CN113286886B - 用于减少朊病毒表达的化合物和方法 - Google Patents

用于减少朊病毒表达的化合物和方法 Download PDF

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CN113286886B
CN113286886B CN201980076256.1A CN201980076256A CN113286886B CN 113286886 B CN113286886 B CN 113286886B CN 201980076256 A CN201980076256 A CN 201980076256A CN 113286886 B CN113286886 B CN 113286886B
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modified
certain embodiments
nucleosides
pharmaceutical composition
sugar
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CN113286886A (zh
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苏珊·M·弗赖尔
H-H·布维
H·赵
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Ionis Pharmaceuticals Inc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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CN201980076256.1A 2018-11-21 2019-11-21 用于减少朊病毒表达的化合物和方法 Active CN113286886B (zh)

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US201862770386P 2018-11-21 2018-11-21
US62/770,386 2018-11-21
PCT/US2019/062681 WO2020106996A1 (en) 2018-11-21 2019-11-21 Compounds and methods for reducing prion expression

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US (2) US12281305B2 (https=)
EP (1) EP3884053A4 (https=)
JP (3) JP7455831B2 (https=)
KR (2) KR102941589B1 (https=)
CN (2) CN113286886B (https=)
AU (2) AU2019384181B2 (https=)
BR (1) BR112021007476A2 (https=)
CA (1) CA3117694A1 (https=)
IL (1) IL283332A (https=)
MX (1) MX2021005886A (https=)
MY (1) MY205095A (https=)
SG (1) SG11202103794QA (https=)
TW (1) TWI841633B (https=)
WO (1) WO2020106996A1 (https=)

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SG11202006528XA (en) 2018-01-12 2020-08-28 Bristol Myers Squibb Co Antisense oligonucleotides targeting alpha-synuclein and uses thereof
CN120310791A (zh) 2018-01-12 2025-07-15 百时美施贵宝公司 靶向α-突触核蛋白的反义寡核苷酸及其用途
US12281305B2 (en) 2018-11-21 2025-04-22 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing prion expression
EP4110913A4 (en) * 2020-02-28 2024-07-24 University of Massachusetts OLIGONUCLEOTIDES FOR PRNP MODULATION
AU2022213384A1 (en) * 2021-01-29 2023-07-20 Ionis Pharmaceuticals, Inc. Compounds and methods for modulating huntingtin
EP4298220A1 (en) * 2021-02-25 2024-01-03 Alnylam Pharmaceuticals, Inc. Prion protein (prnp) irna compositions and methods of use thereof
US20250243492A1 (en) * 2021-10-04 2025-07-31 Atalanta Therapeutics, Inc. Compositions and methods for treatment of prion diseases
EP4453214A4 (en) * 2021-12-22 2026-03-04 Ionis Pharmaceuticals Inc Compounds and methods for modulating glycogen synthase 1
WO2023164696A2 (en) * 2022-02-28 2023-08-31 Ionis Pharmaceuticals, Inc. Rnai agents of prion expression
WO2025137143A2 (en) * 2023-12-21 2025-06-26 Aperture Therapeutics, Inc. Compositions for modulating cd33 expression
WO2025193786A1 (en) * 2024-03-12 2025-09-18 University Of Massachusetts Oligonucleotides for prnp modulation

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