CN113350248A - Preparation and application method of bletilla striata gel freeze-dried powder skin moisturizer - Google Patents
Preparation and application method of bletilla striata gel freeze-dried powder skin moisturizer Download PDFInfo
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- CN113350248A CN113350248A CN202110582982.XA CN202110582982A CN113350248A CN 113350248 A CN113350248 A CN 113350248A CN 202110582982 A CN202110582982 A CN 202110582982A CN 113350248 A CN113350248 A CN 113350248A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
Abstract
The invention relates to a preparation method and a using method of a bletilla striata gel dry powder skin moisturizer, belonging to the technical field of crossing of agricultural technology and light industry; comprises the following steps: crushing, alcohol precipitation, freeze drying, superfine crushing, water dissolving and other steps. The method solves the problems of inconvenient storage and preparation and difficult application of the current whitening cosmetics by using freeze drying and superfine grinding technologies, and has the following advantages: 1. the freeze drying and superfine grinding technology solves the problem that the dissolution processing of the bletilla rubber is faster; 2. no toxic chemical substances are added, and the food grade is achieved; 3. the freeze-dried powder is stored for a long time at normal temperature, is prepared in situ when used, and is visual and safe; 4. the uniform skin lotion can be used for long-acting skin care without cleaning, has better whitening effect compared with the traditional mask or facial cleanser, and obviously reduces the melanin and heme values of the using parts when the mask lasts for 28 days.
Description
Technical Field
The invention relates to a preparation method and a use method of a bletilla striata gel dry powder skin moisturizer, and belongs to the technical field of crossing of agricultural technology and light industry.
Background
The difference in human skin color is caused by the amount of melanin and hemoglobin secreted and the inconsistency of distribution. Melanin is a non-ferrous brown particle, is mostly bound to proteins, and exists in the hair growth layer of the epidermis of the skin, or partially exists among cells. The stain is a common skin disease with brown bread or melanosis and damaged skin due to the increase of skin melanin, and comprises freckle, black spot, chloasma, senile plaque and the like. Therefore, the main problem of whitening and removing freckles is to fade or remove pigment in the skin.
The Bletilla striata is a dry tuber of a Bletilla striata (Bletilla striata) of an Orchidaceae plant, and the main component of the Bletilla striata, namely glucomannan, can promote epithelial cell repair, directly participate in damaged cell repair, and has better wrinkle removing, freckle removing and anti-aging effects; the common bletilla gum is externally applied to eliminate acne spots on the face and make the skin smooth and traceless. The inventor of the invention finds that the existing processing technology of the common bletilla gum product has the defects that: because the molecular weight of the effective components is large and the secondary dissolution is difficult in water, the high-concentration common bletilla gum can only generate semisolid or viscous liquid, and the common bletilla gum can only be used for a facial mask or a facial cleanser cosmetic after being directly used for a whitening skin care product and needing to be cleaned in time after being used; meanwhile, because the secondary dissolution is difficult, the maximum addition amount of the common bletilla gum is less than 0.5 percent in skin care products such as skin care solution and the like which do not need to be cleaned, so that the common bletilla gum is limited to be used as a whitening skin care component to exert the whitening effect. The conventional stirring and dissolving takes long time, and the solution is placed for more than 3 hours after being stirred at least and is completely dissolved; if the dissolving enzyme is added for dissolving, firstly, some physical structures of the bletilla striata gum can be damaged, and the efficacy is reduced, and secondly, the chemical components are added, so that the standard of eating can not be achieved.
The patent document 1 discloses a traditional Chinese medicine composition for purifying and whitening skin and an application thereof, which is mainly characterized in that a small amount of bletilla striata extract is used as a raw material of a whitening compound formula, and the embodiment of the traditional Chinese medicine composition does not provide a solution for preparing whitening products with bletilla striata gel concentration of more than 1%, and the whitening effect of the bletilla striata gel cannot be really verified.
Reference 1: application publication No. CN 112245532A is a Chinese medicinal composition for purifying and whitening skin and its application.
