CN104173895A

CN104173895A - Traditional Chinese medicine composition for treating mental retardation and preparation method of traditional Chinese medicine composition

Info

Publication number: CN104173895A
Application number: CN201410428542.9A
Authority: CN
Inventors: 王玲
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-08-27
Filing date: 2014-08-27
Publication date: 2014-12-03

Abstract

The invention relates to a traditional Chinese medicine composition for treating mental retardation. The traditional Chinese medicine composition for treating mental retardation is prepared from the following raw material medicines in parts by weight: 20-30 parts of turtle shell, 20-30 parts of Chinese wolfberry fruit, 10-20 parts of eucommia ulmoides, 10-20 parts of antler piece, 1-5 parts walnut kernel, 1-5 parts of rhizoma alismatis, 10-20 parts of fructus alpiniae oxyphyllae, 10-20 parts of radix pseudostellariae, 5-10 parts of atractylodes macrocephala, 3-8 parts of poria cocos, 15-25 parts of fructus amomi, 10-20 parts of rhizoma acori graminei, 5-10 parts of polygala tenuifolia, 8-15 parts of coptis chinensis and 10-20 parts of salvia miltiorrhiza. The invention further provides a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition provided by the invention can reinforce kidney to replenish essence, tonify marrow and brain, tonify qi and replenish spleen, disperse blood stasis and enlighten the mind as well as tonify the intelligence and enlighten the brain, and can treat both the symptoms and the root causes aiming at the pathogenesis of mental retardation, and the clinical detection shows that the curative effect is remarkable.

Description

A kind of Chinese medicine composition for the treatment of mental retardation and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of mental retardation, relate in particular to a kind of Chinese medicine composition for the treatment of mental retardation and preparation method thereof.

Background technology

Mental retardation generally refers to obviously low, learning difficulty and social adjustment's behavior difficulty etc. of the intelligence that caused by many reasons in the Mental development phase (in 18 years old).This is the common syndrome of a class, except in utero perinatal stage and raw after various factors cause due to brain structure and functional lesion Brunauer's syndrome, also comprise poisoning, infection, wound, brain organic pathological changes, environment, emotion, psychological factor and mental sickness.World Health Organization (WHO) estimates that the different all kinds of Boys with Mental retardation sickness rate of light and heavy degree are 3%, and wherein 75%～80% is the slight example of suffering from.

At present doctor trained in Western medicine for the treatment of Patients with Mental Retardation to carry out in early days education and training as first-selected therapy, there is no definite, effectively Therapeutic Method, the traditional Chinese medical science is thought, mental retardation belongs to the traditional Chinese medical science " five kinds of growth retardation " scope, because congenital tire is grasped deficiency, deficiency of both the liver and kidney, lose the day after tomorrow and support, the vital essence of the five internal organs can not go up due to Rong Yuan god's internal organs, main employing acupuncture, the tcm therapy treatment Patients with Mental Retardations such as Chinese medicine, obtain certain curative effect, obtain gradually accreditation medically, but use at present the curative effect for the treatment of by Chinese herbs mental retardation still can not be satisfactory.

Summary of the invention

The object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of mental retardation, be intended to solve the still unsafty technical problem of curative effect of current use treatment by Chinese herbs mental retardation.

The present invention is achieved in that a kind of Chinese medicine composition for the treatment of mental retardation, and described Chinese medicine composition is made up of the crude drug of following weight portion: 20～30 parts of Carapax et Plastrum Testudiniss, 20～30 parts of Fructus Lycii, 10～20 parts of the Cortexs Eucommiae, 10～20 parts of Cornu Cervi tablets, 1～5 part of Semen Juglandis, 1～5 part of Rhizoma Alismatis, 10～20 parts of Fructus Alpiniae Oxyphyllae, 10～20 parts of Radix Pseudostellariaes, 5～10 parts of the Rhizoma Atractylodis Macrocephalaes, 3～8 parts, Poria, 15～25 parts of Fructus Amomis, 10～20 parts of Rhizoma Acori Graminei, 5～10 parts of Radix Polygalaes, 8～15 parts of Rhizoma Coptidis, 10～20 parts of Radix Salviae Miltiorrhizaes.

