CN105535797A - Traditional Chinese medicine composition for treating mental retardation and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating mental retardation and preparation method thereof Download PDF

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Publication number
CN105535797A
CN105535797A CN201610083777.8A CN201610083777A CN105535797A CN 105535797 A CN105535797 A CN 105535797A CN 201610083777 A CN201610083777 A CN 201610083777A CN 105535797 A CN105535797 A CN 105535797A
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parts
radix
rhizoma
chinese medicine
medicine composition
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李墨花
田雪
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Individual
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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  • Medicines Containing Plant Substances (AREA)

Abstract

The invention claims protection of a traditional Chinese medicine composition for treating mental retardation and a preparation method thereof. The traditional Chinese medicine composition is characterized by consisting of the following raw materials: tortoise shell, white peony root, codonopsis pilosula, Chinese angelica, spina date seed, platycladi seed, sharpleaf galangal fruit, grass leaf sweelflag rhizome, oriental waterplantain rhizome, calculus bovis factitious, saffron, eucommia bark, cornu cervi pantotrichum, heterophylly faalsestarwort root, largehead atractylodes rhizome, tuckahoe, villous amomum fruit, hinleaf milkwort root-bark, coptis root, danshen root, milkvetch root, manyflower solomonseal rhizome, Szechuan lovage rhizome, barbary wolfberry fruit, desertliving cistanche, Chinese caterpillar fungus, dwarf lilyturf tuber, manyprickle acanthopanax root, rhodiola rosea, kudzuvine root, tall gastrodia tuber, root of redsepal eveningprimrose, raw peach blossom, mulberry fruit, pine leaf, and dried longan pulp. In the preparation method, tablets of the traditional Chinese medicine composition are prepared by using ultraviolet sterilization, radiation sterilization, and pasteurization.

Description

A kind of Chinese medicine composition for the treatment of mental retardation and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine preparation, specifically a kind of Chinese medicine composition for the treatment of mental retardation and preparation method thereof.
Background technology
Current mental retardation disease, the reason that doctor trained in Western medicine is analyzed is many, and what have thinks that the impact of hormonal readiness deficiency is grown, and has plenty of congenital factors, has plenty of exopathogenic factor in growth course and cause, but imposes Western medicine and not can produce effect.The traditional Chinese medical science then thinks that mental retardation is because brain is become homeless foster, may be specifically that the endogenous causes of ill such as, blood-stasis internal-depression obstructed by deficiency of kidney-essence, deficiency of marrow-reservoir, blood vessels cause, what outer disease can be seen have, and dizzy headache, the hypophrenia, dull mind, gait difficulty, soreness of waist foot are soft, Hiccough and deaf, blurring of vision, forgetful insomnia, thready and stringy pulse and empty.From pharmacology, then can consider with disperse blood stasis and dredge collateral, promoting blood circulation, fill up brain, fill up kidney essense and angularly treat.In prescription, the medical material can selected disperse blood stasis and dredge collateral, promoting blood circulation, fill up brain, fill up kidney essense, and supplement fills QI and blood and all kinds of trophism medical materials containing useful ketone and enzyme material of nourishing the brain and improving intelligence are provided, brain foster situation of becoming homeless is improved, the current treatment to mental retardation disease is main mainly with Western medicine, but patient easily produces dependency to medicine, and Western medicine toxic and side effects is strong, as can be produced headache, xerostomia, feels sick and the phenomenon such as hepatic and renal function exception.Whether serious symptom mental illness can by chemical classes cured substance, still belong to unknown, and side effect is a lot, impact is all had, more seriously, from the angle of the traditional Chinese medical science on cardiovascular system, hemopoietic system, liver, endocrine, nervous system etc., long-term taking chemical classes Western medicine can cause irritability stasis, Rong Wei is obstructed, cause patient to be in a very depressed state further, do not like diet, the negative effect that the patient that part anxious state of mind is large can cause is larger.Lack the special Chinese medicine composition medicine of special for treating mental retardation in currently available technology, existing medicine the supplementary brain that rises foster Chinese medicine composition of becoming homeless comprehensive all not.
Summary of the invention
The present invention mainly solves technical problem existing in prior art, thus provides a kind of special medicine for Patients with Mental Retardation, is aided with the special medicinal material that Recent study shows to have significant curative effect simultaneously, and the Chinese medicine composition of allotment.Said composition can either be used for the treatment of separately, also in the process coordinating western medicine, can alleviate and remove the side effect that Western medicine causes patient body.
Above-mentioned technical problem of the present invention is mainly solved by following technical proposals:
A kind of Chinese medicine composition for the treatment of mental retardation, it is characterized in that: described Chinese medicine composition is made up of each component of following weight parts proportioning: Carapax Et Plastrum Testudinis 3-6 part, Radix Paeoniae Alba 12-15 part, Radix Codonopsis 9-12 part, Radix Angelicae Sinensis 2-5 part, Semen Ziziphi Spinosae 2-5 part, Semen Platycladi 3-6 part, Fructus Alpiniae Oxyphyllae 1-5 part, Rhizoma Acori Graminei 3-6 part, Rhizoma Alismatis 2-5 part, artificial Calculus Bovis 2-4 part, Stigma Croci 1-3 part, Cortex Eucommiae 2-4 part, Cornu Cervi Pantotrichum 1-3 part, Radix Pseudostellariae 1-5 part, Rhizoma Atractylodis Macrocephalae 1-3 part, Poria 2-5 part, Fructus Amomi 1-3 part, Radix Polygalae 3-9 part, Rhizoma Coptidis 1-5 part, Radix Salviae Miltiorrhizae 6-12 part, Radix Astragali 3-6 part, Rhizoma Polygonati 1-5 part, Rhizoma Chuanxiong 3-9 part, Fructus Lycii 2-6 part, Herba Cistanches 1-5 part, Cordyceps 1-3 part, Radix Ophiopogonis 2-5 part, Radix Et Caulis Acanthopanacis Senticosi 3-9 part, Radix Rhodiolae 3-6 part, Radix Puerariae 3-15 part, Rhizoma Gastrodiae 4-20 part, Radix Oenotherae erythrosepalae 3-15 part, raw Flos persicae 3-15 part, Fructus Mori 3-15 part, Folium Pini 3-15 part, Arillus Longan 5-20 part.