Disclosure of Invention
The main components of the bletilla striata gum comprise bletilla striata polysaccharide, water-soluble cellulose and the like, which belong to macromolecules slightly soluble in water, and the bletilla striata gum product forms a compact solid phase through water extraction and alcohol precipitation, so that secondary dissolution and processing are more difficult; even if the skin care lotion is stirred, secondary precipitation is easy to occur, and the skin care lotion is difficult to generate and meets the uniform and stable requirements of skin care products such as skin care lotion and the like which do not need to be cleaned.
In order to solve at least one problem, the invention designs a preparation method and a use method of bletilla striata gel freeze-dried powder skin moisturizer.
A preparation method of bletilla striata gel freeze-dried powder skin moisturizer comprises the following steps:
(1) peeling the cleaned and dried rhizoma bletillae tubers, crushing the rhizoma bletillae tubers for 10 to 30min in a crusher with the rotation speed of 200-1000rpm, adding a proper amount of purified water, standing and extracting for 1 to 12h, and filtering to remove filter residues to obtain a mixed solution I; the mass ratio of the rhizoma bletillae tubers to the purified water is 1: 1-100;
(2) adding organic alcohol and stabilizer into the mixed solution I, precipitating, standing for 1-12h, and filtering to obtain solid bletilla gum; the volume ratio of the mixed solution I to the organic alcohol is 1: 1-50;
(3) freeze-drying the solid bletilla gum in a vacuum freeze-drying device at a temperature lower than-45 ℃ and a vacuum degree lower than 100Pa for 1-12h to obtain a bletilla gum freeze-dried product with a mass water content of lower than 0.1%;
(4) micronizing the rhizoma Bletillae lyophilized product at-15 deg.C for 10-60min with an ultramicro pulverizer under the environment with relative humidity below 10% to obtain rhizoma Bletillae lyophilized powder;
(5) sequentially and quantitatively measuring purified water and bletilla striata lyophilized powder in an organic glass container, screwing a bottle cover, violently shaking for 2-7 minutes, and standing for 2 minutes after the bletilla striata lyophilized powder is uniformly dissolved to obtain the bletilla striata lyophilized powder skin moisturizer.
Preferably, the organic alcohol comprises one or more of ethanol, isopropanol, n-propanol, butanol, ethylene glycol, propylene glycol, glycerol, butylene glycol, hexylene glycol, diethylene glycol, methanol and triethylene glycol.
Preferably, the operation in step (5) is currently prepared.
Preferably, the freeze-dried powder is stored at normal temperature for a long time.
Preferably, the stabilizers include modified waxes, modified silicones and modified grease stabilizers.
Preferably, the purified water is selected from spring water.
Preferably, the plexiglass container is sized and shaped for easy use by the average person.
A rhizoma bletilla gel lyophilized powder skin care lotion is prepared according to the above method.
A use method of rhizoma bletilla lyophilized powder skin care lotion comprises quantitatively taking 1-3ml of the lyophilized powder skin care lotion, repeatedly applying face, neck and hands for 1-3 min each time, and repeating for 5-15 times.
The beneficial effects are that:
a preparation method and a use method of a bletilla striata gel dry powder skin moisturizer solve the problems of inconvenient storage and preparation and difficult application of the current bletilla striata whitening cosmetics by using freeze drying and superfine grinding technologies, store the bletilla striata gel dry powder at normal temperature for a long time, and prepare the bletilla striata gel dry powder skin moisturizer in situ when in use, and have the following advantages: 1. the freeze drying and superfine grinding technology is used to ensure that the dissolution processing of the bletilla rubber is faster; 2. the existing preparation is intuitive and safe, the conventional stirring and dissolving takes long time, and the solution is completely dissolved after being stirred for more than 3 hours; if the dissolving enzyme is added for dissolving, firstly, some physical structures of the bletilla striata gum can be damaged, and the effect is reduced, and secondly, chemical components are added, so that the standard of food grade cannot be achieved; 3. the machine glass container with the size and the shape is easy to use by ordinary people, and the use is convenient; 4. the uniform skin lotion can be used for long-acting skin care without cleaning, has better whitening effect compared with the traditional mask or facial cleanser, and obviously reduces the melanin and heme values of the using parts when the mask lasts for 28 days.
