CN113350316A - Inflammation-diminishing pain-relieving plaster and preparation method thereof - Google Patents
Inflammation-diminishing pain-relieving plaster and preparation method thereof Download PDFInfo
- Publication number
- CN113350316A CN113350316A CN202110558113.3A CN202110558113A CN113350316A CN 113350316 A CN113350316 A CN 113350316A CN 202110558113 A CN202110558113 A CN 202110558113A CN 113350316 A CN113350316 A CN 113350316A
- Authority
- CN
- China
- Prior art keywords
- portions
- layer
- pain
- concentrated solution
- inflammation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 208000002193 Pain Diseases 0.000 title claims abstract description 42
- 206010061218 Inflammation Diseases 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 239000011505 plaster Substances 0.000 title claims description 18
- 239000003814 drug Substances 0.000 claims abstract description 32
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims abstract description 15
- 241000723346 Cinnamomum camphora Species 0.000 claims abstract description 15
- 229930008380 camphor Natural products 0.000 claims abstract description 15
- 229960000846 camphor Drugs 0.000 claims abstract description 15
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 14
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 14
- 244000020518 Carthamus tinctorius Species 0.000 claims abstract description 14
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims abstract description 14
- 235000006965 Commiphora myrrha Nutrition 0.000 claims abstract description 14
- 239000004863 Frankincense Substances 0.000 claims abstract description 14
- 235000007265 Myrrhis odorata Nutrition 0.000 claims abstract description 14
- 240000004824 Trimezia steyermarkii Species 0.000 claims abstract description 14
- 230000003110 anti-inflammatory effect Effects 0.000 claims abstract description 14
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229940116229 borneol Drugs 0.000 claims abstract description 14
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000009136 dragon's blood Substances 0.000 claims abstract description 14
- 235000003717 Boswellia sacra Nutrition 0.000 claims abstract description 13
- 240000007551 Boswellia serrata Species 0.000 claims abstract description 13
- 235000012035 Boswellia serrata Nutrition 0.000 claims abstract description 13
- 241000258920 Chilopoda Species 0.000 claims abstract description 13
- 240000007311 Commiphora myrrha Species 0.000 claims abstract description 13
- 241000239226 Scorpiones Species 0.000 claims abstract description 13
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract description 13
- 230000000202 analgesic effect Effects 0.000 claims abstract description 13
- 235000017803 cinnamon Nutrition 0.000 claims abstract description 13
- 235000008397 ginger Nutrition 0.000 claims abstract description 13
- 229940079593 drug Drugs 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 241000257303 Hymenoptera Species 0.000 claims abstract description 4
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 4
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 4
- 244000273928 Zingiber officinale Species 0.000 claims abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 45
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 238000001914 filtration Methods 0.000 claims description 15
- 241000723347 Cinnamomum Species 0.000 claims description 12
- 244000131316 Panax pseudoginseng Species 0.000 claims description 11
- 239000000843 powder Substances 0.000 claims description 11
- 235000003181 Panax pseudoginseng Nutrition 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 7
- 238000004140 cleaning Methods 0.000 claims description 6
- 239000011248 coating agent Substances 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 6
- 238000012869 ethanol precipitation Methods 0.000 claims description 5
- 230000005484 gravity Effects 0.000 claims description 5
- 238000002955 isolation Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 230000001376 precipitating effect Effects 0.000 claims description 5
- 230000001760 anti-analgesic effect Effects 0.000 claims description 4
- 239000012153 distilled water Substances 0.000 claims description 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 4
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 4
- 229940068968 polysorbate 80 Drugs 0.000 claims description 4
- 229920000053 polysorbate 80 Polymers 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- 239000002131 composite material Substances 0.000 claims description 2
- 239000004744 fabric Substances 0.000 claims description 2
- 230000036407 pain Effects 0.000 abstract description 25
- 230000000694 effects Effects 0.000 abstract description 12
- 230000001737 promoting effect Effects 0.000 abstract description 11
- 230000017531 blood circulation Effects 0.000 abstract description 10
- 239000008280 blood Substances 0.000 abstract description 9
- 210000004369 blood Anatomy 0.000 abstract description 9
- 230000008961 swelling Effects 0.000 abstract description 9
- 206010033425 Pain in extremity Diseases 0.000 abstract description 4
- 208000029549 Muscle injury Diseases 0.000 abstract description 3
- 244000223760 Cinnamomum zeylanicum Species 0.000 abstract 1
- 241000234314 Zingiber Species 0.000 description 9
- 230000003467 diminishing effect Effects 0.000 description 8
