CN113350456A - Traditional Chinese medicine mixture for treating calculus removal and preparation method thereof - Google Patents
Traditional Chinese medicine mixture for treating calculus removal and preparation method thereof Download PDFInfo
- Publication number
- CN113350456A CN113350456A CN202110759492.2A CN202110759492A CN113350456A CN 113350456 A CN113350456 A CN 113350456A CN 202110759492 A CN202110759492 A CN 202110759492A CN 113350456 A CN113350456 A CN 113350456A
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- mixture
- traditional chinese
- chinese medicine
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Classifications
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Abstract
The invention discloses a traditional Chinese medicine mixture for treating calculus removal and a preparation method thereof, wherein the mixture is prepared from the following raw material medicines in parts by weight: 16 g of pyrrosia leaf, 16 g of dried rehmannia root, 12 g of cluster mallow seed, 10 g of tuckahoe, 6g of raw liquorice, 12 g of climbing fern spore, 20 g of fried chicken's gizzard-membrane, 6g of scutellaria baicalensis, 12 g of talcum, 10 g of rhizoma alismatis, 10 g of polyporus, 9 g of plantain herb, 15 g of herba patriniae, 10 g of lalang grass rhizome, 20 g of lysimachia christinae hance and 10 g of gardenia jasminoides ellis. The invention has scientific and reasonable formula, novel and reasonable preparation method, high precision of process parameters, less component loss and stable drug effect, is suitable for various urinary calculi diseases such as kidney calculi, urethral calculi and the like, is not easy to relapse after being cured, and meets the requirement of clinical treatment.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine mixture for treating calculus removal and a preparation method thereof.
Background
Urinary calculus is a common disease in urology surgery, and the domestic incidence rate is high. Although various means are applied to clinical treatment at present and good effects are obtained, such as external shock wave lithotripsy, ureteroscope, percutaneous nephroscope, ultrasonic lithotripsy, laser lithotripsy and the like, the postoperative calculus residue rate and the calculus recurrence rate are still high. At present, patients suitable for non-operative therapy generally adopt traditional Chinese medicine for adjuvant therapy, and traditional Chinese medicines for treating calculus in the prior art are rare and have unobvious curative effect. Therefore, it is very necessary to develop a Chinese medicinal mixture for effectively treating calculus.
Disclosure of Invention
The invention aims to make up the defects of the prior art and provides a traditional Chinese medicine mixture for treating calculus removal and a preparation method thereof.
The invention is realized by the following technical scheme:
a traditional Chinese medicine mixture for treating calculus removal is prepared from the following raw material medicines in parts by weight:
14-18 g of pyrrosia leaf, 14-18 g of dried rehmannia root, 10-15 g of malva seed, 8-12 g of tuckahoe, 4-8 g of raw liquorice, 10-14 g of lygodium japonicum, 18-22 g of fried chicken's gizzard-membrane, 4-7 g of scutellaria baicalensis, 10-14 g of talcum, 8-12 g of rhizoma alismatis, 8-12 g of grifola, 7-11 g of plantain herb, 13-17 g of field pennycress, 8-12 g of cogongrass rhizome, 18-22 g of lysimachia christinae hance and 8-12 g of gardenia jasminoides.
The mixture is prepared from the following raw material medicines in parts by weight:
16 g of pyrrosia leaf, 16 g of dried rehmannia root, 12 g of cluster mallow seed, 10 g of tuckahoe, 6g of raw liquorice, 12 g of climbing fern spore, 20 g of fried chicken's gizzard-membrane, 6g of scutellaria baicalensis, 12 g of talcum, 10 g of rhizoma alismatis, 10 g of polyporus, 9 g of plantain herb, 15 g of herba patriniae, 10 g of lalang grass rhizome, 20 g of lysimachia christinae hance and 10 g of gardenia jasminoides ellis.