Drawings
FIG. 1 contact angle of aqueous stabilizer solution;
FIG. 2 sample B skin lotion contact angle;
fig. 3 contact angles for sample a and example 1 lotion.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without making any creative effort, shall fall within the scope of protection of the present disclosure.
Disclosed herein are embodiments of a method for using bletilla striata gel lyophilized powder skin moisturizer, comprising the following steps:
(1) peeling the cleaned and dried rhizoma bletillae tubers, crushing the rhizoma bletillae tubers for 10 to 30min in a crusher with the rotation speed of 200-1000rpm, adding a proper amount of purified water, standing and extracting for 1 to 12h, and filtering to remove filter residues to obtain a mixed solution I; the mass ratio of the rhizoma bletillae tubers to the purified water is 1: 1-100;
(2) adding organic alcohol and stabilizer into the mixed solution I, precipitating, standing for 1-12h, and filtering to obtain solid bletilla gum; the volume ratio of the mixed solution I to the organic alcohol is 1: 1-50;
(3) freeze-drying the solid bletilla gum in a vacuum freeze-drying device at a temperature lower than-45 ℃ and a vacuum degree lower than 100Pa for 1-12h to obtain a bletilla gum freeze-dried product with a mass water content of lower than 0.1%;
(4) micronizing the rhizoma Bletillae lyophilized product at-15 deg.C for 10-60min with an ultramicro pulverizer under the environment with relative humidity below 10% to obtain rhizoma Bletillae lyophilized powder;
(5) sequentially and quantitatively measuring purified water and bletilla striata lyophilized powder in an organic glass container, screwing a bottle cover, violently shaking for 2-7 minutes, and standing for 2 minutes after the bletilla striata lyophilized powder is uniformly dissolved to obtain the bletilla striata lyophilized powder skin moisturizer.
Preferably, the organic alcohol comprises one or more of ethanol, isopropanol, n-propanol, butanol, ethylene glycol, propylene glycol, glycerol, butylene glycol, hexylene glycol, diethylene glycol, methanol and triethylene glycol.
Preferably, the operation in step (5) is currently prepared.
Preferably, the freeze-dried powder is stored at normal temperature for a long time.
Preferably, the purified water is selected from spring water.
Preferably, the stabilizers include modified waxes, modified silicones and modified grease stabilizers.
Preferably, the plexiglass container is sized and shaped for easy use by the average person. As shown in FIG. 1, the contact angle of the aqueous solution of the stabilizer is 80 to 110 degrees.
A rhizoma bletilla gel lyophilized powder skin care lotion is prepared according to the above method.
A use method of rhizoma bletilla lyophilized powder skin care lotion comprises quantitatively taking 1-3ml of the lyophilized powder skin care lotion, repeatedly applying face, neck and hands for 1-3 min each time, and repeating for 5-15 times.
The invention also discloses a whitening and gelatin dry powder which has the characteristics.
In order to better verify the uniformity and stability of the skin moisturizer after the skin moisturizer is added with the modified wax stabilizer, a contact angle characterization method is adopted by contact angle measurement equipment to characterize the stability of the solution.
The machine glass container with the size and the shape is easy to use by ordinary people, is prepared at present, is visual, safe, simple and quick; the rhizoma bletillae lyophilized powder is preserved for a long time at normal temperature without deterioration.
In order to better verify the whitening effect described herein, the present embodiment introduces a whitening effect evaluation method:
the skin melanin and haematochrome test probe is used as skin whitening detection equipment, and the content of melanin and heme in skin is determined by measuring the reflection quantity of light with specific wavelength after being irradiated on the skin of a human body based on the principle of spectral absorption (RGB). The test probe of the pigment detector consists of a light source emitter and a light source receiver, and a spring is additionally arranged to keep the pressure on the skin constant during detection. The emitter of the probe emits light with three wavelengths of 568nm, 660nm and 880nm to the skin surface, and the receiver measures the light reflected from the skin. Since the amount of emitted light is constant, the amount of light absorbed by the skin can be measured, and the content of melanin and hemoglobin in the skin can be measured. The measuring range of the probe is 0-999, and the higher the measuring value is, the higher the content of melanin and heme in the skin is. The same site melanin and heme values were recorded continuously before use, for 7 days, for 14 days, for 21 days, and for 28 days.
