CN113244340A - Traditional Chinese medicine mixture for treating calculus removal and preparation method thereof - Google Patents
Traditional Chinese medicine mixture for treating calculus removal and preparation method thereof Download PDFInfo
- Publication number
- CN113244340A CN113244340A CN202110665804.3A CN202110665804A CN113244340A CN 113244340 A CN113244340 A CN 113244340A CN 202110665804 A CN202110665804 A CN 202110665804A CN 113244340 A CN113244340 A CN 113244340A
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- China
- Prior art keywords
- mixture
- traditional chinese
- chinese medicine
- preparation
- calculus removal
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine mixture for treating calculus removal and a preparation method thereof, wherein the mixture is prepared from the following raw material medicines in parts by weight: 8 g of herba pyrrosiae, 9 g of corn stigma, 12 g of cluster mallow seed, 10 g of fringed pink, 8 g of polygonum aviculare, 45 g of desmodium, 20 g of fried chicken's gizzard-membrane, 9 g of spora lygodii, 6 g of fructus aurantii, 8 g of rhizoma alismatis, 6 g of radix scutellariae, 7 g of gardenia jasminoides ellis, 12 g of talc, 6 g of polygonum cuspidatum, 10 g of raw liquorice and 8 g of fructus forsythiae. The invention has scientific and reasonable formula, novel and reasonable preparation method, high precision of process parameters, less component loss and stable drug effect, is suitable for various urinary calculi diseases such as kidney calculi, urethral calculi and the like, is not easy to relapse after being cured, and meets the requirement of clinical treatment.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine mixture for treating calculus removal and a preparation method thereof.
Background
At present, methods for treating calculus are mainly divided into surgical therapy and non-surgical therapy, patients suitable for the non-surgical therapy generally adopt traditional Chinese medicine for adjuvant therapy, and traditional Chinese medicines for treating calculus in the prior art are rare and have unobvious curative effect. Therefore, it is very necessary to develop a Chinese medicinal mixture for effectively treating calculus.
Disclosure of Invention
The invention aims to make up the defects of the prior art and provides a traditional Chinese medicine mixture for treating calculus removal and a preparation method thereof.
The invention is realized by the following technical scheme:
a traditional Chinese medicine mixture for treating calculus removal is prepared from the following raw material medicines in parts by weight:
5-10 g of herba pyrrosiae, 7-10 g of corn stigma, 10-15 g of cluster mallow seed, 8-12 g of fringed pink, 7-10 g of polygonum aviculare, 43-46 g of desmodium, 18-22 g of fried chicken's gizzard-membrane, 7-10 g of lygodium japonicum, 4-7 g of fructus aurantii, 5-9 g of rhizoma alismatis, 4-7 g of radix scutellariae, 5-9 g of gardenia jasminoides ellis, 10-14 g of talc, 4-7 g of polygonum cuspidatum, 8-12 g of raw liquorice and 7-10 g of fructus forsythiae.
The mixture is prepared from the following raw material medicines in parts by weight:
8 g of herba pyrrosiae, 9 g of corn stigma, 12 g of cluster mallow seed, 10 g of fringed pink, 8 g of polygonum aviculare, 45 g of desmodium, 20 g of fried chicken's gizzard-membrane, 9 g of spora lygodii, 6 g of fructus aurantii, 8 g of rhizoma alismatis, 6 g of radix scutellariae, 7 g of gardenia jasminoides ellis, 12 g of talc, 6 g of polygonum cuspidatum, 10 g of raw liquorice and 8 g of fructus forsythiae.
