CN113267396B - Cell film-making dyeing machine - Google Patents
Cell film-making dyeing machine Download PDFInfo
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- CN113267396B CN113267396B CN202110807591.3A CN202110807591A CN113267396B CN 113267396 B CN113267396 B CN 113267396B CN 202110807591 A CN202110807591 A CN 202110807591A CN 113267396 B CN113267396 B CN 113267396B
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- 238000004043 dyeing Methods 0.000 title claims abstract description 42
- 238000012360 testing method Methods 0.000 claims abstract description 188
- 230000007246 mechanism Effects 0.000 claims abstract description 68
- 239000007788 liquid Substances 0.000 claims abstract description 64
- 238000007789 sealing Methods 0.000 claims abstract description 41
- 238000004519 manufacturing process Methods 0.000 claims abstract description 15
- 238000010186 staining Methods 0.000 claims description 20
- 230000003014 reinforcing effect Effects 0.000 claims description 9
- 238000005728 strengthening Methods 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 4
- 238000000926 separation method Methods 0.000 claims description 4
- 230000007704 transition Effects 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 11
- 230000008569 process Effects 0.000 abstract description 11
- 238000003795 desorption Methods 0.000 abstract description 4
- 239000002699 waste material Substances 0.000 description 26
- 238000003860 storage Methods 0.000 description 20
- 238000003825 pressing Methods 0.000 description 14
- 239000002184 metal Substances 0.000 description 7
- 238000012546 transfer Methods 0.000 description 7
- 238000011084 recovery Methods 0.000 description 5
- 238000005070 sampling Methods 0.000 description 5
- 241000973497 Siphonognathus argyrophanes Species 0.000 description 4
- 210000003323 beak Anatomy 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 210000005239 tubule Anatomy 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 230000000712 assembly Effects 0.000 description 3
- 238000000429 assembly Methods 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 230000005484 gravity Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000012192 staining solution Substances 0.000 description 3
- 230000000903 blocking effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000005452 bending Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 239000003814 drug Substances 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
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- 238000010827 pathological analysis Methods 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 238000009971 piece dyeing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
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- 238000004062 sedimentation Methods 0.000 description 1
- 239000003351 stiffener Substances 0.000 description 1
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
Abstract
The invention provides a cell slice dyeing machine which comprises a rack, a suction nozzle mechanism, a moving mechanism, a cell slice manufacturing platform and a pressure pump set, wherein the suction nozzle mechanism is arranged at the top of the rack through the moving mechanism; the suction nozzle mechanism comprises a large suction nozzle and a fixed block; the upper end of the large suction nozzle is a mounting end which is mounted on the fixing block, the outer surface of the lower end of the large suction nozzle is provided with a small test tube sealing surface, the middle of the large suction nozzle is provided with a large test tube sealing surface, and the large suction nozzle penetrates up and down to be provided with two mutually independent liquid inlet paths. The problem of prior art's suction nozzle can not match the test tube of a plurality of bores, and same suction nozzle pipeline not only will accomplish to pour into and will absorb work and lead to mutual pollution, and the test tube drops from the suction nozzle easily in the simultaneous working process, and the completion is poured into and is absorbed the difficult desorption of work back test tube, has test tube structural strength not enough moreover.
Description
Technical Field
The invention relates to the technical field of a sheet-making dyeing machine, in particular to a cell sheet-making dyeing machine.
Background
Currently, in clinical medicine, the existence of pathological changes in a human body is often judged by observing cell slices of various tissues of the human body. With the rapid development of science and technology and social economy, the development of pathological analysis technology is greatly promoted, so that the second generation liquid-based cell slide preparation technology represented by the sedimentation type liquid-based cell slide preparation technology is more and more widely applied to the preparation of cytopathology specimens.
In the prior art, the process of preparing a liquid-based cytology slice comprises: sampling, centrifuging, smearing and dyeing, wherein each step is respectively carried out in a work area separated from each other, sample transfer is carried out between each step, a transfer mechanism is required, in order to ensure that the samples are not polluted, a disposable test tube is required to be used for sucking and transferring the samples, and in order to ensure the safety and the reliability of the sample transfer process, a suction nozzle of the transfer mechanism and the test tube are firmly connected.
However, the suction nozzle of prior art can not match the test tube of a plurality of bores, and same suction nozzle pipeline both will be accomplished to pour into and will absorb the work and lead to mutual pollution, and the test tube drops from the suction nozzle easily in the simultaneous working process, accomplishes to pour into and absorbs the difficult desorption of test tube after the work, has the problem that test tube structural strength is not enough moreover.
Accordingly, the prior art is deficient and needs improvement.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a cell slice-making dyeing machine.
In order to achieve the purpose, the invention adopts the following specific scheme:
for the test tube of solving prior art's suction nozzle can not match a plurality of bores, same suction nozzle pipeline both will accomplish to pour into and will absorb the work and lead to mutual pollution, and the test tube drops from the suction nozzle easily in the simultaneous working process, and the completion is poured into and is absorbed the difficult desorption of work back test tube, has the not enough problem of test tube structural strength moreover.
The invention provides a cell slice-making dyeing machine, comprising: the cell slide production device comprises a rack, a suction nozzle mechanism, a moving mechanism, a cell slide production platform and a pressure pump set, wherein the suction nozzle mechanism is arranged at the top of the rack through the moving mechanism, the cell slide production platform is arranged at the bottom of the rack, and the pressure pump set is arranged on the side wall of the rack and connected with the suction nozzle mechanism; the suction nozzle mechanism comprises a large suction nozzle and a fixed block; the upper end of the large suction nozzle is a mounting end which is mounted on the fixed block, the outer surface of the lower end of the large suction nozzle is provided with a small test tube sealing surface, the middle of the large suction nozzle is provided with a large test tube sealing surface, the diameter of the middle of the large suction nozzle is larger than the diameters of the upper end and the lower end, and the large test tube sealing surface and the small test tube sealing surface are respectively matched with the inner diameter of the orifice of the large test tube and the inner diameter of the orifice of the small test tube; two mutually independent liquid inlet paths are arranged up and down through the large suction nozzle.