Improve as one, described Chinese medicine composition is made up of the crude drug of following weight portion: 25 parts of Carapax et Plastrum Testudiniss, 25 parts of Fructus Lycii, 15 parts of the Cortexs Eucommiae, 15 parts of Cornu Cervi tablets, 3 parts of Semen Juglandis, 3 parts of Rhizoma Alismatis, 15 parts of Fructus Alpiniae Oxyphyllae, 15 parts of Radix Pseudostellariaes, 8 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts, Poria, 20 parts of Fructus Amomis, 15 parts of Rhizoma Acori Graminei, 8 parts of Radix Polygalaes, 10 parts of Rhizoma Coptidis, 15 parts of Radix Salviae Miltiorrhizaes.

A method of preparing the Chinese medicine composition for the treatment of mental retardation, preparation process is as follows:

S1. take by weight percentage Carapax et Plastrum Testudinis, Fructus Lycii, the Cortex Eucommiae, Cornu Cervi tablet, Fructus Alpiniae Oxyphyllae, Radix Pseudostellariae, Fructus Amomi, Rhizoma Acori Graminei, Radix Salviae Miltiorrhizae, clean dry, for subsequent use;

S2. take by weight percentage Semen Juglandis, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Polygalae, Rhizoma Coptidis, clean dry, for subsequent use;

S3. the material mixing of gained in step S1 was pulverized to 80～120 mesh sieves, obtained former powder A;

S4. the material mixing of gained in step S2 was pulverized to 80～120 mesh sieves, obtained former powder B;

S5. the former powder A of equivalent and former powder B are mixed and obtain mixing former powder, and then get the former powder A that mixes therewith former powder equivalent and mix with it, by that analogy, until finally former powder A has been mixed;

S6. by former the mixing finally obtaining in step S5 powder through 60Coradiation sterilizing (dosage: 5Kgy);

S7. the former powder of mixing after sterilization treatment in step S6 is divided and install to capsule the inside;

The quality of S8. mixing former powder in described step S7 in each capsule is 2～5g.

In the present invention's formula:

Carapax et Plastrum Testudinis, salty in the mouth, sweet, property is flat, enters liver, kidney channel, has nourishing YIN for suppressing the hyperactive YANG, reinforcing the kidney to strengthen the bone, effect of the heart tonifying and tranquilizing that nourishes blood, cure mainly deficiency of kidney yin, hectic fever due to YIN-deficiency consumptive fever, soreness of the waist and knees, lack of preservation of spirit, palpitation with fear fidgets due to deficiency, insomnia forgetfulness, hematemesis and epistaxis, stirring of wind due to deficiency of YIN, the atrophic debility of bones of suffering from a deficiency of the kidney, infantile metopism;

Fructus Lycii, sweet in the mouth, property is flat, enters liver, kidney channel, has effect of nourishing the liver and kidney, replenishing vital essence to improve eyesight, cures mainly asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear;

The Cortex Eucommiae, sweet in the mouth, warm in nature, enter liver, kidney channel, there is invigorating the liver and kidney, bone and muscle strengthening, antiabortive effect, cure mainly soreness of waist and knee joint, muscles and bones is unable, and frequent fetal movement is had a dizzy spell;

Cornu Cervi tablet, salty in the mouth, warm in nature, enter liver, kidney channel, kidney-replenishing, benefiting essence-blood, bone and muscle strengthening, promoting the circulation of blood detumescence, cures mainly the spinal column cold type of pain of suffering from a deficiency of the kidney, impotence and seminal emission, metrorrhagia, frequent micturition frequent micturition, carbuncle of yin nature skin infection, acute mastitis swells and ache, traumatic injury congestive edema, bones and muscles pain;

