CN113332380A - A Chinese medicinal composition for treating diabetic nephropathy and preparation method thereof - Google Patents
A Chinese medicinal composition for treating diabetic nephropathy and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of medicine preparation, and discloses a traditional Chinese medicine composition for treating diabetic nephropathy and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following components: 15mg of natural astaxanthin, 0.5g of pure traditional Chinese medicine coptis extract, 3g of bitter gourd extract, 3.0g of cinnamon extract, 11g of astragalus membranaceus, 11g of rhizoma polygonati, 10g of snow ganoderma, 7g of snow ginseng, 7g of young bird, 5g of aster, 16g of berchemia lineate, 10g of pilose asiabell root and 11g of black-bone sheep blood. The preparation method of the traditional Chinese medicine composition for treating diabetic nephropathy is simple, and the prepared traditional Chinese medicine for treating diabetes has good curative effect and no side effect, can effectively treat diabetes, comprehensively condition metabolic disorder, and has a certain repairing effect on pancreatic tissue injury; meanwhile, the balsam pear extract and the cinnamon extract prepared by the preparation method of the balsam pear extract and the preparation method of the cinnamon extract have high quality, so that the quality of the traditional Chinese medicine composition for treating diabetic nephropathy is greatly improved.
Description
Technical Field
The invention belongs to the technical field of medicine preparation, and particularly relates to a traditional Chinese medicine composition for treating diabetic nephropathy and a preparation method thereof.
Background
Diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by a defect in insulin secretion or an impaired biological action, or both. The chronic hyperglycemia results in chronic damage and dysfunction of various tissues, particularly eyes, kidneys, heart, blood vessels and nerves. Diabetes is a chronic disease, complications of the diabetes can affect all organs of the whole body, the complications have strong hiding property, are easy to overlook in the early stage, and the symptoms are revealed, so that the diabetic patients often lose sight and are disabled or even endanger life. Obtaining diabetes means playing a lifelong role; however, the existing traditional Chinese medicine composition for treating diabetic nephropathy has poor treatment effect and side effect; meanwhile, the quality of the bitter gourd extract and the cinnamon extract is poor, so that the quality of the traditional Chinese medicine composition is poor.
In summary, the problems of the prior art are as follows: the existing traditional Chinese medicine composition for treating diabetic nephropathy has poor treatment effect and side effect; meanwhile, the quality of the bitter gourd extract and the cinnamon extract is poor, so that the quality of the traditional Chinese medicine composition is poor.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a traditional Chinese medicine composition for treating diabetic nephropathy and a preparation method thereof.
The invention is realized in such a way that the preparation method of the traditional Chinese medicine composition for treating diabetic nephropathy comprises the following steps:
step one, preparing a coptis extract, a balsam pear extract and a cinnamon extract; weighing natural astaxanthin, pure traditional Chinese medicine coptis chinensis extract, bitter gourd extract, cinnamon extract, astragalus mongholicus, rhizoma polygonati, snow ganoderma, snow ginseng, black-bone sheep blood according to a certain proportion;
the preparation of the balsam pear extract comprises the following steps:
selecting fresh whole bitter gourd fruits without mildew and peculiar smell, slicing, drying, pulverizing into 100 mesh bitter gourd powder, and mixing bitter gourd powder with water;
extracting with low temperature water in extraction tank to obtain extractive solution, filtering under reduced pressure to obtain filtrate, and concentrating the filtrate under reduced pressure to relative density of 1.14 to obtain fructus Momordicae Charantiae extract;
performing ceramic membrane separation on the obtained extract of the bitter gourd by using a ceramic pot, and adsorbing by adopting macroporous resin to remove impurities;
adding enzyme into the fructus Momordicae Charantiae extract after removing impurities, fermenting at low temperature, embedding at nanometer level with specific embedding agent, pulverizing, and sieving to obtain fructus Momordicae Charantiae extract;
step two, respectively drying the weighed raw materials, then crushing the dried raw materials into fine powder, uniformly mixing the fine powder and the fine powder, putting the mixture into a cooking container, adding 600 parts of water, boiling the mixture for 45min at normal pressure, and carrying out filtration treatment to obtain filtrate a and filter residue a for later use;
the filtering treatment comprises the following steps:
the gauze bag is used for containing the boiled liquid; placing the gauze bag into a box frame, and positioning the gauze bag by using a first felt and a second felt;
pushing the extrusion rod to move back and forth linearly to extrude the gauze bag, filtering the liquid medicine through the gauze bag and the filter plate, allowing the liquid medicine to flow into the bottom of the inner cavity of the box frame, and allowing the liquid medicine to flow out through a discharge thick pipe at the bottom of the box frame and a discharge thin pipe at the bottom of the side of the box frame to obtain filtrate a and filter residue a;
step two, adding 400 parts of water into the filter residue a, boiling for 45min at normal pressure, and then filtering to obtain a filtrate b and a filter residue b for later use;
and step three, uniformly mixing the prepared filtrate a and the prepared filtrate b to obtain the traditional Chinese medicine for treating diabetes.