Furthermore, a liquid separation channel is arranged between the openings of the two liquid inlet paths at the lower end of the large suction nozzle; the liquid dividing channel is a gap with an inverted-U-shaped cross section and penetrates through the lower end of the large suction nozzle.
Furthermore, one or two of a convex ring and an O-shaped ring groove are arranged on the sealing surface of the large test tube; the convex ring is of a three-claw structure or a circular ring structure.
Furthermore, the mounting end of the upper end of the large suction nozzle is provided with an anti-falling groove which is a waist-shaped groove.
Furthermore, the large test tube is conical, the upper end of the large test tube is provided with a tube orifice, the lower end of the large test tube is provided with a sharp nozzle, and the aperture of the tube orifice is larger than that of the sharp nozzle; a clamping groove is formed in the inner side of the pipe orifice and used for fixing the large suction nozzle, and the clamping groove is an annular groove; the tip mouth at the lower end of the large test tube is a U-shaped tip mouth with two inclined sides or an O-shaped tip mouth with one inclined side.
Furthermore, one end of the sharp mouth outside the test tube is provided with a reinforcing rib; the strengthening rib is the slice bar-shaped structure that sets up along the test tube outer wall, and the strengthening rib side is stood on the test tube outer wall.
Further, a reinforcing rib is arranged on the outer side of the pipe orifice at the upper end of the large test tube.
Further, the cell slide staining machine further comprises: a tube-removing fork and a small tube-removing plate; the tube-removing fork is used for removing the large test tube on the large suction nozzle; the small tube dropping plate is used for removing the small test tube on the large suction nozzle; the tube-removing fork comprises a first tube-removing notch and a first mounting hole; the small pipe dropping plate comprises a second pipe dropping notch and a second mounting hole; the opening of the first tube-removing notch is smaller than the outer diameter of the orifice of the large test tube and larger than the diameter of the sealing surface of the large test tube of the corresponding large suction nozzle; the opening of the second tube-removing notch is smaller than the outer diameter of the orifice of the small test tube and larger than the diameter of the sealing surface of the small test tube of the corresponding large suction nozzle; the first mounting hole and the second mounting hole are round holes or threaded holes.
Further, the tube-releasing fork is U-shaped; the first tube-releasing notch of the tube-releasing fork is of a round hole structure, the round hole structure is positioned at the center of the tube-releasing fork in the length direction, and the diameter of the round hole structure is smaller than the outer diameter of the orifice of a large test tube and larger than the diameter of a large test tube sealing surface of a corresponding large suction nozzle; and the outer edge of the tube-releasing fork is provided with a chamfer, and the two edges of the chamfer are equal in length.
Furthermore, the second tube-removing notch is an open slot, and the opening size of the open slot is smaller than the outer diameter of the orifice of the small test tube and larger than the diameter of the sealing surface of the small test tube of the corresponding large suction nozzle; the shape of the small tube dropping plate is that two Z-shaped dropping plates are overlapped up and down, wherein the oblique line between the upper and lower horizontal lines of the Z shape is vertical to the upper and lower horizontal lines; the transition part between different widths of the small pipe dropping plate is rounded.
By adopting the technical scheme of the invention, the invention has the following beneficial effects:
the invention provides a cell slice dyeing machine which comprises a rack, a suction nozzle mechanism, a moving mechanism, a cell slice manufacturing platform and a pressure pump set, wherein the suction nozzle mechanism is arranged at the top of the rack through the moving mechanism; the suction nozzle mechanism comprises a large suction nozzle and a fixed block; the upper end of the large suction nozzle is a mounting end which is mounted on the fixed block, the outer surface of the lower end of the large suction nozzle is provided with a small test tube sealing surface, the middle of the large suction nozzle is provided with a large test tube sealing surface, the diameter of the middle of the large suction nozzle is larger than the diameters of the upper end and the lower end, and the large test tube sealing surface and the small test tube sealing surface are respectively matched with the inner diameter of the orifice of the large test tube and the inner diameter of the orifice of the small test tube; two mutually independent liquid inlet paths are arranged up and down through the large suction nozzle. The problem of prior art's suction nozzle can not match the test tube of a plurality of bores, and same suction nozzle pipeline not only will accomplish to pour into and will absorb work and lead to mutual pollution, and the test tube drops from the suction nozzle easily in the simultaneous working process, and the completion is poured into and is absorbed the difficult desorption of work back test tube, has test tube structural strength not enough moreover.
