CN113181299A - Tibetan incense composition and preparation method and application thereof - Google Patents

Tibetan incense composition and preparation method and application thereof Download PDF

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Publication number
CN113181299A
CN113181299A CN202110447575.8A CN202110447575A CN113181299A CN 113181299 A CN113181299 A CN 113181299A CN 202110447575 A CN202110447575 A CN 202110447575A CN 113181299 A CN113181299 A CN 113181299A
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parts
weight
radix
tibetan incense
tibetan
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谢拉
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Aba Ciyuan National Traditional Culture Co ltd
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Aba Ciyuan National Traditional Culture Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/532—Agastache, e.g. giant hyssop
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/89—Cyperaceae (Sedge family)
    • A61K36/8905—Cyperus (flatsedge)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Abstract

The invention discloses a Tibetan incense composition and a preparation method and application thereof, and the preparation raw materials comprise salvia miltiorrhiza, white paeony root, prepared rhizoma cyperi, liquorice, holy basil, patchouli, borneol, kadsura pepper fruit, radix bupleuri, immature bitter orange, sandalwood, Iran safflower, roasted frankincense, vanilla and angelica dahurica; the Tibetan incense composition is prepared by adopting traditional medicinal materials commonly obtained in Tibetan medicines according to a traditional Tibetan incense preparation method, the proportion is optimized, the obtained Tibetan incense composition is safe and reliable, the efficacy is obvious when the Tibetan incense composition is applied to relieving insomnia, and the Tibetan incense composition has no drug resistance and no toxic or side effect after long-term use.

Description

Tibetan incense composition and preparation method and application thereof
Technical Field
The invention relates to the technical field of medicines, in particular to a Tibetan incense composition and a preparation method and application thereof.
Background
The Tibetan incense is a short form of traditional incense used in Tibetan areas and Tibetan Buddhist worries, is mostly used for Buddhist sacrifice activities and is also used in a small amount at home. The manufacturing process flow of the Chinese character Tibetan language-based Chinese character library contains the essence of Tibetan language. The Tibetan incense is generated in the Tang dynasty approximately, the literary princess enters the Tibetan area and removes Buddha statues, Buddhist channels, incense products, incense prescriptions and the like, and then Tibetan people continuously adjust the incense prescriptions according to the characteristics of local life customs, culture, climate, functions, requirements and the like so as to achieve the fragrance, efficacy and the like more suitable for Tibetan people. The Tibetan incense raw material is mainly prepared from local aromatic plants, and high-grade incense products are added with agilawood, sandalwood, white paeony root, pangolin and tortoise shell. Gold, silver, jewelry and the like are also added into the high-grade religious incense. The real Tibetan incense is very strict in material and compatibility, and forms a set of complete and fragrant incense and program through continuous evidence participation, revision and perfection in the use process of thousands of years, and is born by a generation-transmission form. Even different professions, even some temple, will have own unique formula, unique efficacy of the incense. The basic efficacy of the Tibetan incense is almost the same as that of the Hanxiang, the main ingredients comprise saffron, snow lotus herb, musk, Tibetan nutmeg and the like, the Tibetan incense is fully considered in the composing process and is suitable for people in high and cold areas, and the components of the pangolin, the tortoise shell and the like are mainly used for warming blood, invigorating blood circulation and promoting blood circulation.
With the rapid development of society, the living and working pressure of people is continuously increased, and more modern people have neuropsychiatric diseases such as anxiety, depression, insomnia and the like. In the treatment process, western medicines mainly comprising chemical components are adopted, the initial curative effect is obvious, strong drug resistance is generated along with the prolonging of time, and the effect can be maintained only by increasing the dosage; and the patient has great dependence and side effect, needs to take for life, and suffers from headache and other side effects. Therefore, it is very necessary to develop a product for improving anxiety, depression and insomnia with good curative effect and no side effect
Therefore, those skilled in the art are devoted to develop a Tibetan incense composition and a preparation method and application thereof to solve the above-mentioned deficiencies of the prior art.
Disclosure of Invention
In view of the above defects in the prior art, the technical problem to be solved by the present invention is that in the prior art, western medicines are prone to generate drug resistance, dependence and large side effects in the aspects of anxiety, depression and insomnia improvement.
