CN113382995A - 作为crth2受体拮抗剂的杂环化合物的晶型 - Google Patents
作为crth2受体拮抗剂的杂环化合物的晶型 Download PDFInfo
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- CN113382995A CN113382995A CN202080007335.XA CN202080007335A CN113382995A CN 113382995 A CN113382995 A CN 113382995A CN 202080007335 A CN202080007335 A CN 202080007335A CN 113382995 A CN113382995 A CN 113382995A
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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Abstract
本发明提供式A所示杂环化合物或其水合物的晶型及其制备方法和应用。所述式A化合物或其水合物的晶型在溶解度、引湿性和稳定性方面优于其无定型态。并且，所述晶型还具有优于无定型态的生物利用度。此外，其制备方法简单，因此具有更高的实用性。
Description
PCT国内申请，说明书已公开。
Claims (10)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910024247X | 2019-01-10 | ||
| CN201910024247 | 2019-01-10 | ||
| PCT/CN2020/071479 WO2020143781A1 (zh) | 2019-01-10 | 2020-01-10 | 作为crth2受体拮抗剂的杂环化合物的晶型 |
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| Publication Number | Publication Date |
|---|---|
| CN113382995A true CN113382995A (zh) | 2021-09-10 |
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Country Status (2)
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| CN (1) | CN113382995A (zh) |
| WO (1) | WO2020143781A1 (zh) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090286825A1 (en) * | 2005-08-12 | 2009-11-19 | Zhaoyin Wang | Indole derivatives as crth2 receptor antagonists |
| CN101896178A (zh) * | 2007-10-10 | 2010-11-24 | 凯米科技公司 | 作为crth2受体拮抗剂的杂环化合物 |
-
2020
- 2020-01-10 CN CN202080007335.XA patent/CN113382995A/zh active Pending
- 2020-01-10 WO PCT/CN2020/071479 patent/WO2020143781A1/zh active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090286825A1 (en) * | 2005-08-12 | 2009-11-19 | Zhaoyin Wang | Indole derivatives as crth2 receptor antagonists |
| CN101896178A (zh) * | 2007-10-10 | 2010-11-24 | 凯米科技公司 | 作为crth2受体拮抗剂的杂环化合物 |
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| WO2020143781A1 (zh) | 2020-07-16 |
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