Further, in the first step, the natural astaxanthin, the pure traditional Chinese medicine coptis chinensis extract, the balsam pear extract, the cinnamon extract, the astragalus root, the rhizoma polygonati, the snow ganoderma, the snow ginseng, the bird's tongue, the aster, the berchemia lineate, the root of pilose asiabell and the black-bone sheep blood are weighed according to the proportion and comprise:
weighing raw materials according to 15mg of natural astaxanthin, 0.5g of pure traditional Chinese medicine coptis extract, 3g of bitter gourd extract, 3.0g of cinnamon extract, 11g of astragalus membranaceus, 11g of rhizoma polygonati, 10g of snow ganoderma, 7g of snow ginseng, 7g of bird's tongue, 5g of aster, 16g of berchemia lineata, 10g of pilose asiabell root and 11g of black-bone sheep blood.
Further, the mixing ratio of the balsam pear powder to water is as follows: uniformly mixing according to the mass ratio of 1: 5.
Further, the crushing and sieving to obtain the balsam pear extract comprises: sieving with 80 mesh sieve.
Further, extracting the extract with low-temperature water in the extraction tank to obtain an extract, and filtering the extract under reduced pressure to obtain a filtrate, wherein the filtrate comprises:
the temperature of low-temperature water extraction is 30 ℃; the concentration under reduced pressure is carried out at 30 deg.C and-0.06 MPa.
Further, the ferment is papain, and the embedding medium is pure glue.
Further, the preparation method of the cinnamon extract comprises the following steps:
1) soaking cortex Cinnamomi in water, filtering, separating, and collecting extractive solution and soaked cortex Cinnamomi;
2) mixing the soaked cinnamon with an organic solvent, performing reflux extraction, and collecting a reflux extracting solution;
3) mixing the soaking extractive solution and the refluxing extractive solution to obtain cortex Cinnamomi extract.
Further, the mass ratio of cinnamon to water is 1: 2; the mass ratio of the cinnamon to the organic solvent is 1: 6.
further, the organic solvent is a lower alcohol, preferably ethanol.
Further, the soaking extraction comprises:
the soaking and extracting time is 20 hours; the soaking and extraction temperature is 35 ℃.
Further, the reflux extraction comprises: the reflux extraction time is 5-6 hours.
The invention has the advantages and positive effects that: the preparation method of the traditional Chinese medicine composition for treating diabetic nephropathy is simple, and the prepared traditional Chinese medicine for treating diabetes has good curative effect and no side effect, can effectively treat diabetes, comprehensively condition metabolic disorder, and has a certain repairing effect on pancreatic tissue injury; meanwhile, the balsam pear extract and the cinnamon extract prepared by the preparation method of the balsam pear extract and the preparation method of the cinnamon extract have high quality, so that the quality of the traditional Chinese medicine composition for treating diabetic nephropathy is greatly improved.
Drawings
FIG. 1 is a flow chart of a Chinese medicinal composition for treating diabetic nephropathy and a preparation method thereof.