In order to achieve the above purpose, the first aspect of the invention provides a Tibetan incense composition, which is prepared from the raw materials of, by weight, 50-200 parts of salvia miltiorrhiza, 50-200 parts of radix paeoniae alba, 20-100 parts of prepared rhizoma cyperi, 10-100 parts of radix isatidis, 30-150 parts of holy basil, 20-100 parts of pogostemon cablin, 10-100 parts of borneol, 20-100 parts of pubescent river seeds, 10-80 parts of radix bupleuri, 20-100 parts of immature bitter orange, 1000-5000 parts of sandalwood, 200-500 parts of irgash red flower, 50-150 parts of fried frankincense, 100-300 parts of vanilla and 3000-6000 parts of radix angelicae;
furthermore, the Tibetan incense composition comprises 80-120 parts by weight of salvia miltiorrhiza in the raw materials for preparation;
furthermore, the Tibetan incense composition is prepared from the raw materials of 100-150 parts by weight of white paeony root;
furthermore, the raw materials for preparing the Tibetan incense composition comprise 50-80 parts by weight of prepared rhizoma cyperi;
further, the raw materials for preparing the Tibetan incense composition comprise 20-50 parts by weight of liquorice and green;
further, the raw materials for preparing the Tibetan incense composition comprise 50-100 parts by weight of holy basil;
furthermore, the raw materials for preparing the Tibetan incense composition comprise 30-80 parts by weight of pogostemon cablin;
further, the Tibetan incense composition comprises 10-30 parts by weight of borneol in preparation raw materials;
further, the Tibetan incense composition comprises 30-40 parts of Maohezi by weight of preparation raw materials;
furthermore, the Tibetan incense composition comprises 10-40 parts by weight of radix bupleuri as a raw material for preparation;
further, the raw materials for preparing the Tibetan incense composition comprise 30-60 parts by weight of immature bitter orange;
furthermore, the raw materials for preparing the Tibetan incense composition comprise 3500-4500 parts by weight of sandalwood;
further, the Tibetan incense composition is prepared from 300-400 parts by weight of Iran safflower;
further, the Tibetan incense composition comprises 60-100 parts by weight of roasted frankincense in preparation raw materials;
further, the Tibetan incense composition comprises 100-150 parts of hierochloe odorata by weight in the preparation raw materials;
furthermore, the Tibetan incense composition comprises 4000-5500 parts by weight of radix angelicae in the raw materials for preparation;
in a preferred embodiment of the invention, the raw materials for preparing the Tibetan incense composition comprise 100 parts by weight of salvia miltiorrhiza;
in a preferred embodiment of the invention, the Tibetan incense composition is prepared by using 120 parts by weight of radix paeoniae alba as a raw material;
in a preferred embodiment of the invention, the raw materials for preparing the Tibetan incense composition comprise 60 parts by weight of prepared rhizoma cyperi;
in a preferred embodiment of the invention, the raw materials for preparing the Tibetan incense composition comprise 30 parts by weight of radix glycyrrhizae;
in a preferred embodiment of the invention, the raw materials for preparing the Tibetan incense composition comprise holy basil in 80 parts by weight;
in a preferred embodiment of the invention, the Tibetan incense composition is prepared by using 50 parts by weight of pogostemon cablin;
in a preferred embodiment of the invention, the Tibetan incense composition is prepared by using 20 parts of borneol by weight as raw materials;
in a preferred embodiment of the invention, the Tibetan incense composition is prepared by using 35 parts by weight of Maohezi as a raw material;
in a preferred embodiment of the invention, the raw materials for preparing the Tibetan incense composition comprise 20 parts by weight of bupleurum;
in a preferred embodiment of the invention, the raw materials for preparing the Tibetan incense composition comprise 50 parts by weight of immature bitter orange;
in a preferred embodiment of the invention, the raw materials for preparing the Tibetan incense composition comprise 4000 parts by weight of sandalwood;
in a preferred embodiment of the invention, the Tibetan incense composition is prepared by taking 350 parts of Iranian safflower by weight as a raw material;
in a preferred embodiment of the invention, the raw materials for preparing the Tibetan incense composition comprise 80 parts by weight of roasted frankincense;
in a preferred embodiment of the invention, the Tibetan incense composition is prepared by taking 120 parts of hierochloe odorata by weight as a raw material;
