CN109662928A - 一种具有防晒修复功效的护肤组合物及其应用和制备方法 - Google Patents
一种具有防晒修复功效的护肤组合物及其应用和制备方法 Download PDFInfo
- Publication number
- CN109662928A CN109662928A CN201910115194.2A CN201910115194A CN109662928A CN 109662928 A CN109662928 A CN 109662928A CN 201910115194 A CN201910115194 A CN 201910115194A CN 109662928 A CN109662928 A CN 109662928A
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- skin
- added
- homogeneous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 29
- 230000000694 effects Effects 0.000 title abstract description 26
- 238000002360 preparation method Methods 0.000 title abstract description 11
- 239000000284 extract Substances 0.000 claims abstract description 47
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 34
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 31
- 241000196324 Embryophyta Species 0.000 claims abstract description 29
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 20
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 17
- 229960000458 allantoin Drugs 0.000 claims abstract description 17
- 239000002131 composite material Substances 0.000 claims abstract description 13
- 150000004676 glycans Chemical class 0.000 claims abstract description 13
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 13
- 239000005017 polysaccharide Substances 0.000 claims abstract description 13
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims abstract description 12
- QWGRWMMWNDWRQN-UHFFFAOYSA-N 2-methylpropane-1,3-diol Chemical compound OCC(C)CO QWGRWMMWNDWRQN-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229920002498 Beta-glucan Polymers 0.000 claims abstract description 12
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims abstract description 12
- 150000001408 amides Chemical class 0.000 claims abstract description 12
- 229960003237 betaine Drugs 0.000 claims abstract description 12
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229940100573 methylpropanediol Drugs 0.000 claims abstract description 12
- 210000005036 nerve Anatomy 0.000 claims abstract description 12
- 229940101267 panthenol Drugs 0.000 claims abstract description 12
- 235000020957 pantothenol Nutrition 0.000 claims abstract description 12
- 239000011619 pantothenol Substances 0.000 claims abstract description 12
- 244000020551 Helianthus annuus Species 0.000 claims abstract description 11
- 235000003222 Helianthus annuus Nutrition 0.000 claims abstract description 11
- 241001506047 Tremella Species 0.000 claims abstract description 11
- 230000006378 damage Effects 0.000 claims abstract description 11
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 11
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 10
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 10
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 10
- 235000001543 Corylus americana Nutrition 0.000 claims abstract description 9
- 240000007582 Corylus avellana Species 0.000 claims abstract description 9
- 235000007466 Corylus avellana Nutrition 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims description 41
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 24
- 238000003756 stirring Methods 0.000 claims description 24
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical group CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 16
- 239000006071 cream Substances 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims description 14
- 241001135917 Vitellaria paradoxa Species 0.000 claims description 14
- 239000003755 preservative agent Substances 0.000 claims description 14
- 230000002335 preservative effect Effects 0.000 claims description 14
- 229940057910 shea butter Drugs 0.000 claims description 14
- 229940119170 jojoba wax Drugs 0.000 claims description 13
- 239000003995 emulsifying agent Substances 0.000 claims description 12
- 235000021388 linseed oil Nutrition 0.000 claims description 12
- 239000000944 linseed oil Substances 0.000 claims description 12
- 229920002545 silicone oil Polymers 0.000 claims description 12
- 235000011187 glycerol Nutrition 0.000 claims description 11
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 11
- 150000002148 esters Chemical class 0.000 claims description 10
- FEBUJFMRSBAMES-UHFFFAOYSA-N 2-[(2-{[3,5-dihydroxy-2-(hydroxymethyl)-6-phosphanyloxan-4-yl]oxy}-3,5-dihydroxy-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-4-yl)oxy]-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl phosphinite Chemical group OC1C(O)C(O)C(CO)OC1OCC1C(O)C(OC2C(C(OP)C(O)C(CO)O2)O)C(O)C(OC2C(C(CO)OC(P)C2O)O)O1 FEBUJFMRSBAMES-UHFFFAOYSA-N 0.000 claims description 8
- 229920002305 Schizophyllan Polymers 0.000 claims description 8
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 8
- 239000002738 chelating agent Substances 0.000 claims description 8
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical group CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 8
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 8
- 239000002562 thickening agent Substances 0.000 claims description 8