A preparation method of a traditional Chinese medicine mixture for treating calculus removal comprises the following steps:
(1) removing impurities from folium Pyrrosiae, radix rehmanniae, semen Abutili, Poria, Glycyrrhrizae radix, spora Lygodii, endothelium corneum Gigeriae Galli preparata, Scutellariae radix, Alismatis rhizoma, Polyporus, herba plantaginis, herba Patriniae, pulvis Talci, lalang grass rhizome, herba Lysimachiae Christinae, and fructus Gardeniae, air drying, pulverizing into granules, and soaking in water for 1 hr; putting the soaked raw materials into a multifunctional extraction tank, and decocting with water twice; adding water in an amount which is 10 times that of the total medicinal materials for the first time, decocting for 1.5-2 hours, taking decoction, filtering, adding water in an amount which is 7 times that of the total medicinal materials for the second time, decocting for 1-1.2 hours, taking the two decoctions, mixing, filtering to obtain a first component, and keeping medicine residues for later use;
(2) adding 10-12 times of ethanol into the medicine residues in the step (1), heating, refluxing and extracting for 2 times, each time for 1-2 hours, and merging and standing the extracting solutions of 2 times; recovering ethanol under reduced pressure, concentrating to obtain medicinal liquid with concentration of 0.6g crude drug/mL, vacuum filtering, and obtaining filtrate with relative density of 1.08 at 20 deg.C to obtain component II;
(3) and mixing the first component and the second component, stirring uniformly, weighing and bottling to obtain the mixture.
And (3) placing the component I and the component II into a double-effect vacuum concentrator, concentrating the concentrated solution with the relative density of 1.05 at 90 ℃, refrigerating the concentrated solution at the low temperature of 0-5 ℃ for 24 hours, adding 0.3% of filter aid diatomite into the refrigerated solution, filtering, placing the filtrate into the double-effect vacuum concentrator again, concentrating the filtrate until each 1ml contains 0.1g of crude drug, adding honey and blending to obtain the mixture.
The traditional Chinese medicine used in the invention comprises:
the herba pyrrosiae is a perennial herb of the Spiraeae family, and has bitter and mild taste. Enter lung and bladder meridians, induce diuresis to treat stranguria, clear lung-heat and purge heat. It can be used for treating stranguria, hematuria, lithangiuria, nephritis, metrorrhagia, dysentery, cough due to lung heat, chronic tracheitis, incised wound, and superficial infection.
Radix rehmanniae, which has cool nature and sweet and bitter taste and is responsible for heart, liver and kidney channels, has the efficacies of nourishing yin and tonifying kidney, nourishing blood and enriching blood and cooling blood. It is beneficial to be taken by patients with yin deficiency, blood deficiency and kidney deficiency. In addition, rehmanniae radix has effects of tonifying heart, promoting diuresis, relieving fever, relieving inflammation, promoting blood coagulation and reducing blood sugar.
The semen Abutili belongs to large intestine, small intestine and bladder channels, has effects of promoting diuresis for treating stranguria, smoothing intestine, relaxing bowels and promoting lactation, and can be used for treating gonorrhea, edema, constipation and galactostasis.
Poria is dry sclerotium of Poria cocos (Schw.) wolf of Polyporaceae, and has warm nature and light taste, and can enter heart, spleen and lung channels, eliminate dampness, promote diuresis, benefit spleen and stomach, and tranquilize heart and mind.
The raw licorice root is the dry product of the root and rhizome of the medicinal plant licorice root, has sweet and mild taste and enters spleen, stomach and lung channels. Replenishing qi and strengthening the middle warmer; relieving spasm and pain; moistening lung to arrest cough; purging pathogenic fire and removing toxic substances; harmonize the drugs.
Herba Lysimachiae Christinae is fresh or dried whole herb of herba Lysimachiae Christinae of genus Lysimachia of family Primulaceae, and is bitter, sour and slightly cold in taste. It enters liver, gallbladder, kidney and bladder meridians. Has the functions of clearing away heat and toxic material, promoting urination, removing urinary calculus, promoting blood circulation and dissipating blood stasis.
Endothelium corneum Gigeriae Galli is inner wall of dry ballast of domestic chicken of Phasianidae, sweet and flat. It enters spleen, stomach, small intestine and bladder meridians. Strengthening the stomach to promote digestion, arresting seminal emission and relieving enuresis, and treating stranguria and removing calculus.