in a preferred embodiment of the invention, the Tibetan incense composition is prepared by using the raw materials containing the hierochloe odorata with the weight part of 5000 parts;
in the composition of the Tibetan incense, the raw materials of the Tibetan incense,
saviae Miltiorrhizae radix is dried root and rhizome of Salvia miltiorrhiza Bunge of Labiatae, and has effects of promoting blood circulation for removing blood stasis, dredging channels, relieving pain, clearing heart fire, relieving restlessness, cooling blood and resolving carbuncle; can be used for treating thoracic obstruction, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain;
radix Paeoniae alba is dry root of Paeonia lactiflora pall of Ranunculaceae, and has effects of nourishing blood, regulating menstruation, astringing yin, arresting sweating, softening liver, relieving pain, and suppressing liver yang; can be used for treating blood deficiency, sallow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, limb spasm pain, headache, and vertigo;
the processed cyperus tuber is pungent, slightly bitter and sweet in taste and mild in nature. Has the functions of soothing liver, regulating qi, regulating menstruation and relieving pain. The main components of the composition comprise volatile oil, beta-pinene and camphene; mainly used for treating liver qi stagnation, chest distress, hypochondriac pain, gastropathy and abdominal pain; and menoxenia and dysmenorrhea
The fructus Eriocheir sinensis is dry mature fruit of Terminalia bellirica of Combretaceae, and is harvested in winter, removed of impurities, and dried in the sun. Has the effects of clearing away heat and toxic materials, astringing, nourishing blood, and harmonizing the effects of the other medicines. Can be used for treating various heat syndromes, dysentery, jaundice, liver and gallbladder diseases, and asthenia after illness;
bupleuri radix is dried root of Bupleurum scorzonerifolium or Bupleurum scorzonerifolium of Umbelliferae; . Has the functions of harmonizing exterior and interior, soothing liver and invigorating yang. Can be used for treating common cold, fever, malaria, stagnation of qi due to stagnation of liver-qi, distending pain of chest and hypochondrium, rectocele, uterine prolapse, and menoxenia
Lignum Santali albi is dry heartwood of trunk of lignum Santali albi of Santalaceae, has effects of activating qi-flowing, warming spleen and stomach, promoting appetite and relieving pain, and can be used for treating cold stagnation, qi stagnation, chest distress, chest pain, abdominal pain, emesis and anorexia;
herba Agastaches is herba Agastaches of Labiatae herbaceous plant or aerial part of herba Agastaches, has effects of eliminating dampness and activating spleen, removing filth and regulating stomach, relieving summer-heat, and relieving exterior syndrome, and can be used for treating dampness obstruction of spleen and stomach, abdominal distention, early stage of damp-warm disease, emesis, diarrhea, summer-heat dampness, fever with aversion to cold, aversion to cold with fever, chest and abdominal fullness and distention, etc.;
the herba Cymbopogonis Citrari is of Cymbopogon of Gramineae, and is prepared from rhizome. Collected in spring and autumn, cut into segments and dried in the sun. The main functional indications are as follows: cool blood, stop bleeding, clear heat and induce diuresis. Can be used for treating hematemesis, hematuria, edema due to acute and chronic nephritis, and stranguria due to heat;
the Glycyrrhrizae radix is dried root and rhizome of Leguminosae plant Glycyrrhrizae radix, radix Glycyrrhizae Inflatae or Glycyrrhrizae radix; has the effects of invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the medicines; can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, and sore, and relieving drug toxicity and pungency;
the fructus Aurantii Immaturus is Rutaceae plant Citrus aurantium and its cultivar or dried young fruit of Citrus sinensis; has effects of resolving qi stagnation, eliminating phlegm and relieving oppression; can be used for treating stagnation, abdominal distention, pain, dysentery, constipation, phlegm stagnation, qi stagnation, thoracic obstruction, and viscera prolapse;
the angelica dahurica is a big perennial herb, and has the functions of dispelling diseases, removing dampness, expelling pus, promoting granulation, promoting blood circulation, relieving pain and the like by using the root as a medicine; can be used for treating wind-cold type common cold, headache, rhinitis, and toothache. Leucorrhea with reddish discharge, pain, furuncle and pyogenic infections.