Example 1
On the basis of the disclosed embodiment, the preparation method of the bletilla striata gel freeze-dried powder skin moisturizer is preferably disclosed, and comprises the following steps:
(1) peeling cleaned and dried rhizoma bletillae tubers, crushing the rhizoma bletillae tubers for 30min in a crusher with the rotation speed of 1000rpm, adding a proper amount of purified water, standing and extracting for 12h, and filtering to remove filter residues to obtain a first mixed solution; the mass ratio of the rhizoma bletillae tubers to the purified water is 1: 100;
(2) adding organic alcohol and stabilizer into the mixed solution I, precipitating, standing for 1-12h, and filtering to obtain solid bletilla gum; the volume ratio of the mixed solution I to the organic alcohol is 1: 50;
(3) freeze-drying the solid bletilla striata gum in a vacuum freeze-drying device at-45 ℃ for 12 hours under the vacuum degree of 100Pa to obtain a bletilla striata gum freeze-dried product with the mass water content of 0.1%;
(4) micronizing the rhizoma Bletillae lyophilized product at-15 deg.C for 60min with an ultramicro pulverizer under the environment with relative humidity of 10% to obtain rhizoma Bletillae lyophilized powder;
(5) sequentially and quantitatively measuring purified water and the bletilla striata lyophilized powder in an organic glass container, screwing a bottle cover, shaking for 2-7 minutes, and standing for 1 minute to obtain the bletilla striata lyophilized powder skin moisturizer after the bletilla striata lyophilized powder is uniformly dissolved; the mass ratio of the bletilla striata dry powder to the water is 1: 120.
preferably, the organic alcohol is a combined solution of ethanol and triethylene glycol.
Preferably, the freeze-dried powder is stored at normal temperature for a long time.
Preferably, the purified water is selected from spring water.
Preferably, the plexiglass container is sized and shaped for easy use by the average person.
On the basis of the disclosed embodiment, the application method of the bletilla striata freeze-dried powder skin moisturizer is further disclosed, wherein 20ml of the bletilla striata freeze-dried powder skin moisturizer is quantitatively taken, and the face, the neck and the hands are repeatedly smeared for 5 minutes each time and 10 times, so that the effect of keeping skin tender and white for 5 hours is realized.
The paper also discloses a bletilla striata gel freeze-dried powder skin moisturizer which has the characteristics.
In some optional embodiments, freeze drying and micronization techniques are used to facilitate the dissolution processing of rhizoma bletilla gum;
in some optional embodiments, the modified wax stabilizer is added to improve the stability of the solution of the bletilla rubber component and the addition amount of the effective component;
in some optional embodiments, the uniform skin lotion can be used for long-term skin care without cleaning, has better whitening effect compared with the traditional mask or facial cleanser, and has more obvious reduction of melanin and heme values of the using part when the mask or facial cleanser lasts for 28 days; good whitening and wrinkle-removing effects are achieved on different people and different parts, and the effects are specifically shown as that small wrinkles become light or disappear, facial color spots become light or even disappear, and skin color becomes light or white; the contents of skin melanin and heme are reduced to different degrees under the detection of skin whitening detection equipment.