Semen Juglandis, sweet in the mouth, warm in nature, enter kidney channel, lung, large intestine channel, there is effect of the kidney invigorating warming the lung, loosening bowel to relieve constipation, tonifying the kidney to consolidate the essence, warming the lung Dingchuan, intestine moistening, curing mainly suffers from a deficiency of the kidney breathes heavily and coughs, lumbago flaccidity of the lower limbs, sexual impotence, seminal emission, frequent micturition, stranguria caused by urinary stone, constipation due to dry stool;

Rhizoma Alismatis, sweet in the mouth, light, cold in nature, enter kidney, urinary bladder channel, the effect that have promoting diuresis to eliminate damp pathogen, expels the heat-evil, cures mainly dysuria, edema, has loose bowels, stranguria with turbid discharge, leukorrhagia, sweet light the oozing of Rhizoma Alismatis let out, and its promoting diuresis to eliminate damp pathogen effect is similar to Poria, by retention of water-damp in the body is commonly used, heat cold in nature because of it, to let out kidney and bladder is particularly suitable to damp-heat in lower-JIAO person;

Fructus Alpiniae Oxyphyllae, acrid in the mouth, warm in nature, enter spleen, kidney channel, there is effect warming spleen and stopping diarrha, warming the kidney controlling nocturnal emission with astringent drugs reducing urination, cure mainly stomachache vomitings and diarrhoea, the many salivas of lack of appetite, the enuresis of passing out semen, Fructus Alpiniae Oxyphyllae can warming the spleen cold expelling, can whet the appetite again;

Radix Pseudostellariae, sweet in the mouth, micro-hardship, property is flat, enters spleen, lung meridian, replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung, thirsty for lack of appetite, cough caused by dryness expectorant is few;

The Rhizoma Atractylodis Macrocephalae, bitter in the mouth, sweet, warm in nature, enter spleen, stomach warp, there is air making-up and spleen enlivening, dampness diuretic, strengthening superficial resistance to stop perspiration, antiabortive effect, for deficiency-weakness of spleen-QI, anorexia and loose stool, phlegm retention edema, exterior deficiency spontaneous perspiration, frequent fetal movement, the sweet temperature of the Rhizoma Atractylodis Macrocephalae, the merit of air making-up and spleen enlivening is better;

Poria, sweet in the mouth, light, property is flat, enters the heart, spleen, kidney channel, and the effect of have promoting diuresis to eliminate damp pathogen, spleen invigorating, calming the nerves, is used for the treatment of edema, has loose bowels, dysuria, phlegm retention, cardiopalmus, insomnia, the sweet benefit of Poria, enters heart spleen and invigorating the heart and spleen, mind tranquilizing and the heart calming;

Fructus Amomi, acrid in the mouth, warm in nature, enter spleen, stomach warp, there is removing dampness, circulation of qi promoting, warming middle-JIAO, antiabortive effect, cure mainly retention of damp leading to blockage of QI, abdominal distention, inappetence, cold-damp is had loose bowels, pregnancy reactions, frequent fetal movement, the pungent wet perfume (or spice) of Fructus Amomi, tool removing dampness is amusing, the effect of relieving QI stagnancy in the stomach;

Rhizoma Acori Graminei, acrid in the mouth, warm in nature, enter the heart, stomach warp, having eliminates the phlegm has one's ideas straightened out, effect of removing dampness appetizing, the mind calming and mentality promoting, cures mainly coma, palpitation with fear, insomnia, dementia, forgetful, chest and abdomen swelling and pain, anemofrigid-damp arthralgia, scabies, the pungent temperature of Rhizoma Acori Graminei fragrance, can eliminate the phlegm removing dampness and have one's ideas straightened out, and have calm the nerves, the effect of Fructus Alpiniae Oxyphyllae;