Further, described Chinese medicine composition is made up of each component of following weight parts proportioning:
Carapax Et Plastrum Testudinis 4-6 part, Radix Paeoniae Alba 12-14 part, Radix Codonopsis 9-11 part, Radix Angelicae Sinensis 2-4 part, Semen Ziziphi Spinosae 2-4 part, Semen Platycladi 3-5 part, Fructus Alpiniae Oxyphyllae 1-3 part, Rhizoma Acori Graminei 3-5 part, Rhizoma Alismatis 2-4 part, artificial Calculus Bovis 2-3 part, Stigma Croci 1-2 part, Cortex Eucommiae 2-3 part, Cornu Cervi Pantotrichum 1-2 part, Radix Pseudostellariae 1-3 part, Rhizoma Atractylodis Macrocephalae 1-2 part, Poria 2-3 part, Fructus Amomi 1-2 part, Radix Polygalae 3-6 part, Rhizoma Coptidis 1-3 part, Radix Salviae Miltiorrhizae 6-9 part, Radix Astragali 3-5 part, Rhizoma Polygonati 1-3 part, Rhizoma Chuanxiong 3-6 part, Fructus Lycii 2-5 part, Herba Cistanches 1-3 part, Cordyceps 1-2 part, Radix Ophiopogonis 2-4 part, Radix Et Caulis Acanthopanacis Senticosi 3-6 part, Radix Rhodiolae 3-5 part, Radix Puerariae 12-15 part, Rhizoma Gastrodiae 12-20 part, Radix Oenotherae erythrosepalae 9-15 part, raw Flos persicae 9-15 part, Fructus Mori 9-15 part, Folium Pini 9-15 part, Arillus Longan 9-20 part.
Further, described Chinese medicine composition is made up of each component of following weight parts proportioning: Carapax Et Plastrum Testudinis 5 parts, the Radix Paeoniae Alba 12 parts, Radix Codonopsis 10 parts, Radix Angelicae Sinensis 3 parts, Semen Ziziphi Spinosae 3 parts, Semen Platycladi 4 parts, Fructus Alpiniae Oxyphyllae 2 parts, Rhizoma Acori Graminei 4 parts, Rhizoma Alismatis 3 parts, artificial Calculus Bovis 2 parts, Stigma Croci 1 part, the Cortex Eucommiae 2 parts, 1 part, Cornu Cervi Pantotrichum, Radix Pseudostellariae 2 parts, the Rhizoma Atractylodis Macrocephalae 2 parts, 2 parts, Poria, Fructus Amomi 1 part, Radix Polygalae 5 parts, Rhizoma Coptidis 2 parts, Radix Salviae Miltiorrhizae 8 parts, the Radix Astragali 4 parts, Rhizoma Polygonati 2 parts, Rhizoma Chuanxiong 5 parts, Fructus Lycii 4 parts, Herba Cistanches 2 parts, Cordyceps 2 parts, Radix Ophiopogonis 3 parts, Radix Et Caulis Acanthopanacis Senticosi 5 parts, Radix Rhodiolae 4 parts, Radix Puerariae 14 parts, 18 parts, Rhizoma Gastrodiae, Radix Oenotherae erythrosepalae 12 parts, raw 12 parts, Flos persicae, 12 parts, Fructus Mori, 12 parts, Folium Pini, Arillus Longan 18 parts.Or, described Chinese medicine composition is made up of each component of following weight parts proportioning: Carapax Et Plastrum Testudinis 6 parts, the Radix Paeoniae Alba 14 parts, Radix Codonopsis 11 parts, Radix Angelicae Sinensis 4 parts, Semen Ziziphi Spinosae 4 parts, Semen Platycladi 5 parts, Fructus Alpiniae Oxyphyllae 3 parts, Rhizoma Acori Graminei 5 parts, Rhizoma Alismatis 4 parts, artificial Calculus Bovis 3 parts, Stigma Croci 2 parts, the Cortex Eucommiae 3 parts, 2 parts, Cornu Cervi Pantotrichum, Radix Pseudostellariae 3 parts, the Rhizoma Atractylodis Macrocephalae 2 parts, 3 parts, Poria, Fructus Amomi 2 parts, Radix Polygalae 6 parts, Rhizoma Coptidis 3 parts, Radix Salviae Miltiorrhizae 9 parts, the Radix Astragali 5 parts, Rhizoma Polygonati 3 parts, Rhizoma Chuanxiong 6 parts, Fructus Lycii 5 parts, Herba Cistanches 3 parts, Cordyceps 2 parts, Radix Ophiopogonis 4 parts, Radix Et Caulis Acanthopanacis Senticosi 6 parts, Radix Rhodiolae 5 parts, Radix Puerariae 15 parts, 20 parts, Rhizoma Gastrodiae, Radix Oenotherae erythrosepalae 15 parts, raw 15 parts, Flos persicae, 15 parts, Fructus Mori, 15 parts, Folium Pini, Arillus Longan 20 parts.
