CN113244149A - Stem cell active factor dressing for skin repair and preparation method thereof - Google Patents

Stem cell active factor dressing for skin repair and preparation method thereof Download PDF

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Publication number
CN113244149A
CN113244149A CN202110590907.8A CN202110590907A CN113244149A CN 113244149 A CN113244149 A CN 113244149A CN 202110590907 A CN202110590907 A CN 202110590907A CN 113244149 A CN113244149 A CN 113244149A
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Prior art keywords
facial mask
parts
liquid
preparation
stem cell
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CN202110590907.8A
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Chinese (zh)
Inventor
武丽娜
宝福凯
柳爱华
胡海燕
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Yunnan Helsi Cell Biotechnology Co ltd
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Yunnan Helsi Cell Biotechnology Co ltd
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Priority to CN202110590907.8A priority Critical patent/CN113244149A/en
Publication of CN113244149A publication Critical patent/CN113244149A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0212—Face masks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/733—Alginic acid; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

The invention provides a stem cell active factor dressing for skin repair and a preparation method thereof, wherein facial mask paper is soaked in facial mask liquid, and the facial mask liquid is fully absorbed by the facial mask paper to prepare the dressing; the facial mask liquid contains EGF factors, trehalose, pullulan and a cogongrass extract; by adopting the trehalose, the pullulan and the cogongrass extract, the skin stem cells can be moisturized, the skin barrier can be enhanced, and the skin elasticity can be enhanced; by adopting the EGF factor, the proliferation capacity of skin fibroblasts is improved, the capacity of the skin fibroblasts for synthesizing collagen is promoted, and the EGF factor has good effects on repairing cells, improving cell metabolism and activating aging cells.