Radix Polygalae, bitter in the mouth, pungent, warm in nature, enter the heart, lung, kidney channel, there is the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm have one's ideas straightened out, effect of subduing inflammation, curing mainly palpitation with fear insomnia, dreaminess is forgetful, coma epilepsy, cough with copious phlegm, swollen ulcer drug, Radix Polygalae hardship is let out, pungent loose, Wen Tong, can happy stagnation of QI knot, restoring normal coordination between the heart and kidney and the Fructus Alpiniae Oxyphyllae of calming the nerves, for to hinder the palpitation with fear, the dreaminess that cause not peaceful because of terrified, with controlling insomnia, forgetful, with controlling phlegmatic mental confusion, coma epilepsy;

Rhizoma Coptidis, bitter in the mouth, cold in nature, enter the heart, stomach, liver, large intestine channel, heat clearing and damp drying, eliminating fire and detoxication, cures mainly gastrointestinal damp and hot, vomiting, dysentery, unconsciousness due to high fever, dysphoria and insomnia, heat in blood is told nosebleed, sore swollen toxin, glue ear, eczema, toothache due to stomach-fire, Chinese Drug Rhizomes of Coptis large bitter Great Cold, kind clear damp-heat in middle-JIAO, Rhizoma Coptidis clearing away heat-fire power is strong, is especially good at through excess-fire with removing pathogen in the heart, and can detoxifies;

Radix Salviae Miltiorrhizae, bitter in the mouth, cold nature, enter the heart, pericardium, Liver Channel, there is effect of blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle, nourishing blood to tranquillize the mind, cure mainly menoxenia, trusted subordinate's pain, lumps in the chest and abdomen, rheumatism pyretic arthralgia, skin infection swells and ache, and agitation is insomnia, cardiopalmus, insomnia, the drop-down of the bitter energy of Radix Salviae Miltiorrhizae, cold energy clearing away heat and cooling blood, merit is arrogated to oneself blood circulation promoting and blood stasis dispelling, therefore can be used for the multiple disease that heat in blood stasis blocking causes, removing heat from blood and have nourishing blood to tranquillize the mind can also clear away heart-fire.

The Chinese medicine composition for the treatment of mental retardation provided by the invention, Fructus Lycii, the Cortex Eucommiae, Carapax et Plastrum Testudinis, Semen Juglandis, Cornu Cervi tablet, Fructus Alpiniae Oxyphyllae boosting brain and supplementing kidney, Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Poria invigorating the spleen and benefiting QI, Fructus Amomi circulation of qi promoting, Rhizoma Acori Graminei waking up the patient from unconsciousness by clearing away phlegm, Radix Polygalae intelligent promoting and the mind tranquilizing is had one's ideas straightened out, Radix Salviae Miltiorrhizae nourishes heart, Rhizoma Coptidis heat clearing away, it is turbid that Rhizoma Alismatis lets out clearly kidney, promoting diuresis to eliminate damp pathogen, share with all, can restrict the thick greasy of all medicines, the party is grown and oiliness, invigorating middle warmer has logical, full side's kidney tonifying, essence replenishing, benefit marrow brain-strengthening, QI invigorating spleen reinforcing, blood stasis dispelling is had one's ideas straightened out, consistent refreshment, for the etiology and pathogenesis of mental retardation, treating both the principal and secondary aspects of a disease, through Clinical detection, evident in efficacy.

Detailed description of the invention

In order to make object of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.

Embodiment mono-

Treat a Chinese medicine composition for mental retardation, made by the crude drug of following weight portion: 20 parts of Carapax et Plastrum Testudiniss, 20 parts of Fructus Lycii, 10 parts of the Cortexs Eucommiae, 10 parts of Cornu Cervi tablets, 1 part of Semen Juglandis, 1 part of Rhizoma Alismatis, 10 parts of Fructus Alpiniae Oxyphyllae, 10 parts of Radix Pseudostellariaes, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 3 parts, Poria, 15 parts of Fructus Amomis, 10 parts of Rhizoma Acori Graminei, 5 parts of Radix Polygalaes, 8 parts of Rhizoma Coptidis, 10 parts of Radix Salviae Miltiorrhizaes.

