CN113318030A - Whitening and freckle removing cream and preparation method thereof - Google Patents

Abstract

The application relates to the field of skin care products, and particularly discloses a whitening and freckle removing cream and a preparation method thereof. The whitening and freckle-removing cream comprises the following components: glycyrrhiza glabra root extract, phenethyl resorcinol, 4-butyl resorcinol, coffee extract, polydimethylsiloxane, sodium sulfite, ethylhexyl methoxycinnamate, stabilizers, emulsifiers, thickeners, emollients, moisturizers, skin conditioners, colorants, fragrances, and water; the humectant is one or more of p-hydroxyacetophenone, glycerol, 1, 2-hexanediol and butanediol, ceramide 2 and dipotassium glycyrrhizinate; the thickening agent is one or a combination of xanthan gum, cetostearyl alcohol and PEG-240/HDI copolymer bis-decyltetradecylpolyether-20 ether, and the whitening and freckle removing cream is suitable for long-term use by people and has the advantages of high safety, small irritation and good whitening effect.

Description

Whitening and freckle removing cream and preparation method thereof

Technical Field

The application relates to the field of skin care products, in particular to a whitening and freckle removing cream and a preparation method thereof.

Background

The continuous pursuit of whitening brings prosperous for whitening skin care products, and kojic acid, vitamin C, hydroquinone and the like are products with strong whitening effect, but the irritation and safety of the kojic acid, vitamin C, hydroquinone and the like are too big for the skin care products, and the products are easy to cause the risk of face rotting by carelessness, so that derivatives of the kojic acid, vitamin C, hydroquinone and the like are developed, and the derivatives can greatly improve the safety while retaining whitening activity.

At present, most of kojic acid derivatives, vitamin C derivatives, hydroquinone derivatives and other substances reduce the damage to skin cells to a great extent, but the derivatives still cause certain stimulation to the skin in the using process, the whitening is a long-term process, and whitening skin care products are often required to be used for a long time to see the whitening effect, so the derivatives still easily cause serious damage to the skin after long-term use, and therefore, the improvement space is provided.

Disclosure of Invention

In order to provide the whitening and freckle-removing cream which is suitable for long-term use by people and has high safety and small irritation, the application provides the whitening and freckle-removing cream and the preparation method thereof.

In a first aspect, the application provides a whitening and freckle-removing cream, which adopts the following technical scheme:

the whitening and freckle-removing cream comprises the following components in parts by mass:

1-3% of glycyrrhiza glabra root extract

Phenethyl resorcinol 0.3-0.5%

4-butylresorcinol 0.3-0.5%

Coffee extract 0.8-1.5%

Sodium sulfite 0.03-0.08%

Ethylhexyl methoxycinnamate 0.2-0.6%

Emulsifier 1.3-2.7%

3.2 to 5.6 percent of thickening agent

Emollient 3-7%

Humectant 10.3-16.6%

0.8 to 1.2 percent of film forming agent

Skin conditioner 0-1.1%

0 to 0.23 percent of coloring agent

0 to 0.03 percent of aromatic

The balance of water;

the humectant is one or more of p-hydroxyacetophenone, glycerin, 1, 2-hexanediol, butanediol, ceramide 2 and dipotassium glycyrrhizinate;

the thickening agent is one or more of xanthan gum, cetostearyl alcohol and PEG-240/HDI copolymer bis-decyltetradecylpolyether-20 ether.

When the glycyrrhiza glabra extract, the phenethyl resorcinol and the 4-butyl resorcinol are combined, the synergistic whitening effect can be achieved, and long-term use of the composition can help people keep the skin white and has an obvious freckle removing effect, so that the whitening and freckle removing cream has the characteristic of obvious whitening and freckle removing effects.

The experiment shows that after the phenethyl resorcinol, the 4-butyl resorcinol, the glycyrrhiza glabra root extract and the caffeic acid extract are mixed in a certain proportion, the stimulation of the phenethyl resorcinol and the 4-butyl resorcinol on the skin can be obviously reduced.