The Tibetan incense composition has the efficacy of improving and regulating the nerves of a human body by reasonably proportioning the fifteen Tibetan medicinal materials, so that the purpose of relieving insomnia is achieved.
Further, the Tibetan incense composition is added with pharmaceutically acceptable auxiliary materials when necessary, wherein the auxiliary materials comprise but are not limited to carriers or excipients;
such vectors include, but are not limited to: ion exchangers, aluminum oxide, aluminum stearate, lecithin, serum proteins such as human serum albumin, buffer substances such as phosphates, glycerol, sorbic acid, potassium sorbate, partial glyceride mixtures of saturated vegetable fatty acids, water, salts or electrolytes, such as protamine sulfate, disodium hydrogen phosphate, potassium hydrogen phosphate, sodium chloride, zinc salts, colloidal silica, magnesium trisilicate, polyvinylpyrrolidone, cellulosic substances, polyethylene glycol, sodium carboxymethylcellulose, polyacrylates, beeswax, lanolin;
the excipient refers to an additive other than the main component in the pharmaceutical preparation. The composition has stable property, no incompatibility with main components, no side effect, no influence on curative effect, no deformation at normal temperature, no crack, mildew or worm damage, no harm to human body, no physiological effect, no chemical or physical effect with main components, no influence on content determination of main components, etc.;
the term "main component" used herein refers to a component playing a main role in the Tibetan incense composition, generally a component except for auxiliary materials, in the Tibetan incense composition of the present invention, the main component is salvia miltiorrhiza, white paeony root, prepared nutgrass galingale rhizome, liriope, holy basil, patchouli, borneol, kadsura pepper, bupleurum, immature bitter orange, sandalwood, iran safflower, roasted frankincense, vanilla and angelica dahurica;
the invention also provides a preparation method of the Tibetan incense composition, which comprises the following steps of weighing the root of red-rooted salvia, the root of herbaceous peony, the prepared rhizoma cyperi, the rhizome of spikenard, the lysimachia foenum-graecum, the patchouli, the borneol, the seed of Chinese mosla, the root of Chinese thorowax, the immature bitter orange, the sandalwood, the Iran safflower, the roasted frankincense, the vanilla and the angelica dahurica in parts by weight; detoxifying according to the traditional Tibetan incense processing method, grinding and manufacturing by a winch, and adding pharmaceutically acceptable auxiliary materials if necessary;
in a preferred embodiment of the invention, the preparation method of the Tibetan incense composition comprises the steps of weighing the processed salvia miltiorrhiza, white paeony root, prepared rhizoma cyperi, liquorice, holy basil, patchouli, borneol, semen kadsurae, radix bupleuri, immature bitter orange, sandalwood, Iran safflower, processed frankincense, vanilla and angelica dahurica in parts by weight, grinding with a water mill to obtain mud, uniformly mixing, kneading and extruding to obtain the Tibetan incense composition;
the invention also provides the use of the Tibetan incense composition in the first aspect of the invention for preparing a medicine for relieving insomnia.
The invention also provides the Tibetan incense composition as described in the first aspect of the invention, and the Tibetan incense composition is used for relieving insomnia related diseases.
The present invention also provides a method for alleviating insomnia, which comprises administering to a subject in need thereof an effective amount of the Tibetan incense composition of any one of the first aspect of the present invention;
said applying an effective amount is to ignite the Tibetan incense composition of any of the above first aspect of the present invention;
further, the time for burning the Tibetan incense composition is more than 2 hours.
Compared with the prior art, the Tibetan incense composition is prepared by adopting traditional medicinal materials commonly obtained in Tibetan medicines according to a traditional Tibetan incense preparation method, the proportion is optimized, the obtained Tibetan incense composition is safe and reliable, the efficacy of the Tibetan incense composition for relieving and improving insomnia is remarkable, and the Tibetan incense composition has no drug resistance and no toxic or side effect after long-term use.