- 229960005150 glycerol Drugs 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 7
- OQILCOQZDHPEAZ-UHFFFAOYSA-N Palmitinsaeure-octylester Natural products CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 claims description 6
- 230000003750 conditioning effect Effects 0.000 claims description 6
- 238000001514 detection method Methods 0.000 claims description 6
- GJQLBGWSDGMZKM-UHFFFAOYSA-N ethylhexyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(CC)CCCCC GJQLBGWSDGMZKM-UHFFFAOYSA-N 0.000 claims description 6
- 238000009736 wetting Methods 0.000 claims description 6
- 239000004909 Moisturizer Substances 0.000 claims description 5
- 239000000470 constituent Substances 0.000 claims description 5
- 239000003974 emollient agent Substances 0.000 claims description 5
- 238000000605 extraction Methods 0.000 claims description 5
- 239000006210 lotion Substances 0.000 claims description 5
- 230000001333 moisturizer Effects 0.000 claims description 5
- 239000003963 antioxidant agent Substances 0.000 claims description 4
- 230000003078 antioxidant effect Effects 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 claims description 3
- 241000208680 Hamamelis mollis Species 0.000 claims description 3
- 230000001815 facial effect Effects 0.000 claims description 3
- 238000011069 regeneration method Methods 0.000 claims description 3
- 229940118846 witch hazel Drugs 0.000 claims description 3
- 238000009833 condensation Methods 0.000 claims description 2
- 230000005494 condensation Effects 0.000 claims description 2
- 239000008367 deionised water Substances 0.000 claims description 2
- 229910021641 deionized water Inorganic materials 0.000 claims description 2
- 230000007062 hydrolysis Effects 0.000 claims description 2
- 238000006460 hydrolysis reaction Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical group [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims description 2
- 108010058643 Fungal Proteins Proteins 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 229910052709 silver Inorganic materials 0.000 claims 1
- 239000004332 silver Substances 0.000 claims 1
- 210000003491 skin Anatomy 0.000 abstract description 45
- 238000012423 maintenance Methods 0.000 abstract description 9
- 210000004027 cell Anatomy 0.000 abstract description 6
- 210000004927 skin cell Anatomy 0.000 abstract description 6
- 239000004615 ingredient Substances 0.000 abstract description 5
- 230000008591 skin barrier function Effects 0.000 abstract description 5
- 230000012010 growth Effects 0.000 abstract description 4
- 230000007246 mechanism Effects 0.000 abstract description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 21
- 230000000052 comparative effect Effects 0.000 description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 239000010410 layer Substances 0.000 description 10
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 8
- -1 o-amino benzoyl ketone Chemical class 0.000 description 8
- 239000002537 cosmetic Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 239000003814 drug Substances 0.000 description 6
- 240000006240 Linum usitatissimum Species 0.000 description 5
- 235000004431 Linum usitatissimum Nutrition 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 241000205407 Polygonum Species 0.000 description 4
- 244000178231 Rosmarinus officinalis Species 0.000 description 4
- 229930182558 Sterol Natural products 0.000 description 4
- 244000269722 Thea sinensis Species 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 150000004665 fatty acids Chemical class 0.000 description 4
- 208000014674 injury Diseases 0.000 description 4
- 235000003702 sterols Nutrition 0.000 description 4
- 230000000475 sunscreen effect Effects 0.000 description 4
- 239000000516 sunscreening agent Substances 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 3
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 3
- 244000303040 Glycyrrhiza glabra Species 0.000 description 3
- 244000042664 Matricaria chamomilla Species 0.000 description 3
- 235000004429 Matricaria chamomilla var recutita Nutrition 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 239000004519 grease Substances 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 210000002374 sebum Anatomy 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 208000017520 skin disease Diseases 0.000 description 3
- 239000002023 wood Substances 0.000 description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 2
- DOUMFZQKYFQNTF-WUTVXBCWSA-N (R)-rosmarinic acid Chemical compound C([C@H](C(=O)O)OC(=O)\C=C\C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-WUTVXBCWSA-N 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 241000167550 Centella Species 0.000 description 2
- 244000146462 Centella asiatica Species 0.000 description 2
- 235000004032 Centella asiatica Nutrition 0.000 description 2
- 241000195628 Chlorophyta Species 0.000 description 2
- 206010012438 Dermatitis atopic Diseases 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 241000221095 Simmondsia Species 0.000 description 2