Drawings
FIG. 1 is a perspective view of an embodiment of the present invention;
FIG. 2 is a schematic structural view of a nozzle mechanism according to an embodiment of the present invention (a) in front elevation; (b) a rear view;
FIG. 3 is a perspective view of a cell slide manufacturing stand according to an embodiment of the present invention;
FIG. 4 is an enlarged view at A in FIG. 3;
FIG. 5 is a perspective view of a centrifuge according to an embodiment of the present invention;
FIG. 6 is a perspective view of the centrifuge apparatus of the present invention with the housing and power mechanism removed;
FIG. 7 is a side view of the centrifuge device of an embodiment of the present invention with the housing and power mechanism removed;
FIG. 8 is a cross-sectional view taken at angle A-A of FIG. 7;
FIG. 9 is a perspective view of the centrifuge apparatus of the embodiment of the present invention without the housing, centrifuge tube rack, centrifuge tube and power mechanism;
FIG. 10 is a perspective view of a macro nozzle of an embodiment of the present invention;
FIG. 11 is a front view of a macro nozzle (a) according to an embodiment of the present invention; (b) a left view; (c) a cross-sectional view;
FIG. 12 is a front view of a macro nozzle addition raised ring (a) according to an embodiment of the present invention; (b) a left view; (c) a cross-sectional view;
FIG. 13 is a front view of a macro nozzle with an O-ring groove (a) according to an embodiment of the present invention; (b) a left view; (c) a cross-sectional view;
FIG. 14 is a front view of a macro nozzle of an embodiment of the present invention with an additional raised ring and O-ring groove (a); (b) a left view; (c) a cross-sectional view;
FIG. 15 is an enlarged schematic view of a sealing surface of a large cuvette according to an embodiment of the present invention;
FIG. 16 is an enlarged schematic view of a sealing surface of a cuvette according to an embodiment of the present invention;
FIG. 17 is a perspective view of a tube removal fork and a tube removal plate according to an embodiment of the present invention;
FIG. 18 is a bottom view of a tube release fork (a) according to an embodiment of the present invention; (b) a front view; (c) a side view;
FIG. 19 is a schematic view of a mouthpiece of an embodiment of the present invention with a large test tube removed by a tube removal fork and a small test tube removed by a small tube removal plate;
FIG. 20 is a perspective view of a tubule shedding plate according to an embodiment of the present invention;
FIG. 21 is a front view of a tubule drop plate (a) according to an embodiment of the present invention; (b) a top view; (c) a left view;
FIG. 22 is a perspective view of a U-shaped tip and reinforcing ribs in accordance with an embodiment of the present invention;
FIG. 23 is a front view of a U-shaped nib (a) according to an embodiment of the present invention; (b) a cross-sectional view; (c) a right view;
FIG. 24 is an enlarged view of the neck at the inside of the nozzle according to the embodiment of the present invention;
FIG. 25 is a perspective view of an O-shaped tip and a stiffener according to an embodiment of the present invention;
FIG. 26 is a front view of an O-shaped nib (a) according to an embodiment of the present invention; (b) and (4) a left view.
The attached drawings are marked as follows:
1-a machine frame, wherein the machine frame,
11-a frame base, 12-a side vertical plate, 13-a cover frame and 14-a side plate;
2-a suction nozzle mechanism, wherein,
21-fixed block, 22-dyeing tube fixed plate, 23-dyeing tube fixed block, 24-suction tube,
25-large suction nozzle;
251-a liquid inlet path, 252-a large test tube sealing surface, 253-a small test tube sealing surface, 254-a liquid separation channel, 255-an anti-drop groove, 256-a convex ring and 257-an O-shaped ring groove;
3-a moving mechanism;
4-cell slide making platform;
41-base, 42-first waste bucket, 43-second waste bucket, 44-first waste liquid tank, 45-second waste liquid tank, 46-first mounting rack, 47-sample pipe rack, 48-pressing plate, 49-limiting device, 410-housing of centrifugal device, 411-centrifugal pipe rack, 412-push-pull plate, 413-rotating shaft of rotating mechanism, 414-rotating shaft pipe, 415-rotating shaft pressing ring, 416-fixing plate, 417-rotating plate, 418-pressing pad, 419-push-pull device, 420-push block, 421-push plate, 422-servo motor, 427-gravity pressing block, 428-cover plate, 429-grabbing groove, 430-observation window, 431-mounting seat, 432-supporting plate, 433-groove, 434-buckling position, 435-handle, 436-second mounting rack, 437-large test tube rack, 438-third mounting rack, 439-temporary storage tube rack;
5-a pressure pump group;
6-a pipe-removing mechanism for removing the pipe,
61-tube-removing fork, 62-small tube-removing plate,
611-a threaded hole, and a threaded hole,
612-a circular hole structure, wherein,
613-a fork structure of the fork-shaped structure,
624-open slot;
7-a test tube, wherein the test tube is provided with a test tube,
71-large test tube, 72-small test tube;
711-card slot;
712-reinforcing ribs;
713-beak;
713a-U shaped nib;
713b-O type tip.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the invention and are not limiting of the invention. It should be further noted that, for the convenience of description, only some of the structures related to the present invention are shown in the drawings, not all of the structures.
In the description of the present invention, unless expressly stated or limited otherwise, the terms "connected," "connected," and "fixed" are to be construed broadly, e.g., as meaning permanently connected, removably connected, or integral to one another; can be mechanically or electrically connected; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
In the present invention, unless otherwise expressly stated or limited, "above" or "below" a first feature means that the first and second features are in direct contact, or that the first and second features are not in direct contact but are in contact with each other via another feature therebetween. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly under and obliquely below the second feature, or simply meaning that the first feature is at a lesser elevation than the second feature.
In the description of the present embodiment, the terms "upper", "lower", "left", "right", "front", "rear", and the like are used in the orientations and positional relationships shown in the drawings only for convenience of description and simplicity of operation, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus should not be construed as limiting the present invention. Furthermore, the terms "first", "second", and "third" are used only for descriptive purposes and are not intended to have any special meaning.
Referring to fig. 1 to 26, the invention provides a cell slice dyeing machine, which comprises a frame 1, a suction nozzle mechanism 2, a moving mechanism 3, a cell slice manufacturing platform 4 and a pressure pump set 5, wherein the suction nozzle mechanism 2 is installed at the top of the frame 1 through the moving mechanism 3, the cell slice manufacturing platform 4 is installed at the bottom of the frame 1, and the pressure pump set 5 is installed on the side wall of the frame and connected with the suction nozzle mechanism 2.
The suction nozzle mechanism 2 comprises a suction nozzle assembly, the suction nozzle assembly comprises a group of large suction nozzles 25 which can be sleeved and combined with a large test tube 71 and a small test tube 72 for use, the large suction nozzles 25 can puncture packages of samples to be detected after being sleeved with the large test tube 71, injection operation and suction operation are carried out on the samples, in the injection operation process, injection enters a container through a channel of the large suction nozzles 25, in the suction operation process, suction objects are only contained in the test tube without passing through the channel of the large suction nozzles 25, and after being sleeved with the small test tube 72, centrifugal liquid in the centrifugal tube is sucked into the small test tube 72 and then transferred to the dyeing device.
