CN104474246A - Traditional Chinese medicine for treating rhinitis - Google Patents

Traditional Chinese medicine for treating rhinitis Download PDF

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Publication number
CN104474246A
CN104474246A CN201410666053.7A CN201410666053A CN104474246A CN 104474246 A CN104474246 A CN 104474246A CN 201410666053 A CN201410666053 A CN 201410666053A CN 104474246 A CN104474246 A CN 104474246A
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herba
rhizoma
concentrating
drying
traditional chinese
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王河东
张庆卫
由红运
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WEIHAI NOVODA PHARMACEUTICAL GROUP Co Ltd
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WEIHAI NOVODA PHARMACEUTICAL GROUP Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract

The invention relates to a traditional Chinese medicine for treating rhinitis. The traditional Chinese medicine for treating rhinitis is specifically prepared by the following steps: by taking Chinese herbal medicines as raw materials, respectively cleaning, airing and crushing required traditional Chinese medicines to coarse powder; respectively carrying out ethanol reflux extraction twice on crushed viola, polygonum cuspidate, rhizoma acori graminei, ligusticum wallichii, fructus cnidii and folia perillae acutae, 1.5 hours every time to obtain an extraction liquid, filtering and concentrating the filtrate at reduced pressure, putting the obtained extract in a vacuum drying box to dry at reduced pressure to obtain a dry paste; respectively carrying out water extraction on crushed divaricate saposhnikovia roots, fructus forsythia and agastache rugosus three times, filtering, combining the filtrates and concentrating and drying to obtain a dry paste; carrying out ethanol reflux extraction on crushed asarum and radix ophiopogonis three times, filtering and concentrating till no alcohol smell, degreasing by using ethyl acetate to obtain an aqueous phase; concentrating and drying to obtain a dry paste; and crushing and sieving the dry pastes of the medicinal materials, fully and uniformly mixing and adding auxiliary materials to prepare a troche.