- 230000004054 inflammatory process Effects 0.000 description 8
- 210000000952 spleen Anatomy 0.000 description 5
- 210000003734 kidney Anatomy 0.000 description 4
- 208000005392 Spasm Diseases 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 210000002216 heart Anatomy 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 230000000451 tissue damage Effects 0.000 description 2
- 231100000827 tissue damage Toxicity 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000717739 Boswellia sacra Species 0.000 description 1
- 244000080208 Canella winterana Species 0.000 description 1
- 235000008499 Canella winterana Nutrition 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 241001481833 Coryphaena hippurus Species 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 206010019468 Hemiplegia Diseases 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 240000009023 Myrrhis odorata Species 0.000 description 1
- 241000475481 Nebula Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 206010039710 Scleroderma Diseases 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 206010041497 Spermatorrhoea Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 208000038016 acute inflammation Diseases 0.000 description 1
- 230000006022 acute inflammation Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 229940125716 antipyretic agent Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 229940017545 cinnamon bark Drugs 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 201000001981 dermatomyositis Diseases 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000003958 fumigation Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- 230000008338 local blood flow Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- 230000024121 nodulation Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 208000027753 pain disease Diseases 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/648—Myriapods, e.g. centipedes or millipedes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Insects & Arthropods (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Neurology (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Pain & Pain Management (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides an anti-inflammation analgesic patch and a preparation method thereof, the anti-inflammation analgesic patch comprises a patch body, the patch body comprises an outer layer, an inner layer and a traditional Chinese medicine analgesic and anti-inflammatory layer arranged between the outer layer and the inner layer, and the traditional Chinese medicine analgesic and anti-inflammatory layer comprises the following raw material medicines in parts by weight: 0.4 to 0.7 portion of dragon's blood, 0.8 to 1.5 portions of safflower, 0.8 to 1.2 portions of ants, 0.8 to 1.5 portions of scorpion, 0.8 to 1.5 portions of centipede, 0.3 to 0.6 portion of panax notoginseng, 0.4 to 0.7 portion of dried ginger, 0.3 to 0.8 portion of cinnamon, 1 to 1.5 portions of frankincense, 1 to 1.5 portions of myrrh, 1.8 to 2.5 portions of borneol and 1 to 1.5 portions of camphor. Has the effects of dredging channels, resolving hard mass, promoting blood circulation, removing blood stasis, relieving swelling and pain, and is especially suitable for sub-health people with cervical vertebra, joint, waist and leg pain and muscle injury.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to an anti-inflammatory analgesic patch and a preparation method thereof.
Background
Pain is a complaint about tissue damage or a sensory and emotional experience associated with tissue damage and is described in terms of the extent of damage. Such as traumatic injury, rheumatism, rheumatoid diseases, bone degeneration, and swelling and pain caused by qi and blood stagnation, channels and collaterals obstruction, joint, tendons and bones failing to thrive, acute inflammation, and chronic inflammation due to a certain posture.
With the changes of working environment and life rhythm of modern society and the aggravation of aging of population, various body limb pain diseases such as shoulder and cervical vertebra arthralgia, lumbocrural pain and the like caused by various factors seriously affect the health, daily life and work of people. Aiming at the pain, the conventional western medicine treatment is only simple symptomatic treatment, except local anesthetics, antipyretics and analgesics are mostly used locally or systemically to relieve inflammation and pain in a short time, but local skin irritation and gastrointestinal side effects are often caused, and the treatment is quick in effect but not permanent. The traditional Chinese medicine considers that the shoulder and cervical vertebra pain and the waist and leg pain are caused by the invasion of exogenous pathogenic factors such as wind, cold and dampness, and the treatment is focused on dispelling wind and eliminating dampness. The traditional external treatment method of the traditional Chinese medicine mainly comprises the application of external dosage forms such as traditional Chinese medicine liniment, powder, fumigation lotion, hot compress agent, tincture and the like, but the treatment effect of the traditional medicine is unsatisfactory. Therefore, a new anti-inflammatory and analgesic patch is needed to better dredge the channels and dissipate stagnation, activate blood and remove stasis, and relieve swelling and pain.