The conception, the specific technical solutions and the technical effects of the present invention will be further described with reference to the following embodiments, so as to fully understand the objects, the features and the effects of the present invention.
Detailed Description
The following describes several preferred embodiments of the present invention to make the technical contents thereof clearer and easier to understand. The invention may be embodied in many different forms of embodiments, which are intended to be illustrative only, and the scope of the invention is not intended to be limited to the embodiments shown herein.
If there is an experimental method not specified specific conditions, it is usually carried out according to conventional conditions, such as the relevant instructions or manuals.
Example 1 preparation of a Tibet incense composition
The preparation raw materials comprise:
80g of salvia miltiorrhiza, 100g of radix paeoniae alba, 50g of prepared rhizoma cyperi, 20g of radix isatidis, 500g of holy basil, 300g of pogostemon cablin, 10g of borneol, 30g of pubescent angelica, 10g of radix bupleuri, 30g of immature bitter orange, 3500g of sandalwood, 300g of iranthera flower, 60g of roasted frankincense, 100g of vanilla and 4000g of radix angelicae;
the preparation method specifically comprises the following steps:
weighing 80g of salvia miltiorrhiza, 100g of radix paeoniae alba, 50g of prepared rhizoma cyperi, 20g of radix isatidis, 500g of holy basil, 300g of patchouli, 10g of borneol, 30g of pubescent angelica root, 10g of radix bupleuri, 30g of immature bitter orange, 3500g of sandalwood, 300g of Iran safflower, 60g of roasted frankincense, 100g of vanilla and 4000g of radix angelicae according to the weight of the raw materials, grinding the raw materials of sandalwood by a water vehicle to obtain mud, mixing the other components, powdering, uniformly mixing with the mud, rubbing and extruding to obtain the Tibetan incense composition of the embodiment.
Example 2 preparation of a Tibet incense composition
The preparation raw materials comprise:
120g of salvia miltiorrhiza, 150g of radix paeoniae alba, 80g of prepared rhizoma cyperi, 50g of radix isatidis, 100g of holy basil, 80g of patchouli, 30g of borneol, 40g of pubescent angelica, 40g of radix bupleuri, 60g of immature bitter orange, 4500g of sandalwood, 400g of iranthera flower, 100g of roasted frankincense, 150g of vanilla and 5500g of radix angelicae;
the preparation method is similar to the operation of the embodiment 1.
Example 3 preparation of a Tibet incense composition
100g of salvia miltiorrhiza, 120g of radix paeoniae alba, 60g of prepared rhizoma cyperi, 30g of radix isatidis, 80g of holy basil, 50g of pogostemon cablin, 20g of borneol, 35g of pubescent angelica, 20g of radix bupleuri, 50g of immature bitter orange, 4000g of sandalwood, 350g of iranthera, 80g of roasted frankincense, 120g of vanilla and 5000g of radix angelicae;
the preparation method is similar to the operation of the embodiment 1.
Test example 4, establishment and verification of PCPA insomnia rat model
Establishing an insomnia rat model by using PCPA; an insomnia animal model is adopted to verify the effect of the Tibetan incense extract (water extract, alcohol extract and Tibetan incense combustion extract) of the Tibetan incense composition obtained in the embodiments 1-3 of the invention on treating insomnia. Injecting PCPA into the abdominal cavity to copy a rat insomnia model, intragastrically irrigating the Tibetan incense extract (water extract, alcohol extract and Tibetan incense combustion extract) intervention 3 d of the Tibetan incense composition of the embodiment 1-3, and detecting the levels of peripheral blood serum HPA axis hormones ACTH, CORT and CRF, epigenetic modification main enzymes DNMT1, HDAC activity and serum Acetyl-Histone H3 by an ELISA method;
the experimental result shows that the Tibetan incense extract can obviously reduce the serum HPA axis hormone level of an insomnia rat, the Tibetan incense extract can obviously reduce the serum DNMT1 activity of the insomnia rat, and the Tibetan incense extract can obviously reduce the serum Acetyl-Histone H3 level of the insomnia rat; according to the experimental results, the extract of the Tibetan incense combination obtained in the embodiment can relieve insomnia and restore the homeostasis of the body by adjusting the hormone level of the HPA axis.