A kind of Chinese medicine composition for the treatment of mental retardation, it is characterized in that, choose the traditional Chinese medicine composite of foregoing weight, and be prepared according to following steps and form: 1) take Carapax Et Plastrum Testudinis, the Radix Paeoniae Alba, Radix Codonopsis, Radix Angelicae Sinensis, Semen Ziziphi Spinosae, Semen Platycladi, Fructus Alpiniae Oxyphyllae, Rhizoma Acori Graminei, Rhizoma Alismatis, artificial Calculus Bovis, Stigma Croci, the Cortex Eucommiae, Cornu Cervi Pantotrichum by weight, clean and drying for standby, 2) take the Rhizoma Atractylodis Macrocephalae, Poria, Fructus Amomi, Radix Polygalae, Rhizoma Coptidis, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Polygonati, Rhizoma Chuanxiong, Herba Cistanches, Cordyceps, Radix Ophiopogonis, Radix Puerariae by weight, clean and drying for standby, 3) step (1) gained to be cleaned and dry medical material co-grinding crosses 100-150 mesh sieve, obtain former powder A, and stir and to sterilize 30-60min with ultra violet lamp, step (2) gained to be cleaned and dry medical material co-grinding crosses 100-150 mesh sieve, obtain former powder B, and stir and use co-60 radiation sterilizing, dosage 1Kgy, 4) by former powder A and former powder B ratio mixing by weight, add distilled water reflux, extract, 3-5 time containing 30-60% ethanol, the alcohol reflux 0.3-1 hour of each 2-5 times amount, filter merge extractive liquid, and reclaim ethanol, be concentrated into relative density 1.2-1.5, add 75% appropriate amount of ethanol, medicinal liquid alcohol content is made to promote one times, limit edged fully stirs, leave standstill 12-24h, filter, reclaim ethanol extremely without alcohol taste, obtain clear paste, add DDW again to containing crude drug 0.5-4g/ml, medicinal liquid adds 1% active carbon, after heated and boiled, cooling, stand at low temperature 6-12h after filtering, obtain water-soluble medicine soup, elimination medicinal residues obtain fried medicinal liquid, 5) Radix Pseudostellariae, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Radix Rhodiolae, Rhizoma Gastrodiae, Radix Oenotherae erythrosepalae, raw Flos persicae, Fructus Mori, Folium Pini, Arillus Longan all to be shelled peeling enucleation, squeeze into juice, and be mixed to get raw pharmacy liquid, life pharmacy liquid is heated to 65 ~ 75 DEG C, and keeps this temperature 30-60min to be cooled to 5 DEG C rapidly later, 6) by aforementioned for step (4) gained fried medicinal liquid and step (5) sterilized after the mixing of raw pharmacy liquid, slow evaporation is concentrated becomes thickness ointment, obtains described Chinese medicine composition.
Further, cleaning and drying for standby in described step (1), (2), what refer to washes repeatedly with distilled water, and described drying is not at high temperature carry out drying; Described step (6) is by after aforementioned fried medicinal liquid and raw pharmacy liquid mixing, carry out multiple times of filtration again to remove medicinal residues fully, carry out evaporation and concentration again, and in evaporating concentration process, suitably add adjuvant, when residual moisture is between 5%-10%, the preparation of tablet is carried out by the mode of mechanical presses, humidity strip drying is carried out under extraordinary air flow communication, dry 3-5 days at 30-40 DEG C, sampling 2-3% determines tablet whether sufficiently dry, obtains the Chinese medicine composition tablet made.
Further, aforementioned medical material co-grinding step (1) gained being cleaned also drying crosses 100-150 mesh sieve, obtain the step of former powder A, co-grinding is specifically as follows following steps: add yellow wine and mix thoroughly, vexed 30-60 minute, chopping, fry to micro-yellow degree of being with little fire, take out dry, smash into mixing fine powders to pieces, cross 100-150 mesh sieve, obtain former powder A.
Further, aforementioned medical material co-grinding step (2) gained being cleaned also drying crosses 100-150 mesh sieve, obtain former powder B, be specifically as follows following steps: step (2) gained is cleaned also dry medical material and be placed in traditional Chinese medicine drying machine, dry 50-100 minute, takes out, is ground into fine powder, cross 100-150 mesh sieve, obtain former powder B.
Further, aforementionedly carry out multiple times of filtration again to remove the step of medicinal residues fully by after aforementioned fried medicinal liquid and raw pharmacy liquid mixing, according to circumstances choose, if fried medicinal liquid and raw pharmacy liquid are all without any medicinal residues, precipitation etc. is not produced after mixing yet, then without the need to carrying out, if still there is precipitation or floccule, then this step can be carried out.The adjuvant added in evaporation and concentration, as fructose, crystal sugar, Mel, starch, cyclodextrin etc., is all for covering or offset the common adjuvant that Chinese medicine bitter taste is master.