A preparation method of a traditional Chinese medicine mixture for treating calculus removal comprises the following steps:
(1) respectively drying folium Pyrrosiae, stigma Maydis, semen Abutili, herba Dianthi, herba Polygoni Avicularis, endothelium corneum Gigeriae Galli preparata, herba Lysimachiae Christinae, and spora Lygodii, grinding into fine powder, mixing the fine powders, ultrasonic extracting with 80% ethanol solution to obtain extractive solution and residue, and mixing the extractive solution with n-butanol at a volume ratio of 1: (2-3) mixing, extracting, concentrating and recovering n-butyl alcohol to obtain an extract for later use;
(2) placing fructus Aurantii, Alismatis rhizoma, Scutellariae radix, fructus Gardeniae, pulvis Talci, rhizoma Polygoni Cuspidati, Glycyrrhrizae radix, and fructus forsythiae into an extraction tank, adding 5-8 times of water, soaking for 20-30 min, heating to extract volatile oil, storing the volatile oil at 0-4 deg.C, and collecting the residue;
(3) mixing the medicine residues obtained in the step 1 and the step 2, pouring the mixture into a medicine boiler, adding 3-6 times of mass water, soaking for 20-30 minutes, heating to boil, decocting for 60-120 minutes with slow fire, and filtering to obtain a liquid medicine for later use;
(4) mixing the extract obtained in the step 1 and the liquid medicine obtained in the step 3, feeding the mixture into a medicine boiler, heating, stirring and concentrating to obtain concentrated liquid medicine, cooling to normal temperature, adding the volatile oil obtained in the step 2, stirring uniformly, weighing and bottling to obtain the mixture.
Adding a sweetening agent after the temperature is reduced to the normal temperature in the step (4).
The sweetening agent is stevioside, and the adding amount is 0.2-0.5 g/L.
The traditional Chinese medicine used in the invention comprises:
the herba pyrrosiae is a perennial herb of the Spiraeae family, and has bitter and mild taste. Enter lung and bladder meridians, induce diuresis to treat stranguria, clear lung-heat and purge heat. It can be used for treating stranguria, hematuria, lithangiuria, nephritis, metrorrhagia, dysentery, cough due to lung heat, chronic tracheitis, incised wound, and superficial infection.
The corn stigma has the effects of promoting urination and reducing swelling, and clearing liver and benefiting gallbladder; can be used for treating edema, dribbling urination, jaundice, cholecystitis, cholelithiasis, hypertension, diabetes, and galactostasis.
The semen Abutili belongs to large intestine, small intestine and bladder channels, has effects of promoting diuresis for treating stranguria, smoothing intestine, relaxing bowels and promoting lactation, and can be used for treating gonorrhea, edema, constipation and galactostasis.
Dianthus superbus is the dry overground part of Dianthus superbus or Dianthus caryophyllus of Dianthus family, and is bitter in taste and cold in nature. It enters heart and small intestine meridians. Has effects of inducing diuresis for treating stranguria, promoting blood circulation and dredging channels. Can be used for treating heat stranguria, blood stranguria, stranguria with stone, difficulty in micturition, dribbling urination, pain, and amenorrhea and blood stasis.
Herba Polygoni Avicularis has effects of clearing heat, diminishing inflammation, and expelling parasites.
Herba Lysimachiae Christinae is fresh or dried whole herb of herba Lysimachiae Christinae of genus Lysimachia of family Primulaceae, and is bitter, sour and slightly cold in taste. It enters liver, gallbladder, kidney and bladder meridians. Has the functions of clearing away heat and toxic material, promoting urination, removing urinary calculus, promoting blood circulation and dissipating blood stasis.
Endothelium corneum Gigeriae Galli is inner wall of dry ballast of domestic chicken of Phasianidae, sweet and flat. It enters spleen, stomach, small intestine and bladder meridians. Strengthening the stomach to promote digestion, arresting seminal emission and relieving enuresis, and treating stranguria and removing calculus.
Spora Lygodii is dry mature spore of spora Lygodii of the family Lygodiaceae, and has sweet, salty and cold properties. It enters bladder and small intestine meridians. Clear damp-heat, relieve stranguria and alleviate pain. Can be used for treating pyretic stranguria, urolithic stranguria, bloody stranguria, chylous stranguria, and urethral astringency and pain.