FIG. 2 is a flow chart of a process for preparing an extract of Momordica charantia provided in the practice of the present invention.
Fig. 3 is a flow chart of a method for extracting an extracting solution by low-temperature water in an extracting tank, filtering the extracting solution under reduced pressure to obtain a filtrate, and concentrating the filtrate under reduced pressure until the relative density is 1.14.
Fig. 4 is a flow chart of a method for preparing cinnamon extract according to the present invention.
Fig. 5 is a flow chart of a method for performing a filtering process in accordance with an embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The application of the principles of the present invention will now be further described with reference to the accompanying drawings.
The traditional Chinese medicine composition for treating diabetic nephropathy provided by the embodiment of the invention comprises the following medicinal materials in parts by mass:
15mg of natural astaxanthin, 0.5g of pure traditional Chinese medicine coptis extract, 3g of bitter gourd extract, 3.0g of cinnamon extract, 11g of astragalus membranaceus, 11g of rhizoma polygonati, 10g of snow ganoderma, 7g of snow ginseng, 7g of young bird, 5g of aster, 16g of berchemia lineate, 10g of pilose asiabell root and 11g of black-bone sheep blood.
As shown in fig. 1, the preparation method of the traditional Chinese medicine composition for treating diabetic nephropathy provided by the embodiment of the present invention comprises the following steps:
s101, preparing a coptis extract, a bitter gourd extract and a cinnamon extract, and weighing natural astaxanthin, a pure traditional Chinese medicine coptis extract, the bitter gourd extract, the cinnamon extract, astragalus membranaceus, rhizoma polygonati, arenaria kansuensis, snow ginseng, black pennywort, aster, berchemia lineate, codonopsis pilosula and black-bone sheep blood according to a proportion;
s102, respectively drying the weighed raw materials, then crushing the dried raw materials into fine powder, uniformly mixing the fine powder and the fine powder, putting the mixture into a cooking container, adding 600 parts of water, boiling the mixture for 45min at normal pressure, and then filtering the mixture to obtain filtrate a and filter residue a for later use;
s103, adding 400 parts of water into the filter residue a, boiling for 45min at normal pressure, and then filtering to obtain a filtrate b and a filter residue b for later use;
s104, uniformly mixing the prepared filtrate a and the prepared filtrate b to obtain the traditional Chinese medicine for treating diabetes.
As shown in fig. 2, the preparation method of the extract of momordica charantia provided by the embodiment of the present invention is as follows:
s201, selecting fresh whole bitter gourd fruits which are not mildewed and have no peculiar smell, slicing, drying, crushing into 100-mesh bitter gourd powder, and uniformly mixing the bitter gourd powder and water according to a mass ratio of 1: 5;
s202, placing the bitter gourd into an extraction tank, extracting the bitter gourd with low-temperature water to obtain an extracting solution, filtering the extracting solution under reduced pressure to obtain a filtrate, and concentrating the filtrate under reduced pressure until the relative density is 1.14 to obtain an extract of the bitter gourd;
s203, performing ceramic membrane separation on the obtained bitter gourd extract by using a ceramic pot, and adsorbing by using macroporous resin to remove impurities;
and S204, adding enzyme into the impurity-removed bitter gourd extract for low-temperature fermentation, carrying out nano-scale embedding by using a specific embedding agent, crushing, and sieving by using a 80-mesh sieve to obtain the bitter gourd extract.
As shown in fig. 3, the extracting at low temperature in the extraction tank provided in the embodiment of the present invention includes extracting to obtain an extracting solution, filtering the extracting solution under reduced pressure to obtain a filtrate, and concentrating the filtrate under reduced pressure until the relative density is 1.14:
s301, carrying out low-temperature water extraction in an extraction tank at 30 ℃ to obtain an extracting solution;
s302, filtering the extracting solution at 30 ℃ and under the pressure of-0.06 Mpa to obtain filtrate, and concentrating the filtrate under the reduced pressure until the relative density is 1.14.
The ferment provided by the embodiment of the invention is papain, and the embedding medium is pure glue.