Disclosure of Invention
The invention aims to solve the technical problems in the prior art. Therefore, the invention provides an anti-inflammation and pain-relieving plaster and a preparation method thereof, and aims to facilitate the meridian dredging, the stasis dissipating, the blood circulation promoting, the blood stasis removing, the swelling subsiding and the pain relieving of sub-health people suffering from cervical vertebra, joint, waist and leg pains and muscle injuries.
Based on the purpose, the invention provides an anti-inflammation and pain-relieving plaster which comprises a plaster body, wherein the plaster body comprises an outer layer, an inner layer and a traditional Chinese medicine pain-relieving and inflammation-relieving layer arranged between the outer layer and the inner layer, and the traditional Chinese medicine pain-relieving and inflammation-relieving layer comprises the following raw material medicines in parts by weight: 0.4 to 0.7 portion of dragon's blood, 0.8 to 1.5 portions of safflower, 0.8 to 1.2 portions of ants, 0.8 to 1.5 portions of scorpion, 0.8 to 1.5 portions of centipede, 0.3 to 0.6 portion of panax notoginseng, 0.4 to 0.7 portion of dried ginger, 0.3 to 0.8 portion of cinnamon, 1 to 1.5 portions of frankincense, 1 to 1.5 portions of myrrh, 1.8 to 2.5 portions of borneol and 1 to 1.5 portions of camphor.
Preferably, the traditional Chinese medicine pain-relieving and inflammation-diminishing layer comprises the following raw material medicines in parts by weight: 0.5 part of dragon's blood, 1 part of safflower, 1 part of ant, 1 part of scorpion, 1 part of centipede, 0.5 part of pseudo-ginseng, 0.5 part of dried ginger, 0.5 part of cinnamon, 1 part of frankincense, 1 part of myrrh, 2 parts of borneol and 1 part of camphor.
The invention also provides a preparation method of the anti-inflammation pain-relieving plaster, which comprises the following steps:
step one, taking 0.5 part of dragon's blood, 1 part of safflower, 1 part of ant, 1 part of scorpion, 1 part of centipede, 0.5 part of pseudo-ginseng, 0.5 part of dried ginger, 0.5 part of cinnamon, 1 part of frankincense, 1 part of myrrh, 2 parts of borneol and 1 part of camphor, cleaning, drying and crushing into coarse powder;
step two, adding 10-15 times of water into the coarse powder, decocting for 2-3h, and filtering; decocting the residue with 6-8 times of water for 1-2 hr, filtering, mixing filtrates, and concentrating to obtain concentrated solution A;
adding the concentrated solution A into 95% ethanol to enable the alcohol content to reach 50%, precipitating with ethanol overnight, filtering, recovering ethanol from the filtrate to obtain an ethanol precipitation solution, recovering ethanol, and concentrating to obtain a final concentrated solution B, wherein the specific gravity of the final concentrated solution B is 1-1.02;
and step four, coating the concentrated solution B on the outer layer, drying, and then pasting an isolation layer as an inner layer to obtain the anti-inflammatory and analgesic paste.
The preparation method also comprises the steps of adding 50mL of polysorbate-80 into 200mL of distilled water before decocting the coarse powder with water, extracting the medicinal components by an extraction method, and removing the extraction solvent to obtain the medicinal extract.
The preparation method also comprises sterilizing the concentrated solution B at 120 deg.C for 1-2h before coating the concentrated solution B on the outer layer, and introducing nitrogen gas for protection.
The outer layer is a fabric layer of a composite waterproof layer.
Dragon's blood is warm and mild in nature, sweet in taste, salty in flavor, non-toxic, enters blood system, enters lung, spleen and kidney meridians, and has the obvious effects of promoting blood circulation to remove blood stasis, relieving swelling and pain, astringing to stop bleeding, softening hardness to dissipate stagnation, promoting tissue regeneration and healing sore.
Safflower, nature and taste: pungent and warm. Hua enters into the medicine for unblocking meridians and promoting blood circulation.