Bitter, pungent and sour fructus aurantii, slightly cold, entering spleen and stomach channels, regulating qi-flowing for relieving epigastric distention, activating stagnancy and relieving distension, and can be used for treating qi stagnation in chest and hypochondrium, fullness and pain, indigestion, phlegm-fluid retention, and viscera prolapse.
Rhizoma alismatis is sweet and light in flavor and cold in nature; it enters kidney and bladder meridians. Has the effects of promoting diuresis, eliminating dampness, clearing heat and treating stranguria. It can be used for treating dysuria, pyretic stranguria, odynuria, edema, diarrhea, phlegm retention, vertigo, and spermatorrhea.
Scutellariae radix has effects of clearing heat and eliminating dampness, clearing pathogenic fire and removing toxic substance, stopping bleeding, and preventing miscarriage, and can be used for treating damp warmth, summer dampness, chest distress and nausea, damp heat and fullness, dysentery, jaundice, cough due to lung heat, hyperpyrexia and polydipsia, blood heat and epistaxis, carbuncle, swelling, sore and toxin, and threatened abortion.
Gardenia jasminoides is the fruit of gardenia belonging to the family Rubiaceae, bitter and cold. It enters heart, lung and triple energizer meridians. Purging pathogenic fire, relieving restlessness, clearing away heat, promoting diuresis, cooling blood, and removing toxic substances; it can be used topically for relieving swelling and pain.
Talc is a common silicate mineral, sweet, bland and cold. It enters bladder, lung and stomach meridians. Induce diuresis to treat stranguria, clear away summer-heat, dispel dampness and heal wound. Can be used for treating pyretic stranguria, urolithiasis, odynuria, summer-heat dampness polydipsia, damp-heat watery diarrhea; it can be used for treating eczema, and miliaria.
Rhizoma Polygoni Cuspidati has effects of promoting diuresis, eliminating jaundice, clearing heat and detoxicating, removing blood stasis, relieving pain, relieving cough and eliminating phlegm. Can be used for treating jaundice due to damp-heat pathogen, stranguria with turbid discharge, leukorrhagia, rheumatalgia, carbuncle, swelling, sore, scald due to water and fire, amenorrhea, abdominal mass, contusion injury, and cough due to lung heat.
The raw licorice root is the dry product of the root and rhizome of the medicinal plant licorice root, has sweet and mild taste and enters spleen, stomach and lung channels. Replenishing qi and strengthening the middle warmer; relieving spasm and pain; moistening lung to arrest cough; purging pathogenic fire and removing toxic substances; harmonize the drugs.
Lian Qiao clears away heat and toxic material, dissipates swelling and dissipates stagnation. For warm heat, erysipelas, macula, superficial infection, swelling, scrofula, stranguria with urine, it is indicated for five stranguria, urinary obstruction, small intestine and pus discharge. For sores and furuncles, it can alleviate pain.
The invention has the advantages that: the formula of the invention is scientific and reasonable, the corn stigma has the effects of inducing diuresis to reduce edema, clearing liver and benefiting gallbladder, and has good calculus removing effect on gallstones, and the radix scutellariae has the effects of clearing heat and drying dampness, purging fire and detoxifying, can induce diuresis to reduce edema, promote blood circulation to remove meridian obstruction, and is beneficial to removing calculus; the calculus is dissolved layer by using a plurality of medicines with the effects of promoting diuresis, excreting dampness and treating stranguria and dissolving calculus such as corn stigma, longhairy antenoron herb, oriental waterplantain rhizome, herba pyrrosiae, chicken's gizzard-membrane and the like, and the effects of promoting urination and reducing swelling can promote the peristalsis of a ureter, expand the ureter and promote blood circulation and remove meridian obstruction by using cluster mallow, Japanese climbing fern seed, Japanese climbing fern spore, giant knotweed rhizome and the like as auxiliary medicines, so that the calculus is promoted to be discharged, and a treatment mode integrating dissolving, eliminating calculus and discharging calculus is formed, and the calculus is more thoroughly and cleanly discharged; the preparation method is novel and reasonable, the precision of process parameters is high, the loss of components is less, the drug effect is stable, the traditional Chinese medicine composition is suitable for various urinary calculi diseases such as kidney calculi, urethral calculi and the like, the diseases are not easy to relapse after being cured, and the clinical treatment requirements are met.