- 235000004433 Simmondsia californica Nutrition 0.000 description 2
- 208000028990 Skin injury Diseases 0.000 description 2
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 201000008937 atopic dermatitis Diseases 0.000 description 2
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 235000004426 flaxseed Nutrition 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 229940072008 glycyrrhiza glabra extract Drugs 0.000 description 2
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 229960003160 hyaluronic acid Drugs 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 230000035790 physiological processes and functions Effects 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 150000008442 polyphenolic compounds Chemical class 0.000 description 2
- 235000013824 polyphenols Nutrition 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 229940031439 squalene Drugs 0.000 description 2
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 2
- 150000003432 sterols Chemical class 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 1
- KVGZZAHHUNAVKZ-UHFFFAOYSA-N 1,4-Dioxin Chemical compound O1C=COC=C1 KVGZZAHHUNAVKZ-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical class NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 1
- NRTLIYOWLVMQBO-UHFFFAOYSA-N 5-chloro-1,3-dimethyl-N-(1,1,3-trimethyl-1,3-dihydro-2-benzofuran-4-yl)pyrazole-4-carboxamide Chemical compound C=12C(C)OC(C)(C)C2=CC=CC=1NC(=O)C=1C(C)=NN(C)C=1Cl NRTLIYOWLVMQBO-UHFFFAOYSA-N 0.000 description 1
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 1
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 206010000234 Abortion spontaneous Diseases 0.000 description 1
- 206010000242 Abortion threatened Diseases 0.000 description 1
- 235000019737 Animal fat Nutrition 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 241000208173 Apiaceae Species 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241000208837 Asterales Species 0.000 description 1
- 108091072128 B family Proteins 0.000 description 1
- 102000040350 B family Human genes 0.000 description 1
- 235000016068 Berberis vulgaris Nutrition 0.000 description 1
- 241000335053 Beta vulgaris Species 0.000 description 1
- SGNBVLSWZMBQTH-FGAXOLDCSA-N Campesterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@H](C(C)C)C)C)CC4)CC3)CC=2)CC1 SGNBVLSWZMBQTH-FGAXOLDCSA-N 0.000 description 1
- 241000288570 Chionochloa conspicua Species 0.000 description 1
- 244000247747 Coptis groenlandica Species 0.000 description 1
- 235000002991 Coptis groenlandica Nutrition 0.000 description 1
- 235000002673 Dioscorea communis Nutrition 0.000 description 1
- 241000544230 Dioscorea communis Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
- 206010019049 Hair texture abnormal Diseases 0.000 description 1
- BTEISVKTSQLKST-UHFFFAOYSA-N Haliclonasterol Natural products CC(C=CC(C)C(C)(C)C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C BTEISVKTSQLKST-UHFFFAOYSA-N 0.000 description 1
- 241000208690 Hamamelis Species 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 206010023138 Jaundice neonatal Diseases 0.000 description 1
- 241000366676 Justicia pectoralis Species 0.000 description 1
- 108010028554 LDL Cholesterol Proteins 0.000 description 1
- 108010007622 LDL Lipoproteins Proteins 0.000 description 1
- 102000007330 LDL Lipoproteins Human genes 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- 239000000232 Lipid Bilayer Substances 0.000 description 1
- 235000017945 Matricaria Nutrition 0.000 description 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 1
- 244000067946 Matricaria chamomilla var. recutita Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102000014171 Milk Proteins Human genes 0.000 description 1
- 108010011756 Milk Proteins Proteins 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 201000006346 Neonatal Jaundice Diseases 0.000 description 1
- 206010029164 Nephrotic syndrome Diseases 0.000 description 1
- 201000009053 Neurodermatitis Diseases 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 208000035753 Periorbital contusion Diseases 0.000 description 1
- 235000014676 Phragmites communis Nutrition 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 241000219050 Polygonaceae Species 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 240000001341 Reynoutria japonica Species 0.000 description 1
- 235000018167 Reynoutria japonica Nutrition 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- ZZAFFYPNLYCDEP-HNNXBMFYSA-N Rosmarinsaeure Natural products OC(=O)[C@H](Cc1cccc(O)c1O)OC(=O)C=Cc2ccc(O)c(O)c2 ZZAFFYPNLYCDEP-HNNXBMFYSA-N 0.000 description 1
- 241001529742 Rosmarinus Species 0.000 description 1
- 241000207929 Scutellaria Species 0.000 description 1
- 240000004534 Scutellaria baicalensis Species 0.000 description 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 241000251778 Squalus acanthias Species 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 208000005985 Threatened Abortion Diseases 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- HZYXFRGVBOPPNZ-UHFFFAOYSA-N UNPD88870 Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)=CCC(CC)C(C)C)C1(C)CC2 HZYXFRGVBOPPNZ-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 210000001643 allantois Anatomy 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 239000003699 antiulcer agent Substances 0.000 description 1