Compared with prior art, the invention has the advantages that: the brain can effectively treating and improve Patients with Mental Retardation is become homeless foster situation, or the situation of toxic and side effects that causes of long-term taking Western medicine and the Chinese medicine composition allocated.Said composition can either be used for the treatment of mental retardation separately, also in the process coordinating western medicine, can alleviate and remove the side effect that Western medicine causes patient body.
Detailed description of the invention
Below the preferred embodiments of the present invention are described in detail, can be easier to make advantages and features of the invention be readily appreciated by one skilled in the art, thus more explicit defining is made to protection scope of the present invention.
Embodiment 1
A kind of Chinese medicine composition for the treatment of mental retardation is made up of each component of following weight parts proportioning: Carapax Et Plastrum Testudinis 5 parts, the Radix Paeoniae Alba 12 parts, Radix Codonopsis 10 parts, Radix Angelicae Sinensis 3 parts, Semen Ziziphi Spinosae 3 parts, Semen Platycladi 4 parts, Fructus Alpiniae Oxyphyllae 2 parts, Rhizoma Acori Graminei 4 parts, Rhizoma Alismatis 3 parts, artificial Calculus Bovis 2 parts, Stigma Croci 1 part, the Cortex Eucommiae 2 parts, 1 part, Cornu Cervi Pantotrichum, Radix Pseudostellariae 2 parts, the Rhizoma Atractylodis Macrocephalae 2 parts, 2 parts, Poria, Fructus Amomi 1 part, Radix Polygalae 5 parts, Rhizoma Coptidis 2 parts, Radix Salviae Miltiorrhizae 8 parts, the Radix Astragali 4 parts, Rhizoma Polygonati 2 parts, Rhizoma Chuanxiong 5 parts, Fructus Lycii 4 parts, Herba Cistanches 2 parts, Cordyceps 2 parts, Radix Ophiopogonis 3 parts, Radix Et Caulis Acanthopanacis Senticosi 5 parts, Radix Rhodiolae 4 parts, Radix Puerariae 14 parts, 18 parts, Rhizoma Gastrodiae, Radix Oenotherae erythrosepalae 12 parts, raw 12 parts, Flos persicae, 12 parts, Fructus Mori, 12 parts, Folium Pini, Arillus Longan 18 parts.
A kind of preparation method for the treatment of the Chinese medicine composition of mental retardation, it is characterized in that, choose the traditional Chinese medicine composite of foregoing weight, and be prepared according to following steps and form: 1) take Carapax Et Plastrum Testudinis, the Radix Paeoniae Alba, Radix Codonopsis, Radix Angelicae Sinensis, Semen Ziziphi Spinosae, Semen Platycladi, Fructus Alpiniae Oxyphyllae, Rhizoma Acori Graminei, Rhizoma Alismatis, artificial Calculus Bovis, Stigma Croci, the Cortex Eucommiae, Cornu Cervi Pantotrichum by weight, clean and drying for standby, 2) take the Rhizoma Atractylodis Macrocephalae, Poria, Fructus Amomi, Radix Polygalae, Rhizoma Coptidis, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Polygonati, Rhizoma Chuanxiong, Herba Cistanches, Cordyceps, Radix Ophiopogonis, Radix Puerariae by weight, clean and drying for standby, 3) step (1) gained to be cleaned and dry medical material co-grinding crosses 100 mesh sieves, obtain former powder A, and stir and to sterilize 30min with ultra violet lamp, by step (2), gained is cleaned and dry medical material co-grinding crosses 100 mesh sieves, obtains former powder B, and stirs and use co-60 radiation sterilizing, dosage 1Kgy, 4) by former powder A and former powder B ratio mixing by weight, add the distilled water reflux, extract, 3 times containing 30% ethanol, the alcohol reflux of each use 3 times amount 0.3 hour, filter merge extractive liquid, and reclaim ethanol, be concentrated into relative density 1.2, add 75% appropriate amount of ethanol, medicinal liquid alcohol content is made to promote one times, limit edged fully stirs, leave standstill 12h, filter, reclaim ethanol extremely without alcohol taste, obtain clear paste, add DDW again to containing crude drug 1g/ml, medicinal liquid adds 1% active carbon, after heated and boiled, cooling, stand at low temperature 6h after filtering, obtain water-soluble medicine soup, elimination medicinal residues obtain fried medicinal liquid, 5) Radix Pseudostellariae, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Radix Rhodiolae, Rhizoma Gastrodiae, Radix Oenotherae erythrosepalae, raw Flos persicae, Fructus Mori, Folium Pini, Arillus Longan all to be shelled peeling enucleation, squeeze into juice, and be mixed to get raw pharmacy liquid, life pharmacy liquid is heated to 65 DEG C, and keeping this temperature 30min to be cooled to 5 DEG C rapidly later, this is the embody rule belonging to pasteurization, 6) by aforementioned for step (4) gained fried medicinal liquid and step (5) sterilized after the mixing of raw pharmacy liquid, slow evaporation is concentrated becomes thickness ointment, obtains described Chinese medicine composition.Cleaning and drying for standby in described step (1), (2), what refer to washes repeatedly with distilled water, and described drying is not at high temperature carry out drying; Described step (6) is by after aforementioned fried medicinal liquid and raw pharmacy liquid mixing, carry out multiple times of filtration again to remove medicinal residues fully, carry out evaporation and concentration again, and in evaporating concentration process, suitably add adjuvant, residual moisture at 5%-6% time, carry out the preparation of tablet by the mode of mechanical presses, humidity strip drying is carried out under extraordinary air flow communication, at 30-40 DEG C dry 3 days, sampling 2-3% determined tablet whether sufficiently dry, obtains the Chinese medicine composition tablet made.