However, the phenethyl resorcinol, 4-butyl resorcinol and the glycyrrhiza glabra root extract have the problems of poor stability, the whitening activity of the whitening and freckle-removing cream is reduced and the irritation is enhanced to a certain extent after the whitening and freckle-removing cream is irradiated for a period of time, and the stability of the phenethyl resorcinol, 4-butyl resorcinol and the glycyrrhiza glabra root extract is greatly improved by adding sodium sulfite and ethylhexyl methoxycinnamate in a specific ratio, so that the activities of the phenethyl resorcinol, 4-butyl resorcinol and the glycyrrhiza glabra root extract are in a balanced state under the mutual coordination effect of the components, the whitening and freckle-removing cream can keep the whitening activity, and meanwhile, the irritation to the skin is not easily generated, so that the skin is white and healthy after the skin is used for a long time by consumers.

Preferably, the skin conditioner is one or more of malva sylvestris extract, paeonia lactiflora extract, lonicera japonica extract, chamomile flower extract, dandelion rhizome/root extract, viola yedoensis extract, aloe barbadensis leaf juice, ceramide 2, and dipotassium glycyrrhizinate.

By adding the malva sylvestris extract, the paeonia lactiflora root extract, the honeysuckle flower extract, the chamomile flower extract, the dandelion rhizome/root extract, the Chinese violet extract, the aloe vera leaf juice, the ceramide 2 and the dipotassium glycyrrhizinate, the permeability of the whitening and freckle-removing cream is improved, so that the whitening and freckle-removing cream is beneficial to relieving skin and deeply moisturizing, and the effects of quickly relieving skin problems and resisting skin sensitivity are achieved

Further, the skin conditioner consists of the following components in percentage by mass:

extract of Malva sylvestris 0.005-0.01%

Radix Paeoniae extract 0.01-0.03%

Flos Lonicerae extract 0.005-0.01%

0.01-0.03% of chamomile extract

Extract of Taraxacum officinale rhizome/root 0.01-0.03%

Herba Violae extract 0.01-0.03%

Aloe barbadensis leaf juice 0.005-0.01%

Ceramide 20.3-0.6%

0.1 to 0.3 percent of dipotassium glycyrrhizinate.

The skin conditioner with a specific proportion is added, so that the irritation of phenethyl resorcinol and 4-butyl resorcinol to the skin can be further reduced, the skin can be helped to resist the invasion of the external environment, the stability of the skin barrier is improved, the whitening effect can be further exerted in an auxiliary way, and the skin is more white, healthy and stable after the skin conditioner is used by a consumer for a long time.

Preferably, the emulsifier consists of the following components in percentage by mass:

cetyl glucoside 0.1-0.3%

PEG-100 stearate 0.6-1.2%

0.6 to 1.2 percent of glycerol stearate.

The cetyl glucoside is used as a main emulsifier, and the PEG-100 stearate and the glyceryl stearate are used as auxiliary emulsifiers, so that the emulsification effect of each component in the whitening and freckle-removing cream is better, the components keep better dispersion stability, the whitening and freckle-removing cream is beneficial to keeping mild and non-irritating, the whitening stability is kept better, and consumers are more white and healthy after long-term use.

Preferably, the colorant is composed of the following components in percentage by mass:

caramel color 0.08-0.15%

CI 19140 0.03-0.08％。

By adding caramel color and CI 19140, the whitening and freckle-removing cream is in a beige cream shape, which is beneficial to reducing the influence of external illumination on the stability of phenylethyl resorcinol, 4-butyl resorcinol and glycyrrhiza glabra root extracts, and is beneficial to further improving the stability of phenylethyl resorcinol, 4-butyl resorcinol and glycyrrhiza glabra root extracts, so that the whitening and freckle-removing cream keeps better whitening effect.

Preferably, the thickener consists of the following components in percentage by mass:

xanthan gum 0.1-0.3%

Cetostearyl alcohol 3-5%

PEG-240/HDI copolymer bis-decyltetradecyl alcohol polyether-20 ether 0.1-0.3%.

By adding xanthan gum, cetostearyl alcohol and PEG-240/HDI copolymer bis-decyltetradecylpentath-20 ether, the whitening and freckle-removing cream has better thickness and is convenient to apply and store.

Preferably, the emollient is composed of the following components in percentage by mass:

isononyl isononanoate 2-4%

1-3% of caprylic/capric triglyceride.

Isononyl isononanoate and caprylic/capric triglyceride are matched and filled in cracks among dry skin keratinocytes, so that the skin becomes soft and smooth, active substances in the whitening and freckle-removing cream can permeate into the deep layer of the skin, and the components can synergistically act in the deep layer of the skin, so that the cells in the deep layer of the skin are more stable and healthy.

