榄果油、角鲨烷、霍霍巴籽油、白油、葡糖苷类、聚甘油类、鲸蜡硬脂醇，混合后，加热至70-80℃，制得A相；
(2)按上述质量百分比分别取木糖醇、葡萄糖、维生素原B5、甘油和增稠剂，混合后，加热至70-80℃，制得B相；将B相与A相混合后，于900-1500r/min条件下均质搅拌10-15分钟，制得混合相；
(3)将混合相降温至40-45℃，添加水解酵母蛋白、羟苯基丙酰胺苯甲酸、皮肤屏障修复剂、修复组合物和防腐剂，搅拌10-15分钟，制得润乳剂。
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| CN115463071A (zh) * | 2022-08-30 | 2022-12-13 | 山东花物堂生物科技有限公司 | 一种长效保湿修护组合物及其制备方法和应用 |
| CN115463071B (zh) * | 2022-08-30 | 2024-06-04 | 山东花物堂生物科技有限公司 | 一种长效保湿修护组合物及其制备方法和应用 |
| CN117752565A (zh) * | 2023-12-18 | 2024-03-26 | 广州她她生物科技有限公司 | 一种祛痘精华及其制备方法 |
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