Description

Stem cell active factor dressing for skin repair and preparation method thereof
Technical Field
The invention relates to the technical field of stem cells, in particular to a stem cell active factor dressing for skin repair and a preparation method thereof.
Background
In brief, a stem cell is a type of cell that has unlimited or immortal self-renewal capacity, and is capable of producing at least one type of highly differentiated progeny cell. The definition of stem cells has been revised and defined from different levels over the years. Most biologists and physicians now believe that stem cells are a class of cells derived from embryonic, fetal, or adult cells that have the ability to self-renew and proliferate and differentiate without restriction under certain conditions, and that are capable of producing daughter cells with the same phenotype and genotype as themselves, and also capable of producing specialized cells that make up body tissues and organs, and also capable of differentiating into progenitor cells.
Because the epidermal stem cells of the human face are exposed in the external environment for a long time, and simultaneously, the water loss is fast, the regeneration capacity is reduced, the death and the shedding of the epidermal cells, the hypofunction and other reasons are caused, the aging signs such as spots, wrinkles and the like can appear on the skin after the skin is accumulated for a long time.
Disclosure of Invention
The invention provides a stem cell active factor dressing for skin repair and a preparation method thereof, which are used for solving the problems of death and shedding of epidermal stem cells and function decline caused by water shortage of skin stem cells.
The specific technical scheme is as follows: soaking facial mask paper in facial mask liquid, and fully absorbing the facial mask liquid by the facial mask paper to prepare the facial mask liquid; the facial mask liquid contains EGF factors, trehalose, pullulan and a cogongrass extract.
As a preferred technical scheme of the invention, the mask liquid comprises the following components: 1-9 parts of lower alcohol, 2-4 parts of lysine polypeptide, 2-40 parts of EGF factor liquid, 2-7 parts of trehalose, 0.7-1.2 parts of sodium alginate, 3-5 parts of PEG-75 shea butter glyceride, 5 parts of rose water, 0.5-1.3 parts of pullulan polysaccharide, 0.4-1.0 part of sodium hyaluronate, 1-10 parts of cogongrass extract and a proper amount of water to 100 parts.
As a preferred technical scheme of the invention, the manufacturing method comprises the following manufacturing steps:
step 1, uniformly mixing sodium hyaluronate, sodium alginate and lower alcohol, adding 70-80 ℃ hot water which is 10 times of the weight of the sodium hyaluronate, stirring to dissolve, and cooling to 30-35 ℃;
step 2, adding trehalose, rose water, lysine polypeptide, PEG-75 shea butter glyceride, EGF factor liquid, pullulan and the extract liquor of the cogongrass into the liquid obtained in the previous step, and stirring to dissolve the extract liquor to obtain facial mask liquid;
step 3, soaking facial mask paper in the facial mask liquid obtained in the previous step for 2-5 hours to enable the facial mask paper to fully absorb the facial mask liquid;
and 4, taking out the soaked facial mask paper, and sealing and packaging.
In a preferred embodiment of the present invention, the lower alcohol is selected from glycerol, propylene glycol, and butylene glycol.
As a preferable technical scheme of the invention, the facial mask paper is silk facial mask cloth or alginate fiber.
The invention has the beneficial effects that: by adopting the trehalose, the pullulan and the cogongrass extract, the skin stem cells can be moisturized, the skin barrier can be enhanced, and the skin elasticity can be enhanced; by adopting the EGF factor, the proliferation capacity of skin fibroblasts is improved, the capacity of the skin fibroblasts for synthesizing collagen is promoted, and the EGF factor has good effects on repairing cells, improving cell metabolism and activating aging cells.
Detailed Description
The technical solution of the present invention will be described in detail by specific examples.
Example 1
The preparation method of the stem cell active factor dressing for skin repair comprises the steps of soaking facial mask paper in facial mask liquid, and fully absorbing the facial mask liquid by the facial mask paper; the facial mask liquid contains EGF factors, trehalose, pullulan and a cogongrass extract.
Further, the facial mask liquid comprises the following components: 6 parts of lower alcohol, 2.8 parts of lysine polypeptide, 20 parts of EGF factor liquid, 4.5 parts of trehalose, 0.9 part of sodium alginate, 3.5 parts of PEG-75 shea butter glyceride, 5 parts of rose water, 0.9 part of pullulan, 0.8 part of sodium hyaluronate, 5.5 parts of cogongrass extract and a proper amount of water to 100 parts.
Further, the manufacturing method comprises the following manufacturing steps:
step 1, uniformly mixing sodium hyaluronate, sodium alginate and lower alcohol, adding hot water with the weight being about 10 times that of the sodium hyaluronate and the temperature being 76 ℃, stirring to dissolve the sodium hyaluronate and cooling to 32 ℃;
step 2, adding trehalose, rose water, lysine polypeptide, PEG-75 shea butter glyceride, EGF factor liquid, pullulan and the extract liquor of the cogongrass into the liquid obtained in the previous step, and stirring to dissolve the extract liquor to obtain facial mask liquid;
step 3, soaking facial mask paper in the facial mask liquid obtained in the previous step for 3.5 hours to enable the facial mask paper to fully absorb the facial mask liquid;
and 4, taking out the soaked facial mask paper, and sealing and packaging.
Further, the lower alcohol is selected from glycerol, propylene glycol and butanediol.
Furthermore, the facial mask paper is silk facial mask cloth or alginate fiber.
Example 2
The preparation method of the stem cell active factor dressing for skin repair comprises the steps of soaking facial mask paper in facial mask liquid, and fully absorbing the facial mask liquid by the facial mask paper; the facial mask liquid contains EGF factors, trehalose, pullulan and a cogongrass extract.
Further, the facial mask liquid comprises the following components: 1 part of lower alcohol, 2 parts of lysine polypeptide, 2 parts of EGF factor liquid, 2 parts of trehalose, 0.7 part of sodium alginate, 3 parts of PEG-75 shea butter glyceride, 5 parts of rose water, 0.5 part of pullulan, 0.4 part of sodium hyaluronate, 1 part of cogongrass extract and a proper amount of water to 100 parts.
Further, the manufacturing method comprises the following manufacturing steps:
step 1, uniformly mixing sodium hyaluronate, sodium alginate and lower alcohol, adding 70 ℃ hot water with the weight being about 10 times that of the sodium hyaluronate, stirring to dissolve, and cooling to 30 ℃;
step 2, adding trehalose, rose water, lysine polypeptide, PEG-75 shea butter glyceride, EGF factor liquid, pullulan and the extract liquor of the cogongrass into the liquid obtained in the previous step, and stirring to dissolve the extract liquor to obtain facial mask liquid;
step 3, soaking facial mask paper in the facial mask liquid obtained in the previous step for 2 hours to enable the facial mask paper to fully absorb the facial mask liquid;
and 4, taking out the soaked facial mask paper, and sealing and packaging.
Further, the lower alcohol is selected from glycerol, propylene glycol and butanediol.
Furthermore, the facial mask paper is silk facial mask cloth or alginate fiber.
Example 3
The preparation method of the stem cell active factor dressing for skin repair comprises the steps of soaking facial mask paper in facial mask liquid, and fully absorbing the facial mask liquid by the facial mask paper; the facial mask liquid contains EGF factors, trehalose, pullulan and a cogongrass extract.
Further, the facial mask liquid comprises the following components: 9 parts of lower alcohol, 4 parts of lysine polypeptide, 40 parts of EGF factor liquid, 7 parts of trehalose, 1.2 parts of sodium alginate, 5 parts of PEG-75 shea butter glyceride, 5 parts of rose water, 1.3 parts of pullulan polysaccharide, 1 part of sodium hyaluronate, 10 parts of a cogongrass extract and a proper amount of water to 100 parts.
Further, the manufacturing method comprises the following manufacturing steps:
step 1, uniformly mixing sodium hyaluronate, sodium alginate and lower alcohol, adding 80 ℃ hot water with the weight being about 10 times that of the sodium hyaluronate, stirring to dissolve, and cooling to 35 ℃;
step 2, adding trehalose, rose water, lysine polypeptide, PEG-75 shea butter glyceride, EGF factor liquid, pullulan and the extract liquor of the cogongrass into the liquid obtained in the previous step, and stirring to dissolve the extract liquor to obtain facial mask liquid;
step 3, soaking facial mask paper in the facial mask liquid obtained in the previous step for 5 hours to enable the facial mask paper to fully absorb the facial mask liquid;
and 4, taking out the soaked facial mask paper, and sealing and packaging.
Further, the lower alcohol is selected from glycerol, propylene glycol and butanediol.
Furthermore, the facial mask paper is silk facial mask cloth or alginate fiber.
Although the present invention has been described in detail with reference to the specific embodiments, the present invention is not limited to the above embodiments, and various changes and modifications without inventive changes may be made within the knowledge of those skilled in the art without departing from the spirit of the present invention.