As shown in fig. 4, the preparation method of the cinnamon extract provided by the embodiment of the present invention is as follows:
s401, soaking cinnamon in water, filtering and separating after soaking and extracting, and respectively collecting a soaking extracting solution and the soaked cinnamon;
s402, mixing the soaked cinnamon with an organic solvent, performing reflux extraction, and collecting a reflux extracting solution;
and S403, mixing the soaking extract and the refluxing extract to obtain the cinnamon extract.
The mass ratio of cinnamon to water provided by the embodiment of the invention is 1: 2; the mass ratio of the cinnamon to the organic solvent is 1: 6.
the organic solvent provided by the embodiment of the invention is low-carbon alcohol, preferably ethanol.
The cinnamon is soaked in water, filtered and separated after soaking and extraction, and soaking extract and soaked cinnamon are respectively collected for processing at the time and temperature:
setting the soaking and extracting time to be 20 hours; the temperature for the soaking extraction was set at 35 ℃.
The reflux extraction time provided by the embodiment of the invention is 5 hours, and preferably 6 hours.
As shown in fig. 5, the filtering process provided by the embodiment of the present invention includes:
s501, containing the boiled liquid by using a gauze bag; placing the gauze bag into a box frame, and positioning the gauze bag by using a first felt and a second felt;
s502, pushing the extrusion rod to move linearly back and forth to extrude the gauze bag, filtering the liquid medicine through the gauze bag and the filter plate, and enabling the liquid medicine to flow into the bottom of the inner cavity of the box frame;
and S503, enabling the filter liquor a and the filter residue a to flow out through a discharge thick pipe at the bottom of the box frame and a discharge thin pipe at the side bottom of the box frame.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (10)
1. A preparation method of a traditional Chinese medicine composition for treating diabetic nephropathy is characterized by comprising the following steps:
step one, preparing a coptis extract, a balsam pear extract and a cinnamon extract; weighing natural astaxanthin, pure traditional Chinese medicine coptis chinensis extract, bitter gourd extract, cinnamon extract, astragalus mongholicus, rhizoma polygonati, snow ganoderma, snow ginseng, black-bone sheep blood according to a certain proportion;
the preparation of the balsam pear extract comprises the following steps:
selecting fresh whole bitter gourd fruits without mildew and peculiar smell, slicing, drying, pulverizing into 100 mesh bitter gourd powder, and mixing bitter gourd powder with water;
extracting with low temperature water in extraction tank to obtain extractive solution, filtering under reduced pressure to obtain filtrate, and concentrating the filtrate under reduced pressure to relative density of 1.14 to obtain fructus Momordicae Charantiae extract;
performing ceramic membrane separation on the obtained extract of the bitter gourd by using a ceramic pot, and adsorbing by adopting macroporous resin to remove impurities;
adding enzyme into the fructus Momordicae Charantiae extract after removing impurities, fermenting at low temperature, embedding at nanometer level with specific embedding agent, pulverizing, and sieving to obtain fructus Momordicae Charantiae extract;
step two, respectively drying the weighed raw materials, then crushing the dried raw materials into fine powder, uniformly mixing the fine powder and the fine powder, putting the mixture into a cooking container, adding 600 parts of water, boiling the mixture for 45min at normal pressure, and carrying out filtration treatment to obtain filtrate a and filter residue a for later use;
the filtering treatment comprises the following steps:
the gauze bag is used for containing the boiled liquid; placing the gauze bag into a box frame, and positioning the gauze bag by using a first felt and a second felt;
pushing the extrusion rod to move back and forth linearly to extrude the gauze bag, filtering the liquid medicine through the gauze bag and the filter plate, allowing the liquid medicine to flow into the bottom of the inner cavity of the box frame, and allowing the liquid medicine to flow out through a discharge thick pipe at the bottom of the box frame and a discharge thin pipe at the bottom of the side of the box frame to obtain filtrate a and filter residue a;
step two, adding 400 parts of water into the filter residue a, boiling for 45min at normal pressure, and then filtering to obtain a filtrate b and a filter residue b for later use;
and step three, uniformly mixing the prepared filtrate a and the prepared filtrate b to obtain the traditional Chinese medicine for treating diabetes.