Preferably, the humectant consists of the following components in percentage by mass:

0.3 to 0.6 percent of p-hydroxyacetophenone

1-3% of glycerin

1, 2-hexanediol 1-3%

8-10% of butanediol.

The p-hydroxyacetophenone, the glycerin, the 1, 2-hexanediol and the butanediol are matched with the emollient to absorb moisture, so that a moist feeling can be provided for the skin, the skin is not easy to dry, and the skin is healthier and more elastic.

In a second aspect, the application provides a preparation method of a whitening and freckle-removing cream, which adopts the following technical scheme:

a preparation method of whitening and freckle-removing cream comprises the following steps:

step 1, mixing water, glycerol, PEG-240/HDI copolymer bis-decyltetradecanol polyether-20 ether, dipotassium glycyrrhizinate and xanthan gum, heating to 80-85 ℃, and homogenizing for 15-20min to obtain an emulsion;

step 2, mixing cetostearyl alcohol, an emollient, an emulsifier, polydimethylsiloxane, ethylhexyl methoxycinnamate, tocopherol and ceramide 2, heating to 75-80 ℃, and stirring for 15-20min to obtain an oil phase liquid;

step 3, pumping the oil phase liquid into the emulsion, homogenizing and emulsifying for 5-10min, keeping the temperature for 12-20min, and cooling to 65-70 ℃ to obtain a mixed liquid A;

step 4, mixing and stirring 1, 2-hexanediol and p-hydroxyacetophenone until the mixture is dissolved, then adding the mixture into the mixed solution A, uniformly stirring, and cooling to 30-40 ℃ to obtain a mixed solution B;

step 5, mixing and stirring butanediol, phenethyl resorcinol and 4-butyl resorcinol until the butanediol, the phenethyl resorcinol and the 4-butyl resorcinol are dissolved, then adding the mixture into the mixed solution B, stirring uniformly, adding a coffee extract dissolved by water in advance and sodium sulfite, and stirring uniformly to obtain a mixed solution C;

and 6, finally, adding a skin conditioner, a coloring agent and an aromatic into the mixed solution C, and uniformly stirring to obtain the whitening and freckle-removing cream.

The whitening and freckle-removing cream prepared by the preparation method has the advantages of simple operation and the preparation method.

In summary, the present application has the following beneficial effects:

1. after the phenethyl resorcinol, the 4-butyl resorcinol, the glycyrrhiza glabra root extract and the caffeic acid extract are mixed according to a certain proportion, the stimulation effect of the phenethyl resorcinol and the 4-butyl resorcinol on the skin can be obviously reduced; by adding polydimethylsiloxane, sodium sulfite and ethylhexyl methoxycinnamate in a specific proportion, the phenethyl resorcinol, 4-butyl resorcinol, the glycyrrhiza glabra root extract and the caffeic acid extract keep stable, so that the stability of the whitening and freckle-removing cream is improved, and the irritation is reduced.

2. In the application, cetyl glucoside is preferably used as a main emulsifier, and PEG-100 stearate and glyceryl stearate are preferably used as auxiliary emulsifiers, so that the emulsifying effect of each component in the whitening and freckle-removing cream is better, and simultaneously, better whitening stability is kept.

3. By adding caramel color and CI 19140, the stability of phenylethyl resorcinol, 4-butyl resorcinol and glycyrrhiza glabra root extract is further improved, so that the whitening and freckle removing cream keeps better whitening effect.

Detailed Description

The present application will be described in further detail with reference to examples.

The following is the source information of the raw materials in the examples and comparative examples of the present application.

The extract of Malva sylvestris is purchased from Shaanxi Sinot Biotechnology Co.

Radix Paeoniae extract is purchased from Shanxi New Tian territory Biotechnology GmbH.

Honeysuckle flower extract was purchased from shanxi scanty biotechnology limited.

Matricaria chamomilla L.extract was purchased from seqens group, France

Chamomile titrates the extract.

The extract of the rhizome/root of Taraxacum officinale is available from Shaanxi Sinot Biotechnology GmbH under the reference 20200105.

The herba Violae extract is obtained from Shaanxi Sinuote Biotech GmbH, having a product number of 20201120

Aloe VERA leaf juice was purchased from the HGLY ALOE VERA Aloe VERA extract of seqens group, France.

Glycyrrhiza glabra extract was purchased from Hibiscus parviensis Biotech, Inc.

Coffee extracts were purchased from Shanxi New Tian Domain Biotech, Inc.

Cetyl glucoside was purchased from warrior scientific biotechnology limited.