Example 2
On the basis of the disclosed embodiment, the preparation method of the bletilla striata gel freeze-dried powder skin moisturizer is preferably disclosed, and comprises the following steps:
(1) peeling cleaned and dried rhizoma bletillae tubers, crushing the rhizoma bletillae tubers for 10min in a crusher with the rotation speed of 200rpm, adding a proper amount of purified water, standing and extracting for 1h, and filtering to remove filter residues to obtain a first mixed solution; the mass ratio of the rhizoma bletillae tubers to the purified water is 1: 10;
(2) adding organic alcohol and stabilizer into the mixed solution I, precipitating, standing for 1-12h, and filtering to obtain solid bletilla gum; the volume ratio of the mixed solution I to the organic alcohol is 1: 10;
(3) freeze-drying the solid bletilla striata gum in a vacuum freeze-drying device at-55 ℃ and under the vacuum degree of 50Pa for 1h to obtain a bletilla striata gum freeze-dried product with the mass water content of 0.02%;
(4) micronizing the rhizoma Bletillae lyophilized product at-25 deg.C for 10min with an ultramicro pulverizer under the environment with relative humidity of 8% to obtain rhizoma Bletillae lyophilized powder;
(5) sequentially and quantitatively measuring purified water and bletilla striata lyophilized powder in an organic glass container, screwing a bottle cover, violently taking out for 3 minutes up and down, and standing for 10 minutes after the bletilla striata lyophilized powder is uniformly dissolved to obtain the bletilla striata lyophilized powder skin moisturizer; the mass ratio of the bletilla striata dry powder to the water is 1: 80.
preferably, the organic alcohol is a combined solution of ethanol and isopropanol.
Preferably, the freeze-dried powder is stored at normal temperature for a long time.
Preferably, the purified water is selected from spring water.
Preferably, the plexiglass container is sized and shaped for easy use by the average person.
On the basis of the disclosed embodiment, the application method of the bletilla striata freeze-dried powder skin care lotion is further disclosed, wherein 10ml of the bletilla striata freeze-dried powder skin care lotion is quantitatively taken, and the face, the neck and the hands are repeatedly smeared for 3 minutes and 5 times every time, so that the effect of keeping skin tender and white for 3 hours is realized.
The paper also discloses a bletilla striata gel freeze-dried powder skin moisturizer which has the characteristics.
In some optional embodiments, freeze drying and micronization techniques are used to facilitate the dissolution processing of rhizoma bletilla gum;
in some optional embodiments, the modified silicon stabilizer is added to improve the stability of the solution of the bletilla gum component and increase the addition amount of the effective components;
in some optional embodiments, the uniform skin lotion can be used for long-term skin care without cleaning, has better whitening effect compared with the traditional mask or facial cleanser, and has more obvious reduction of melanin and heme values of the using part when the mask or facial cleanser lasts for 28 days; good whitening and wrinkle-removing effects are achieved on different people and different parts, and the effects are specifically shown as that small wrinkles become light or disappear, facial color spots become light or even disappear, and skin color becomes light or white; the contents of skin melanin and heme are reduced to different degrees under the detection of skin whitening detection equipment.
Example 3
On the basis of the disclosed embodiment, the preparation method of the bletilla striata gel freeze-dried powder skin moisturizer is preferably disclosed, and comprises the following steps:
(1) peeling cleaned and dried rhizoma bletilla tuber, pulverizing in a pulverizer with the rotation speed of 500rpm for 20min, adding appropriate amount of purified water, standing and extracting for 12h, filtering to remove filter residue to obtain a first mixed solution; the mass ratio of the rhizoma bletillae tubers to the purified water is 1: 50;
(2) adding organic alcohol and a stabilizer into the mixed solution I, precipitating and standing for 6 hours, and filtering to obtain a bletilla gum solid; the volume ratio of the mixed solution I to the organic alcohol is 1: 20;
(3) freeze-drying the solid bletilla striata gum in a vacuum freeze-drying device at-55 ℃ and under the vacuum degree of 90Pa for 12h to obtain a bletilla striata gum freeze-dried product with the mass water content of 0.08%;
(4) micronizing the rhizoma Bletillae lyophilized product at-8 deg.C for 30min with an ultramicro pulverizer under an environment with relative humidity of 5% to obtain rhizoma Bletillae lyophilized powder;
(5) sequentially and quantitatively measuring purified water and bletilla striata lyophilized powder in an organic glass container, screwing a bottle cover, violently taking the bottle cover up and down for 5 minutes, and standing for 10 minutes after the bletilla striata lyophilized powder is uniformly dissolved to obtain the bletilla striata lyophilized powder skin moisturizer; the mass ratio of the bletilla striata dry powder to the water is 1: 100.
preferably, the organic alcohol is a combined solution of isopropanol alcohol and triethylene glycol.