- 239000010692 aromatic oil Substances 0.000 description 1
- 210000001188 articular cartilage Anatomy 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 238000009412 basement excavation Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 1
- 239000012965 benzophenone Substances 0.000 description 1
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 235000000431 campesterol Nutrition 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 229940119217 chamomile extract Drugs 0.000 description 1
- 235000020221 chamomile extract Nutrition 0.000 description 1
- 229930002875 chlorophyll Natural products 0.000 description 1
- 235000019804 chlorophyll Nutrition 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000007596 consolidation process Methods 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 201000010251 cutis laxa Diseases 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 210000003989 endothelium vascular Anatomy 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 241001233957 eudicotyledons Species 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000003630 growth substance Substances 0.000 description 1
- 239000011121 hardwood Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- MNWFXJYAOYHMED-UHFFFAOYSA-N heptanoic acid Chemical compound CCCCCCC(O)=O MNWFXJYAOYHMED-UHFFFAOYSA-N 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- 230000001795 light effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 108010022197 lipoprotein cholesterol Proteins 0.000 description 1
- 239000012263 liquid product Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000008099 melanin synthesis Effects 0.000 description 1
- 235000021239 milk protein Nutrition 0.000 description 1
- 208000015994 miscarriage Diseases 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- SLCVBVWXLSEKPL-UHFFFAOYSA-N neopentyl glycol Chemical compound OCC(C)(C)CO SLCVBVWXLSEKPL-UHFFFAOYSA-N 0.000 description 1
- 208000009928 nephrosis Diseases 0.000 description 1
- 231100001027 nephrosis Toxicity 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 229940068065 phytosterols Drugs 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- DOUMFZQKYFQNTF-MRXNPFEDSA-N rosemarinic acid Natural products C([C@H](C(=O)O)OC(=O)C=CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-MRXNPFEDSA-N 0.000 description 1
- 235000020748 rosemary extract Nutrition 0.000 description 1
- TVHVQJFBWRLYOD-UHFFFAOYSA-N rosmarinic acid Natural products OC(=O)C(Cc1ccc(O)c(O)c1)OC(=Cc2ccc(O)c(O)c2)C=O TVHVQJFBWRLYOD-UHFFFAOYSA-N 0.000 description 1
- 235000015639 rosmarinus officinalis Nutrition 0.000 description 1
- 150000003902 salicylic acid esters Chemical class 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 208000000995 spontaneous abortion Diseases 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 235000016831 stigmasterol Nutrition 0.000 description 1
- 229940032091 stigmasterol Drugs 0.000 description 1
- BFDNMXAIBMJLBB-UHFFFAOYSA-N stigmasterol Natural products CCC(C=CC(C)C1CCCC2C3CC=C4CC(O)CCC4(C)C3CCC12C)C(C)C BFDNMXAIBMJLBB-UHFFFAOYSA-N 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000000498 stratum granulosum Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 210000001258 synovial membrane Anatomy 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical class [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- 238000005809 transesterification reaction Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
本发明涉及一种具有防晒修复功效的护肤组合物及其应用和制备方法。所述组合物按重量份计，包括植物舒敏剂0.1‑3重量份；依可多因0.01‑1.0重量份；水解酵母蛋白0.1‑1.0重量份；绿藻提取物0.01‑0.5重量份；金缕梅提取液0.01‑0.1重量份；银耳多糖0.01‑0.1重量份；燕麦葡聚糖0.1‑1.0重量份；尿囊素0.1‑1.0重量份；复合神经酰胺0.01‑1.0重量份；向日葵不皂化物0.01‑1.0重量份；甘油1.0‑10.0重量份、甲基丙二醇1.0‑10.0重量份、透明质酸钠0.01‑1.0重量份、甜菜碱0.1‑10.0重量份、泛醇0.1‑1.0重量份中一种或几种。本发明利用各成分不同的药用机理，充分发挥各成分间的协同增效作用，使得所得的组合物能够增强细胞自我修护功能，促进皮肤细胞的分裂和生长，抵御紫外线伤害，修护皮肤屏障功能。
Description
技术领域
本发明涉及日化产品技术领域，尤其涉及一种具有防晒修复功效的护肤组合物及其应用和制备方法。
背景技术
皮肤的主要功能是保护机体免受外界有害环境因素的伤害。因此成为最容易受到伤害的器官。皮肤的老化，主要表现为皮肤光泽、润性、弹性、滑性的减退，水分的减少。
究其原因一方面是因防紫外线造成的损伤。由于紫外光线的波长很短，能量颇高，破坏力很强，长时间的照射不但会引起皮肤损伤和皮肤疾病，还会加速皮肤的老化。为了防止皮肤损伤和皮肤疾病，防晒产品的应用越来越广泛。早期的用作化妆品紫外防护剂的主要是有机物，多为二苯甲酮类、邻氨基苯甲酮类、水杨酸酯类、对氨基苯甲酸类、肉桂酸酯类等有机化合物,虽然可以在一定程度上屏蔽紫外线的伤害，但是由于不稳定、寿命短,并且副作用较大，添加过量甚至可能导致皮肤疾病。
另一方面是角质层的破损。角质层是皮肤表皮的四层组织(基底层、棘层、颗粒层、角质层)的最外层，由约30μm宽，0.8μm厚的扁平六角形的角质细胞组成，一般为10-20层细胞，厚度为10-15μm。表皮的最上层还有双层脂质形成皮脂膜，它是由汗液和皮脂混合而形成的一层保护膜。从生理意义上来讲，角质层为防止皮肤细胞内部水分丢失、外界微生物和化学物质的侵蚀提供极为有效的屏障作用。根据调查，60％以上的亚洲女性和50％的欧洲女性都自我感觉是“敏感性皮肤”。这类人群的皮肤特征是：容易过敏，脸上的红血丝明显皮肤容易泛红，容易受坏境因素、季节变化及面部保养品刺激等等。
因此，防晒和恢复自我修复功能是防止皮肤老化的重要措施。
发明内容
为了解决上述问题，本发明提供一种护肤品，不仅能够增强细胞自我修护功能，促进皮肤细胞的分裂和生长，抵御紫外线伤害，修护皮肤屏障功能，还能够刺激细胞外一些大分子(如透明质酸和胶原白等)的合成与分泌，并且能够深层润养皮肤，使得皮肤重回健康与活力。
本发明是采用如下技术方案实现的。一种用于护肤的组合物，包括如下重量份的组分：
其中，所述皮肤调理剂选自植物舒敏剂、依可多因、水解酵母蛋白、绿藻提取物、金缕梅提取液、银耳多糖、燕麦葡聚糖、尿囊素、复合神经酰胺、向日葵不皂化物中的一种或几种；更优选包括上述全部组分；