Description

A kind of Chinese medicine for the treatment of rhinitis
Technical field
[0001] the present invention relates to a kind of Chinese medicine for the treatment of rhinitis, is specifically Chinese medicine preparation prepared by raw material with Chinese herbal medicine.
Background technology
[0002] the related inflammation traditional Chinese medical science such as rhinitis demonstration, majority is relevant with the health of lung, lung is that pipe is breathed, one side is sent to oxygen for body inner blood and is discharged the waste gas that in body, life process produces, the moisture of adjustment body-internal-circulation on the one hand, if there is problem in the health of lung, nose and larynx will be affected, because " lung is opened and is good at nose ", " nose is that lung is skilful ", " larynx is the door of lung ", namely nose communicates with larynx and is coupled to lung, nose and larynx are the doors (people of long-time rhinitis in fact, generally also having pharyngitis, is related) breathed.When impaired lung function, the water liquid passage of lung to body-internal-circulation just can not be dredged normally and regulate, and the water liquid of body-internal-circulation will flow out from nasal cavity.The health of nose also receives impact on account of illness in addition, and the mucosal tissue of nasal cavity (the inside and outside gas temperature of balance) is destroyed, bacteriological infection or have inflammation.This generates rhinitis and flow blue or green nasal mucus in a large number, the phenomenon of yellow nasal mucus or nasal obstruction, lesion tissue can be caused time serious and be piled into nasal polyp.
Obtain rhinitis and have a variety of reason, wherein one is exactly that long flu does not heal, or classical Chinese some say be because of " diseases caused by exogenous pathogenic factor six climate exopathogens (wind, cold, summer-heat, wet, dry, fiery or hot); or internal damage by the excessive seven emotions (happiness, anger, melancholy, think of, compassion, fear, shy) " etc. ill under certain conditions, damage health, treatment or body constitution do not differ from slowly in time, the state of an illness damages the function of people further, but say from basis, because self pulmonary function is not enough, or body constitution is poor, resistance is poor, immunity low sick after have impact on pulmonary function.
The harm of rhinitis: the clinical symptoms of rhinitis morbidity is different, very harmful, when affecting the physiological function of nasal cavity, there will be respiratory disorder, cause blood oxygen concentration to reduce, affect function and the metabolism of other tissue and organ, and occur that some are as headache, dizzy, hypomnesis, chest pain, uncomfortable in chest, lethargy etc., even can the severe complication such as Complicated with Pulmonary edema due to disorder of QI, pulmonary heart disease, asthma.And when rhinitis fails to get timely medical treatment, when affecting olfactory sensation mucosa, just there will be olfactory disorder, cause hearing not good and foul smells abnormal smells from the patient such as grade.When the sinusitis of prolonged and repeated outbreak is not got timely medical treatment, inflammation will diffuse to adjacent organs, tissue, and concurrent as multiple critical emergency cases such as osteomyelitis of frontal bone, socket of the eye bone wall osteitis and periostitis, subperiosteal orbital abscess, orbital cellulitis, retrobulbar neuritis, spinal epidural absceess, subdural abscess, purulent meningitis, brain abscess, cavernous sinus thrombophlebitiss.
Rhinitis belongs to commonly encountered diseases in the north, though be not what serious disease, but once suffer from that this is sick, is also very perplex people: light then nasal cavity pain, and yellow pus nasal mucus is constantly, heavy then cause headache, affects working and learning.Though use the medicine of some the treatment rhinitis on market can alleviate symptom for the moment, long-term effect can't bear desirable.
Summary of the invention
Chinese materia medica is thought, treatment rhinitis generally will note two aspects: tonneau nose is skilful on the one hand, dispelling wind, heat clearing away, cold expelling, antiinflammatory, toxin expelling etc., focuses on the one hand adjusting lung meridian, tonifying the lung gas, health invigorating, improves resistance, and the latter is crucial, is also the process of a nourishing.
The advantage that the present invention treats rhinitis is by effect complementary between medicine, moistens pulmonary, improves lung power, strengthens the contractile function of human lung, and the lung that relaxes, except pus, treats rhinitis from root, instant effect, without bounce-back.
For achieving the above object, treat a Chinese medicine for rhinitis, it is characterized in that the weight portion of raw material is: Herba Violae 120-160 part, Rhizoma Polygoni Cuspidati 80-110 part, Radix Saposhnikoviae 170-200 part, Rhizoma Acori Graminei 90-130 part, Rhizoma Chuanxiong 100-140 part, Fructus Forsythiae 130-160 part, Fructus Cnidii 40-60 part, Folium Perillae 200-240 part, Herba Asari 120-140 part, Herba Pogostemonis 40-60 part, Radix Ophiopogonis 180-220 part.
In medicine of the present invention, Herba Violae: heat-clearing and toxic substances removing; Control the high heat of epidemic febrile disease irritated, influenza, infectious hepatitis, nephritis, scrofula, parotitis, furuncle and other pyogenic infection.Rhizoma Polygoni Cuspidati: micro-hardship, is slightly cold; Dispel the wind, dampness removing, removing blood stasis with potent drugs, stimulates the menstrual flow; Dispelling the wind and dampness pathogens bones and muscles pain, jaundice due to damp-heat, stranguria with turbid discharge leukorrhagia, women's amenorrhea, lochiostasis, lump in the abdomen, anal fistula hematochezia; Injury from falling down, scalds, malignant boil tinea disease; Arrhythmia and anti-cardiac muscle are lost blood blood circulation promoting and blood stasis dispelling.Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature; Radix Saposhnikoviae expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic, cure mainly affection of exogenous wind-cold, headache general pain, rheumatic arthralgia, joint is ached, stomachache is had loose bowels, discharging fresh blood stool, tetanus, rubella pruritus.Rhizoma Acori Graminei: removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae; Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness; Regulate the flow of vital energy, invigorate blood circulation, loose wind, dries; Control epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.Rhizoma Chuanxiong: pungent, temperature; Activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain; Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores; For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Fructus Forsythiae: bitter, cool; Heat clearing away, removing toxic substances, eliminating stagnation, detumescence; Control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.Fructus Cnidii: warm in nature, bitter in the mouth; Warming the kidney to invigorate YANG, dampness, dispels the wind, parasite killing; For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis.Folium Perillae: pungent, tepor, nontoxic; Affection of exogenous wind-cold, fever with aversion to cold, has a headache lossless, cough and asthma, and gastral cavity abdominal distention is vexed, and vomiting and nausea is suffered from diarrhoea, and block in pharynx, pregnancy reactions, frequent fetal movement, ichthyophagy Eriocheir sinensis is poisoning, and carbuncle skin ulcer snake venom is peppery.Herba Asari: induce sweat cold expelling, wind-expelling pain-stopping is sensible, warming the lung to resolve fluid-retention; For anemofrigid cold, headache, toothache, nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.Herba Pogostemonis: pungent, tepor; Eliminating turbid pathogen with aromatics, and middle preventing or arresting vomiting, deliver expelling summer-heat; For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is vomitted, heat-damp in summer exterior syndrome, hygropyrexia from the beginning of, heating asthenia, uncomfortable in chestly do not relax, cold-damp closes summer-heat, and stomachache is vomited and diarrhoea, nasosinusitis headache.Radix Ophiopogonis: feeble QI is fragrant, sweet in the mouth, micro-hardship; YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire; For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.
specific implementation method
Embodiment 1
Treat a Chinese medicine for rhinitis, it is characterized in that the weight portion of raw material is: Herba Violae 120-160 part, Rhizoma Polygoni Cuspidati 80-110 part, Radix Saposhnikoviae 170-200 part, Rhizoma Acori Graminei 90-130 part, Rhizoma Chuanxiong 100-140 part, Fructus Forsythiae 130-160 part, Fructus Cnidii 40-60 part, Folium Perillae 200-240 part, Herba Asari 120-140 part, Herba Pogostemonis 40-60 part, Radix Ophiopogonis 180-220 part.
Embodiment 2
Treat a Chinese medicine for rhinitis, its preferred weight part is: Herba Violae 140 parts, Rhizoma Polygoni Cuspidati 100 parts, Radix Saposhnikoviae 190 parts, Rhizoma Acori Graminei 110 parts, Rhizoma Chuanxiong 120 parts, Fructus Forsythiae 150 parts, Fructus Cnidii 45 parts, Folium Perillae 230 parts, Herba Asari 120 parts, Herba Pogostemonis 40 parts, Radix Ophiopogonis 210 parts.
Above-mentioned Chinese crude drug is cleaned respectively, dries and be ground into coarse powder, respectively by the Herba Violae after pulverizing, Rhizoma Polygoni Cuspidati, Rhizoma Acori Graminei, Rhizoma Chuanxiong, Fructus Cnidii and Folium Perillae with 95% alcohol reflux 2 times, each 1.5 hours, obtain extracting solution, filter, filtrate is carried out concentrating under reduced pressure, and extract obtained vacuum drying oven of putting into carries out drying under reduced pressure, obtains dry cream; Respectively the Radix Saposhnikoviae after pulverizing, Fructus Forsythiae, Herba Pogostemonis are carried 3 times at the Water Under of 80 DEG C, filter, merging filtrate, concentrate drying, obtains dry cream; By the Herba Asari after pulverizing, Radix Ophiopogonis with 60% alcohol reflux 3 times, filtration, filtrate is concentrated into without alcohol taste, carries out defat, obtain aqueous phase by ethyl acetate, carries out concentrating, drying, and obtains dry cream.By broken for the dried cream powder of each medical material, sieve, fully mix, mixing, add adjuvant make tablet.Specification: the heavy 0.3g of every sheet.Usage and consumption: oral, one time 2, every day 3 times.
1. clinical data
1.1 physical data: this is organized 76 examples and clarifies a diagnosis as patients with rhinitis, wherein male 46 example, women 30 example; The oldest is 48 years old, and minimum is 22 years old; 8 years that the course of disease is the longest, the shortest 5 months.
1.2 symptom features: recurrent exerbation, respiratory disorder appears in each outbreak, cause blood oxygen concentration reduces, with symptoms such as headache, dizziness, hypomnesis, chest pain, uncomfortable in chest, lethargy, severe patient meeting Complicated with Pulmonary edema due to disorder of QI, pulmonary heart disease, asthma etc.
2. take mode: oral, one time 2, every day 3 times.
3. therapeutic outcome
3.1 efficacy assessment standards are recovered: ill symptoms disappears, and drug withdrawal was not recurred after 1 year.Take a turn for the better: ill symptoms disappears, and drug withdrawal was recurred after 1 year, or the rear ill symptoms for the treatment of obviously alleviates, recurrent number reduces.Invalid: after treatment, ill symptoms is without being clearly better or using other method persons instead.
3.2 therapeutic effect 15 days are a course for the treatment of, the general 1-2 of the lighter the recovery from illness course for the treatment of, the general 3-4 of severe one the recovery from illness course for the treatment of.By 46 examples of fully recovering after above-mentioned standard care, account for 60.5%; Take a turn for the better 25 examples, accounts for 32.9%; Invalid 5 examples, account for 6.6%, total effective rate is 93.4%.
4. toxic and side effects does not find obvious side effect in clinical studies.
The technology those of ordinary skill of this area all can be understood, and it is all possible in protection scope of the present invention, modifying for above-described embodiment, adding and replacing, and it does not all exceed protection scope of the present invention.