Ants, to tonify the kidney and replenish vital essence; clearing and activating the channels and collaterals; detoxify and detumescence. Dizziness and tinnitus due to kidney deficiency; insomnia and dreaminess; impotence and spermatorrhea; rheumatic arthralgia; stroke hemiplegia 6; numbness of hands and feet; lupus erythematosus; scleroderma; dermatomyositis; carbuncle and furuncle; bite by poisonous snake.
Quan Xie is neutral in nature and toxic in property, mainly pertains to liver meridian, and has the actions of extinguishing wind and relieving spasm, counteracting toxic pathogen and dissipating nodulation, and unblocking collaterals to alleviate pain.
Wu Gong, calming endogenous wind and relieving spasm, removing toxicity and resolving hard mass, unblocking collaterals and alleviating pain.
Notoginseng radix and Ginseng radix have effects of promoting blood circulation, stopping bleeding, removing blood stasis and relieving pain.
Gan Jiang is pungent and hot in nature and flavor and enters spleen, stomach, heart and kidney meridians. The effect and action of gan Jiang is warming middle energizer to dispel cold, restoring yang to activate collaterals, warming lung to resolve retained fluid.
Cinnamon bark, cortex Cinnamomi, acts to tonify yang, warm the spleen and stomach, remove cold accumulation, and promote blood circulation. It is indicated for decline of vital gate fire, cold limbs and pulse, yang exhaustion and collapse, abdominal pain and diarrhea, cold hernia and dolphin, cold pain in waist and knee, amenorrhea, deep rooted carbuncle, abscess, and floating yang, upper heat and lower cold.
Olibanum, with effects of promoting qi and blood circulations of viscera, can be used for treating chest and back pain, epigastric pain, dysmenorrhea, puerperal stagnation, and abdominal pain; it can be used for treating rheumatism, spasm of channels and collaterals, traumatic injury, swelling, and pyocutaneous disease.
Myrrh, bitter and neutral in nature and taste, has the main effects of promoting blood circulation to relieve pain, promoting blood circulation to remove blood stasis, and eliminating swelling and promoting granulation.
Camphor, pungent, hot and toxic in property, enters heart and spleen meridians. The camphor has the effects of removing dampness, killing insects, dispelling heat, relieving pain, inducing resuscitation and removing dirt.
Borneol, pungent and bitter in flavor, enters heart, spleen and lung meridians, and has the effects of dredging orifices, dispelling stagnated fire, inducing resuscitation, restoring consciousness, removing nebula, improving eyesight, relieving swelling and alleviating pain.
The invention has the beneficial effects that:
1. the inflammation diminishing and pain relieving plaster has the effects of stimulating the menstrual flow, dissipating stagnation, promoting blood circulation, removing blood stasis, diminishing swelling and relieving pain, and is particularly suitable for sub-health people suffering from cervical vertebra, joint, waist and leg pain and muscle injury.
2. The invention can be used for first aid, has the functions of absorbing, bonding and resisting bacteria for pollutants attached to the wound surface, is easy for cleaning and disinfecting in the later period and preventing the wound surface from being infected, and has no anaphylactic reaction.
3. The plaster stuck on the body surface stimulates nerve endings, expands blood vessels through reflection, promotes local blood circulation, improves the nutrition of peripheral tissues and achieves the purposes of detumescence, antiphlogosis and analgesia.
4. The invention has good stability, simple operation and low price, and is suitable for the requirement of large-scale industrial production.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to specific embodiments below.
It is to be noted that technical terms or scientific terms used in the embodiments of the present invention should have the ordinary meanings as understood by those having ordinary skill in the art to which the present disclosure belongs, unless otherwise defined.
Example 1
The utility model provides an anti-inflammation and pain-relieving plaster, includes the subsides body, the subsides body includes skin, inlayer and locates the traditional chinese medicine layer of diminishing inflammation that relieves pain between skin and the inlayer, and the traditional chinese medicine layer of diminishing inflammation that relieves pain includes the bulk drug of following part by weight: 0.5 part of dragon's blood, 1 part of safflower, 1 part of ant, 1 part of scorpion, 1 part of centipede, 0.5 part of pseudo-ginseng, 0.5 part of dried ginger, 0.5 part of cinnamon, 1 part of frankincense, 1 part of myrrh, 2 parts of borneol and 1 part of camphor.