PEG-100 stearate was purchased from Haian petrochemical plants of Jiangsu province.

Glyceryl stearate was purchased from Jiangsu Caesami Biotech Ltd.

Xanthan gum is purchased from Shenzhen Lefu Biotech, Inc.

Cetearyl alcohol was purchased from Hubei double-Yan chemical Co.

PEG-240/HDI copolymer bis-decyltetradecanol polyether-20 ether was purchased from Wuhanxin Jiali Biotech Ltd.

Isononyl isononanoate was purchased from Shandong Yuanhua Biotech limited.

Caprylic/capric acid triglycerides are available from Hubei Xin Rundchemical Co., Ltd.

CI 19140 is available from Wang Biotech, Inc. of Henan kang under the brand FDC yellow 5.

Example 1

A whitening and freckle-removing cream comprises 1g of glycyrrhiza glabra root extract, 0.3g of phenethyl resorcinol, 0.3g of 4-butyl resorcinol, 0.8g of coffee extract, 0.8g of polydimethylsiloxane, 0.03g of sodium sulfite, 0.2g of ethylhexyl methoxycinnamate, 1.3g of emulsifier, 3.2g of thickener, 3g of emollient, 10.3g of humectant, 0.8g of film forming agent and water, and is specifically shown in Table 1.

Wherein the emulsifier is a combination of 0.1g cetearyl glucoside, 0.6g PEG-100 stearate and 0.6g glyceryl stearate.

The thickener was a combination of 0.1g xanthan gum, 3g cetostearyl alcohol and 0.1g PEG-240/HDI copolymer bis-decyltetradecylpolyether-20 ether.

The emollient was a combination of 2g isononyl isononanoate and 1g caprylic/capric triglyceride.

The humectant is a combination of 0.3g of p-hydroxyacetophenone, 1g of glycerin, 1g of 1, 2-hexanediol, 8g of butanediol, 0.3g of ceramide 2, and 0.1g of dipotassium glycyrrhizinate.

The film forming agent is polydimethylsiloxane.

A preparation method of whitening and freckle-removing cream comprises the following steps:

step 1, adding water, glycerol, PEG-240/HDI copolymer bis-decyltetradecanol polyether-20 ether, dipotassium glycyrrhizinate and xanthan gum into an emulsifying pot, heating to 80 ℃, and homogenizing for 10min to obtain an emulsion.

Step 2, adding cetostearyl alcohol, isononyl isononanoate, PEG-100 stearate, glyceryl stearate, caprylic/capric triglyceride, cetearyl glucoside, polydimethylsiloxane, ethylhexyl methoxycinnamate, tocopherol and ceramide 2 into an oil phase pot, heating to 75 ℃, and stirring for 15min to obtain an oil phase liquid.

And 3, pumping the oil phase liquid into the emulsion, homogenizing and emulsifying for 5min, keeping the temperature for 12min, and cooling to 65 ℃ to obtain a mixed liquid A.

And 4, mixing and stirring the 1, 2-hexanediol and the p-hydroxyacetophenone until the 1, 2-hexanediol and the p-hydroxyacetophenone are dissolved, adding the mixture into the mixed solution A, stirring the mixture for 10min at the rotating speed of 65r/min, uniformly stirring the mixture, and cooling the mixture to 40 ℃ to obtain a mixed solution B.

And 5, mixing and stirring the butanediol, the phenethyl resorcinol and the 4-butyl resorcinol until the butanediol, the phenethyl resorcinol and the 4-butyl resorcinol are dissolved, adding the mixture into the mixed solution B, stirring uniformly, adding the coffee extract and the sodium sulfite dissolved by water in advance, stirring for 5min at the rotating speed of 50r/min, and stirring uniformly to obtain a mixed solution C.

And 6, finally adding the glycyrrhiza glabra extract into the obtained mixed solution C, stirring for 10min at the rotating speed of 60r/min, and uniformly stirring to obtain the whitening and freckle-removing cream.

Example 2

A cream for whitening skin and resolving macula comprises 3g Glycyrrhrizae radix extract, 0.5g phenethyl resorcinol, 0.5g 4-butyl resorcinol, 0.12g coffee extract, 1.2g polydimethylsiloxane, 0.08g sodium sulfite and 0.6g ethylhexyl methoxycinnamate, 2.7g emulsifier, 5.6g thickener, 7g emollient, 16.6g humectant, 1.2g film forming agent and water, and is shown in Table 1.