Claims (2)

1. treat the Chinese medicine of rhinitis for one kind, its preparation method is: adopt Herba Violae, Rhizoma Polygoni Cuspidati, Radix Saposhnikoviae, Rhizoma Acori Graminei, Rhizoma Chuanxiong, Fructus Forsythiae, Fructus Cnidii, Folium Perillae, Herba Asari, Herba Pogostemonis and Radix Ophiopogonis to be raw material, each medical material is cleaned respectively, dries and be ground into coarse powder, respectively by the Herba Violae after pulverizing, Rhizoma Polygoni Cuspidati, Rhizoma Acori Graminei, Rhizoma Chuanxiong, Fructus Cnidii and Folium Perillae with 95% alcohol reflux 2 times, each 1.5 hours, obtain extracting solution, filter, filtrate is carried out concentrating under reduced pressure, extract obtained vacuum drying oven of putting into carries out drying under reduced pressure, obtains dry cream; Respectively the Radix Saposhnikoviae after pulverizing, Fructus Forsythiae, Herba Pogostemonis are carried 3 times at the Water Under of 80 DEG C, filter, merging filtrate, concentrate drying, obtains dry cream; By the Herba Asari after pulverizing, Radix Ophiopogonis with 60% alcohol reflux 3 times, filtration, filtrate is concentrated into without alcohol taste, carries out defat by ethyl acetate, aqueous phase, carry out concentrating, drying, obtain dry cream, by broken for the dried cream powder of each medical material, sieve, abundant mixing, mixing, adds adjuvant and makes tablet.
2. pharmaceutical formulation prepared by, is characterized in that the weight portion of raw material is: Herba Violae 120-160 part, Rhizoma Polygoni Cuspidati 80-110 part, Radix Saposhnikoviae 170-200 part, Rhizoma Acori Graminei 90-130 part, Rhizoma Chuanxiong 100-140 part, Fructus Forsythiae 130-160 part, Fructus Cnidii 40-60 part, Folium Perillae 200-240 part, Herba Asari 120-140 part, Herba Pogostemonis 40-60 part, Radix Ophiopogonis 180-220 part.
CN201410666053.7A 2014-11-20 2014-11-20 Traditional Chinese medicine for treating rhinitis Pending CN104474246A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104825883A (en) * 2015-05-15 2015-08-12 王健军 Traditional Chinese medicine prescription for treating rhinitis
CN104825968A (en) * 2015-05-15 2015-08-12 王健军 Traditional Chinese medicine medicament for treating rhinitis and preparation method thereof
CN107551072A (en) * 2017-10-11 2018-01-09 李敏 Bi Yan Qing capsule and preparation method thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104825883A (en) * 2015-05-15 2015-08-12 王健军 Traditional Chinese medicine prescription for treating rhinitis
CN104825968A (en) * 2015-05-15 2015-08-12 王健军 Traditional Chinese medicine medicament for treating rhinitis and preparation method thereof
CN107551072A (en) * 2017-10-11 2018-01-09 李敏 Bi Yan Qing capsule and preparation method thereof

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Application publication date: 20150401