Embodiment 2
A kind of Chinese medicine composition for the treatment of mental retardation is made up of each component of following weight parts proportioning: Carapax Et Plastrum Testudinis 6 parts, the Radix Paeoniae Alba 14 parts, Radix Codonopsis 11 parts, Radix Angelicae Sinensis 4 parts, Semen Ziziphi Spinosae 4 parts, Semen Platycladi 5 parts, Fructus Alpiniae Oxyphyllae 3 parts, Rhizoma Acori Graminei 5 parts, Rhizoma Alismatis 4 parts, artificial Calculus Bovis 3 parts, Stigma Croci 2 parts, the Cortex Eucommiae 3 parts, 2 parts, Cornu Cervi Pantotrichum, Radix Pseudostellariae 3 parts, the Rhizoma Atractylodis Macrocephalae 2 parts, 3 parts, Poria, Fructus Amomi 2 parts, Radix Polygalae 6 parts, Rhizoma Coptidis 3 parts, Radix Salviae Miltiorrhizae 9 parts, the Radix Astragali 5 parts, Rhizoma Polygonati 3 parts, Rhizoma Chuanxiong 6 parts, Fructus Lycii 5 parts, Herba Cistanches 3 parts, Cordyceps 2 parts, Radix Ophiopogonis 4 parts, Radix Et Caulis Acanthopanacis Senticosi 6 parts, Radix Rhodiolae 5 parts, Radix Puerariae 15 parts, 20 parts, Rhizoma Gastrodiae, Radix Oenotherae erythrosepalae 15 parts, raw 15 parts, Flos persicae, 15 parts, Fructus Mori, 15 parts, Folium Pini, Arillus Longan 20 parts.
A kind of preparation method for the treatment of the Chinese medicine composition of mental retardation, it is characterized in that, choose the traditional Chinese medicine composite of foregoing weight, and be prepared according to following steps and form: 1) take Carapax Et Plastrum Testudinis, the Radix Paeoniae Alba, Radix Codonopsis, Radix Angelicae Sinensis, Semen Ziziphi Spinosae, Semen Platycladi, Fructus Alpiniae Oxyphyllae, Rhizoma Acori Graminei, Rhizoma Alismatis, artificial Calculus Bovis, Stigma Croci, the Cortex Eucommiae, Cornu Cervi Pantotrichum by weight, clean and drying for standby, 2) take the Rhizoma Atractylodis Macrocephalae, Poria, Fructus Amomi, Radix Polygalae, Rhizoma Coptidis, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Polygonati, Rhizoma Chuanxiong, Herba Cistanches, Cordyceps, Radix Ophiopogonis, Radix Puerariae by weight, clean and drying for standby, 3) step (1) gained to be cleaned and dry medical material co-grinding crosses 120 mesh sieves, obtain former powder A, and stir and to sterilize 45min with ultra violet lamp, by step (2), gained is cleaned and dry medical material co-grinding crosses 120 mesh sieves, obtains former powder B, and stirs and use co-60 radiation sterilizing, dosage 1Kgy, 4) by former powder A and former powder B ratio mixing by weight, add the distilled water reflux, extract, 4 times containing 45% ethanol, the alcohol reflux of each use 4 times amount 0.8 hour, filter merge extractive liquid, and reclaim ethanol, be concentrated into relative density 1.35, add 75% appropriate amount of ethanol, medicinal liquid alcohol content is made to promote one times, limit edged fully stirs, leave standstill 18h, filter, reclaim ethanol extremely without alcohol taste, obtain clear paste, add DDW again to containing crude drug 2g/ml, medicinal liquid adds 1% active carbon, after heated and boiled, cooling, stand at low temperature 9h after filtering, obtain water-soluble medicine soup, elimination medicinal residues obtain fried medicinal liquid, 5) Radix Pseudostellariae, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Radix Rhodiolae, Rhizoma Gastrodiae, Radix Oenotherae erythrosepalae, raw Flos persicae, Fructus Mori, Folium Pini, Arillus Longan all to be shelled peeling enucleation, squeeze into juice, and be mixed to get raw pharmacy liquid, life pharmacy liquid is heated to 70 DEG C, and keeping this temperature 45min to be cooled to 5 DEG C rapidly later, this is the embody rule belonging to pasteurization, 6) by aforementioned for step (4) gained fried medicinal liquid and step (5) sterilized after the mixing of raw pharmacy liquid, slow evaporation is concentrated becomes thickness ointment, obtains described Chinese medicine composition.Cleaning and drying for standby in described step (1), (2), what refer to washes repeatedly with distilled water, and described drying is not at high temperature carry out drying; Described step (6) is by after aforementioned fried medicinal liquid and raw pharmacy liquid mixing, carry out multiple times of filtration again to remove medicinal residues fully, carry out evaporation and concentration again, and in evaporating concentration process, suitably add adjuvant, when residual moisture is between 7-8%, carry out the preparation of tablet by the mode of mechanical presses, humidity strip drying is carried out under extraordinary air flow communication, at 30-40 DEG C dry 4 days, sampling 2-3% determined tablet whether sufficiently dry, obtains the Chinese medicine composition tablet made.