Preferably, the freeze-dried powder is stored at normal temperature for a long time.
Preferably, the purified water is selected from spring water.
Preferably, the plexiglass container is sized and shaped for easy use by the average person.
On the basis of the disclosed embodiment, the application method of the bletilla striata freeze-dried powder skin moisturizer is further disclosed, 15ml of the bletilla striata freeze-dried powder skin moisturizer is quantitatively taken, and the face, the neck and the hands are repeatedly smeared for 4 minutes each time and 8 times, so that the effect of keeping skin tender and white for 4 hours is realized.
The paper also discloses a bletilla striata gel freeze-dried powder skin moisturizer which has the characteristics.
In some optional embodiments, freeze drying and micronization techniques are used to facilitate the dissolution processing of rhizoma bletilla gum;
in some optional embodiments, the modified fat stabilizer is added to improve the stability of the solution of the bletilla gum component and increase the addition amount of the effective components;
in some optional embodiments, the uniform skin lotion can be used for long-term skin care without cleaning, has better whitening effect compared with the traditional mask or facial cleanser, and has more obvious reduction of melanin and heme values of the using part when the mask or facial cleanser lasts for 28 days; good whitening and wrinkle-removing effects are achieved on different people and different parts, and the effects are specifically shown as that small wrinkles become light or disappear, facial color spots become light or even disappear, and skin color becomes light or white; the contents of skin melanin and heme are reduced to different degrees under the detection of skin whitening detection equipment.
Example 4
On the basis of the disclosed embodiment, the application method of the bletilla striata gel dry powder skin moisturizer is disclosed as follows:
liu women in Guizhou Xingyi city, age 55, always pay attention to beauty treatment, and the skin is fair and dry every winter when the conventional beauty products are used for decades. The bletilla striata freeze-dried powder skin moisturizer is used from 2019 and 10 months, purified water and bletilla striata freeze-dried powder are sequentially measured in a quantitative manner in an organic glass container and an organic glass container, a bottle cover is screwed, the upper part and the lower part of the container are strenuous for 5 minutes, and the bletilla striata freeze-dried powder skin moisturizer is obtained after the bletilla striata freeze-dried powder is uniformly dissolved and stands for 10 minutes; the mass ratio of the bletilla striata dry powder to the water is 1: 1-100. 15ml of the bletilla striata gel dry powder skin moisturizer is measured quantitatively, and the face, the neck and the hands are repeatedly smeared for 8 times in 4 minutes each time, so that the effect of keeping skin tender and white in 4 hours is realized. In 2020 winter, skin does not dry, and skin color becomes white and tender.
The dry powder of whitening and gelatin prepared by any method disclosed in examples 1-3 is used for tests involving Liu women, the skin condition of Liu women is recorded before and after the tests, and the content of skin melanin and heme is detected by using skin whitening detection equipment, wherein the observation of wrinkles and spots is based on the observation of naked eyes, and the table is as follows:
test results show that the whitening and whitening gelatin dry powder has obvious wrinkle removing, freckle removing and whitening effects on the skin of Liu women; after the whitening and whitening gel dry powder is continuously used for 28 days, the improvement effect of small wrinkles and small color spots is obvious, and the large wrinkles and large color spots are lightened to different degrees, so that the whitening and whitening gel dry powder is proved to have the effects of removing wrinkles, freckles and whitening. The above demonstrates that the method for evaluating the wrinkle, freckle and whitening effects of whitening and glue disclosed herein has the quantitative and direct characteristics, and demonstrates the beneficial effects.