Claims (5)

1. The stem cell active factor dressing for skin repair and the preparation method are characterized in that: soaking facial mask paper in facial mask liquid, and fully absorbing the facial mask liquid by the facial mask paper to prepare the facial mask liquid; the facial mask liquid contains EGF factors, trehalose, pullulan and a cogongrass extract.
2. The stem cell active factor dressing for skin repair and the preparation method thereof according to claim 1, wherein: the facial mask liquid comprises the following components: 1-9 parts of lower alcohol, 2-4 parts of lysine polypeptide, 2-40 parts of EGF factor liquid, 2-7 parts of trehalose, 0.7-1.2 parts of sodium alginate, 3-5 parts of PEG-75 shea butter glyceride, 5 parts of rose water, 0.5-1.3 parts of pullulan polysaccharide, 0.4-1.0 part of sodium hyaluronate, 1-10 parts of cogongrass extract and a proper amount of water to 100 parts.
3. The stem cell active factor dressing for skin repair and the preparation method thereof according to claim 1, wherein: the preparation method comprises the following preparation steps:
step 1: uniformly mixing sodium hyaluronate, sodium alginate and lower alcohol, adding hot water with the weight being about 10 times that of the sodium hyaluronate and the temperature being 70-80 ℃, stirring to dissolve, and cooling to 30-35 ℃;
step 2: adding trehalose, rose water, lysine polypeptide, PEG-75 shea butter glyceride, EGF factor liquid, pullulan polysaccharide and cogongrass extract into the liquid obtained in the previous step, and stirring to dissolve the extract to obtain facial mask liquid;
and step 3: soaking facial mask paper in the facial mask liquid obtained in the last step for 2-5 hours to enable the facial mask paper to fully absorb the facial mask liquid;
and 4, step 4: and taking out the soaked facial mask paper, sealing and packaging.
4. The stem cell active factor dressing for skin repair and the preparation method thereof according to claim 2, wherein: the lower alcohol is selected from glycerol, propylene glycol, and butanediol.
5. The stem cell active factor dressing for skin repair and the preparation method thereof according to claim 1, wherein: the facial mask paper is silk facial mask cloth or alginate fiber.
CN202110590907.8A 2021-05-28 2021-05-28 Stem cell active factor dressing for skin repair and preparation method thereof Pending CN113244149A (en)

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Application Number Priority Date Filing Date Title
CN202110590907.8A CN113244149A (en) 2021-05-28 2021-05-28 Stem cell active factor dressing for skin repair and preparation method thereof

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Application Number Priority Date Filing Date Title
CN202110590907.8A CN113244149A (en) 2021-05-28 2021-05-28 Stem cell active factor dressing for skin repair and preparation method thereof

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CN113244149A true CN113244149A (en) 2021-08-13

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115350196A (en) * 2022-10-17 2022-11-18 山东科金生物发展有限公司 Biological preparation for reducing skin aging and improving skin injury repair

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115350196A (en) * 2022-10-17 2022-11-18 山东科金生物发展有限公司 Biological preparation for reducing skin aging and improving skin injury repair
CN115350196B (en) * 2022-10-17 2023-02-03 山东科金生物发展有限公司 Biological preparation for reducing skin aging and improving skin injury repair

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Application publication date: 20210813

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