Detailed Description
A traditional Chinese medicine mixture for treating calculus removal is prepared from the following raw material medicines in parts by weight:
8 g of herba pyrrosiae, 9 g of corn stigma, 12 g of cluster mallow seed, 10 g of fringed pink, 8 g of polygonum aviculare, 45 g of desmodium, 20 g of fried chicken's gizzard-membrane, 9 g of spora lygodii, 6 g of fructus aurantii, 8 g of rhizoma alismatis, 6 g of radix scutellariae, 7 g of gardenia jasminoides ellis, 12 g of talc, 6 g of polygonum cuspidatum, 10 g of raw liquorice and 8 g of fructus forsythiae.
A preparation method of a traditional Chinese medicine mixture for treating calculus removal comprises the following steps:
(1) respectively drying folium Pyrrosiae, stigma Maydis, semen Abutili, herba Dianthi, herba Polygoni Avicularis, endothelium corneum Gigeriae Galli preparata, herba Lysimachiae Christinae, and spora Lygodii, grinding into fine powder, mixing the fine powders, ultrasonic extracting with 80% ethanol solution to obtain extractive solution and residue, and mixing the extractive solution with n-butanol at a volume ratio of 1: (2-3) mixing, extracting, concentrating and recovering n-butyl alcohol to obtain an extract for later use;
(2) placing fructus Aurantii, Alismatis rhizoma, Scutellariae radix, fructus Gardeniae, pulvis Talci, rhizoma Polygoni Cuspidati, Glycyrrhrizae radix, and fructus forsythiae into an extraction tank, adding 5-8 times of water, soaking for 20-30 min, heating to extract volatile oil, storing the volatile oil at 0-4 deg.C, and collecting the residue;
(3) mixing the medicine residues obtained in the step 1 and the step 2, pouring the mixture into a medicine boiler, adding 3-6 times of mass water, soaking for 20-30 minutes, heating to boil, decocting for 60-120 minutes with slow fire, and filtering to obtain a liquid medicine for later use;
(4) mixing the extract obtained in the step 1 and the liquid medicine obtained in the step 3, feeding the mixture into a medicine boiler, heating, stirring and concentrating to obtain concentrated liquid medicine, cooling to normal temperature, adding the volatile oil obtained in the step 2, stirring uniformly, weighing and bottling to obtain the mixture.
Adding a sweetening agent after the temperature is reduced to the normal temperature in the step (4).
The sweetening agent is stevioside, and the adding amount is 0.2-0.5 g/L.
Typical case 1
Liu Yi, women, age 40, often left waist pain, right kidney slight calculus if going to hospital examination, calculus at left ureter bladder entrance, calculus size of 1.3 x 1.2cm, after operation treatment and drug treatment, a period of time is good, recurrence after half a year, going to hospital examination, calculus at left ureter bladder entrance still exists, calculus size of 0.8 x 1.0cm, diagnosis before introduction, calculus size of 0.6 x 0.4cm after one month of taking the mixture of the invention, continued consolidation treatment for 2 months, b ultrasonic examination, calculus basically disappeared, no recurrence after follow-up diagnosis.
Typical case 2
He, male, 22 years old, work in the building site, and stay up overnight for a long time, often appeared the waist pain, through doctor consultation and abdomen B ultrasonic examination, the result confirmed diagnosis is left kidney stone, the stone size is 8 millimeters. After a patient takes the mixture for one month, the symptoms are obviously improved, no waist pain or discomfort in the kidney areas is caused, and the patient is shown to have no calculus in the left kidney and completely healed after rechecking the examination result again.