The cell slide production machine is characterized in that the rack 1 comprises a rack base 11, a side vertical plate 12, a cover frame 13 and a side plate 14, the rack base 11 is horizontally placed, a cell slide production table 4 is arranged on the rack base 11, the side vertical plate 12 is installed on the rack base 11, a moving mechanism 3 and a pressure pump set 5 are installed on the side vertical plate, the cover frame 13 is installed on the side plate 14 and used for protecting the suction nozzle mechanism 2 and the moving mechanism 3, and the other end of the moving mechanism 3 is installed on the cover frame 13 through a guide rail to prevent an operator from entering the cover frame and being bruised.
The suction nozzle mechanism 2 comprises a fixing block 21, a dyeing tube fixing plate 22, a dyeing tube fixing block 23 and a plurality of suction pipes 24, wherein the fixing block 21 is installed on the moving mechanism 3, the dyeing tube fixing plate 22 is installed on the fixing block 21 through a guide post, the dyeing tube fixing block 23 is installed on the dyeing tube fixing plate 22, the dyeing tube fixing block 23 is provided with the suction pipes 24 and is connected to the pressure pump set 5, each suction pipe 24 is connected with a pressure pump, the large suction nozzle 25 is installed on the fixing block 21 and is connected with the pressure pump set 5, and the large suction nozzle is located above the dyeing tube fixing plate 22. The plurality of suction pipes 24 include a plurality of dyeing needle pipes and a waste liquid suction pipe, wherein the number of the dyeing needle pipes is generally 4, and the number of the large suction nozzles 25 is 3.
The moving mechanism 3 comprises an X-axis moving structure, a Y-axis moving structure and a Z-axis moving structure, and is respectively used for controlling the suction nozzle mechanism 2 to move in the X-axis direction, the Y-axis direction and the Z-axis direction. Wherein, the X-axis moving structure is installed on the top of the side vertical plate 12 of the frame 1, the Y-axis moving structure is installed on the X-axis moving structure, and the Z-axis moving structure is installed on the Y-axis moving structure and connected with the fixed block 21 of the suction nozzle mechanism 2.
The cell slide manufacturing station 4 includes a base 41, a first temporary storage device, a centrifugation device, a slide staining device, a second temporary storage device, a third temporary storage device, a first waste tank 42, a second waste tank 43, a first waste liquid tank 44, and a second waste liquid tank 45; the first temporary storage device, the centrifugal device and the slide staining device are sequentially arranged on the base 41 from left to right, the first temporary storage device is used for temporarily storing a sample, the centrifugal device is used for realizing cell centrifugation, and the slide staining device is used for realizing that cells are settled on a slide and stained; the second temporary storage device is arranged on the base 41 at the front side of the first temporary storage device and is used for temporarily storing the large test tube 71; the third temporary storage device is arranged on the base 41 at the front side of the slide staining device and is used for temporarily storing the small test tube 72; the first waste bucket 42 is arranged on the base 41 between the second temporary storage device and the third temporary storage device and is used for recovering waste large test tubes 71; the second waste bin 43 is mounted on the base 41 at the right side of the third temporary storage device, and is used for recycling the waste small test tubes 72; the first waste liquid tank 44 is arranged on the base 41 between the centrifugal device and the second temporary storage device and is used for recovering sample waste liquid; the second waste liquid tank 45 is mounted on the base 41 at the rear side of the slide dyeing apparatus, and is used for recovering dyeing waste liquid.
In this embodiment, the first buffer device includes a first mounting rack 46 disposed on the base 41, a sample tube rack 47 detachably disposed on the first mounting rack 46, and a pressing plate 48 rotatably disposed on the first mounting rack 46 above the sample tube rack 47; a plurality of sample tube holes are uniformly formed in the sample tube frame 47, each sample tube hole is used for placing a sample bottle containing a sample, and handles are respectively arranged on the left side and the right side of the sample tube frame 47, so that the sample tube frame 47 can be conveniently transferred; and sampling holes are formed in the positions, corresponding to the sample tube holes, of the pressing plate 48 and used for being matched with the moving mechanism 3 to realize positioning sampling.
Further, the first mounting bracket 46 is provided with a limiting device 49 on the left side of the pressing plate 48, the limiting device 49 is composed of a knob fixing block mounted on the first mounting bracket 46 and a knob rotatably mounted on the knob fixing block, and the pressing plate 48 is pressed or released by twisting the knob during use, so that the limiting operation of the pressing plate 48 is realized.
In this embodiment, the centrifugal device includes a housing 410, a power mechanism, a rotating mechanism, and a plurality of centrifuge tube racks 411; the shell 410 is arranged on the base 41 on the right side of the first mounting frame 46, a centrifugal cavity is arranged in the shell 410, the rotating mechanism is arranged in the centrifugal cavity, a plurality of centrifuge tube racks 411 are rotatably arranged on the top of the rotating mechanism, a plurality of centrifuge tube holes are uniformly arranged on each centrifuge tube rack 411, each centrifuge tube hole is used for placing a centrifuge tube, and the bottom of the rotating mechanism penetrates out of the shell 410 downwards; the power mechanism is arranged below the shell 410, and the output end of the power mechanism is connected with the end part of the rotating mechanism, which is positioned outside the shell 410; the rotating mechanism comprises a push-pull assembly, a push-pull plate 412 is arranged on the inner edge of each centrifuge tube rack 411, and the push-pull assembly is used for pushing the push-pull plate 412; during use, one of the push-pull pieces 412 is pushed through the action of the push-pull assembly, so that the push-pull pieces 412 can drive the centrifuge tube rack 411 connected with the push-pull pieces to incline towards the inner side of the rotating mechanism, liquid injected into the centrifuge tube can slowly flow into the centrifuge tube along the tube wall of the centrifuge tube, feeding is smooth, liquid oscillation is not easily caused, cells are prevented from being dispersed in each liquid layer, cell curling distortion after centrifugation is reduced, and the practical use experience is good.