优选地，所述皮肤调理剂的组分含量植物舒敏剂0.1-3重量份、依可多因0.01-1.0重量份、水解酵母蛋白0.1-1.0重量份、绿藻提取物0.01-0.5重量份、金缕梅提取液0.01-0.1重量份、银耳多糖0.01-0.1重量份、燕麦葡聚糖0.1-1.0重量份、尿囊素0.1-1.0重量份、复合神经酰胺0.01-1.0重量份、向日葵不皂化物0.01-1.0重量份中的一种或几种。
所述保湿剂选自甘油、甲基丙二醇、透明质酸钠、甜菜碱、泛醇中的一种或几种；更优选包括上述全部组分；
优选地，所述保湿剂的组分含量甘油1.0-10.0重量份、甲基丙二醇1.0-10.0重量份、透明质酸钠0.01-1.0重量份、甜菜碱0.1-10.0重量份、泛醇0.1-1.0重量份中的一种或几种。
润肤剂选自乳木果油、霍霍巴油、亚麻籽油、辛基硅油、植物角鲨烷、植物甾醇酯中的一种或几种；更优选包括上述全部组分。
优选地，润肤剂的组分含量乳木果油0.1-10.0重量份、霍霍巴油0.1-1.0重量份、亚麻籽油0.1-1.0重量份、辛基硅油1.0-10.0重量份、植物角鲨烷0.1-10.0重量份、植物甾醇酯中0.1-1.0重量份的一种或几种。
优选地，抗氧剂VE；所述VE为0.1-1.0重量份。
其中，尿囊素，别名5-尿基乙内酰胺。广泛存在于烟草种子、甜菜、小麦芽、尿膜液等动植物界。在医药方面，尿囊素是皮肤创伤的良好愈合剂和抗溃疡药剂。在化妆品方面，尿囊素能够促进组织生长，细胞新陈代谢，软化角质层蛋白。在农业上：尿囊素是优良的植物生长调节剂。
乳木果油的提取源自乳油木，乳油木大多生长在非洲塞内加尔与尼日利亚之间的热带雨林区，是一种硬木，成年树高达15至20米，树龄往往可达数百年。
乳木果广泛分布于非洲几内亚等地，其果实可供食用，果仁则用来生产乳木果油。乳木果油适用于抗衰老产品，晚霜、敏感性肌肤和干性肌肤的护理产品、冬季用产品、护手霜、护足霜、体用乳液婴儿产品、剃须用舒滑液等产品；适用于防晒产品及晒后修护产品；医疗方面，适用于关节软组织润滑、关节软骨组织修复、滑膜修复，有效缓解及治愈关节软组织病变引起的各种不适病症；防晒方面，适用于防晒产品及晒后修护产品；彩妆产品方面，适用于唇膏和粉底蜜；发用产品：适用于干性头发的营养香波和护发素，染发后护理产品。
新戊二醇二庚酸酯可以免除长时间使用硅油后皮肤变硬的毛病，低粘度十字架结构的支链油酯，透气性极佳，非常干爽，铺展性好，具有优异的渗透性质，可促进活性成份的吸收，使用后能给皮肤留下优美的丝般感受。
霍霍巴油，荷荷巴(又名霍霍巴)是一种墨西哥原生的植物，用以治疗癌、高血压、冠心病、肾病、皮疹、粉刺、牛皮癣、神经性皮炎、创伤，还可作为青霉素生产的消沫剂及超级抗菌剂。由于荷荷芭油的经济价值极高，被称为“液体黄金”，它又是一种可再生资源。荷荷芭叶，渣里面能提取很多昂贵的特殊物质用于化妆品。
亚麻籽油由亚麻(LINUM USITATISSIMUM)籽制取而成，亚麻籽是亚麻的籽实，属亚麻科，别称胡麻，改善皮肤脂肪含量，使肌肤更幼滑、滋润、柔软有弹性，同时令皮肤呼吸及排汗正常，减轻种种皮肤问题。
角鲨烷是从深海鲨鱼肝脏中提取的角鲨烯经氢化制得一种烃类油脂，故又名深海鲨鱼肝油。科学研究发现，角鲨烷是少有的化学稳定性高，使用感极佳的动物油脂，对皮肤有较好的亲和性，具有较低的极性和中等的铺展性。
植物甾醇酯一般由植物甾醇与脂肪酸通过酯化反应或转酯化反应制得。由于可以用于制造植物甾醇酯的甾醇和脂肪酸种类都较多，因此可以得到多种不同理化性质的植物甾醇酯，三种主要植物甾醇酯为β－谷甾醇酯，豆甾醇酯，菜油甾醇酯。甾醇酯能够在人体内转化成甾醇和脂肪酸，所以其生理功能包括植物甾醇和脂肪酸两部分所具有的生理功能，具有与游离植物甾醇同等的减低血浆总胆固醇和低密度脂蛋白胆固醇的效果，在某些方面甚至效果更好。
金缕梅提取物为金缕梅花的醇提物或水提物，内含单宁质多种如Ellagtannin和Hamamlitannin可以调节皮脂分泌、具保湿及嫩白作用。促进淋巴血液循环，可克服早晨眼脬和黑眼圈。具有镇静、安抚的效果，对龟裂、晒伤、粉刺有改善效果。可有效帮助肌肤夜间的再生能力。去除眼袋、放松以及缓和对於油性肌肤或是过敏的肌肤都有很优异的效果。有舒缓、收敛、抗菌、抗衰老的效果，因有收敛控油、杀菌的显著疗效。
水解酵母蛋白，酵母细胞的水解产物。通过自溶或通过外加酶水解得到。其中含有大量的氨基酸、小肽、丰富的B族维生素、谷胱甘肽及核苷酸类物质。加入化妆品中有抗氧化，降低油脂功效，也能给肌肤补充营养。
绿藻提取物为绿藻的醇提物或水提物。绿藻(CHLOROPHYTA SPP.)，为弱碱性，含有丰富均衡的各种营养成份，富含蛋白质、脂质、多糖、膳食纤维、维生素A、B、C、D、E、微量元素、矿物质、叶酸、叶绿素及珍贵的生物活性素。此外，绿藻中还含有一种最重要的成份：绿藻促进生长因子(CGF)，它具有诱发干扰素，激发人体防御、免疫组织中的巨噬细胞、T细胞和B细胞的作用，又能促进对以二恶英为代表污染环境的有害物质的解毒、排泄作用。
积雪草提取物为积雪草的醇提物或水提物。积雪草(Centella asiatica(L.)Urban)，为伞形科多年生草本，茎匍匐，细长，节上生根。分布于中国多省区。药理学表明，积雪草具有紧致表皮与真皮连接部分，能使皮肤变柔软，有助于解决皮肤松弛现象，使皮肤光滑有弹性；帮助促进真皮层中胶原蛋白形成，使纤维蛋白再生，重新连接起来，从根本上消除妈妈纹，使肌肤达到紧致光滑的效果。还可帮助受损的组织愈合及紧实肌肤。
虎杖根提取物为虎杖根的醇提物或水提物。虎杖，中药名。为蓼科植物虎杖(Polygonum cuspidatum Sieb.et Zucc.)的干燥根茎和根。春、秋二季采挖，除去须根，洗净，趁鲜切短段或厚片，晒干。分布于西北、华东、华中、华南及西南等地。虎杖在中国和日本传统医药中被用于治疗多种病痛，具有利湿退黄，清热解毒，散瘀止痛，止咳化痰的功效。用于湿热黄疸，淋浊，带下，风湿痹痛，痈肿疮毒，水火烫伤，经闭，症瘕，趺打损伤，肺热咳嗽。
黄芩根提取物为黄芩根的醇提物或水提物。黄芩(Scutellaria baicalensisGeorgi)，别名山茶根、土金茶根，是唇形科黄芩属多年生草本植物；药理学表明，黄芩具有黄芩的根入药，味苦、性寒，有清热燥湿、泻火解毒、止血、安胎等功效。主治温热病、上呼吸道感染、肺热咳嗽、湿热黄胆、肺炎、痢疾、咳血、目赤、胎动不安、高血压、痈肿疖疮等症。黄芩的临床抗菌性比黄连好，而且不产生抗药性。
茶提取物为茶的醇提物或水提物。茶提取物的成分主要包括茶多酚(儿茶素)、咖啡碱、芳香油、水分、矿物质、色素、碳水化合物、蛋白质、氨基酸、维生素等。茶多酚具有抗氧化、清除自由基等作用，明显降低高脂血症的血清总胆固醇、甘油三脂、低密度脂蛋白胆固醇含量，同时具有恢复和保护血管内皮功能的作用。
光果甘草根提取物为光果甘草根的醇提物或水提物。光果甘草(Glycyrrhizaglabra L.)又名洋甘草(北疆)多年生草本，根与根状茎粗壮，直径0.5-3cm，根皮褐色，里面黄色，具甜味。光果甘草提取物能深入皮肤内部并保持高活性，有效抑制黑色素生成过程中多种酶(如抑制酪氨酸酶)的活性，是一种快速、高效、安全、绿色的防晒、美白祛斑化妆品添加剂。同时光果甘草提取物还具有防止皮肤粗糙及抗炎、抗菌的功效。
母菊花提取物为母菊花的醇提物或水提物。母菊(Matricaria recutita L.)，是桔梗目、菊科、母菊属一年生草本植物。主要分布于新疆北部和西部，含丰富的甘菊蓝,具有防止皮肤发炎的功效,亦具有清洁、安定肌肤的效果。在化妆品中作皮肤调理剂使用。
迷迭香提取物为迷迭香醇提物或水提物。迷迭香(Rosmarinus officinalis)，是双子叶植物纲、唇形科、迷迭香属植物灌木。药理学表明，迷迭香具有抑菌、抗炎、抗病毒、抗肿瘤、抗过敏、抗氧化、抗血栓抗血小板聚集、防辐射和免疫抑制作用，迷迭香酸对神经系统有抗焦虑作用，对细胞损伤有保护作用，加之产品的延缓食品变质；安全、无毒；抑菌；耐高温；色素护色等特点，在各种烘焙食品、卤制食品、水产制品、调味品、高级糖果、药品、保健品各类化妆洗涤用品和生物农药等产品中都有应用。
作为本发明的优选技术方案，提供一种组合物，由以下组分组成：
植物舒敏剂0.1-3重量份、依可多因0.01-1.0重量份、水解酵母蛋白0.1-1.0重量份、绿藻提取物0.01-0.5重量份、金缕梅提取液0.01-0.1重量份、银耳多糖0.01-0.1重量份、燕麦葡聚糖0.1-1.0重量份、尿囊素0.1-1.0重量份、复合神经酰胺0.01-1.0重量份、向日葵不皂化物0.01-1.0重量份、甘油1.0-10.0重量份、甲基丙二醇1.0-10.0重量份、透明质酸钠0.01-1.0重量份、甜菜碱0.1-10.0重量份、泛醇0.1-1.0重量份、乳木果油0.1-10.0重量份、霍霍巴油0.1-1.0重量份、亚麻籽油0.1-1.0重量份、辛基硅油1.0-10.0重量份、植物角鲨烷0.1-10.0重量份、植物甾醇酯中0.1-1.0重量份、VE为0.1-1.0重量份。
本发明所提供的上述任一项技术方案所述的组合物皆具有显著地有保湿及抵抗自由基的功效。
本发明意外地发现，在组合物中添加上述原料中的全部可显著提高组合物的功效。
本发明还提供上述任一一项技术方案所述的组合物在制备增强细胞自我修护功能，促进皮肤细胞的分裂和生长，抵御紫外线伤害，修护皮肤屏障功能的护肤品中的应用。其中，所述护肤品包括面膜、面霜、精华素、爽肤水、乳液、凝胶、凝露等。
所述的护肤品以上述任意一项技术方案所得组合物作为活性组分。
具体地，本发明提供一种面霜，包括如下重量份的组分：
活性组分：
辅料：
优选地，所述乳化剂选自M68、燕麦乳化剂、氢化卵磷脂中的一种或几种；
所述助乳化剂选自鲸蜡硬脂醇；
所述增稠剂选自小核菌胶或卡波U20；
所述螯合剂选自EDTA二钠；
所述PH调节剂选自氢氧化钠；
所述无添加防腐剂选自对羟基苯乙酮；
所述溶剂选自去离子水。
本发明所提供的面霜，能够显著增强细胞自我修护功能，促进皮肤细胞的分裂和生长，抵御紫外线伤害，修护皮肤屏障功能。
本发明还提供一种上述面霜的制备方法，包括：将上述活性组分(组合物)混合，制得面霜。
所述面霜的制备方法包括如下步骤：
A、将原料增稠剂撒入盛放原料溶剂和螯合剂的配置锅中，待完全润湿下30Hz搅拌并加热；将预分散的甲基丙二醇、小核菌胶、透明质酸钠加入配置锅继续搅拌至均匀，加热至80℃；
B、将原料甘油、甜菜碱、尿囊素、对羟基苯乙酮依次加入配置锅中30Hz搅拌至均匀等待均质；
C、将原料M68、燕麦乳化剂、氢化卵磷脂、鲸蜡硬脂醇、乳木果油、霍霍巴油、亚麻籽油、植物角鲨烷、棕榈酸乙基己酯、植物甾醇酯、复合神经酰胺加到油相锅加热至80℃，临均质前将原料VE、辛基硅油加到油相锅搅拌均匀等待均质；
D、待两相均一后将主锅开启真空-0.04mpa，然后将油相抽入主锅均质，边抽边均质，均质3mins，然后30Hz搅拌开始降温；
E、降温至65℃将原料氢氧化钠稀释成10％溶液加入配置锅，30Hz搅拌继续降温；
F、降温至45℃将原料无添加防腐剂、泛醇、依可多因依次加到配置锅中30Hz搅拌至均匀，然后将原料燕麦葡聚糖、银耳多糖、金缕梅提取液、植物舒敏剂加到配置锅中30Hz搅拌至均匀；
G、降温至40℃后将原料无添加防腐剂、绿藻提取物、向日葵不皂化物加入到配置锅30Hz搅拌至均匀；取料检测，合格后直接出料。
本发明所述技术方案具有如下有益效果：
本发明利用各成分不同的药用机理，充分发挥各成分间的协同增效作用，使得所得的组合物能够增强细胞自我修护功能，促进皮肤细胞的分裂和生长，抵御紫外线伤害，修护皮肤屏障功能。刺激细胞外一些大分子(如透明质酸和胶原白等)的合成与分泌、深层润养皮肤，使得皮肤重回健康与活力，本发明组合物也可以作为特异性皮炎和湿疹患者的辅疗产品。
具体实施方式
下面给出的实施例拟对本发明内容作进一步详细说明。
实施例1-3及对比例1-3分别提供一种组合物，按重量份计，其配方如下
表1.