Typical case 3
Xie for a woman, 55 years old, right waist and abdomen pain, difficult urination and pain in the bladder area, the color Doppler ultrasonography shows that stones on the left ureter wall section are in hospital examination, the mixture of the invention is introduced to be taken by the person, the symptoms of difficult urination, diuresis, discomfort in the bladder area and the like do not exist after two weeks, the urinary color Doppler ultrasonography is rechecked after one month, the stones are discharged, and no relapse occurs in follow-up diagnosis.
Claims (5)
1. A traditional Chinese medicine mixture for treating calculus removal is characterized in that: the mixture is prepared from the following raw material medicines in parts by weight:
5-10 g of herba pyrrosiae, 7-10 g of corn stigma, 10-15 g of cluster mallow seed, 8-12 g of fringed pink, 7-10 g of polygonum aviculare, 43-46 g of desmodium, 18-22 g of fried chicken's gizzard-membrane, 7-10 g of lygodium japonicum, 4-7 g of fructus aurantii, 5-9 g of rhizoma alismatis, 4-7 g of radix scutellariae, 5-9 g of gardenia jasminoides ellis, 10-14 g of talc, 4-7 g of polygonum cuspidatum, 8-12 g of raw liquorice and 7-10 g of fructus forsythiae.
2. The traditional Chinese medicine mixture for treating calculus removal according to claim 1, which is characterized in that: the mixture is prepared from the following raw material medicines in parts by weight: 8 g of herba pyrrosiae, 9 g of corn stigma, 12 g of cluster mallow seed, 10 g of fringed pink, 8 g of polygonum aviculare, 45 g of desmodium, 20 g of fried chicken's gizzard-membrane, 9 g of spora lygodii, 6 g of fructus aurantii, 8 g of rhizoma alismatis, 6 g of radix scutellariae, 7 g of gardenia jasminoides ellis, 12 g of talc, 6 g of polygonum cuspidatum, 10 g of raw liquorice and 8 g of fructus forsythiae.
3. A preparation method of a traditional Chinese medicine mixture for treating calculus removal is characterized by comprising the following steps: the method comprises the following steps:
(1) respectively drying folium Pyrrosiae, stigma Maydis, semen Abutili, herba Dianthi, herba Polygoni Avicularis, endothelium corneum Gigeriae Galli preparata, herba Lysimachiae Christinae, and spora Lygodii, grinding into fine powder, mixing the fine powders, ultrasonic extracting with 80% ethanol solution to obtain extractive solution and residue, and mixing the extractive solution with n-butanol at a volume ratio of 1: (2-3) mixing, extracting, concentrating and recovering n-butyl alcohol to obtain an extract for later use;
(2) placing fructus Aurantii, Alismatis rhizoma, Scutellariae radix, fructus Gardeniae, pulvis Talci, rhizoma Polygoni Cuspidati, Glycyrrhrizae radix, and fructus forsythiae into an extraction tank, adding 5-8 times of water, soaking for 20-30 min, heating to extract volatile oil, storing the volatile oil at 0-4 deg.C, and collecting the residue;
(3) mixing the medicine residues obtained in the step 1 and the step 2, pouring the mixture into a medicine boiler, adding 3-6 times of mass water, soaking for 20-30 minutes, heating to boil, decocting for 60-120 minutes with slow fire, and filtering to obtain a liquid medicine for later use;
(4) mixing the extract obtained in the step 1 and the liquid medicine obtained in the step 3, feeding the mixture into a medicine boiler, heating, stirring and concentrating to obtain concentrated liquid medicine, cooling to normal temperature, adding the volatile oil obtained in the step 2, stirring uniformly, weighing and bottling to obtain the mixture.
4. The preparation method of the traditional Chinese medicine mixture for treating calculus removal according to claim 3, which is characterized by comprising the following steps: adding a sweetening agent after the temperature is reduced to the normal temperature in the step (4).
5. The preparation method of the traditional Chinese medicine mixture for treating calculus removal according to claim 4, which is characterized by comprising the following steps: the sweetening agent is stevioside, and the adding amount is 0.2-0.5 g/L.
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Application publication date: 20210813 |