2. The method according to claim 1, wherein the step of weighing the natural astaxanthin, the pure Chinese herbal coptidis rhizoma extract, the balsam pear extract, the cinnamon extract, the astragalus membranaceus, the polygonatum sibiricum, the snow ganoderma lucidum, the snow ginseng, the bird's tongue, the aster, the berchemia lineate, the wenshen root and the black-bone goat blood in proportion comprises the following steps:
weighing raw materials according to 15mg of natural astaxanthin, 0.5g of pure traditional Chinese medicine coptis extract, 3g of bitter gourd extract, 3.0g of cinnamon extract, 11g of astragalus membranaceus, 11g of rhizoma polygonati, 10g of snow ganoderma, 7g of snow ginseng, 7g of bird's tongue, 5g of aster, 16g of berchemia lineata, 10g of pilose asiabell root and 11g of black-bone sheep blood.
3. The preparation method of the traditional Chinese medicine composition for treating diabetic nephropathy according to claim 1, wherein the mixing ratio of the balsam pear powder and water is as follows: uniformly mixing according to the mass ratio of 1: 5.
4. The method of claim 1, wherein the pulverizing and sieving to obtain the extract of Momordica charantia comprises: sieving with 80 mesh sieve.
5. The method of claim 1, wherein the extracting tank is used for extracting the low-temperature water to obtain an extracting solution, and the filtering of the extracting solution under reduced pressure to obtain a filtrate comprises:
the temperature of low-temperature water extraction is 30 ℃; the concentration under reduced pressure is carried out at 30 deg.C and-0.06 MPa.
6. The method of claim 1, wherein the enzyme is papain and the embedding agent is pure gelatin.
7. The method of claim 1, wherein the cinnamon extract is prepared by the following steps:
1) soaking cortex Cinnamomi in water, filtering, separating, and collecting extractive solution and soaked cortex Cinnamomi;
2) mixing the soaked cinnamon with an organic solvent, performing reflux extraction, and collecting a reflux extracting solution;
3) mixing the soaking extractive solution and the refluxing extractive solution to obtain cortex Cinnamomi extract.
8. The preparation method of the traditional Chinese medicine composition for treating diabetic nephropathy of claim 1, wherein the mass ratio of cinnamon to water is 1: 2; the mass ratio of the cinnamon to the organic solvent is 1: 6.
9. the method of claim 7, wherein the organic solvent is a lower alcohol, preferably ethanol.
10. The method of claim 7, wherein the soaking and extracting comprises:
the soaking and extracting time is 20 hours; the soaking and extraction temperature is 35 ℃.
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| CN115089642A (en) * | 2022-06-27 | 2022-09-23 | 上海市普陀区中心医院 | Preparation method of traditional Chinese medicine for treating type 2 diabetes |
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| CN104258064A (en) * | 2014-10-23 | 2015-01-07 | 香格里拉糖尿病研究所 | Traditional Chinese medicine for treating diabetes and preparation method thereof |
| CN108786235A (en) * | 2018-06-15 | 2018-11-13 | 温州医科大学 | Shunting Chinese medicine dreg filter and its filter method |
| CN108851076A (en) * | 2018-06-06 | 2018-11-23 | 李云逸 | A kind of preparation method and application of Bitter Melon P.E |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104258064A (en) * | 2014-10-23 | 2015-01-07 | 香格里拉糖尿病研究所 | Traditional Chinese medicine for treating diabetes and preparation method thereof |
| CN108851076A (en) * | 2018-06-06 | 2018-11-23 | 李云逸 | A kind of preparation method and application of Bitter Melon P.E |
| CN108786235A (en) * | 2018-06-15 | 2018-11-13 | 温州医科大学 | Shunting Chinese medicine dreg filter and its filter method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115089642A (en) * | 2022-06-27 | 2022-09-23 | 上海市普陀区中心医院 | Preparation method of traditional Chinese medicine for treating type 2 diabetes |
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