Wherein the emulsifier is a combination of 0.3g cetearyl glucoside, 1.2g PEG-100 stearate and 1.2g glyceryl stearate.

The thickener was a combination of 0.3g xanthan gum, 5g cetostearyl alcohol and 0.3g PEG-240/HDI copolymer bis-decyltetradecylpolyether-20 ether.

The emollient was a combination of 4g isononyl isononanoate and 3g caprylic/capric triglyceride.

The humectant is a combination of 0.6g of p-hydroxyacetophenone, 3g of glycerin, 3g of 1, 2-hexanediol, 10g of butanediol, 0.6g of ceramide 2, and 0.3g of dipotassium glycyrrhizinate.

The film forming agent is polydimethylsiloxane.

A preparation method of whitening and freckle-removing cream comprises the following steps:

step 1, adding water, glycerol, PEG-240/HDI copolymer bis-decyltetradecanol polyether-20 ether, dipotassium glycyrrhizinate and xanthan gum into an emulsifying pot, heating to 85 ℃, and homogenizing for 15min to obtain an emulsion.

Step 2, adding cetostearyl alcohol, isononyl isononanoate, PEG-100 stearate, glyceryl stearate, caprylic/capric triglyceride, cetearyl glucoside, polydimethylsiloxane, ethylhexyl methoxycinnamate, tocopherol and ceramide 2 into an oil phase pot, heating to 80 ℃, and stirring for 20min to obtain an oil phase liquid.

And 3, pumping the oil phase in the oil pan into an emulsifying pan, homogenizing and emulsifying for 10min, keeping the temperature for 20min, and cooling to 70 ℃ to obtain a mixed solution A.

And 4, mixing and stirring the 1, 2-hexanediol and the p-hydroxyacetophenone until the 1, 2-hexanediol and the p-hydroxyacetophenone are dissolved, adding the mixture into the mixed solution A, stirring the mixture for 15min at the rotating speed of 70r/min, uniformly stirring the mixture, and cooling the mixture to 30 ℃ to obtain a mixed solution B.

And 5, mixing and stirring the butanediol, the phenethyl resorcinol and the 4-butyl resorcinol until the butanediol, the phenethyl resorcinol and the 4-butyl resorcinol are dissolved, adding the mixture into the mixed solution B, stirring uniformly, adding the coffee extract and the sodium sulfite dissolved by water in advance, stirring for 10min at the rotating speed of 65r/min, and stirring uniformly to obtain a mixed solution C.

And step 6, finally adding the glycyrrhiza glabra extract into the mixed liquid C, stirring for 5min at the rotating speed of 75r/min, and uniformly stirring to obtain the whitening and freckle-removing cream.

Example 3

A whitening and freckle-removing cream is different from the cream in example 1 only in that: skin conditioning agents are also added. The skin conditioner comprises 0.005g of malva sylvestris extract, 0.01g of peony root extract, 0.005g of honeysuckle flower extract, 0.01g of chamomile flower extract, 0.01g of dandelion rhizome/root extract, 0.01g of Chinese violet extract, 0.005g of aloe barbadensis leaf juice, 0.005g of phenoxyethanol and 0.001g of ethylhexylglycerin, and is specifically shown in Table 1.

The preparation method of the whitening and freckle-removing cream is different from the embodiment 1 in that: in step 6, the mallow flower extract, the peony root extract, the honeysuckle flower extract, the chamomile flower extract, the dandelion rhizome/root extract, the Chinese violet extract, the aloe barbadensis leaf juice, the phenoxyethanol, the ethylhexyl glycerin and the glycyrrhiza glabra extract are added into the obtained mixed solution C together, and the mixture is stirred uniformly to obtain the whitening and freckle-removing cream.

Example 4

A whitening and freckle-removing cream is different from the cream in example 3 only in that: skin conditioning agents are also added. The skin conditioner comprises 0.01g of malva sylvestris extract, 0.03g of peony root extract, 0.01g of honeysuckle flower extract, 0.03g of chamomile flower extract, 0.03g of dandelion rhizome/root extract, 0.03g of Chinese violet extract, 0.01g of aloe barbadensis leaf juice, 0.01g of phenoxyethanol and 0.003g of ethylhexylglycerin, which are detailed in Table 1.

Example 5

A whitening and freckle-removing cream is different from the cream in example 1 only in that: a colorant is also added. The colorant consisted of 0.08g caramel color and 0.03gCI 19140, as detailed in Table 1.

The preparation method of the whitening and freckle-removing cream is different from the embodiment 1 in that: in step 6, caramel, CI 19140 and Glycyrrhiza glabra extract are added into the obtained mixed solution C together, and the mixture is stirred uniformly to obtain the whitening and freckle-removing cream.

Example 6

A whitening and freckle-removing cream is different from the cream in example 3 only in that: colorants and fragrances were also added as detailed in table 1.

The colorant consisted of 0.08g caramel color and 0.03gCI 19140.

The aromatic is 0.01g essence.

The preparation method of the whitening and freckle-removing cream is different from the embodiment 3 in that: in step 6, caramel color, CI 19140, essence and Glycyrrhiza glabra extract are added into the obtained mixed solution C together, and the mixture is stirred uniformly to obtain the whitening and freckle-removing cream.

Example 7

A whitening and freckle-removing cream is different from the cream in example 6 only in that: coloring agent and aromatic agent are also added.

The colorant consisted of 0.15g caramel color and 0.08gCI 19140.

The aromatic is 0.03g essence.

TABLE 1

Comparative example 1

A whitening and freckle-removing cream is different from the cream in example 1 in that: in the preparation method of the whitening and freckle-removing cream, the glycyrrhiza glabra root extract is replaced by equal amount of water.

Comparative example 2

A whitening and freckle-removing cream is different from the cream in example 1 in that: in the preparation method of the whitening and freckle-removing cream, the coffee extract is replaced by equal amount of water.

Comparative example 3

A whitening and freckle-removing cream is different from the cream in example 1 in that: in the preparation method of the whitening and freckle-removing cream, sodium sulfite is replaced by water in an equivalent manner.

Comparative example 4

A whitening and freckle-removing cream is different from the cream in example 1 in that: in the preparation method of the whitening and freckle-removing cream, water is used for replacing ethylhexyl methoxycinnamate in an equivalent manner.

Comparative example 5

A whitening and freckle-removing cream is different from the cream in example 1 in that: in the preparation method of the whitening and freckle-removing cream, the dosage of the glycyrrhiza glabra root extract is 0.5g, and the dosage of the coffee extract is 2 g.

Comparative example 6

A whitening and freckle-removing cream is different from the cream in example 1 in that: in the preparation method of the whitening and freckle-removing cream, the dosage of the glycyrrhiza glabra root extract is 5g, and the dosage of the coffee extract is 0.1 g.

EXAMPLE 1

The glycyrrhiza glabra root extract contains a large amount of glabridin, and the whitening activity of the glycyrrhiza glabra root extract is represented by the glabridin. The concentration of glabridin, phenethyl resorcinol and 4-butyl resorcinol was measured using the freshly prepared whitening and spot-removing cream of each example and comparative example as experimental group, and the concentration of glabridin, phenethyl resorcinol and 4-butyl resorcinol was calculated using the whitening and spot-removing cream of each example and comparative example after being stored for 60 days under light condition as control group, and the change rate of glabridin, phenethyl resorcinol and 4-butyl resorcinol was calculated.

Wherein A1 is the concentration of the experimental group sample, and A2 is the concentration of the control group sample.

The test results are detailed in table 2.

TABLE 2

	Glabridin	Phenethylresorcinol	4-butylresorcinol
				Example 1	2.6	1.5	1.6
Example 2	2.1	1.4	1.5
				Example 3	2.2	1.1	1.2
Example 4	2.1	1.1	1.2
				Example 5	2.7	1.5	1.5
Example 6	2.1	1.1	1.2
				Example 7	2.2	1.1	1.2
Comparative example 1	0	1.1	1.6
				Comparative example 2	32.4	24.3	26.4
Comparative example 3	89.6	92.3	94.6
				Comparative example 4	91.3	95.6	98.4
Comparative example 5	3.4	1.5	1.7
				Comparative example 6	98.8	98.8	96.3

As can be seen by comparing the data of comparative example 1 and example 1 in Table 2, the change rate of phenethyl resorcinol and 4-butyl resorcinol was not large by adding the Glycyrrhiza glabra root extract, demonstrating that the Glycyrrhiza glabra root extract does not affect the stability of phenethyl resorcinol and 4-butyl resorcinol.

As can be seen by comparing the data of comparative example 2 and example 1 in Table 2, the rate of change of phenethyl resorcinol and 4-butyl resorcinol was somewhat reduced by the addition of the coffee extract, demonstrating that the coffee extract can somewhat improve the stability of phenethyl resorcinol and 4-butyl resorcinol.