S3. the material mixing of gained in step S1 was pulverized to 80 mesh sieves, obtained former powder A;

S4. the material mixing of gained in step S2 was pulverized to 80 mesh sieves, obtained former powder B;

Embodiment bis-

Treat a Chinese medicine composition for mental retardation, made by the crude drug of following weight portion: 30 parts of Carapax et Plastrum Testudiniss, 30 parts of Fructus Lycii, 20 parts of the Cortexs Eucommiae, 20 parts of Cornu Cervi tablets, 5 parts of Semen Juglandis, 5 parts of Rhizoma Alismatis, 20 parts of Fructus Alpiniae Oxyphyllae, 20 parts of Radix Pseudostellariaes, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts, Poria, 25 parts of Fructus Amomis, 20 parts of Rhizoma Acori Graminei, 10 parts of Radix Polygalaes, 15 parts of Rhizoma Coptidis, 20 parts of Radix Salviae Miltiorrhizaes.

S3. the material mixing of gained in step S1 was pulverized to 100 mesh sieves, obtained former powder A;

S4. the material mixing of gained in step S2 was pulverized to 100 mesh sieves, obtained former powder B;

Embodiment tri-

Treat a Chinese medicine composition for mental retardation, made by the crude drug of following weight portion: 25 parts of Carapax et Plastrum Testudiniss, 25 parts of Fructus Lycii, 15 parts of the Cortexs Eucommiae, 15 parts of Cornu Cervi tablets, 3 parts of Semen Juglandis, 3 parts of Rhizoma Alismatis, 15 parts of Fructus Alpiniae Oxyphyllae, 15 parts of Radix Pseudostellariaes, 8 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts, Poria, 20 parts of Fructus Amomis, 15 parts of Rhizoma Acori Graminei, 8 parts of Radix Polygalaes, 10 parts of Rhizoma Coptidis, 15 parts of Radix Salviae Miltiorrhizaes.

S3. the material mixing of gained in step S1 was pulverized to 120 mesh sieves, obtained former powder A;

S4. the material mixing of gained in step S2 was pulverized to 120 mesh sieves, obtained former powder B;

Chinese medicine composition of the present invention is selected capsule formulation, outward appearance is bright and clean, attractive in appearance, can cover the foreign odor of medicine, be easy to clinically be accepted by most of patients, and with tablet comparison, when preparation, because not needing to add binding agent and tabletting, after generally taking, disintegrate discharges medicine rapidly, good absorbing, bioavailability is high.The quality of the Chinese medicine composition in each capsule is 2～5g, can be according to the concrete state of an illness, and every day is oral twice, taking 30 days as a course for the treatment of.

The present invention treats through the patient who 90 examples is met to primary disease diagnostic criteria, and specific standards is as follows: (1) Mental development is obstructed or not exclusively, especially taking mental retardation as feature, intelligence detects the IQ IQ of gained or grows business DQ all below 70 points; (2) consider according to the age, have the defect on behavior adjustment simultaneously or weaken; (3) 18 years old with interior onset, its mild or moderate (IQ or DQ are between 50～70 points) 60 examples, moderate (IQ or DQ are between 35～49 points) 24 examples, severe (IQ or DQ are between 50～70 points) 6 examples, boy's 54 examples, girl's 36 examples, 57 examples within 3 years old age, 3 years old above 33 examples, the cause of disease has antenatal factor as infection 30 examples of trimester of pregnancy rubella, herpes, cytomegalic inclusion virus etc., perinatal stage factor comprises 42 examples such as premature labor, birth process deutocerebral region maternal infuries, perinatal asphyxia, and after birth, factor, as encephalitis and in raw later six months, 18 examples such as malnutrition occurs.

Take after the present invention after the course for the treatment of, statistics curative effect, concrete statistical standard is as follows: treat after 3 months IQ or growth business and social-life ability all improve 10～15 be divided into effective, improving 5～10 is divided into effectively, statistical result is as follows: effective 45 examples, effective 30 examples, invalid 15 examples, total effective rate 83.3%.