Test example 5 study on sleep-promoting mechanism of Tibetan incense extract for regulating and controlling neurotransmitter and electroencephalogram activity of insomnia model rat
The small-platform water environment method deprives rats of sleep replication of an insomnia animal model, takes eszopiclone as a control, randomly divides 80 rats into a blank group, a model group, a western medicine group and a Tibetan incense group, and performs whole-body change, neurotransmitter content and electroencephalogram activity condition on each group of rats after the modeling is finished;
the experimental results show that the blank group of rats has good mental state, agility in locomotion, quick response, glossy hair and obviously increased weight; the rats in the model group are weakened in all items; compared with the blank group, the weight increment, the total sleep time, the 5-HT, the IL-1, the IL-6, the TNF-alpha content and the NREMS proportion of the rats in the model group are obviously reduced, the sleep latency period is prolonged, and the awakening proportion is increased (P is less than 0.05); compared with the model group, the weight increment of rats in the Tibetan incense group and the western medicine group, the total sleep time, 5-HT, IL-1, IL-6 and TNF-alpha content are obviously increased, the sleep latency period is shortened, and the arousal proportion is obviously reduced (P is less than 0.05); according to experimental results, the Tibetan incense composition obtained in the embodiments 1 to 3 can better improve the general symptoms and sleep state of the rat with the insomnia model, and effectively control the weight loss of the rat.
Test examples 6,
The Tibetan incense composition prepared in the embodiment 1-3 is used for a patient diagnosed with insomnia and is set off indoors for 2-5 hours for relieving treatment;
after long-time use and tracking, the result shows that the Tibetan incense composition is used for daily use of patients suffering from mental diseases such as insomnia and the like, and the sleep time of the patients is improved from 2-3 hours/day to 5-6 hours/day; the sleep quality is good, and the mental state of the patient is obviously improved. The Tibetan incense composition prepared in the embodiments 1-3 of the application has obvious improvement effect on mental diseases and symptoms such as insomnia and the like; adverse reactions are not seen in the using process;
test example 7:
tracking and recording the long-term use condition of the patient, and tracking the long-term use condition of other medicines for treating insomnia, namely ramelteon, for treating insomnia, wherein the tracking time is 1-2 years;
in the long-term population taking ramelteon for treating insomnia, 60% of users have one or more side effect symptoms of dizziness, headache, somnolence, fatigue, insomnia aggravation, depression, arthralgia, myalgia, gastrointestinal tract reaction, taste change, upper respiratory tract infection and heavy anaphylaxis during tracking;
the Tibetan incense composition obtained in the embodiments 1-3 of the invention has no obvious side effect phenomenon in the process of treating insomnia by long-term setting off, and has no drug resistance, and the setting off time and the periodic dosage of a patient are stable and not increased; no obvious dependence is found after the medicine is taken out of the patient for 2 years.
In conclusion, the Tibetan incense composition can relieve neuropsychiatric diseases, has the beneficial effect of obviously improving symptoms, has an obvious curative effect, does not have side effect, and does not have obvious drug resistance and drug dependence.
The Tibetan incense compositions of other embodiments of the present invention have similar benefits as described above.
The Tibetan incense composition obtained by the technical scheme of other embodiments of the invention also has similar beneficial effects as the above.
The foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations could be devised by those skilled in the art in light of the present teachings without departing from the inventive concepts. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.

Claims (8)

1. A Tibetan incense composition is characterized by comprising, by weight, 50-200 parts of red sage root, 50-200 parts of white peony root, 20-100 parts of prepared rhizoma cyperi, 10-100 parts of azure, 30-150 parts of holy basil, 20-100 parts of pogostemon cablin, 10-100 parts of borneol, 20-100 parts of pubescent angelica root, 10-80 parts of radix bupleuri, 20-100 parts of immature bitter orange, 1000-5000 parts of sandalwood, 200-500 parts of Irania tinctoria, 50-150 parts of roasted frankincense, 100-300 parts of hierochloe odorata and 3000-6000 parts of radix angelicae.