The preparation method of the anti-inflammation pain-relieving plaster comprises the following steps:
step one, taking 0.5 part of dragon's blood, 1 part of safflower, 1 part of ant, 1 part of scorpion, 1 part of centipede, 0.5 part of pseudo-ginseng, 0.5 part of dried ginger, 0.5 part of cinnamon, 1 part of frankincense, 1 part of myrrh, 2 parts of borneol and 1 part of camphor, cleaning, drying and crushing into coarse powder;
step two, adding 10 times of water into the coarse powder, decocting for 2 hours, and filtering; decocting the residue with 7 times of water for 2 hr, filtering, mixing filtrates, and concentrating to obtain concentrated solution A;
adding the concentrated solution A into 95% ethanol to enable the alcohol content to reach 50%, precipitating with ethanol overnight, filtering, recovering ethanol from the filtrate to obtain an ethanol precipitation solution, recovering ethanol, and concentrating to obtain a final concentrated solution B, wherein the specific gravity of the final concentrated solution B is 1.02;
and step four, coating the concentrated solution B on the outer layer, drying, and then pasting an isolation layer as an inner layer to obtain the anti-inflammatory and analgesic paste.
Example 2
The utility model provides an anti-inflammation and pain-relieving plaster, includes the subsides body, the subsides body includes skin, inlayer and locates the traditional chinese medicine layer of diminishing inflammation that relieves pain between skin and the inlayer, and the traditional chinese medicine layer of diminishing inflammation that relieves pain includes the bulk drug of following part by weight: 0.4 part of dragon's blood, 1.5 parts of safflower, 0.8 part of ant, 0.8 part of scorpion, 0.8 part of centipede, 0.3 part of pseudo-ginseng, 0.4 part of dried ginger, 0.8 part of cinnamon, 1 part of frankincense, 1 part of myrrh, 1.8 parts of borneol and 1 part of camphor.
The preparation method of the anti-inflammation pain-relieving plaster comprises the following steps:
step one, taking 0.4 part of dragon's blood, 1.5 parts of safflower, 0.8 part of ant, 0.8 part of scorpion, 0.8 part of centipede, 0.3 part of pseudo-ginseng, 0.4 part of dried ginger, 0.8 part of cinnamon, 1 part of frankincense, 1 part of myrrh, 1.8 parts of borneol and 1 part of camphor, cleaning, drying and crushing into coarse powder; adding 50mL of polysorbate-80 into 200mL of distilled water, extracting the medicinal components by an extraction method, and removing the extraction solvent to obtain a medicinal extract;
step two, adding 10 times of water into the medicine extract, decocting for 2 hours, and filtering; decocting the residue with 7 times of water for 2 hr, filtering, mixing filtrates, and concentrating to obtain concentrated solution A;
adding the concentrated solution A into 95% ethanol to enable the alcohol content to reach 50%, precipitating with ethanol overnight, filtering, recovering ethanol from the filtrate to obtain an ethanol precipitation solution, recovering ethanol, and concentrating to obtain a final concentrated solution B, wherein the specific gravity of the final concentrated solution B is 1.02;
step four, sterilizing the concentrated solution B for 1 hour at 100 ℃, and filling nitrogen for protection in the whole process;
and step five, coating the concentrated solution B on the outer layer, drying, and then pasting an isolation layer as an inner layer to obtain the anti-inflammatory analgesic paste.
Example 3
The utility model provides an anti-inflammation and pain-relieving plaster, includes the subsides body, the subsides body includes skin, inlayer and locates the traditional chinese medicine layer of diminishing inflammation that relieves pain between skin and the inlayer, and the traditional chinese medicine layer of diminishing inflammation that relieves pain includes the bulk drug of following part by weight: 0.5 part of dragon's blood, 1 part of safflower, 1 part of ant, 1 part of scorpion, 1 part of centipede, 0.5 part of pseudo-ginseng, 0.5 part of dried ginger, 0.5 part of cinnamon, 1 part of frankincense, 1 part of myrrh, 2 parts of borneol and 1 part of camphor.