Embodiment 3
A kind of Chinese medicine composition for the treatment of mental retardation, it is characterized in that: described Chinese medicine composition is made up of each component of following weight parts proportioning: Carapax Et Plastrum Testudinis 3 parts, the Radix Paeoniae Alba 12 parts, Radix Codonopsis 9 parts, Radix Angelicae Sinensis 2 parts, Semen Ziziphi Spinosae 2 parts, Semen Platycladi 3 parts, Fructus Alpiniae Oxyphyllae 1 part, Rhizoma Acori Graminei 3 parts, Rhizoma Alismatis 2 parts, artificial Calculus Bovis 2 parts, Stigma Croci 1 part, the Cortex Eucommiae 2 parts, 1 part, Cornu Cervi Pantotrichum, Radix Pseudostellariae 1 part, the Rhizoma Atractylodis Macrocephalae 1 part, 2 parts, Poria, Fructus Amomi 1 part, Radix Polygalae 3 parts, Rhizoma Coptidis 1 part, Radix Salviae Miltiorrhizae 6 parts, the Radix Astragali 3 parts, Rhizoma Polygonati 1 part, Rhizoma Chuanxiong 3 parts, Fructus Lycii 2 parts, Herba Cistanches 1 part, Cordyceps 1 part, Radix Ophiopogonis 2 parts, Radix Et Caulis Acanthopanacis Senticosi 3 parts, Radix Rhodiolae 3 parts, Radix Puerariae 3 parts, 4 parts, Rhizoma Gastrodiae, Radix Oenotherae erythrosepalae 3 parts, raw 3 parts, Flos persicae, 3 parts, Fructus Mori, 3 parts, Folium Pini, Arillus Longan 5 parts.
A kind of preparation method for the treatment of the Chinese medicine composition of mental retardation, it is characterized in that, choose the traditional Chinese medicine composite of foregoing weight, and be prepared according to following steps and form: 1) take Carapax Et Plastrum Testudinis, the Radix Paeoniae Alba, Radix Codonopsis, Radix Angelicae Sinensis, Semen Ziziphi Spinosae, Semen Platycladi, Fructus Alpiniae Oxyphyllae, Rhizoma Acori Graminei, Rhizoma Alismatis, artificial Calculus Bovis, Stigma Croci, the Cortex Eucommiae, Cornu Cervi Pantotrichum by weight, clean and drying for standby, 2) take the Rhizoma Atractylodis Macrocephalae, Poria, Fructus Amomi, Radix Polygalae, Rhizoma Coptidis, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Polygonati, Rhizoma Chuanxiong, Herba Cistanches, Cordyceps, Radix Ophiopogonis, Radix Puerariae by weight, clean and drying for standby, 3) step (1) gained to be cleaned and dry medical material co-grinding crosses 150 mesh sieves, obtain former powder A, and stir and to sterilize 60min with ultra violet lamp, by step (2), gained is cleaned and dry medical material co-grinding crosses 150 mesh sieves, obtains former powder B, and stirs and use co-60 radiation sterilizing, dosage 1Kgy, 4) by former powder A and former powder B ratio mixing by weight, add the distilled water reflux, extract, 5 times containing 60% ethanol, the alcohol reflux of each use 5 times amount 1 hour, filter merge extractive liquid, and reclaim ethanol, be concentrated into relative density 1.5, add 75% appropriate amount of ethanol, medicinal liquid alcohol content is made to promote one times, limit edged fully stirs, leave standstill 24h, filter, reclaim ethanol extremely without alcohol taste, obtain clear paste, add DDW again to containing crude drug 4g/ml, medicinal liquid adds 1% active carbon, after heated and boiled, cooling, stand at low temperature 12h after filtering, obtain water-soluble medicine soup, elimination medicinal residues obtain fried medicinal liquid, 5) Radix Pseudostellariae, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Radix Rhodiolae, Rhizoma Gastrodiae, Radix Oenotherae erythrosepalae, raw Flos persicae, Fructus Mori, Folium Pini, Arillus Longan all to be shelled peeling enucleation, squeeze into juice, and be mixed to get raw pharmacy liquid, life pharmacy liquid is heated to 75 DEG C, and keeping this temperature 60min to be cooled to 5 DEG C rapidly later, this is the embody rule belonging to pasteurization, 6) by aforementioned for step (4) gained fried medicinal liquid and step (5) sterilized after the mixing of raw pharmacy liquid, slow evaporation is concentrated becomes thickness ointment, obtains described Chinese medicine composition.Cleaning and drying for standby in described step (1), (2), what refer to washes repeatedly with distilled water, and described drying is not at high temperature carry out drying; Described step (6) is by after aforementioned fried medicinal liquid and raw pharmacy liquid mixing, carry out multiple times of filtration again to remove medicinal residues fully, carry out evaporation and concentration again, and in evaporating concentration process, suitably add adjuvant, when residual moisture is between 8%-10%, the preparation of tablet is carried out by the mode of mechanical presses, humidity strip drying is carried out under extraordinary air flow communication, drying 5 days at 30-40 DEG C, sampling 2-3% determines tablet whether sufficiently dry, obtains the Chinese medicine composition tablet made.
The above, be only the specific embodiment of the present invention, but protection scope of the present invention is not limited thereto, and any change of expecting without creative work or replacement, all should be encompassed within protection scope of the present invention.Therefore, the protection domain that protection scope of the present invention should limit with claims is as the criterion.