Model case is as follows:

Case one

Lee, man, 8 years old, premature infant, mother tell infant speak since the childhood, walk all late than child of the same age, at primary school after, study does not always catch up with, and especially mathematics is poor especially, likes at ordinary times quiet, can carry out daily interchange, can recite simple nursery rhymes and Tang poetry, but it is inmatureer to speak, thing is slow, mother just thinks that son is stupid at the beginning, and going hospital's test intelligence is 60 points, diagnosis: " mental retardation ".After taking one course for the treatment of of medicine of the present invention, test intelligence is 75 points, memory, faculty of understanding are all improved, and can recite the text of certain length, computing power has certain improvement, mathematics achievement is significantly improved, and verbal expression skill and reading ability obviously improve, and can say the statement that some complexity are grown.

Case two

Zhang, man, 33 monthly ages, stand up late, in one one full year of life to external world things reaction with monthly age youngster without significant difference, within 14 months, can express " Papa and Mama ", only can express afterwards " mother ", 24 monthly ages can be expressed " uncle ", vocabulary quantity is extremely low, things is lacked to lasting interest, game attention can not be concentrated, do not like with the external world and contact, interaction ability, Motor development postpones, balanced capacity is poor, learn an elder of maternal family through understanding family's medical history, adult, clinical manifestation: anthropometic is normal, intelligent development sluggishness, childhood development of speech is lower than child of the same age, do not like to express and exchange, be carrying out property, after growing up, intelligence is equivalent to 10 years old left and right child, study and logical thinking ability are low, can not accurately pronounce, ability to express is poor, can understand daily ethics custom, life can be taken care of oneself, can be engaged in unskilled job, infant is " mental retardation " after diagnosing, after taking two courses for the treatment of of medicine of the present invention, can grasp some vocabulary, and it is clear to pronounce, things shows great interest to external world, can be absorbed in and put in game, and playfellow close to the age plays very joyous mutually, the reaction of things and dwindling with the obvious difference between the child of age bracket to external world.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments of doing within the spirit and principles in the present invention, be equal to and replace and improvement etc., within all should being included in protection scope of the present invention.

Claims

1. a Chinese medicine composition for the treatment of mental retardation, is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight portion: 20～30 parts of Carapax et Plastrum Testudiniss, 20～30 parts of Fructus Lycii, 10～20 parts of the Cortexs Eucommiae, 10～20 parts of Cornu Cervi tablets, 1～5 part of Semen Juglandis, 1～5 part of Rhizoma Alismatis, 10～20 parts of Fructus Alpiniae Oxyphyllae, 10～20 parts of Radix Pseudostellariaes, 5～10 parts of the Rhizoma Atractylodis Macrocephalaes, 3～8 parts, Poria, 15～25 parts of Fructus Amomis, 10～20 parts of Rhizoma Acori Graminei, 5～10 parts of Radix Polygalaes, 8～15 parts of Rhizoma Coptidis, 10～20 parts of Radix Salviae Miltiorrhizaes.

2. the Chinese medicine composition for the treatment of mental retardation according to claim 1, is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight portion: 25 parts of Carapax et Plastrum Testudiniss, 25 parts of Fructus Lycii, 15 parts of the Cortexs Eucommiae, 15 parts of Cornu Cervi tablets, 3 parts of Semen Juglandis, 3 parts of Rhizoma Alismatis, 15 parts of Fructus Alpiniae Oxyphyllae, 15 parts of Radix Pseudostellariaes, 8 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts, Poria, 20 parts of Fructus Amomis, 15 parts of Rhizoma Acori Graminei, 8 parts of Radix Polygalaes, 10 parts of Rhizoma Coptidis, 15 parts of Radix Salviae Miltiorrhizaes.

3. a method of preparing the Chinese medicine composition of the treatment mental retardation described in claim 1 or 2, is characterized in that, preparation process is as follows: