CN113302193A - 双环吡咯并三唑酮化合物及其使用方法 - Google Patents

双环吡咯并三唑酮化合物及其使用方法 Download PDF

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Publication number
CN113302193A
CN113302193A CN202080008933.9A CN202080008933A CN113302193A CN 113302193 A CN113302193 A CN 113302193A CN 202080008933 A CN202080008933 A CN 202080008933A CN 113302193 A CN113302193 A CN 113302193A
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Prior art keywords
disease
compound
pharmaceutically acceptable
fluoro
acceptable salt
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English (en)
Chinese (zh)
Inventor
S·帕特尔
G·汉密尔顿
赵桂玲
陈慧芬
B·达涅尔斯
C·斯蒂瓦拉
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN113302193A publication Critical patent/CN113302193A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202080008933.9A 2019-01-11 2020-01-09 双环吡咯并三唑酮化合物及其使用方法 Pending CN113302193A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962791118P 2019-01-11 2019-01-11
US62/791,118 2019-01-11
PCT/US2020/012908 WO2020146615A1 (en) 2019-01-11 2020-01-09 Bicyclic pyrrolotriazolr ketone compounds and methods of use thereof

Publications (1)

Publication Number Publication Date
CN113302193A true CN113302193A (zh) 2021-08-24

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CN202080008933.9A Pending CN113302193A (zh) 2019-01-11 2020-01-09 双环吡咯并三唑酮化合物及其使用方法

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US (2) US12344612B2 (enExample)
EP (1) EP3908586B1 (enExample)
JP (1) JP7585205B2 (enExample)
CN (1) CN113302193A (enExample)
AR (1) AR119673A1 (enExample)
TW (1) TW202043229A (enExample)
WO (1) WO2020146615A1 (enExample)

Families Citing this family (2)

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KR20230165238A (ko) * 2021-04-02 2023-12-05 제넨테크, 인크. 비시클릭 케톤 화합물 제조 공정
WO2023225041A1 (en) * 2022-05-19 2023-11-23 Merck Sharp & Dohme Llc Ripk1 inhibitors and methods of use

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AR119673A1 (es) 2022-01-05
JP2022516651A (ja) 2022-03-01
TW202043229A (zh) 2020-12-01
EP3908586B1 (en) 2022-12-21
US20250282788A1 (en) 2025-09-11
EP3908586A1 (en) 2021-11-17
US20210340151A1 (en) 2021-11-04
JP7585205B2 (ja) 2024-11-18
US12344612B2 (en) 2025-07-01
WO2020146615A1 (en) 2020-07-16

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