CN113195706A - Ciml nk细胞及其方法 - Google Patents

Ciml nk细胞及其方法 Download PDF

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Publication number
CN113195706A
CN113195706A CN201980082326.4A CN201980082326A CN113195706A CN 113195706 A CN113195706 A CN 113195706A CN 201980082326 A CN201980082326 A CN 201980082326A CN 113195706 A CN113195706 A CN 113195706A
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cells
ciml
cell
mixture
expanded
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CN201980082326.4A
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Chinese (zh)
Inventor
罗希特·杜加尔
拉吉特·辛哈
李文钊
詹森·艾萨克森
派翠克·松吉翁
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ImmunityBio Inc
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NantKwest Inc
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0646Natural killers cells [NK], NKT cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4613Natural-killer cells [NK or NK-T]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]
    • C12N2501/2312Interleukin-12 (IL-12)
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]
    • C12N2501/2315Interleukin-15 (IL-15)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]
    • C12N2501/2318Interleukin-18 (IL-18)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50Cell markers; Cell surface determinants
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50Cell markers; Cell surface determinants
    • C12N2501/515CD3, T-cell receptor complex
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00Methods for the dissociation of cells, e.g. specific use of enzymes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
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  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
CN201980082326.4A 2019-07-08 2019-07-08 Ciml nk细胞及其方法 Pending CN113195706A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2019/040889 WO2021006876A1 (fr) 2019-07-08 2019-07-08 Cellules nk ciml et procédés associés

Publications (1)

Publication Number Publication Date
CN113195706A true CN113195706A (zh) 2021-07-30

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980082326.4A Pending CN113195706A (zh) 2019-07-08 2019-07-08 Ciml nk细胞及其方法

Country Status (9)

Country Link
EP (1) EP3853353A4 (fr)
JP (1) JP2022540267A (fr)
KR (1) KR20210079381A (fr)
CN (1) CN113195706A (fr)
AU (1) AU2019456438A1 (fr)
CA (1) CA3117134A1 (fr)
IL (1) IL283997A (fr)
SG (1) SG11202104256XA (fr)
WO (1) WO2021006876A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4301846A1 (fr) * 2021-03-03 2024-01-10 ImmunityBio, Inc. Cellules m-cenk hautement puissantes et procédés

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007297291A (ja) * 2006-04-28 2007-11-15 Yutaka Terunuma リンパ球の活性・増殖に係る培養方法
US20150374790A1 (en) * 2014-06-30 2015-12-31 Altor Bioscience Corporation Il-15-based molecules and methods of use thereof
CN105219713A (zh) * 2015-11-20 2016-01-06 崔长友 用于肿瘤过继性免疫的高增殖力、高杀伤力nk细胞
WO2018158350A1 (fr) * 2017-02-28 2018-09-07 Affimed Gmbh Combinaison d'un anticorps anti-cd16a avec une cytokine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10300089B2 (en) * 2016-11-08 2019-05-28 University Of Central Florida Research Foundation, Inc. Methods for high scale therapeutic production of memory NK cells
US11129883B2 (en) * 2017-03-06 2021-09-28 Altor BioScience, LLC. IL-15-based fusions to IL-12 and IL-18

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007297291A (ja) * 2006-04-28 2007-11-15 Yutaka Terunuma リンパ球の活性・増殖に係る培養方法
US20150374790A1 (en) * 2014-06-30 2015-12-31 Altor Bioscience Corporation Il-15-based molecules and methods of use thereof
CN105219713A (zh) * 2015-11-20 2016-01-06 崔长友 用于肿瘤过继性免疫的高增殖力、高杀伤力nk细胞
WO2018158350A1 (fr) * 2017-02-28 2018-09-07 Affimed Gmbh Combinaison d'un anticorps anti-cd16a avec une cytokine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LOCKE D. UPPENDAHL等: "Cytokine-induced memory-like natural killer cells have enhanced function, proliferation, and in vivo expansion against ovarian cancer cells", GYNECOLOGIC ONCOLOGY, vol. 153, pages 149 - 157 *

Also Published As

Publication number Publication date
WO2021006876A1 (fr) 2021-01-14
CA3117134A1 (fr) 2021-01-14
IL283997A (en) 2021-07-29
JP2022540267A (ja) 2022-09-15
SG11202104256XA (en) 2021-05-28
EP3853353A4 (fr) 2022-05-18
EP3853353A1 (fr) 2021-07-28
AU2019456438A1 (en) 2021-05-20
KR20210079381A (ko) 2021-06-29

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Application publication date: 20210730