The rotating mechanism further comprises a rotating shaft 413, a rotating shaft pipe 414, a rotating shaft pressing ring 415, a fixing plate 416 and a rotating plate 417; the rotating shaft 413 is arranged in the centrifugal cavity, the rotating plate 417 is arranged at the top of the rotating shaft 413, the rotating plate 417 is uniformly provided with mounting bins matched with the centrifuge tube racks 411 in number, and each mounting bin is rotatably provided with the centrifuge tube racks 411; the rotating shaft pressing ring 415 is arranged on the rotating shaft 413 below the rotating plate 417; the rotating shaft tube 414 is arranged on the rotating shaft 413 below the rotating shaft pressing ring 415, and the pushing and pulling assembly is arranged on the rotating shaft tube 414; the fixing plate 416 is disposed on the rotating shaft 413 below the rotating shaft tube 414, and the fixing plate 416 is further connected to the housing 410 and the base 41 to function as a fixing support; the bottom of the rotating shaft 413 passes through the housing 410 and the base 41 and is connected to the output end of the power mechanism.
The servo motor 422 is directly coupled to the rotating shaft 413 by a coupling.
The application of encoder effectively ensures that servo motor 422 work the number of turns of rotation every time and all be the fixed value to ensure that every centrifuge tube rack 411 all resets initial position after accomplishing centrifugal treatment, realize centrifuge tube rack 411's locate function.
The rotating plate 417 is provided with a pressure pad 418 above each centrifuge tube rack 411, so as to limit the centrifuge tube racks 411; pass through during the use the pressure pad 418 realizes the control to centrifuge tube rack 411 swing direction and angle in centrifugal process, effectively avoids bumping between the centrifuging tube on the centrifuge tube rack 411 of two relative settings, ensures the integrality of centrifuging tube.
The push-pull assembly comprises two push-pull devices 419 arranged on two opposite sides of the rotating shaft tube 414, a push block 420 connected with the output ends of the two push-pull devices 419, and a push plate 421 arranged on the push block 420; when in use, the push block 420 pulls the push plate 421 to move through the action of the push-pull device 419 connected with the push block, so that the push plate 421 can push and push the pull tab 412; specifically, the push-pull device 419 is driven to move by an electric cylinder or a push-pull electromagnet.
The outer edge of the bottom of each centrifuge tube shelf 411 is provided with a gravity pressing block 427, when the centrifugal work is completed, an electric cylinder or a push-pull type magnet returns, and each centrifuge tube shelf 411 can automatically return under the gravity action of the gravity pressing block 427;
a cover plate accommodating groove is formed in the shell 410, and a cover plate 428 is arranged on the cover plate accommodating groove; the cover plate 428 is provided with a grabbing groove 429 for grabbing the cover plate 428; the cover plate 428 is further provided with an observation window 430 at one side of the grabbing groove 429, so that an operator can observe the working state in the centrifugal chamber conveniently.
The quantity of centrifuge tube rack 411 is four, and each evenly be equipped with twelve pipe holes on the centrifuge tube rack 411, it is corresponding, the quantity of installation storehouse also is four.
In the present embodiment, the slide staining apparatus includes several slide staining assemblies;
each of the slide staining assemblies includes:
the dyeing bottle is hollow, the bottom of the dyeing bottle is provided with an annular bulge and a rubber ring, and two opposite sides of the annular bulge are respectively extended with a lug;
a mounting seat 431 disposed on the base 41 at the right side of the centrifuge for receiving a carrier plate 432;
the carrier plate 432 is provided with grooves 433 arranged in an array, the grooves 433 are used for accommodating slides, and two inner sides of each groove 433 are provided with buckling positions 434 for buckling annular raised bumps at the bottom of the dyeing bottle;
a dyeing needle tube for inserting into a dyeing bottle and adding a dyeing liquid for cell dyeing;
a needle-shaped waste liquid suction pipe which is inserted into the bottom of the staining bottle and sucks staining solution on the slide;
wherein, handles 435 are arranged on two sides of the carrier plate 432 for transferring the carrier plate 432;
preferably, the number of slide staining assemblies is two.
In this embodiment, the second buffer device comprises a second mounting rack 436 disposed on the base 41 at the front side of the first mounting rack 46 and a large test tube rack 437 detachably disposed on the second mounting rack 436; evenly be equipped with a plurality of big test tube holes on big test-tube rack 437, each big test tube hole all is used for laying big test tube to the realization is to the temporary storage of big test tube, just be equipped with the handle on the left and right sides of big test-tube rack 437 respectively, be convenient for big test-tube rack 437 shift.
In this embodiment, the third buffer device comprises a third mounting rack 438 disposed on the base 41 at the front side of the mounting seat 431, and a buffer pipe rack 439 disposed on the third mounting rack 438; be equipped with a plurality of temporary storage tube holes on temporary storage pipe support 439, each the temporary storage tube hole all is used for laying little test tube 72 to the realization is to the temporary storage of little test tube 72.
The upper end of the large suction nozzle 25 is a mounting end which is mounted on the fixed block 21, the outer surface of the lower end of the large suction nozzle 25 is provided with a small test tube sealing surface 253, the middle of the large suction nozzle 25 is provided with a large test tube sealing surface 252, the diameter of the middle of the large suction nozzle 25 is larger than that of the upper end and the lower end, and the large test tube sealing surface 252 and the small test tube sealing surface 253 are respectively matched with the inner diameter of the orifice of the large test tube and the inner diameter of the orifice of the small test tube; two mutually independent liquid inlet paths 251 are arranged vertically through the large suction nozzle 25.
Two mutually independent liquid inlet paths 251 are arranged vertically through the large suction nozzle 25; for injecting and sucking liquids, respectively;
the large tube sealing surface 252 and the small tube sealing surface 253 match the inner diameter of the orifice of the large tube 71 and the inner diameter of the orifice of the small tube 72, respectively.
A liquid separation channel 254 is arranged between the openings of the two liquid inlet paths 251 at the lower end of the large suction nozzle 25; the liquid dividing channel 254 is a gap with a reversed U-shaped cross section and penetrates through the lower end of the large suction nozzle 25, when liquid is added through one of the liquid inlet channels 251, the liquid dividing channel 254 divides the liquid in the liquid inlet channel 251, and the liquid in the liquid inlet channel is prevented from flowing to the other liquid inlet channel, so that mutual pollution is prevented.