Spora Lygodii is dry mature spore of spora Lygodii of the family Lygodiaceae, and has sweet, salty and cold properties. It enters bladder and small intestine meridians. Clear damp-heat, relieve stranguria and alleviate pain. Can be used for treating pyretic stranguria, urolithic stranguria, bloody stranguria, chylous stranguria, and urethral astringency and pain.
The herba plantaginis is whole plant of herba plantaginis and herba Plantago Plantaginaceae, and has sweet taste and cold property. Has effects of promoting urination, clearing heat away, improving eyesight, and eliminating phlegm. Can be used for treating urinary obstruction, stranguria with turbid urine, leukorrhagia, hematuria, jaundice, edema, dysentery, diarrhea, epistaxis, conjunctival congestion, sore throat, cough, skin ulcer, etc.
Rhizoma alismatis is sweet and light in flavor and cold in nature; it enters kidney and bladder meridians. Has the effects of promoting diuresis, eliminating dampness, clearing heat and treating stranguria. It can be used for treating dysuria, pyretic stranguria, odynuria, edema, diarrhea, phlegm retention, vertigo, and spermatorrhea.
Polyporus umbellatus is medicinal fungus of Grifola of Polyporaceae of Aphyllophorales, and has sweet, light and neutral taste, and has effects of invigorating heart, spleen, stomach, lung and kidney channels, promoting diuresis, and eliminating dampness, and can be used for treating dysuresia, edema, diarrhea, stranguria with turbid urine, and leukorrhagia.
Scutellariae radix has effects of clearing heat and eliminating dampness, clearing pathogenic fire and removing toxic substance, stopping bleeding, and preventing miscarriage, and can be used for treating damp warmth, summer dampness, chest distress and nausea, damp heat and fullness, dysentery, jaundice, cough due to lung heat, hyperpyrexia and polydipsia, blood heat and epistaxis, carbuncle, swelling, sore and toxin, and threatened abortion.
Gardenia jasminoides is the fruit of gardenia belonging to the family Rubiaceae, bitter and cold. It enters heart, lung and triple energizer meridians. Purging pathogenic fire, relieving restlessness, clearing away heat, promoting diuresis, cooling blood, and removing toxic substances; it can be used topically for relieving swelling and pain.
Talc is a common silicate mineral, sweet, bland and cold. It enters bladder, lung and stomach meridians. Induce diuresis to treat stranguria, clear away summer-heat, dispel dampness and heal wound. Can be used for treating pyretic stranguria, urolithiasis, odynuria, summer-heat dampness polydipsia, damp-heat watery diarrhea; it can be used for treating eczema, and miliaria.
Herba Patriniae is dry whole plant of herba Patriniae of Patrinia, and has cold, pungent and bitter taste. Enter liver, stomach and large intestine meridians. Clear heat and remove toxicity, dispel phlegm and expel pus.
The cogongrass rhizome enters lung, stomach and bladder channels, cools blood and stops bleeding, clears heat and promotes urination. Can be used for treating hematemesis due to blood heat, epistaxis, hematuria, fever polydipsia, cough due to lung heat, stomach heat emesis, jaundice due to damp-heat pathogen, edema oliguria, stranguria with astringency and pain.
The invention has the advantages that: the invention has the functions of clearing away heat and toxic material, inducing diuresis for treating stranguria, promoting blood circulation to reduce swelling, resisting bacteria and diminishing inflammation, inducing diuresis for treating stranguria, increasing the excretion of urea, uric acid and sodium chloride, increasing urine volume, diluting the concentration of anions such as oxalic acid ions and calcium ions in urine and reducing the occurrence of calculi. Meanwhile, the invention also has anti-inflammatory effect, and avoids the damage of tissues and cells caused by the injury factors directly or indirectly. The invention has scientific and reasonable formula, novel and reasonable preparation method, high precision of process parameters, less component loss and stable drug effect, is suitable for various urinary calculi diseases such as kidney calculi, urethral calculi and the like, is not easy to relapse after being cured, and meets the requirement of clinical treatment.