实施例1-3组合物的制备方法均为如下步骤：
A、将原料增稠剂撒入盛放原料溶剂和螯合剂的配置锅中，待完全润湿下30Hz搅拌并加热；将预分散的甲基丙二醇、小核菌胶、透明质酸钠加入配置锅继续搅拌至均匀，加热至80℃；
B、将原料甘油、甜菜碱、尿囊素、对羟基苯乙酮依次加入配置锅中30Hz搅拌至均匀等待均质；
C、将原料M68、燕麦乳化剂、氢化卵磷脂、鲸蜡硬脂醇、乳木果油、霍霍巴油、亚麻籽油、植物角鲨烷、棕榈酸乙基己酯、植物甾醇酯、复合神经酰胺加到油相锅加热至80℃，临均质前将原料VE、辛基硅油加到油相锅搅拌均匀等待均质；
D、待两相均一后将主锅开启真空-0.04mpa，然后将油相抽入主锅均质，边抽边均质，均质3mins，然后30Hz搅拌开始降温；
E、降温至65℃将原料氢氧化钠稀释成10％溶液加入配置锅，30Hz搅拌继续降温；
F、降温至45℃将原料无添加防腐剂、泛醇、依可多因依次加到配置锅中30Hz搅拌至均匀，然后将原料燕麦葡聚糖、银耳多糖、金缕梅提取液、植物舒敏剂加到配置锅中30Hz搅拌至均匀；
G、降温至40℃后将原料无添加防腐剂、水解酵母蛋白、绿藻提取物、向日葵不皂化物加入到配置锅30Hz搅拌至均匀；取料检测，合格后直接出料。
对比例1组合物的制备方法，包括以下步骤：
A、将原料增稠剂撒入盛放原料溶剂和螯合剂的配置锅中，待完全润湿下30Hz搅拌并加热；将预分散的甲基丙二醇、小核菌胶、透明质酸钠加入配置锅继续搅拌至均匀，加热至80℃；
B、将原料甘油、甜菜碱、对羟基苯乙酮依次加入配置锅中30Hz搅拌至均匀等待均质；
C、将原料M68、燕麦乳化剂、氢化卵磷脂、鲸蜡硬脂醇、乳木果油、霍霍巴油、亚麻籽油、植物角鲨烷、棕榈酸乙基己酯、植物甾醇酯加到油相锅加热至80℃，临均质前将原料VE、辛基硅油加到油相锅搅拌均匀等待均质；
D、待两相均一后将主锅开启真空-0.04mpa，然后将油相抽入主锅均质，边抽边均质，均质3mins，然后30Hz搅拌开始降温；
E、降温至65℃将原料氢氧化钠稀释成10％溶液加入配置锅，30Hz搅拌继续降温；
F、降温至45℃将原料无添加防腐剂、泛醇依次加到配置锅中30Hz搅拌至均匀；
G、降温至40℃后将原料无添加防腐剂加入到配置锅30Hz搅拌至均匀；取料检测，合格后直接出料。
对比例2组合物的制备方法，包括以下步骤：
A、将原料增稠剂撒入盛放原料溶剂和螯合剂的配置锅中，待完全润湿下30Hz搅拌并加热；将预分散的小核菌胶加入配置锅继续搅拌至均匀，加热至80℃；
B、将原料尿囊素、对羟基苯乙酮依次加入配置锅中30Hz搅拌至均匀等待均质；
C、将原料M68、燕麦乳化剂、氢化卵磷脂、鲸蜡硬脂醇、乳木果油、霍霍巴油、亚麻籽油、植物角鲨烷、棕榈酸乙基己酯、植物甾醇酯、复合神经酰胺加到油相锅加热至80℃，临均质前将原料VE、辛基硅油加到油相锅搅拌均匀等待均质；
D、待两相均一后将主锅开启真空-0.04mpa，然后将油相抽入主锅均质，边抽边均质，均质3mins，然后30Hz搅拌开始降温；
E、降温至65℃将原料氢氧化钠稀释成10％溶液加入配置锅，30Hz搅拌继续降温；
F、降温至45℃将原料无添加防腐剂、依可多因依次加到配置锅中30Hz搅拌至均匀，然后将原料燕麦葡聚糖、银耳多糖、金缕梅提取液、植物舒敏剂加到配置锅中30Hz搅拌至均匀；
G、降温至40℃后将原料无添加防腐剂、水解酵母蛋白、绿藻提取物、向日葵不皂化物加入到配置锅30Hz搅拌至均匀；取料检测，合格后直接出料。
对比例3组合物的制备方法，包括以下步骤：
A、将原料增稠剂撒入盛放原料溶剂和螯合剂的配置锅中，待完全润湿下30Hz搅拌并加热；将预分散的甲基丙二醇、小核菌胶、透明质酸钠加入配置锅继续搅拌至均匀，加热至80℃；
B、将原料甘油、甜菜碱、尿囊素、对羟基苯乙酮依次加入配置锅中30Hz搅拌至均匀等待均质；
C、将原料M68、燕麦乳化剂、氢化卵磷脂、鲸蜡硬脂醇、棕榈酸乙基己酯、复合神经酰胺加到油相锅加热至80℃，搅拌均匀等待均质；
D、待两相均一后将主锅开启真空-0.04mpa，然后将油相抽入主锅均质，边抽边均质，均质3mins，然后30Hz搅拌开始降温；
E、降温至65℃将原料氢氧化钠稀释成10％溶液加入配置锅，30Hz搅拌继续降温；
F、降温至45℃将原料无添加防腐剂、泛醇、依可多因依次加到配置锅中30Hz搅拌至均匀，然后将原料燕麦葡聚糖、银耳多糖、金缕梅提取液、植物舒敏剂加到配置锅中30Hz搅拌至均匀；
G、降温至40℃后将原料无添加防腐剂、水解酵母蛋白、绿藻提取物、向日葵不皂化物加入到配置锅30Hz搅拌至均匀；取料检测，合格后直接出料。
防晒效果测试:根据QB/T 2410-1998规定的防晒化妆品防晒效果的评价方法进行操作。取实施例1-3和对比例1-3中的面霜样品各1克。均匀涂敷在3M医用透气胶带上，然后放置30min后贴在比色皿透光面一侧进行数据测定。在紫外分光光度计上测其在280～320nm波长范围的吸光度A值，通过吸光度A值的大小，判断乳液在紫外线下的防晒效果。
表2.实施例1-3及对比例1-3UVB紫外吸光度A值测定结果波长/nm
| 实验组 | 280 | 290 | 300 | 310 | 320 | 平均值 |
| 实施例1 | 1.955 | 1.913 | 1.923 | 1.905 | 1.916 | 1.922 |
| 实施例2 | 1.931 | 1.912 | 1.908 | 1.923 | 1.941 | 1.923 |
| 实施例3 | 1.921 | 1.931 | 1.922 | 1.891 | 1.911 | 1.915 |
| 对比例1 | 1.391 | 1.423 | 1.662 | 1.463 | 1.441 | 1.476 |
| 对比例2 | 1.454 | 1.660 | 1.412 | 1.521 | 1.390 | 1.487 |
| 对比例3 | 1.229 | 1.331 | 1.290 | 1.390 | 1.310 | 1.310 |
通过表2可见实施1-3具有高效防护紫外光效果，紫外吸光度A值明显高于对比例1-3。
保湿测试：采用水分测试仪Corneometer(CM825，C+K公司，德国)测试水分含量。其度量所用单位A.C.U.测定范围从0到120A.C.U.。采用皮肤水分流失(TEWL)测试仪Tewameter(TM300，C+K公司，德国)测试水分流失率，皮肤保护层越完好，水分的含量就会越高，皮肤水分流失TEWL的数值就越低。
共选取180名志愿者，在湿度相同的环境中，分为六组，分别采用实施例1-3，对比例1-3。每天以1.75μl/cm2涂敷密度均匀涂敷两次，使用前测试初始值，45天后测试结果，见表3.
表3.