The sealed face 252 of big test tube sets up a bulge loop 256, and bulge loop 256 is three-jaw structure or ring structure for block big test tube 71, has draw-in groove 711 structure on the big test tube 71 promptly, and when big test tube 71 was got to big suction nozzle 25, the bulge loop 256 on the big suction nozzle 25 got into the draw-in groove 711 of big test tube 71, prevented that big test tube 71 from blocking in the reagent bottle lid when getting sample liquid.
The sealed face 252 of big test tube sets up an O type circle groove 257 for it is sealed, when big suction nozzle 25 got big test tube 71, can compress O type circle groove 257, O type circle groove 257 produces elasticity and blocks big test tube 71, realizes the sealed to big test tube 71, prevents that big test tube 71 from blocking in the reagent bottle lid and the sample liquid that big test tube 71 absorbs when getting sample liquid drips in the transfer process.
The large tube sealing surface 252 may also be provided with both a male ring 256 and an O-ring groove 257.
The upper end of the large suction nozzle 25 is provided with an anti-drop groove 255, and the anti-drop groove 255 is a waist-shaped groove.
The diameter of the sealed face 252 of big test tube and the sealed face 253 of little test tube all down reduces from last gradually, and the sealed face 252 of big test tube and the sealed face 253 of little test tube all has a numerical value and equals with the orificial internal diameter of the big test tube 71 mouth of pipe and the little test tube 72 that corresponds to sealed face matches with the test tube mouth of pipe that corresponds.
The pipe-removing mechanism 6 comprises: a tube release fork 61 and a small tube release plate 62; the tube removing fork 61 is used for removing the large test tube 71 on the large suction nozzle 25; the small tube dropping plate 62 is used for dropping the small test tube 72 on the large suction nozzle 25; the tube-removing fork 61 comprises a first tube-removing notch and a first mounting hole; the small pipe dropping plate comprises a second pipe dropping notch and a second mounting hole; the opening of the first tube-removing notch is smaller than the outer diameter of the orifice of the large test tube and larger than the diameter of the corresponding large test tube sealing surface 252 of the suction nozzle; the opening of the second tube-removing notch is smaller than the outer diameter of the orifice of the small test tube and larger than the diameter of the small test tube sealing surface 253 of the corresponding suction nozzle; the same nozzle contains a large tube sealing surface 252 and a small tube sealing surface 253 for mating with a large tube and a small tube, respectively.
In order to cope with the removal work of test tubes of different sizes, a tube-removing fork 61 and a small tube-removing plate 62 are required to be provided in one piece-dyeing machine.
A tube removing fork 61 for removing a relatively large-sized test tube;
including threaded hole 611, circular hole structure 612 and fork structure 613;
two threaded holes 611 are adopted to fix the pipe removing mechanism 6 in the horizontal direction, so that the pipe removing mechanism is prevented from rotating; the round hole structure 612 can pass through the large suction nozzle 25 and cannot pass through the large test tube 71, so that the large test tube 71 falls off; a fork structure 613 for forking the large test tube 71.
The mounting hole of the tube-releasing fork 61 can be a round hole or a threaded hole; the round hole is fixed by a straight nail; the threaded hole is fixed by a screw, and the outer diameter of the threaded hole 611 is 4 mm.
A U-shaped notch is formed in the middle of the tube-releasing fork 61, a round hole structure 612 is arranged in the middle of the U-shaped notch, the round hole structure 612 is located in the center of the U-shaped notch in the length direction, and the diameter of the round hole structure is smaller than the outer diameter of the orifice of the small test tube and larger than the diameter of the sealing surface of the large test tube of the corresponding suction nozzle; the tube-removing fork 61 is in a structure that a U shape is formed by removing a cuboid in the middle of the cuboid, a cylindrical space is dug in the center along the length direction of the cuboid, a round hole structure 612 is formed, a chamfer is arranged on the outer side edge of the tube-removing fork 61, the two edges of the chamfer are equal in length, and the length of the edge of the chamfer is 1 mm.
A vial removal plate 62 for removing relatively small-sized test tubes;
containing an open slot 624 for removal of cuvette 72.
The specific processing process of the small pipe dropping plate 62 is that the sheet metal plate is bent at right angles for 4 times; the inner side of the opening groove 624 is a semicircle, the radius of the semicircle is 3mm, and the opening size of the opening groove 624 is smaller than the outer diameter of the orifice of the small test tube 72 and larger than the diameter of the small test tube sealing surface 253 of the corresponding suction nozzle.
The shape of the small pipe dropping plate 62 is that two Z are superposed up and down, wherein the oblique line in the middle of the upper and lower horizontal lines of the Z is perpendicular to the upper and lower horizontal lines, the dropping plate is formed by bending a T-shaped sheet metal for 4 times at right angles, the T-shaped sheet metal is bent for the first time in the direction of 270 degrees, the T-shaped sheet metal is bent for the second time in the direction of 180 degrees, the T-shaped sheet metal is bent for the third time in the direction of 270 degrees, and the T-shaped sheet metal is bent for the fourth time in the direction of 180 degrees; transition parts between different widths of the T-shaped sheet metal are rounded, and the radius of the rounded corner is 3mm and 5 mm.
A large cuvette 71 comprising: the test tube is conical, the upper end of the test tube is provided with a tube opening, the lower end of the test tube is provided with a sharp mouth 713, and the aperture of the tube opening is larger than that of the sharp mouth 713;
the inside of the pipe orifice is provided with a clamping groove 711 for fixing an external suction nozzle, and the clamping groove 711 is an annular groove along the inside of the pipe orifice.
The sharp mouth one end in the test tube outside is provided with strengthening rib 712, and strengthening rib 712 is the slice bar-shaped structure that sets up along the test tube outer wall, and strengthening rib 712 stands on the test tube outer wall on the side.