Detailed Description
A traditional Chinese medicine mixture for treating calculus removal is prepared from the following raw material medicines in parts by weight:
16 g of pyrrosia leaf, 16 g of dried rehmannia root, 12 g of cluster mallow seed, 10 g of tuckahoe, 6g of raw liquorice, 12 g of climbing fern spore, 20 g of fried chicken's gizzard-membrane, 6g of scutellaria baicalensis, 12 g of talcum, 10 g of rhizoma alismatis, 10 g of polyporus, 9 g of plantain herb, 15 g of herba patriniae, 10 g of lalang grass rhizome, 20 g of lysimachia christinae hance and 10 g of gardenia jasminoides ellis.
A preparation method of a traditional Chinese medicine mixture for treating calculus removal comprises the following steps:
(1) removing impurities from folium Pyrrosiae, radix rehmanniae, semen Abutili, Poria, Glycyrrhrizae radix, spora Lygodii, endothelium corneum Gigeriae Galli preparata, Scutellariae radix, Alismatis rhizoma, Polyporus, herba plantaginis, herba Patriniae, pulvis Talci, lalang grass rhizome, herba Lysimachiae Christinae, and fructus Gardeniae, air drying, pulverizing into granules, and soaking in water for 1 hr; putting the soaked raw materials into a multifunctional extraction tank, and decocting with water twice; adding water in an amount which is 10 times that of the total medicinal materials for the first time, decocting for 1.5-2 hours, taking decoction, filtering, adding water in an amount which is 7 times that of the total medicinal materials for the second time, decocting for 1-1.2 hours, taking the two decoctions, mixing, filtering to obtain a first component, and keeping medicine residues for later use;
(2) adding 10-12 times of ethanol into the medicine residues in the step (1), heating, refluxing and extracting for 2 times, each time for 1-2 hours, and merging and standing the extracting solutions of 2 times; recovering ethanol under reduced pressure, concentrating to obtain medicinal liquid with concentration of 0.6g crude drug/mL, vacuum filtering, and obtaining filtrate with relative density of 1.08 at 20 deg.C to obtain component II;
(3) and mixing the first component and the second component, stirring uniformly, weighing and bottling to obtain the mixture.
And (3) placing the component I and the component II into a double-effect vacuum concentrator, concentrating the concentrated solution with the relative density of 1.05 at 90 ℃, refrigerating the concentrated solution at the low temperature of 0-5 ℃ for 24 hours, adding 0.3% of filter aid diatomite into the refrigerated solution, filtering, placing the filtrate into the double-effect vacuum concentrator again, concentrating the filtrate until each 1ml contains 0.1g of crude drug, adding honey and blending to obtain the mixture.
Typical case 1
In a certain Wang, a male has no obvious reason to cause right waist pain before 34 years old and 2 years old, the pain is continuously dull, special treatment is not carried out all the time, the symptoms of the waist pain repeatedly occur, the patient can see a doctor later in a hospital, the patient is diagnosed with the right kidney stone, the size of the stone is 0.4 multiplied by 0.5cm, the patient can see the doctor before introducing the doctor after the patient is hospitalized for a period of time, the patient can take the mixture for one month to relieve the symptoms, the symptoms of nausea, vomiting, chilliness, fever, diarrhea and the like do not exist during taking the mixture, the patient can continue to take the mixture for 2 months, the stone basically disappears after b-ultrasonography, and the patient can not relapse after follow-up diagnosis.
Typical case 2
Yang is a female in 40 years old, the patient has no obvious reason to suddenly appear lumbago, the pain is intermittent dull pain and accompanied with nausea and vomiting, and after the hospital visits, the doctor diagnoses and color Doppler ultrasound shows kidney stones. After the patient is treated by purchasing medicines from an individual clinic, the patient has no improvement, night sweat, poor spirit and appetite and poor sleep are caused, after the patient takes the mixture for one month, the symptoms are obviously improved, no waist pain and no discomfort of double kidney areas are caused, and the patient is proved to have no calculus on the left kidney and be completely cured by rechecking the examination result again.