如表3所示，可见采用本发明实施例1-3的保湿效果明显高于是对比例1-3。
皮肤修复及改善测试：
共选取180名试用者，分为6组，每组30人，分别采用实施例1-3和对比例1-3中的乳液产品，结果如表4所示
表4.皮肤总体各项指标效果测试
总结：从表4的检测值可以看出，实施例1-3的各项指标效果明显好于对比例1-3的各项指标，而实施例1-3的结果来看，实施例2较好于实施例1和实施例2。
以上对本发明的具体实施例进行了详细描述，但其只是作为范例，本发明并不限制于以上描述的具体实施例。对于本领域技术人员而言，任何对本发明进行的等同修改和替代也都在本发明的范畴之中。因此，在不脱离本发明的精神和范围下所作的均等变换和修改，都应涵盖在本发明的范围内。
Claims (10)
1.一种组合物，其特征在于，按重量份计，包括：
2.根据权利要求1所述的组合物，其特征在于，
所述皮肤调理剂选自植物舒敏剂、依可多因、水解酵母蛋白、绿藻提取物、金缕梅提取液、银耳多糖、燕麦葡聚糖、尿囊素、复合神经酰胺、向日葵不皂化物中的一种或几种；
所述保湿剂选自甘油、甲基丙二醇、透明质酸钠、甜菜碱、泛醇中的一种或几种；
所述润肤剂选自乳木果油、霍霍巴油、亚麻籽油、辛基硅油、植物角鲨烷、植物甾醇酯中的一种或几种；
所述抗氧剂选自VE。
3.根据权利要求2所述的组合物，其特征在于，
所述皮肤调理剂包括植物舒敏剂、依可多因、水解酵母蛋白、绿藻提取物、金缕梅提取液、银耳多糖、燕麦葡聚糖、尿囊素、复合神经酰胺、向日葵不皂化物中的一种或几种；
所述保湿剂包括甘油、甲基丙二醇、透明质酸钠、甜菜碱、泛醇中的一种或几种；
所述润肤剂包括乳木果油、霍霍巴油、亚麻籽油、辛基硅油、植物角鲨烷、植物甾醇酯中的一种或几种；
所述抗氧剂包括VE。
4.根据权利要求3所述的组合物，其特征在于，
所述皮肤调理剂组分含量为植物舒敏剂0.1-3重量份、依可多因0.01-1.0重量份、水解酵母蛋白0.1-1.0重量份、绿藻提取物0.01-0.5重量份、金缕梅提取液0.01-0.1重量份、银耳多糖0.01-0.1重量份、燕麦葡聚糖0.1-1.0重量份、尿囊素0.1-1.0重量份、复合神经酰胺0.01-1.0重量份、向日葵不皂化物0.01-1.0重量份；
所述保湿剂组分含量为甘油1.0-10.0重量份、甲基丙二醇1.0-10.0重量份、透明质酸钠0.01-1.0重量份、甜菜碱0.1-10.0重量份、泛醇0.1-1.0重量；
所述润肤剂组分含量为乳木果油0.1-10.0重量份、霍霍巴油0.1-1.0重量份、亚麻籽油0.1-1.0重量份、辛基硅油1.0-10.0重量份、植物角鲨烷0.1-10.0重量份、植物甾醇酯中0.1-1.0重量份；
所述VE为0.1-1.0重量份。
5.权利要求1-4任一项所述的组合物在制备自我修复、抵御紫外线伤害的护肤品种的应用。
6.根据权利要求5所述的护肤品，其特征在于，所述护肤品包括面膜、面霜、精华素、爽肤水、乳液、凝胶、凝露。
7.一种面霜，其特征在于，包括如权利要求1-4任一项所述的组合物作为活性组分。
8.根据权利要求7所述的面霜，其特征在于，所述面霜还包括：
9.根据权利要求8所述的面霜，其特征在于，
乳化剂选自M68、燕麦乳化剂、氢化卵磷脂中的一种或几种；
助乳化剂选自鲸蜡硬脂醇；
增稠剂选自小核菌胶或卡波U20；
螯合剂选自EDTA二钠；
PH调节剂选自氢氧化钠；
无添加防腐剂选自对羟基苯乙酮；
溶剂选自去离子水。
10.一种制备权利要求7-9任一项所述的面霜的方法，其特征在于，包括如下步骤：
A、将原料增稠剂撒入盛放原料溶剂和螯合剂的配置锅中，待完全润湿下30Hz搅拌并加热；将预分散的甲基丙二醇、小核菌胶、透明质酸钠加入配置锅继续搅拌至均匀，加热至80℃；
B、将原料甘油、甜菜碱、尿囊素、对羟基苯乙酮依次加入配置锅中30Hz搅拌至均匀等待均质；
C、将原料M68、燕麦乳化剂、氢化卵磷脂、鲸蜡硬脂醇、乳木果油、霍霍巴油、亚麻籽油、植物角鲨烷、棕榈酸乙基己酯、植物甾醇酯、复合神经酰胺加到油相锅加热至80℃，临均质前将原料VE、辛基硅油加到油相锅搅拌均匀等待均质；
D、待两相均一后将主锅开启真空-0.04mpa，然后将油相抽入主锅均质，边抽边均质，均质3mins，然后30Hz搅拌开始降温；
E、降温至65℃将原料氢氧化钠稀释成10％溶液加入配置锅，30Hz搅拌继续降温；
F、降温至45℃将原料无添加防腐剂、泛醇、依可多因依次加到配置锅中30Hz搅拌至均匀，然后将原料燕麦葡聚糖、银耳多糖、金缕梅提取液、植物舒敏剂加到配置锅中30Hz搅拌至均匀；
G、降温至40℃后将原料无添加防腐剂、绿藻提取物、向日葵不皂化物加入到配置锅30Hz搅拌至均匀；取料检测，合格后直接出料。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910115194.2A CN109662928A (zh) | 2019-02-14 | 2019-02-14 | 一种具有防晒修复功效的护肤组合物及其应用和制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910115194.2A CN109662928A (zh) | 2019-02-14 | 2019-02-14 | 一种具有防晒修复功效的护肤组合物及其应用和制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109662928A true CN109662928A (zh) | 2019-04-23 |
Family
ID=66151218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910115194.2A Pending CN109662928A (zh) | 2019-02-14 | 2019-02-14 | 一种具有防晒修复功效的护肤组合物及其应用和制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109662928A (zh) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109966186A (zh) * | 2019-05-15 | 2019-07-05 | 伊犁弥玥泉生物科技有限公司 | 一种含矿物温泉的舒缓保湿修护组合物 |
| CN109966182A (zh) * | 2019-04-30 | 2019-07-05 | 莱博药妆技术（上海）股份有限公司 | 一种含有亚麻籽油的化妆品及其制备方法 |
| CN110051601A (zh) * | 2019-05-09 | 2019-07-26 | 伊犁弥玥泉生物科技有限公司 | 一种含矿物泉水的活颜修护组合物 |
| CN110448494A (zh) * | 2019-09-08 | 2019-11-15 | 葆姿(成都)健康管理有限公司 | 一种具有抗衰修复功效的护肤组合物及其应用和制备方法 |
| CN111214386A (zh) * | 2020-03-12 | 2020-06-02 | 广州品域美妆创新科技有限公司 | 一种含有依克多因的舒缓修护组合物及其应用 |
| CN112842985A (zh) * | 2021-02-08 | 2021-05-28 | 广州花出见生物科技有限公司 | 一种保湿修护组合物 |
| CN113599310A (zh) * | 2021-09-18 | 2021-11-05 | 上海新高姿化妆品有限公司 | 一种保湿组合物及其在化妆品中的应用 |
| CN113786358A (zh) * | 2021-09-02 | 2021-12-14 | 科盈生物科技(惠州)有限公司 | 一种绿藻舒缓头皮护理素 |
| CN116035944A (zh) * | 2022-12-29 | 2023-05-02 | 植然天成(北京)生物科技有限公司 | 一种仿生胎脂组合物、化妆品及其制备方法 |
| CN116751318A (zh) * | 2023-07-04 | 2023-09-15 | 广西中医药大学 | 一种向日葵花托提取多糖及其制备方法和应用 |