The number of the reinforcing ribs can be 4, and in actual production, the number of the reinforcing ribs can be 2 or more.
There are two embodiments of the nozzle tip 713 at the lower end of the cuvette:
1) one of the beak 713 is a U-shaped beak 713a with both sides inclined;
2) another nib 713 is an O-shaped nib 713b with one side inclined.
The U-shaped beak 713a is formed by bilaterally symmetric beveling of the nozzle, and the O-shaped beak 713b is formed by unilateral beveling of the nozzle.
The outside of the tube mouth at the upper end of the test tube is provided with a reinforcing rib 712, and in order to enhance the structural strength of the tube mouth end, the outside of the tube mouth end is also provided with 2 or more reinforcing ribs 712.
The working principle of the invention is as follows: firstly, a large test tube 71 is placed on a large test tube rack 437, a small test tube 72 is placed on a temporary storage tube rack 439, a specimen reagent bottle is placed on a sample tube rack 47, a slide and a staining bottle are placed on a support plate 432, then a centrifugal tube is placed in a centrifugal tube hole of a centrifugal tube rack 411, after the centrifugal tube is placed, a moving mechanism 3 drives a large suction nozzle 25 to move to the position above the large test tube rack 437 to grab the large test tube 71, and therefore the combination of the large test tube 71 and the large suction nozzle 25 is completed; then, the moving mechanism 3 drives the large test tube 71 to move to the upper part of the sample tube rack 47, and inserts the large test tube 71 into the sample bottle on the sample tube rack 47 for sampling; then, the sample moving mechanism 3 is used for driving the large test tube 71 to move to the upper part of the centrifuge tube rack 411, meanwhile, the electric cylinder or the push-pull type electromagnet pushes the centrifuge tube to rotate for a certain angle, the large test tube 71 is inserted into the centrifuge tube on the centrifuge tube rack 411, and the sample in the large test tube 71 is injected into the centrifuge tube; then, the large test tube 71 used in the large suction nozzle 25 is discarded into the first waste material barrel 42, the large suction nozzle 25 again grabs a new large test tube 71 at another position, the rotating plate 417 rotates 180 degrees, and then the above operations of sampling and injecting samples are repeated until all the centrifugal tubes are injected with samples as required; starting the servo motor 422, rotating the centrifuge tube rack 411 under the driving of the servo motor 422, and rotating the centrifuge tube along with the rotation of the centrifuge tube rack 411; the servo motor 422 rotates to the preset number of turns of the encoder and stops to finish the centrifugal treatment of the centrifugal tube; then, the moving mechanism 3 drives the large suction nozzle 25 to move to the position above the temporary storage pipe frame 439 to grab the small test tube 72, the moving mechanism 3 drives the small test tube 72 to move to the position above the centrifugal tube, the cell sample in the centrifugal tube is transferred to the staining bottle, so that the staining solution can be dripped on the slide, after sufficient staining, redundant staining solution is sucked away through the needle-shaped waste liquid suction tube, and after multiple times of staining (staining with different colors), the cell slide can be obtained.
When the tablet-making dyeing machine needs to add liquid into the centrifugal tube, the Z axis on the tablet-making dyeing machine moves to a corresponding position, liquid is added into the centrifugal tube from one of the liquid inlet paths 251 of the large suction nozzle 25, and the liquid in the one path cannot flow to the other path due to the liquid separating channel 254 arranged on the large suction nozzle 25, so that mutual pollution of the two paths of liquid is prevented.
When the slice-making dyeing machine needs to transfer the sample liquid to a centrifuge tube, the slice-making dyeing machine moves to a coordinate position corresponding to a large test tube 71 placing plate, the Z shaft moves downwards to a fixed position where a large suction nozzle 25 enters the large test tube 71, the large test tube 71 is extracted to suck the sample liquid in a reagent bottle into the large test tube 71, the sample liquid is transferred to the centrifuge tube, then the sample liquid moves to the upper part of a recovery box of the large test tube 71, the Z shaft moves upwards, the large suction nozzle 25 enters a tube-removing fork 61, the tube-removing fork 61 supports against the large test tube 71, and therefore the large test tube 71 falls into the recovery box of the large test tube 71.
When the slice-making dyeing machine needs to draw the centrifugal waste liquid from the centrifugal tube, the slice-making dyeing machine runs to the coordinate position corresponding to the placing plate of the large test tube 71, the Z axis runs downwards to the fixed position where the large suction nozzle 25 enters the large test tube 71, the large test tube 71 is extracted to draw the centrifugal waste liquid in the centrifugal tube, the centrifugal waste liquid is transferred to the waste liquid tank when the Z axis runs downwards, then the centrifugal waste liquid is transferred to the waste liquid tank when the Z axis runs upwards, the large suction nozzle 25 enters the tube-removing fork 61, the tube-removing fork 61 supports the large test tube 71, and therefore the large test tube 71 falls into the large test tube 71 recovery box.
