CN113227400A - 与子宫内膜异位症相关的线粒体dna缺失 - Google Patents

与子宫内膜异位症相关的线粒体dna缺失 Download PDF

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Publication number
CN113227400A
CN113227400A CN201980085361.1A CN201980085361A CN113227400A CN 113227400 A CN113227400 A CN 113227400A CN 201980085361 A CN201980085361 A CN 201980085361A CN 113227400 A CN113227400 A CN 113227400A
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Prior art keywords
nucleotide
seq
nucleotides
mtdna
deletion
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CN201980085361.1A
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Chinese (zh)
Inventor
珍妮弗·克里特
安德烈娅·马格拉
布赖恩·赖古伊
安德烈·哈博特尔
罗伯特·厄舍
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MDNA LIFE SCIENCES Inc
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MDNA LIFE SCIENCES Inc
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Publication of CN113227400A publication Critical patent/CN113227400A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/364—Endometriosis, i.e. non-malignant disorder in which functioning endometrial tissue is present outside the uterine cavity

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201980085361.1A 2018-12-22 2019-12-20 与子宫内膜异位症相关的线粒体dna缺失 Pending CN113227400A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862784403P 2018-12-22 2018-12-22
US62/784,403 2018-12-22
US201962931173P 2019-11-05 2019-11-05
US62/931,173 2019-11-05
PCT/US2019/068098 WO2020132596A2 (en) 2018-12-22 2019-12-20 Mitochondrial dna deletions associated with endometriosis

Publications (1)

Publication Number Publication Date
CN113227400A true CN113227400A (zh) 2021-08-06

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980085361.1A Pending CN113227400A (zh) 2018-12-22 2019-12-20 与子宫内膜异位症相关的线粒体dna缺失

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Country Link
US (1) US20220251655A1 (enExample)
EP (1) EP3899050A2 (enExample)
JP (2) JP7649745B2 (enExample)
KR (1) KR20210107719A (enExample)
CN (1) CN113227400A (enExample)
AU (2) AU2019401465A1 (enExample)
CA (1) CA3124497A1 (enExample)
SG (1) SG11202106711YA (enExample)
WO (1) WO2020132596A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116200485A (zh) * 2022-11-01 2023-06-02 广东省生殖科学研究所(广东省生殖医院) 一种甲基化位点在子宫内膜异位症诊断和分型中的应用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112200270B (zh) * 2020-11-17 2022-12-20 金弗康生物科技(上海)股份有限公司 一种用于纠正高通量组学数据缺失的数据分区填充方法
GB202114374D0 (en) * 2021-10-07 2021-11-24 Univ Edinburgh Endometriosis biomarker
GB202204595D0 (en) * 2022-03-30 2022-05-11 Univ Newcastle Methods dor determining mitochondrial DNA damage

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080318237A1 (en) * 2007-04-25 2008-12-25 Regents Of The University Of California Methods of diagnosing endometriosis
CN107011428A (zh) * 2008-03-28 2017-08-04 Mdna生命科学有限公司 异常线粒体dna、相关的融合转录物及其杂交探针

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080318237A1 (en) * 2007-04-25 2008-12-25 Regents Of The University Of California Methods of diagnosing endometriosis
CN107011428A (zh) * 2008-03-28 2017-08-04 Mdna生命科学有限公司 异常线粒体dna、相关的融合转录物及其杂交探针

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SHU-HUEI KAO等: "Oxidative Damage and Mitochondrial DNA Mutations with Endometriosis", ANN. N.Y. ACAD. SCI., vol. 1042, 31 December 2005 (2005-12-31), pages 186 - 194, XP071400780, DOI: 10.1196/annals.1338.021 *
SURESH GOVATATI等: "Mitochondrial Genome Variations in Advanced Stage Endometriosis: A Study in South Indian Population", PLOS ONE, vol. 7, no. 7, 17 July 2012 (2012-07-17), pages 1 - 12, XP055671740, DOI: 10.1371/journal.pone.0040668 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116200485A (zh) * 2022-11-01 2023-06-02 广东省生殖科学研究所(广东省生殖医院) 一种甲基化位点在子宫内膜异位症诊断和分型中的应用
CN116200485B (zh) * 2022-11-01 2023-12-15 广东省生殖科学研究所(广东省生殖医院) 一种甲基化位点在子宫内膜异位症诊断和分型中的应用

Also Published As

Publication number Publication date
CA3124497A1 (en) 2020-06-25
SG11202106711YA (en) 2021-07-29
AU2026202367A1 (en) 2026-04-16
KR20210107719A (ko) 2021-09-01
WO2020132596A3 (en) 2020-07-23
AU2019401465A1 (en) 2021-07-22
JP2025087867A (ja) 2025-06-10
JP2022514924A (ja) 2022-02-16
EP3899050A2 (en) 2021-10-27
WO2020132596A2 (en) 2020-06-25
JP7649745B2 (ja) 2025-03-21
US20220251655A1 (en) 2022-08-11

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Application publication date: 20210806