The preparation method of the anti-inflammation pain-relieving plaster comprises the following steps:
step one, taking 0.5 part of dragon's blood, 1 part of safflower, 1 part of ant, 1 part of scorpion, 1 part of centipede, 0.5 part of pseudo-ginseng, 0.5 part of dried ginger, 0.5 part of cinnamon, 1 part of frankincense, 1 part of myrrh, 2 parts of borneol and 1 part of camphor, cleaning, drying and crushing into coarse powder; adding 50mL of polysorbate-80 into 200mL of distilled water, extracting the medicinal components by an extraction method, and removing the extraction solvent to obtain a medicinal extract;
step two, adding 12 times of water into the medicine extract, decocting for 2 hours, and filtering; decocting the residue with 7 times of water for 2 hr, filtering, mixing filtrates, and concentrating to obtain concentrated solution A;
adding the concentrated solution A into 95% ethanol to enable the alcohol content to reach 50%, precipitating with ethanol overnight, filtering, recovering ethanol from the filtrate to obtain an ethanol precipitation solution, recovering ethanol, and concentrating to obtain a final concentrated solution B, wherein the specific gravity of the final concentrated solution B is 1.02;
step four, sterilizing the concentrated solution B for 1 hour at 100 ℃, and filling nitrogen for protection in the whole process;
and step five, coating the concentrated solution B on the outer layer, drying, and then pasting an isolation layer as an inner layer to obtain the anti-inflammatory analgesic paste.
Those of ordinary skill in the art will understand that: the discussion of any embodiment above is meant to be exemplary only, and is not intended to intimate that the scope of the disclosure, including the claims, is limited to these examples; within the idea of the invention, also features in the above embodiments or in different embodiments may be combined, steps may be implemented in any order, and there are many other variations of the different aspects of the invention as described above, which are not provided in detail for the sake of brevity.
The embodiments of the invention are intended to embrace all such alternatives, modifications and variances that fall within the broad scope of the appended claims. Therefore, any omissions, modifications, substitutions, improvements and the like that may be made without departing from the spirit and principles of the invention are intended to be included within the scope of the invention.
Claims (6)
1. The anti-inflammation and pain-relieving plaster comprises a plaster body, and is characterized in that the plaster body comprises an outer layer, an inner layer and a traditional Chinese medicine pain-relieving and inflammation-relieving layer arranged between the outer layer and the inner layer, wherein the traditional Chinese medicine pain-relieving and inflammation-relieving layer comprises the following raw material medicines in parts by weight: 0.4 to 0.7 portion of dragon's blood, 0.8 to 1.5 portions of safflower, 0.8 to 1.2 portions of ants, 0.8 to 1.5 portions of scorpion, 0.8 to 1.5 portions of centipede, 0.3 to 0.6 portion of panax notoginseng, 0.4 to 0.7 portion of dried ginger, 0.3 to 0.8 portion of cinnamon, 1 to 1.5 portions of frankincense, 1 to 1.5 portions of myrrh, 1.8 to 2.5 portions of borneol and 1 to 1.5 portions of camphor.
2. The anti-inflammation and analgesic patch as claimed in claim 1, wherein the traditional Chinese medicine analgesic and anti-inflammatory layer comprises the following raw material medicines in parts by weight: 0.5 part of dragon's blood, 1 part of safflower, 1 part of ant, 1 part of scorpion, 1 part of centipede, 0.5 part of pseudo-ginseng, 0.5 part of dried ginger, 0.5 part of cinnamon, 1 part of frankincense, 1 part of myrrh, 2 parts of borneol and 1 part of camphor.
3. The method for preparing an anti-inflammatory analgesic patch according to claim 1, characterized by comprising the steps of:
step one, taking 0.5 part of dragon's blood, 1 part of safflower, 1 part of ant, 1 part of scorpion, 1 part of centipede, 0.5 part of pseudo-ginseng, 0.5 part of dried ginger, 0.5 part of cinnamon, 1 part of frankincense, 1 part of myrrh, 2 parts of borneol and 1 part of camphor, cleaning, drying and crushing into coarse powder;
step two, adding 10-15 times of water into the coarse powder, decocting for 2-3h, and filtering; decocting the residue with 6-8 times of water for 1-2 hr, filtering, mixing filtrates, and concentrating to obtain concentrated solution A;
adding the concentrated solution A into 95% ethanol to enable the alcohol content to reach 50%, precipitating with ethanol overnight, filtering, recovering ethanol from the filtrate to obtain an ethanol precipitation solution, recovering ethanol, and concentrating to obtain a final concentrated solution B, wherein the specific gravity of the final concentrated solution B is 1-1.02;
and step four, coating the concentrated solution B on the outer layer, drying, and then pasting an isolation layer as an inner layer to obtain the anti-inflammatory and analgesic paste.