Typical case 3
Li Shi, 45 years old, truck driver, sitting for a long time, drinking less water, often appeared the sensation of waist soreness and low back pain, especially obvious in the morning, arrived local hospital and carried out the uropoiesis color ultrasound examination show: mild right-kidney hydrops, moderate left-kidney hydrops, left-kidney stones (0.4 cm), urinary flat-scan + enhancement examination show: the left side renal pelvis hydrops, the junction of the left side renal pelvis and the ureter is narrow, the frequency, urgency and pain of urination of a patient are poor in sleep, the patient repeatedly attacks after going out of hospital for a period of time after a hospital is in a hospital visit, the symptoms of the frequency, urgency and pain of urination are relieved after two weeks, the discomfort of a bladder area is caused by introducing and taking the mixture, the urinary color ultrasound is rechecked after one month, stones are discharged, and the patient is free of recurrence after follow-up diagnosis.
Claims (4)
1. A traditional Chinese medicine mixture for treating calculus removal is characterized in that: the mixture is prepared from the following raw material medicines in parts by weight:
14-18 g of pyrrosia leaf, 14-18 g of dried rehmannia root, 10-15 g of malva seed, 8-12 g of tuckahoe, 4-8 g of raw liquorice, 10-14 g of lygodium japonicum, 18-22 g of fried chicken's gizzard-membrane, 4-7 g of scutellaria baicalensis, 10-14 g of talcum, 8-12 g of rhizoma alismatis, 8-12 g of grifola, 7-11 g of plantain herb, 13-17 g of field pennycress, 8-12 g of cogongrass rhizome, 18-22 g of lysimachia christinae hance and 8-12 g of gardenia jasminoides.
2. The traditional Chinese medicine mixture for treating calculus removal according to claim 1, which is characterized in that: the mixture is prepared from the following raw material medicines in parts by weight:
16 g of pyrrosia leaf, 16 g of dried rehmannia root, 12 g of cluster mallow seed, 10 g of tuckahoe, 6g of raw liquorice, 12 g of climbing fern spore, 20 g of fried chicken's gizzard-membrane, 6g of scutellaria baicalensis, 12 g of talcum, 10 g of rhizoma alismatis, 10 g of polyporus, 9 g of plantain herb, 15 g of herba patriniae, 10 g of lalang grass rhizome, 20 g of lysimachia christinae hance and 10 g of gardenia jasminoides ellis.
3. A preparation method of a traditional Chinese medicine mixture for treating calculus removal is characterized by comprising the following steps: the method comprises the following steps:
(1) removing impurities from folium Pyrrosiae, radix rehmanniae, semen Abutili, Poria, Glycyrrhrizae radix, spora Lygodii, endothelium corneum Gigeriae Galli preparata, Scutellariae radix, Alismatis rhizoma, Polyporus, herba plantaginis, herba Patriniae, pulvis Talci, lalang grass rhizome, herba Lysimachiae Christinae, and fructus Gardeniae, air drying, pulverizing into granules, and soaking in water for 1 hr; putting the soaked raw materials into a multifunctional extraction tank, and decocting with water twice; adding water in an amount which is 10 times that of the total medicinal materials for the first time, decocting for 1.5-2 hours, taking decoction, filtering, adding water in an amount which is 7 times that of the total medicinal materials for the second time, decocting for 1-1.2 hours, taking the two decoctions, mixing, filtering to obtain a first component, and keeping medicine residues for later use;
(2) adding 10-12 times of ethanol into the medicine residues in the step (1), heating, refluxing and extracting for 2 times, each time for 1-2 hours, and merging and standing the extracting solutions of 2 times; recovering ethanol under reduced pressure, concentrating to obtain medicinal liquid with concentration of 0.6g crude drug/mL, vacuum filtering, and obtaining filtrate with relative density of 1.08 at 20 deg.C to obtain component II;
(3) and mixing the first component and the second component, stirring uniformly, weighing and bottling to obtain the mixture.
4. The preparation method of the traditional Chinese medicine mixture for treating calculus removal according to claim 3, which is characterized by comprising the following steps: and (3) placing the component I and the component II into a double-effect vacuum concentrator, concentrating the concentrated solution with the relative density of 1.05 at 90 ℃, refrigerating the concentrated solution at the low temperature of 0-5 ℃ for 24 hours, adding 0.3% of filter aid diatomite into the refrigerated solution, filtering, placing the filtrate into the double-effect vacuum concentrator again, concentrating the filtrate until each 1ml contains 0.1g of crude drug, adding honey and blending to obtain the mixture.
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