Claims (6)

1. treat a Chinese medicine composition for mental retardation, it is characterized in that: described Chinese medicine composition is made up of each component of following weight parts proportioning:
Carapax Et Plastrum Testudinis 3-6 part, Radix Paeoniae Alba 12-15 part, Radix Codonopsis 9-12 part, Radix Angelicae Sinensis 2-5 part, Semen Ziziphi Spinosae 2-5 part, Semen Platycladi 3-6 part, Fructus Alpiniae Oxyphyllae 1-5 part, Rhizoma Acori Graminei 3-6 part, Rhizoma Alismatis 2-5 part, artificial Calculus Bovis 2-4 part, Stigma Croci 1-3 part, Cortex Eucommiae 2-4 part, Cornu Cervi Pantotrichum 1-3 part, Radix Pseudostellariae 1-5 part, Rhizoma Atractylodis Macrocephalae 1-3 part, Poria 2-5 part, Fructus Amomi 1-3 part, Radix Polygalae 3-9 part, Rhizoma Coptidis 1-5 part, Radix Salviae Miltiorrhizae 6-12 part, Radix Astragali 3-6 part, Rhizoma Polygonati 1-5 part, Rhizoma Chuanxiong 3-9 part, Fructus Lycii 2-6 part, Herba Cistanches 1-5 part, Cordyceps 1-3 part, Radix Ophiopogonis 2-5 part, Radix Et Caulis Acanthopanacis Senticosi 3-9 part, Radix Rhodiolae 3-6 part, Radix Puerariae 3-15 part, Rhizoma Gastrodiae 4-20 part, Radix Oenotherae erythrosepalae 3-15 part, raw Flos persicae 3-15 part, Fructus Mori 3-15 part, Folium Pini 3-15 part, Arillus Longan 5-20 part.
2. a kind of Chinese medicine composition for the treatment of mental retardation according to claim 1, is characterized in that: described Chinese medicine composition is made up of each component of following weight parts proportioning:
Carapax Et Plastrum Testudinis 4-6 part, Radix Paeoniae Alba 12-14 part, Radix Codonopsis 9-11 part, Radix Angelicae Sinensis 2-4 part, Semen Ziziphi Spinosae 2-4 part, Semen Platycladi 3-5 part, Fructus Alpiniae Oxyphyllae 1-3 part, Rhizoma Acori Graminei 3-5 part, Rhizoma Alismatis 2-4 part, artificial Calculus Bovis 2-3 part, Stigma Croci 1-2 part, Cortex Eucommiae 2-3 part, Cornu Cervi Pantotrichum 1-2 part, Radix Pseudostellariae 1-3 part, Rhizoma Atractylodis Macrocephalae 1-2 part, Poria 2-3 part, Fructus Amomi 1-2 part, Radix Polygalae 3-6 part, Rhizoma Coptidis 1-3 part, Radix Salviae Miltiorrhizae 6-9 part, Radix Astragali 3-5 part, Rhizoma Polygonati 1-3 part, Rhizoma Chuanxiong 3-6 part, Fructus Lycii 2-5 part, Herba Cistanches 1-3 part, Cordyceps 1-2 part, Radix Ophiopogonis 2-4 part, Radix Et Caulis Acanthopanacis Senticosi 3-6 part, Radix Rhodiolae 3-5 part, Radix Puerariae 12-15 part, Rhizoma Gastrodiae 12-20 part, Radix Oenotherae erythrosepalae 9-15 part, raw Flos persicae 9-15 part, Fructus Mori 9-15 part, Folium Pini 9-15 part, Arillus Longan 9-20 part.
3. a kind of Chinese medicine composition for the treatment of mental retardation according to claim 2, is characterized in that: described Chinese medicine composition is made up of each component of following weight parts proportioning:
Carapax Et Plastrum Testudinis 5 parts, the Radix Paeoniae Alba 12 parts, Radix Codonopsis 10 parts, Radix Angelicae Sinensis 3 parts, Semen Ziziphi Spinosae 3 parts, Semen Platycladi 4 parts, Fructus Alpiniae Oxyphyllae 2 parts, Rhizoma Acori Graminei 4 parts, Rhizoma Alismatis 3 parts, artificial Calculus Bovis 2 parts, Stigma Croci 1 part, the Cortex Eucommiae 2 parts, 1 part, Cornu Cervi Pantotrichum, Radix Pseudostellariae 2 parts, the Rhizoma Atractylodis Macrocephalae 2 parts, 2 parts, Poria, Fructus Amomi 1 part, Radix Polygalae 5 parts, Rhizoma Coptidis 2 parts, Radix Salviae Miltiorrhizae 8 parts, the Radix Astragali 4 parts, Rhizoma Polygonati 2 parts, Rhizoma Chuanxiong 5 parts, Fructus Lycii 4 parts, Herba Cistanches 2 parts, Cordyceps 2 parts, Radix Ophiopogonis 3 parts, Radix Et Caulis Acanthopanacis Senticosi 5 parts, Radix Rhodiolae 4 parts, Radix Puerariae 14 parts, 18 parts, Rhizoma Gastrodiae, Radix Oenotherae erythrosepalae 12 parts, raw 12 parts, Flos persicae, 12 parts, Fructus Mori, 12 parts, Folium Pini, Arillus Longan 18 parts.
