CN113329765A - 用于副结核病的免疫原性组合物 - Google Patents

用于副结核病的免疫原性组合物 Download PDF

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Publication number
CN113329765A
CN113329765A CN201980059761.5A CN201980059761A CN113329765A CN 113329765 A CN113329765 A CN 113329765A CN 201980059761 A CN201980059761 A CN 201980059761A CN 113329765 A CN113329765 A CN 113329765A
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CN
China
Prior art keywords
polypeptide
seq
ala
amino acid
leu
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Pending
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CN201980059761.5A
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English (en)
Chinese (zh)
Inventor
约翰·赫尔蒙-泰勒
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HAV Vaccines Ltd
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HAV Vaccines Ltd
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Application filed by HAV Vaccines Ltd filed Critical HAV Vaccines Ltd
Publication of CN113329765A publication Critical patent/CN113329765A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980059761.5A 2018-07-11 2019-07-10 用于副结核病的免疫原性组合物 Pending CN113329765A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1811382.9 2018-07-11
GBGB1811382.9A GB201811382D0 (en) 2018-07-11 2018-07-11 Vaccine
PCT/GB2019/051933 WO2020012177A1 (en) 2018-07-11 2019-07-10 Immunogenic composition for paratuberculosis

Publications (1)

Publication Number Publication Date
CN113329765A true CN113329765A (zh) 2021-08-31

Family

ID=63273113

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980059761.5A Pending CN113329765A (zh) 2018-07-11 2019-07-10 用于副结核病的免疫原性组合物

Country Status (14)

Country Link
US (2) US12186382B2 (enExample)
EP (1) EP3820507A1 (enExample)
JP (2) JP2021524485A (enExample)
KR (1) KR20210033490A (enExample)
CN (1) CN113329765A (enExample)
AU (1) AU2019301899A1 (enExample)
BR (1) BR112021000312A2 (enExample)
CA (1) CA3105763A1 (enExample)
GB (1) GB201811382D0 (enExample)
IL (1) IL280070B2 (enExample)
MA (1) MA53131A (enExample)
MX (1) MX2020013924A (enExample)
SG (1) SG11202100120TA (enExample)
WO (1) WO2020012177A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201700487D0 (en) * 2017-01-11 2017-02-22 Hermon-Taylor John Diagnostic
WO2026041756A1 (en) 2024-08-21 2026-02-26 Hav Vaccines Limited Treatment of crohn's disease by mycobacterium avium subsp. paratuberculosis agent

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007017635A1 (en) * 2005-08-09 2007-02-15 St George's Enterprises Limited Immunogenic constructs
US20070042383A1 (en) * 2002-03-06 2007-02-22 Vivek Kapur Mycobacterial diagnostics
WO2014114812A1 (en) * 2013-01-28 2014-07-31 Danmarks Tekniske Universitet A single or multistage mycobacterium avium subsp. paratuberculosis subunit vaccine

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US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US5225324A (en) 1987-04-24 1993-07-06 Bioscience International, Inc. Diagnostics for mycobacteria in public health, medical, and veterinary practice
GB8709803D0 (en) 1987-04-24 1987-05-28 Mcfadden J J Treatment of crohn's disease &c
DK0737750T3 (da) 1989-03-21 2003-09-01 Vical Inc Ekspression af exogene polynucleotidsekvenser i vertebrater
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5279833A (en) 1990-04-04 1994-01-18 Yale University Liposomal transfection of nucleic acids into animal cells
US5283185A (en) 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
JPH07505283A (ja) 1992-03-20 1995-06-15 ベイラー・カレッジ・オブ・メディシン Ｄｎａトランスポーター系および使用方法
AU682308C (en) 1992-04-03 2006-08-17 Regents Of The University Of California, The Self-assembling polynucleotide delivery system
US5651981A (en) 1994-03-29 1997-07-29 Northwestern University Cationic phospholipids for transfection
US5527928A (en) 1994-09-30 1996-06-18 Nantz; Michael H. Cationic transport reagents
GB9526178D0 (en) 1995-12-21 1996-02-21 Taylor John Hermon Novel polynuceotides and polypeptides in pathogenic mycobacteria and their use as diagnostics,vaccines and targets for chemotherapy
GB9806093D0 (en) 1998-03-20 1998-05-20 Taylor John Hermon Diagnostics and vaccines for mycobacterial infections of animals and humans
US8609097B2 (en) 2009-06-10 2013-12-17 Hoffmann-La Roche Inc. Use of an anti-Tau pS422 antibody for the treatment of brain diseases
CN102596236B (zh) 2009-07-30 2015-06-24 辉瑞疫苗有限责任公司 抗原性Tau肽及其用途
EP2710151A4 (en) 2011-05-19 2014-12-10 Univ Central Florida Res Found MICROBEND DETECTION BY HYBRIDIZATION OF MAGNETIC RELAXATION NANOSENSORS
WO2014016737A1 (en) 2012-07-24 2014-01-30 Pfizer Inc. Novel chicken monoclonal antibodies against human phosphorylated tau and uses thereof
GB201700487D0 (en) * 2017-01-11 2017-02-22 Hermon-Taylor John Diagnostic

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070042383A1 (en) * 2002-03-06 2007-02-22 Vivek Kapur Mycobacterial diagnostics
WO2007017635A1 (en) * 2005-08-09 2007-02-15 St George's Enterprises Limited Immunogenic constructs
WO2014114812A1 (en) * 2013-01-28 2014-07-31 Danmarks Tekniske Universitet A single or multistage mycobacterium avium subsp. paratuberculosis subunit vaccine

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BULL等: "A Novel Multi-Antigen Virally Vectored Vaccine against Mycobacterium avium Subspecies paratuberculosis", 《PLOS ONE》, 28 November 2007 (2007-11-28), pages 1229 *
GENBANK DATABASE: "Mycobacterium avium subsp. paratuberculosis insertion sequence IS900 transposase gene, partial cds", GENBANK DATABASE, 26 July 2016 (2016-07-26), pages 974347 *
GENBANK DATABASE: "Mycobacterium avium subsp. paratuberculosis strain C4A4 contig_7, whole genome shotgun sequence", GENBANK DATABASE, 6 June 2017 (2017-06-06), pages 01000007 *
PARK等: "Development of vaccines to Mycobacterium avium subsp. paratuberculosis infection", 《CLINICAL AND EXPERIMENTAL VACCINE RESEARCH》, 29 July 2016 (2016-07-29), pages 108 - 116 *
杨益隆: "金黄色葡萄球菌SasA蛋白免疫保护性的研究", 《中国博士学位论文全文数据库（医药卫生科技辑）电子期刊》, 15 November 2016 (2016-11-15), pages 059 - 20 *

Also Published As

Publication number Publication date
US20210338791A1 (en) 2021-11-04
IL280070A (en) 2021-03-01
JP2021524485A (ja) 2021-09-13
IL280070B1 (en) 2023-12-01
US20250152691A1 (en) 2025-05-15
IL280070B2 (en) 2024-04-01
MX2020013924A (es) 2021-03-02
CA3105763A1 (en) 2020-01-16
KR20210033490A (ko) 2021-03-26
MA53131A (fr) 2021-05-19
SG11202100120TA (en) 2021-02-25
JP2024153666A (ja) 2024-10-29
GB201811382D0 (en) 2018-08-29
EP3820507A1 (en) 2021-05-19
WO2020012177A1 (en) 2020-01-16
AU2019301899A1 (en) 2021-01-14
BR112021000312A2 (pt) 2021-04-13
US12186382B2 (en) 2025-01-07

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Application publication date: 20210831

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