Example 5
On the basis of the disclosed embodiment, a case of a use method of a beautifying and gelatin dry powder is disclosed:
women in Anlong county, Guizhou, aged 52 years have no attention on beauty treatment and dark skin color. Sequentially and quantitatively measuring purified water and bletilla striata lyophilized powder in an organic glass container and an organic glass container from 7 months in 2020, screwing a bottle cap, violently dissolving the bletilla striata lyophilized powder for 5 minutes up and down, and standing for 10 minutes to obtain the bletilla striata lyophilized powder skin care solution; the mass ratio of the bletilla striata dry powder to the water is 1: 1-100. 15ml of the bletilla striata gel dry powder skin moisturizer is measured quantitatively, and the face, the neck and the hands are repeatedly smeared for 8 times in 4 minutes each time, so that the effect of keeping skin tender and white in 4 hours is realized. Each time for 30 minutes, the skin color became clearly white after 1 month.
The whitening and whitening lotion prepared by any of the methods disclosed in examples 1-3 was used in a test involving women, wherein the left cheek of women was subjected to the whitening test using the whitening gel, the right cheek was not subjected to the test and was not used with any cosmetics, the skin condition of women was recorded before and after the test and the skin melanin and heme contents were measured using a skin whitening test device, wherein wrinkles and spots were observed on a macroscopic basis as follows:
test results show that the whitening and gelatin dry powder skin moisturizer has obvious effects of removing wrinkles, freckles and whitening skin for women; the left and right cheek contrast tests are more direct, the improvement effect of small wrinkles and small color spots is obvious after the whitening gel is continuously used for 28 days, and the large wrinkles and large color spots are lightened to different degrees, so that the whitening gel dry powder has the effects of removing wrinkles, removing freckles and whitening. The above demonstrates that the method for evaluating the wrinkle, freckle and whitening effects of whitening and glue disclosed herein has the quantitative and direct characteristics, and demonstrates the beneficial effects.
Experimental example 1
On the basis of the disclosed embodiments, an experimental case of a whitening and gel dry powder skin moisturizer: respectively setting a sample A, and preparing the skin moisturizer by adopting the method disclosed in the embodiment 1; sample B, a skin lotion was prepared as disclosed in example 1 without the addition of any stabilizer component; sample C, skin lotion was prepared according to the method disclosed in example 1, except that the lyophilized bletilla gum was directly dissolved in water without micronization; sample D, a skin care lotion is prepared according to the ratio of bletilla striata gum to water of 1:200, no stabilizer component is added, the bletilla striata skin care lotion in the prior art is simulated, and the using method is the same as that of example 1; sample E, a skin care product is prepared according to the ratio of the bletilla striata gum to the water of 1:50, no stabilizer component is added, and the bletilla striata skin care cream or facial mask in the prior art is simulated, and the bletilla striata skin care cream or facial mask is the same as the example 1 in the rest, because more bletilla striata components need to be cleaned in time after use; sample F, which was not micronized, was added with 0.5-1% of lytic enzyme to facilitate dissolution of bletilla gum, simulating the dissolution of bletilla in the prior art to prepare a skin lotion, as in example 1.
As shown in fig. 2 and 3, the initial contact angles of the prepared samples B and a sample a are shown, and the specific contact angle test results are shown in the following table:
TABLE-standing stability test
| Experimental group | 0d | 7d | 14d | 21d | 28d |
| A | 66° | 64° | 63.5° | 63.2° | 63° |
| B | 52° | 41° | 39° | 38° | 39° |
The test results show that: after the sample is kept still for 28 days, the components of the bletilla striata in the sample B without the stabilizer are separated from the solution, so that the contact angle of the solution is reduced and the value is stabilized at 39 degrees; the addition of the stabilizer sample A shows that the components of the common bletilla gum and the contact angle decrease relatively slowly due to the existence of the stabilizer, which shows that the stabilizer has an outstanding effect on improving the stability of the components of the common bletilla gum in the skin care lotion.
In the test process, compared with the skin care lotion prepared by superfine grinding, such as A/B/D/E/F, the skin care lotion prepared by the sample C is very slowly dissolved, and even if the skin care lotion is stirred, sediment still exists at the bottom, so that the dissolving efficiency of the skin care lotion prepared by the sample C is far lower than that of a superfine grinding product.
The samples A, D, E and F were selected and 50 persons were selected for each of the 28d whitening effect experiments, and the statistical results are shown in the following table:
skin whitening effect test of the second Table
The test results show that:
compared with the sample D and the sample E, the selected sample A has more obvious reduction on the wrinkle and stain removal rate and the content average value of detected melanin and heme, and the technical scheme has better whitening effect compared with the prior art of the sample D, the sample E and the sample F; the reason is that the whitening effect of the sample D is poor due to instability and effective component settlement; the sample E cannot be used for a long time due to the need of timely cleaning, so that the whitening effect is poor; sample F had poor whitening effect due to the active ingredients being destroyed by lytic enzymes.
It will be understood by those of ordinary skill in the art that the foregoing embodiments are specific examples for carrying out the invention, and that various changes in form and details may be made therein without departing from the spirit and scope of the invention in practice.
Claims (8)
1. A preparation method of bletilla striata gel freeze-dried powder skin moisturizer is characterized by comprising the following steps:
(1) peeling the cleaned and dried rhizoma bletillae tubers, crushing the rhizoma bletillae tubers for 10 to 30min in a crusher with the rotation speed of 200-1000rpm, adding a proper amount of purified water, standing and extracting for 1 to 12h, and filtering to remove filter residues to obtain a mixed solution I; the mass ratio of the rhizoma bletillae tubers to the purified water is 1: 1-100;
(2) adding organic alcohol and stabilizer into the mixed solution I, precipitating, standing for 1-12h, and filtering to obtain solid bletilla gum; the volume ratio of the mixed solution I to the organic alcohol is 1: 1-50;
(3) freeze-drying the solid bletilla gum in a vacuum freeze-drying device at a temperature lower than-45 ℃ and a vacuum degree lower than 100Pa for 1-12h to obtain a bletilla gum freeze-dried product with a mass water content of lower than 0.1%;
(4) micronizing the rhizoma Bletillae lyophilized product at-15 deg.C for 10-60min with an ultramicro pulverizer under the environment with relative humidity below 10% to obtain rhizoma Bletillae lyophilized powder;
(5) sequentially and quantitatively measuring purified water and bletilla striata lyophilized powder in an organic glass container, screwing a bottle cover, violently shaking for 2-7 minutes, and standing for 2 minutes after the bletilla striata lyophilized powder is uniformly dissolved to obtain the bletilla striata lyophilized powder skin moisturizer.
2. The method for preparing the bletilla striata gel dry powder skin moisturizer as claimed in claim 1, wherein the organic alcohol comprises one or more of ethanol, isopropanol, n-propanol, butanol, ethylene glycol, propylene glycol, glycerol, butylene glycol, hexylene glycol, diethylene glycol, methanol and triethylene glycol.
3. The method for preparing the bletilla striata lyophilized powder skin moisturizer as claimed in claim 1, wherein the operation in the step (5) is carried out as ready-to-use.
4. The method for preparing the bletilla striata gel dry powder skin moisturizer as claimed in claim 1, wherein the purified water is spring water.
5. The method for preparing the bletilla striata gel lyophilized powder skin moisturizer as claimed in claim 1, wherein the organic glass container is sized and shaped for easy use by the average person.
6. The preparation method of the bletilla striata freeze-dried powder skin moisturizer according to claim 1, wherein the mass ratio of the bletilla striata freeze-dried powder to purified water is 1: 80-120.
7. A bletilla striata gel lyophilized powder skin moisturizer which is characterized by being prepared according to the method of any one of claims 1 to 6.
8. The lyophilized bletilla striata skin moisturizer prepared according to any one of claims 1 to 6 and the use method of the lyophilized bletilla striata skin moisturizer according to claim 7 are characterized in that 1 to 3ml of the lyophilized bletilla striata skin moisturizer is taken quantitatively and repeatedly applied to the face, the neck and the hands for 1 to 3 minutes each time and repeated for 5 to 15 times.
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