When the pelleter dyeing machine needs to transfer the centrifugate in the centrifuge tube to the dyeing device, the pelleter dyeing machine runs to the small test tube 72 to place the coordinate position corresponding to the plate, the Z axis moves downwards to the fixed position where the large suction nozzle 25 enters the small test tube 72, the small test tube 72 is extracted to suck the centrifugate in the centrifuge tube into the small test tube 72, then the centrifugate is transferred to the dyeing device, then the centrifugate runs to the open slot of the tubule doffing plate 62 above the small test tube 72 recovery box, the Z axis moves upwards, the open slot of the tubule doffing plate 62 clamps the small test tube, the Z axis continues to move upwards, and the small test tube in a row drops to the small test tube recovery box.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention, and all modifications and equivalents of the present invention, which are made by the contents of the present specification and the accompanying drawings, or directly/indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (5)
1. A cell slide staining machine comprising: the cell slide production device comprises a rack, a suction nozzle mechanism, a moving mechanism, a cell slide production platform and a pressure pump set, wherein the suction nozzle mechanism is arranged at the top of the rack through the moving mechanism, the cell slide production platform is arranged at the bottom of the rack, and the pressure pump set is arranged on the side wall of the rack and connected with the suction nozzle mechanism;
the suction nozzle mechanism is characterized by comprising a large suction nozzle and a fixed block;
the upper end of the large suction nozzle is a mounting end which is mounted on the fixed block, the outer surface of the lower end of the large suction nozzle is provided with a small test tube sealing surface, the middle of the large suction nozzle is provided with a large test tube sealing surface, the diameter of the middle of the large suction nozzle is larger than the diameters of the upper end and the lower end,
the sealing surface of the large test tube and the sealing surface of the small test tube are respectively matched with the inner diameter of the orifice of the large test tube and the inner diameter of the orifice of the small test tube;
two mutually independent liquid inlet paths are arranged vertically through the large suction nozzle;
a liquid separation channel is arranged between the openings of the two liquid inlet paths at the lower end of the large suction nozzle;
the liquid dividing channel is a gap with an inverted-U-shaped cross section and penetrates through the lower end of the large suction nozzle;
the mounting end at the upper end of the large suction nozzle is provided with an anti-drop groove which is a waist-shaped groove;
the cell preparation dyeing machine further comprises: a tube-removing fork and a small tube-removing plate; the tube-removing fork is used for removing the large test tube on the large suction nozzle; the small tube dropping plate is used for removing the small test tube on the large suction nozzle;
the tube-removing fork comprises a first tube-removing notch and a first mounting hole; the small pipe dropping plate comprises a second pipe dropping notch and a second mounting hole; the opening of the first tube-removing notch is smaller than the outer diameter of the orifice of the large test tube and larger than the diameter of the sealing surface of the large test tube of the corresponding large suction nozzle; the opening of the second tube-removing notch is smaller than the outer diameter of the orifice of the small test tube and larger than the diameter of the sealing surface of the small test tube of the corresponding large suction nozzle;
the first mounting hole and the second mounting hole are round holes or threaded holes;
the tube-releasing fork is U-shaped;
the first tube-releasing notch of the tube-releasing fork is of a round hole structure, the round hole structure is positioned at the center of the tube-releasing fork in the length direction, and the diameter of the round hole structure is smaller than the outer diameter of the orifice of a large test tube and larger than the diameter of a large test tube sealing surface of a corresponding large suction nozzle;
the outer edge of the tube-removing fork is provided with a chamfer, and two edges of the chamfer are equal in length;
the second tube-removing notch is an open slot, and the opening size of the open slot is smaller than the outer diameter of the orifice of the small test tube and larger than the diameter of the sealing surface of the small test tube of the corresponding large suction nozzle;
the shape of the small tube dropping plate is that two Z-shaped dropping plates are overlapped up and down, wherein the oblique line between the upper and lower horizontal lines of the Z shape is vertical to the upper and lower horizontal lines;
the transition part between different widths of the small pipe dropping plate is rounded.
2. Cell slide staining machine according to claim 1,
one or two of a convex ring and an O-shaped ring groove are arranged on the sealing surface of the large test tube;
the convex ring is of a three-claw structure or a circular ring structure.
3. Cell slide staining machine according to claim 1,
the large test tube is conical, the upper end of the large test tube is provided with a tube orifice, the lower end of the large test tube is provided with a sharp nozzle, and the aperture of the tube orifice is larger than that of the sharp nozzle;
a clamping groove is formed in the inner side of the pipe orifice and used for fixing the large suction nozzle, and the clamping groove is an annular groove;
the tip mouth at the lower end of the large test tube is a U-shaped tip mouth with two inclined sides or an O-shaped tip mouth with one inclined side.
4. Cell slide staining machine according to claim 3,
one end of the sharp mouth outside the large test tube is provided with a reinforcing rib;
the strengthening rib is the slice bar-shaped structure that sets up along the test tube outer wall, and the strengthening rib side is stood on the test tube outer wall.
5. Cell slide staining machine according to claim 3,
and reinforcing ribs are arranged on the outer side of the pipe orifice at the upper end of the large test tube.
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| CN202110807591.3A CN113267396B (en) | 2021-07-16 | 2021-07-16 | Cell film-making dyeing machine |
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| JP2005168455A (en) * | 2003-12-15 | 2005-06-30 | Olympus Corp | Apparatus for producing cell array substrate and method for producing cell array substrate |
| CN101566537B (en) * | 2009-06-03 | 2010-09-01 | 武汉宏强医疗器械有限公司 | Injector for cellular assay |
| WO2011002522A2 (en) * | 2009-07-02 | 2011-01-06 | Medimmune, Llc | Methods of making and using synthetic viruses |
| CN103405337A (en) * | 2013-08-28 | 2013-11-27 | 苏州创扬医药包装科技有限公司 | Polypropylene double-head connector for large infusion bag and production method thereof |
| CN205593817U (en) * | 2016-04-14 | 2016-09-21 | 中山市康乃欣生物医疗科技有限公司 | Automatic application of sample needle moves back tubular construction for liquid -based thin -layer cell pelleter |
| CN205786025U (en) * | 2016-06-25 | 2016-12-07 | 南京健邦锦源医疗仪器有限公司 | A kind of cell separation film-making dyeing all-in-one |
| CN207391417U (en) * | 2017-09-26 | 2018-05-22 | 北京旌准医疗科技有限公司 | A kind of transfer pipet(te) for poba gene test experience |
| CN210844766U (en) * | 2019-06-11 | 2020-06-26 | 大理白族自治州人民医院 | Universal joint for connecting oxygen hose and oxygen bag |
| CN211426013U (en) * | 2019-10-28 | 2020-09-04 | 宁波美生医疗器材有限公司 | Lifting liquid suction mechanical arm |
| CN112179738B (en) * | 2020-09-30 | 2021-07-13 | 易普森生物科技(深圳)有限公司 | Novel cell pelleter |
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