| WO2025181266A1 (fr) * | 2024-02-29 | 2025-09-04 | Laboratoires Expanscience | Huile de lin concentree en insaponifiables et ses applications |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106420471A (zh) * | 2016-10-31 | 2017-02-22 | 广东科玮生物技术股份有限公司 | 一种兼具防晒及晒后修复功能的护肤品及其制备方法 |
| CN106511151A (zh) * | 2016-10-31 | 2017-03-22 | 广东科玮生物技术股份有限公司 | 一种叶绿素防晒及晒后修复护肤品 |
-
2019
- 2019-02-14 CN CN201910115194.2A patent/CN109662928A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106420471A (zh) * | 2016-10-31 | 2017-02-22 | 广东科玮生物技术股份有限公司 | 一种兼具防晒及晒后修复功能的护肤品及其制备方法 |
| CN106511151A (zh) * | 2016-10-31 | 2017-03-22 | 广东科玮生物技术股份有限公司 | 一种叶绿素防晒及晒后修复护肤品 |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109966182A (zh) * | 2019-04-30 | 2019-07-05 | 莱博药妆技术（上海）股份有限公司 | 一种含有亚麻籽油的化妆品及其制备方法 |
| CN110051601A (zh) * | 2019-05-09 | 2019-07-26 | 伊犁弥玥泉生物科技有限公司 | 一种含矿物泉水的活颜修护组合物 |
| CN109966186B (zh) * | 2019-05-15 | 2022-04-26 | 伊犁弥玥泉生物科技有限公司 | 一种含矿物温泉的舒缓保湿修护组合物 |
| CN109966186A (zh) * | 2019-05-15 | 2019-07-05 | 伊犁弥玥泉生物科技有限公司 | 一种含矿物温泉的舒缓保湿修护组合物 |
| CN110448494A (zh) * | 2019-09-08 | 2019-11-15 | 葆姿(成都)健康管理有限公司 | 一种具有抗衰修复功效的护肤组合物及其应用和制备方法 |
| CN111214386A (zh) * | 2020-03-12 | 2020-06-02 | 广州品域美妆创新科技有限公司 | 一种含有依克多因的舒缓修护组合物及其应用 |
| CN112842985A (zh) * | 2021-02-08 | 2021-05-28 | 广州花出见生物科技有限公司 | 一种保湿修护组合物 |
| CN113786358A (zh) * | 2021-09-02 | 2021-12-14 | 科盈生物科技(惠州)有限公司 | 一种绿藻舒缓头皮护理素 |
| CN113599310A (zh) * | 2021-09-18 | 2021-11-05 | 上海新高姿化妆品有限公司 | 一种保湿组合物及其在化妆品中的应用 |
| CN113599310B (zh) * | 2021-09-18 | 2023-02-10 | 上海新高姿化妆品有限公司 | 一种保湿组合物及其在化妆品中的应用 |
| CN116035944A (zh) * | 2022-12-29 | 2023-05-02 | 植然天成(北京)生物科技有限公司 | 一种仿生胎脂组合物、化妆品及其制备方法 |
| CN116035944B (zh) * | 2022-12-29 | 2023-09-22 | 植然天成(北京)生物科技有限公司 | 一种仿生胎脂组合物、化妆品及其制备方法 |
| CN116751318A (zh) * | 2023-07-04 | 2023-09-15 | 广西中医药大学 | 一种向日葵花托提取多糖及其制备方法和应用 |
| WO2025181266A1 (fr) * | 2024-02-29 | 2025-09-04 | Laboratoires Expanscience | Huile de lin concentree en insaponifiables et ses applications |
| FR3159742A1 (fr) * | 2024-02-29 | 2025-09-05 | Laboratoires Expanscience | Huile de lin concentree en insaponifiables et ses applications |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109662928A (zh) | 一种具有防晒修复功效的护肤组合物及其应用和制备方法 | |
| KR101373636B1 (ko) | 천연물 복합 발효 추출물을 유효성분으로 하는 피부 및 두피 상태 개선용 조성물 | |
| CN109700753A (zh) | 一种具有保湿抗氧化功效的护肤组合物及其应用和制备方法 | |
| CN107737041A (zh) | 一种新型皮肤抗敏修护组合物、皮肤修复霜及其制备方法 | |
| CN102293733A (zh) | 全方位美白祛斑护肤产品 | |
| CN108670943A (zh) | 一种保湿、美白、淡斑植物提取物组合物 | |
| CN109662904A (zh) | 一种具有美白抗氧化功效的护肤组合物及其应用和制备方法 | |
| CN109453087B (zh) | 美白透肌水及其制备方法和美白化妆品添加剂 | |
| WO2009125182A1 (en) | A product for topical administration | |
| CN104784507A (zh) | 一种具有多重美容功效的中药组合物及其制备方法和应用 | |
| CN110403880A (zh) | 一种中药发酵物及其制备的护手霜 | |
| KR102776324B1 (ko) | 피부 트러블 완화 효과가 우수한 피부 재생용 화장료, 이의 제조방법 및 이를 포함하는 화장품 | |
| CN108888563A (zh) | 一种水润平衡保湿面膜及其制备方法 | |
| CN113368018A (zh) | 抗炎祛痘组合物及其制备方法 | |
| KR20220168132A (ko) | 소나무 수피 추출물을 포함하는 부종완화, 셀룰라이트 감소 및 미백 효능을 갖는 피부용 조성물 및 이를 이용한 피부용 크림 | |
| CN109303724A (zh) | 一种新型含艾叶的舒缓修护原液组合物 | |
| CN108670933B (zh) | 兼具保湿、美白、抗衰老的护肤组合物及其应用 | |
| CN112137904A (zh) | 一种幻彩水光肌底精华液及其制备方法 | |
| KR20110128384A (ko) | 미담 경옥고를 이용한 피부 주름, 보습, 미백을 위한 조성물질 및 제조법 | |
| CN115414303A (zh) | 一种身体舒悦滋养植物按摩霜 | |
| CN109700747A (zh) | 一种具有皮肤修复功能的护肤组合物及其制备方法 | |
| CN104398426A (zh) | 一种用于治疗寻常性痤疮的面膜 | |
| CN118105321B (zh) | 一种舒缓、保湿、修护组合物及其应用 | |
| KR102686879B1 (ko) | 레티놀과 콜라겐 유효성분을 포함하는 주름 및 모공 개선 조성물 및 이의 제조법 | |
| KR102051417B1 (ko) | 튼살 예방 및 개선용 화장료 조성물 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190423 |
|
| WD01 | Invention patent application deemed withdrawn after publication |