As can be seen by comparing the data of comparative examples 3 to 4 and example 1 in Table 2, the addition of sodium sulfite and ethylhexyl methoxycinnamate advantageously reduces the rate of change of glabridin, phenethyl resorcinol and 4-butyl resorcinol, and improves the glycyrrhiza glabra root extract, phenethyl resorcinol and 4-butyl resorcinol and stability.

As can be seen by comparing the data of comparative examples 5-6 and example 1 in Table 2, the stability of phenethyl resorcinol and 4-butyl resorcinol was significantly reduced after varying the ratio of Glycyrrhiza glabra root extract to coffee extract. When the glycyrrhiza glabra root extract and the coffee extract are added according to a specific proportion, the change rate of the glabridin, the phenethyl resorcinol and the 4-butyl resorcinol is obviously reduced, so that the glabridin, the phenethyl resorcinol and the 4-butyl resorcinol obtain better stability.

As can be seen from comparison of the data of comparative examples 1 to 6 in Table 2 with the data of example 1, the addition of sodium sulfite and ethylhexyl methoxycinnamate in a specific ratio in combination with glycyrrhiza glabra root extract and coffee extract in a specific ratio can greatly improve the stability of glabridin, phenethyl resorcinol and 4-butyl resorcinol.

Experiment 2

After washing the face in the morning and evening, 33 adult volunteers with healthy skin are selected, the whitening and freckle-removing cream prepared in each embodiment and comparative example is smeared on the left cheek, the whitening and freckle-removing cream prepared in each embodiment and comparative example is smeared on the right cheek after being stored for 60 days, the irritation of the whitening and freckle-removing cream is graded after the adult volunteers are continuously used for 30 days and 60 days, the grading grade is 0-10, wherein 0 is no obvious irritation, 1-2 is slight irritation, 3-4 is strong irritation, 5-6 is medium irritation, 7-8 is strong irritation, and 9-10 is severe irritation.

The test results are detailed in table 3.

TABLE 3

According to the comparison of the data of comparative examples 1 to 2 and comparative examples 5 to 6 and example 1 in table 3, the irritation of the whitening and freckle-removing cream is remarkably reduced by adding the glycyrrhiza glabra root extract and the coffee extract in a specific ratio, and it is proved that the irritation caused by phenethyl resorcinol and 4-butyl resorcinol can be reduced by simultaneously adding the glycyrrhiza glabra root extract and the coffee extract in a specific ratio.

Experiment 3

The skin melanin content of the left and right faces of the adult volunteers of experiment 2 before and on day 30 was tested using MX18 melanin tester from CK company, germany.

The test results are detailed in table 4.

TABLE 4

As can be seen from comparison of data of comparative example 1 and example 1 in table 4, the whitening effect of the whitening and freckle-removing cream is improved by adding the glabridin root extract, which proves that the glabridin root extract can better improve the whitening effect of the whitening and freckle-removing cream.

As can be seen from comparison of the data of comparative example 2 and example 1 in table 4, the difference of skin melanin of the left and right cheeks was not large by adding the coffee extract, demonstrating that the whitening effect of the whitening spot-removing cream was not greatly changed.

As can be seen from comparison of the data of comparative examples 3 to 4 and example 1 in table 4, the difference of skin melanin of the left and right cheeks was significantly reduced by adding sodium sulfite and ethylhexyl methoxycinnamate, demonstrating that sodium sulfite and ethylhexyl methoxycinnamate have significant effects on maintaining the whitening effect of the whitening spot-removing cream stably.

The data of comparative examples 5 to 6 and example 1 in table 4 are compared, and the simultaneous addition of the glabridin root extract and the coffee extract in a specific ratio can significantly improve the whitening effect of the whitening and freckle-removing cream, which proves that the glabridin root extract and the coffee extract can better improve the whitening effect of the whitening and freckle-removing cream after being combined together.

The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.