4. The preparation method of the anti-inflammatory analgesic patch as claimed in claim 3, wherein the preparation method further comprises the steps of adding 50mL of polysorbate-80 into 200mL of distilled water before decocting the coarse powder with water, extracting the drug components by an extraction method, and removing the extraction solvent to obtain the drug extract.
5. The preparation method of the anti-inflammatory analgesic patch as claimed in claim 3, wherein the preparation method further comprises sterilizing the concentrated solution B at 120 ℃ for 1-2h before applying the concentrated solution B on the outer layer, and introducing nitrogen for protection.
6. The method for preparing an anti-inflammatory analgesic patch as claimed in claim 3, wherein the outer layer is a fabric layer of a composite waterproof layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110558113.3A CN113350316A (en) | 2021-05-21 | 2021-05-21 | Inflammation-diminishing pain-relieving plaster and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110558113.3A CN113350316A (en) | 2021-05-21 | 2021-05-21 | Inflammation-diminishing pain-relieving plaster and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113350316A true CN113350316A (en) | 2021-09-07 |
Family
ID=77527153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110558113.3A Withdrawn CN113350316A (en) | 2021-05-21 | 2021-05-21 | Inflammation-diminishing pain-relieving plaster and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113350316A (en) |
-
2021
- 2021-05-21 CN CN202110558113.3A patent/CN113350316A/en not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102488869B (en) | Traditional Chinese medicinal external-use liniment for muscle and bone ache | |
| CN103520579A (en) | Medicinal liquor used for treating lumbocrural pain, hyperostosis and sciatica | |
| CN108635557A (en) | A kind of traditional Chinese medicine foot-bath powder and preparation method thereof | |
| CN113350316A (en) | Inflammation-diminishing pain-relieving plaster and preparation method thereof | |
| CN109793849A (en) | One kind dispel releasing ache and health care patch | |
| CN106421255B (en) | External Chinese herbal medicine composition and application thereof | |
| CN110538272A (en) | swelling-reducing and collateral-dredging powder for treating soft tissue injury and joint swelling and pain and preparation method thereof | |
| CN104758527A (en) | Traditional Chinese medicine composition for treating pain in waists and legs | |
| CN105641282B (en) | External traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain | |
| CN102895450B (en) | External Chinese herbal preparation for treating angiitis fester and gangrene and method for preparing external Chinese herbal preparation for treating angiitis fester and gangrene | |
| CN108465006B (en) | Composition and plaster for treating knee osteoarthritis | |
| CN104491641A (en) | Fuming and washing medicine for promoting healing of pulled muscles | |
| CN114796369A (en) | Health-care powder for clearing and activating channels and collaterals | |
| CN106860626A (en) | A kind of foot bath external use traditional Chinese for treating rheumatism | |
| CN113491738A (en) | Traditional Chinese medicine composition and preparation method and application thereof | |
| CN104524017A (en) | Traditional Chinese medicine preparation for treating angiitis | |
| CN111840495A (en) | Plaster specially used for treating neck, shoulder, waist and leg pains | |
| CN111905072A (en) | Clove antibacterial powder and preparation method thereof | |
| CN117224648A (en) | Black plaster and preparation method thereof | |
| CN1333052A (en) | Lotion for treating beriberi | |
| CN113425769A (en) | Traditional Chinese medicine composition for treating arthralgia and preparation method thereof | |
| CN111035749A (en) | Traditional Chinese medicine mud film for mud moxibustion and preparation method thereof | |
| CN115300569A (en) | Traditional Chinese medicine composition for treating rheumatic bone pain and muscle injury and application thereof | |
| CN113082172A (en) | Externally applied medicinal liquor for synovitis | |
| CN112823805A (en) | Bacteriostatic and analgesic spray and preparation process thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20210907 |
|
| WW01 | Invention patent application withdrawn after publication |