4. a kind of Chinese medicine composition for the treatment of mental retardation according to claim 2, is characterized in that: described Chinese medicine composition is made up of each component of following weight parts proportioning:
Carapax Et Plastrum Testudinis 6 parts, the Radix Paeoniae Alba 14 parts, Radix Codonopsis 11 parts, Radix Angelicae Sinensis 4 parts, Semen Ziziphi Spinosae 4 parts, Semen Platycladi 5 parts, Fructus Alpiniae Oxyphyllae 3 parts, Rhizoma Acori Graminei 5 parts, Rhizoma Alismatis 4 parts, artificial Calculus Bovis 3 parts, Stigma Croci 2 parts, the Cortex Eucommiae 3 parts, 2 parts, Cornu Cervi Pantotrichum, Radix Pseudostellariae 3 parts, the Rhizoma Atractylodis Macrocephalae 2 parts, 3 parts, Poria, Fructus Amomi 2 parts, Radix Polygalae 6 parts, Rhizoma Coptidis 3 parts, Radix Salviae Miltiorrhizae 9 parts, the Radix Astragali 5 parts, Rhizoma Polygonati 3 parts, Rhizoma Chuanxiong 6 parts, Fructus Lycii 5 parts, Herba Cistanches 3 parts, Cordyceps 2 parts, Radix Ophiopogonis 4 parts, Radix Et Caulis Acanthopanacis Senticosi 6 parts, Radix Rhodiolae 5 parts, Radix Puerariae 15 parts, 20 parts, Rhizoma Gastrodiae, Radix Oenotherae erythrosepalae 15 parts, raw 15 parts, Flos persicae, 15 parts, Fructus Mori, 15 parts, Folium Pini, Arillus Longan 20 parts.
5. treat a preparation method for the Chinese medicine composition of mental retardation, it is characterized in that, choose the traditional Chinese medicine composite of the weight as claim 1 or 2, and be prepared according to following steps and form:
1) take Carapax Et Plastrum Testudinis, the Radix Paeoniae Alba, Radix Codonopsis, Radix Angelicae Sinensis, Semen Ziziphi Spinosae, Semen Platycladi, Fructus Alpiniae Oxyphyllae, Rhizoma Acori Graminei, Rhizoma Alismatis, artificial Calculus Bovis, Stigma Croci, the Cortex Eucommiae, Cornu Cervi Pantotrichum by weight, clean and drying for standby;
2) take the Rhizoma Atractylodis Macrocephalae, Poria, Fructus Amomi, Radix Polygalae, Rhizoma Coptidis, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Polygonati, Rhizoma Chuanxiong, Herba Cistanches, Cordyceps, Radix Ophiopogonis, Radix Puerariae by weight, clean and drying for standby;
3) step (1) gained to be cleaned and dry medical material co-grinding crosses 100-150 mesh sieve, obtain former powder A, and stir and to sterilize 30-60min with ultra violet lamp; Step (2) gained to be cleaned and dry medical material co-grinding crosses 100-150 mesh sieve, obtain former powder B, and stir and use co-60 radiation sterilizing, dosage 1Kgy;
4) by former powder A and former powder B ratio mixing by weight, add distilled water reflux, extract, 3-5 time containing 30-60% ethanol, the alcohol reflux 0.3-1 hour of each 2-5 times amount, filter merge extractive liquid, and reclaim ethanol, be concentrated into relative density 1.2-1.5, add 75% appropriate amount of ethanol, medicinal liquid alcohol content is made to promote one times, limit edged fully stirs, leave standstill 12-24h, filter, reclaim ethanol extremely without alcohol taste, obtain clear paste, add DDW again to containing crude drug 0.5-4g/ml, medicinal liquid adds 1% active carbon, after heated and boiled, cooling, stand at low temperature 6-12h after filtering, obtain water-soluble medicine soup, elimination medicinal residues obtain fried medicinal liquid,
5) Radix Pseudostellariae, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Radix Rhodiolae, Rhizoma Gastrodiae, Radix Oenotherae erythrosepalae, raw Flos persicae, Fructus Mori, Folium Pini, Arillus Longan all to be shelled peeling enucleation, squeeze into juice, and be mixed to get raw pharmacy liquid, life pharmacy liquid is heated to 65 ~ 75 DEG C, and keeps this temperature 30-60min to be cooled to 5 DEG C rapidly later;
6) by aforementioned for step (4) gained fried medicinal liquid and step (5) sterilized after the mixing of raw pharmacy liquid, slow evaporation is concentrated becomes thickness ointment, obtains described Chinese medicine composition.
6. a preparation method for the Chinese medicine composition for the treatment of mental retardation as claimed in claim 5, is characterized in that:
Cleaning and drying for standby in described step (1), (2), what refer to washes repeatedly with distilled water, and described drying is not at high temperature carry out drying; Described step (6) is by after aforementioned fried medicinal liquid and raw pharmacy liquid mixing, carry out multiple times of filtration again to remove medicinal residues fully, carry out evaporation and concentration again, and in evaporating concentration process, suitably add adjuvant, when residual moisture is between 5%-10%, the preparation of tablet is carried out by the mode of mechanical presses, humidity strip drying is carried out under extraordinary air flow communication, dry 3-5 days at 30-40 DEG C, sampling 2-3% determines tablet whether sufficiently dry, obtains the Chinese medicine composition tablet made.
CN201610083777.8A 2016-02-05 2016-02-05 Traditional Chinese medicine composition for treating mental retardation and preparation method thereof Pending CN105535797A (en)

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CN110101772A (en) * 2019-04-19 2019-08-09 中泰宜佳健康科技（北京）有限责任公司 A kind of composition for relieving physical fatigue and its preparation and preparation method

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Application publication date: 20160504