Claims (9)

1. The whitening and freckle-removing cream is characterized in that: the composition comprises the following components in parts by mass:

1-3% of glycyrrhiza glabra root extract

Phenethyl resorcinol 0.3-0.5%

4-butylresorcinol 0.3-0.5%

Coffee extract 0.8-1.5%

Sodium sulfite 0.03-0.08%

Ethylhexyl methoxycinnamate 0.2-0.6%

Emulsifier 1.3-2.7%

3.2 to 5.6 percent of thickening agent

Emollient 3-7%

Humectant 10.3-16.6%

0.8 to 1.2 percent of film forming agent

Skin conditioner 0-1.1%

0 to 0.23 percent of coloring agent

0 to 0.03 percent of aromatic

The balance of water;

the humectant is one or more of p-hydroxyacetophenone, glycerin, 1, 2-hexanediol, butanediol, ceramide 2 and dipotassium glycyrrhizinate;

the thickening agent is one or more of xanthan gum, cetostearyl alcohol and PEG-240/HDI copolymer bis-decyltetradecylpolyether-20 ether.

2. The whitening spot-removing cream according to claim 1, characterized in that: the skin conditioner is one or more of malva sylvestris extract, radix Paeoniae extract, flos Lonicerae extract, flos Matricariae Chamomillae extract, Taraxacum officinale rhizome/root extract, herba Violae extract, Aloe Barbadensis leaf juice, ceramide 2 and dipotassium glycyrrhizinate.

3. The whitening and freckle-removing cream according to claim 2, wherein: the skin conditioner comprises the following components in percentage by mass:

extract of Malva sylvestris 0.005-0.01%

Radix Paeoniae extract 0.01-0.03%

Flos Lonicerae extract 0.005-0.01%

0.01-0.03% of chamomile extract

Extract of Taraxacum officinale rhizome/root 0.01-0.03%

Herba Violae extract 0.01-0.03%

Aloe barbadensis leaf juice 0.005-0.01%.

4. The whitening spot-removing cream according to claim 1, characterized in that: the emulsifier comprises the following components in percentage by mass:

cetyl glucoside 0.1-0.3%

PEG-100 stearate 0.6-1.2%

0.6 to 1.2 percent of glycerol stearate.

5. The whitening spot-removing cream according to claim 1, characterized in that: the colorant comprises the following components in percentage by mass:

caramel color 0.08-0.15%

CI 19140 0.03-0.08%。

6. The whitening spot-removing cream according to claim 1, characterized in that: the thickening agent comprises the following components in percentage by mass:

xanthan gum 0.1-0.3%

Cetostearyl alcohol 3-5%

PEG-240/HDI copolymer bis-decyltetradecyl alcohol polyether-20 ether 0.1-0.3%.

7. The whitening spot-removing cream according to claim 1, characterized in that: the emollient is composed of the following components in percentage by mass:

isononyl isononanoate 2-4%

1-3% of caprylic/capric triglyceride.

8. The whitening spot-removing cream according to claim 1, characterized in that: the humectant consists of the following components in percentage by mass:

0.3 to 0.6 percent of p-hydroxyacetophenone

1-3% of glycerin

1, 2-hexanediol 1-3%

8-10% of butanediol.

9. A method for preparing the whitening and freckle-removing cream according to claim 1, which is characterized by comprising the following steps: the method comprises the following steps: step 1, mixing water, glycerol, PEG-240/HDI copolymer bis-decyltetradecanol polyether-20 ether, dipotassium glycyrrhizinate and xanthan gum, heating to 80-85 ℃, and homogenizing for 15-20min to obtain an emulsion;

step 2, mixing cetostearyl alcohol, an emollient, an emulsifier, polydimethylsiloxane, ethylhexyl methoxycinnamate, tocopherol and ceramide 2, heating to 75-80 ℃, and stirring for 15-20min to obtain an oil phase liquid;

step 3, pumping the oil phase liquid into the emulsion, homogenizing and emulsifying for 5-10min, keeping the temperature for 12-20min, and cooling to 65-70 ℃ to obtain a mixed liquid A;

step 4, mixing and stirring 1, 2-hexanediol and p-hydroxyacetophenone until the mixture is dissolved, then adding the mixture into the mixed solution A, uniformly stirring, and cooling to 30-40 ℃ to obtain a mixed solution B;

step 5, mixing and stirring butanediol, phenethyl resorcinol and 4-butyl resorcinol until the butanediol, the phenethyl resorcinol and the 4-butyl resorcinol are dissolved, then adding the mixture into the mixed solution B, stirring uniformly, adding a coffee extract dissolved by water in advance and sodium sulfite, and stirring uniformly to obtain a mixed solution C;

and 6, finally, adding a skin conditioner, a coloring agent and an aromatic into the mixed solution C, and uniformly stirring to obtain the whitening and freckle-removing cream.