2. The Tibetan incense composition as claimed in claim 1, wherein the raw materials for preparation comprise 80-120 parts by weight of radix Salviae Miltiorrhizae, 100-150 parts by weight of radix Paeoniae alba, 50-80 parts by weight of rhizoma Cyperi preparata, 20-50 parts by weight of radix Et rhizoma Nardostachyos, 50-100 parts by weight of herba Lysimachiae Foenumgraeci, 30-80 parts by weight of herba Pogostemonis, 10-30 parts by weight of Borneolum Syntheticum, 30-40 parts by weight of rhizoma Drynariae, 10-40 parts by weight of radix bupleuri, 30-60 parts by weight of fructus Aurantii Immaturus, 3500-4500 parts by weight of lignum Santali albi, 300-400 parts by weight of Irania flos Carthami, 60-100 parts by weight of Olibanum preparata, 100-150 parts by weight of herba Pogostemonis, and 4000-5500 parts by weight of radix Angelicae Dahuricae.
3. The Tibetan incense composition as claimed in claim 1, wherein the preparation raw materials comprise 100 parts by weight of radix Salviae Miltiorrhizae, 120 parts by weight of radix Paeoniae alba, 60 parts by weight of rhizoma Cyperi preparata, 30 parts by weight of radix Et rhizoma Nardostachyos, 80 parts by weight of herba Lysimachiae Foenumgraeci, 50 parts by weight of herba Pogostemonis, 20 parts by weight of Borneolum Syntheticum, 35 parts by weight of rhizoma Drynariae, 20 parts by weight of radix bupleuri, 50 parts by weight of fructus Aurantii Immaturus, 4000 parts by weight of lignum Santali albi, 350 parts by weight of Irania grandiflora, 80 parts by weight of Olibanum, 120 parts by weight of herba Imperatae, and 5000 parts by weight of radix Angelicae Dahuricae.
4. A preparation method of a Tibetan incense composition is characterized by comprising the following steps of weighing radix salviae miltiorrhizae, radix paeoniae alba, prepared rhizoma cyperi, radix isatidis, holy basil, patchouli, borneol, semen kadsurae, radix bupleuri, immature bitter orange, sandalwood, Iran safflower, roasted frankincense, vanilla and radix angelicae in parts by weight; detoxifying according to the traditional Tibetan incense processing method, grinding and manufacturing by a winch, and adding pharmaceutically acceptable auxiliary materials if necessary.
5. The method of claim 4, wherein the Tibetan incense composition is prepared by weighing the processed radix Salviae Miltiorrhizae, radix Paeoniae alba, rhizoma Cyperi preparata, radix Et rhizoma Nardostachyos, herba Lysimachiae Foenumgraeci, herba Pogostemonis, Borneolum Syntheticum, semen Origani, radix bupleuri, fructus Aurantii Immaturus, lignum Santali albi, Iran flos Carthami, Olibanum, herba Pogostemonis, and radix Angelicae Dahuricae in parts by weight, grinding with water mill to obtain a paste, mixing well, kneading, and extruding to obtain the Tibetan incense composition.
6. Use of the Tibetan incense composition as set forth in any one of claims 1 to 3 for the preparation of a medicament for alleviating insomnia.
7. The method for preparing the Tibetan incense composition for relieving insomnia disease of any one of claims 1 to 3, wherein an effective amount of the Tibetan incense composition is applied to a subject in need thereof, wherein the effective application amount is burning the Tibetan incense composition.
8. A method for relieving insomnia, comprising burning the Tibetan incense composition of claims 1-3 to a subject in need thereof; it is characterized in that the time for burning the Tibetan incense composition is more than 2 hours.
CN202110447575.8A 2021-04-25 2021-04-25 Tibetan incense composition and preparation method and application thereof Pending CN113181299A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1101575A (en) * 1993-10-12 1995-04-19 孙惠民 The Eight Diagrams pillow
CN108968616A (en) * 2018-08-31 2018-12-11 阿坝州慈愿民族传统文化有限责任公司 A kind of santal taste joss stick produced in Xizang and preparation method thereof
CN109105393A (en) * 2018-08-31 2019-01-01 阿坝州慈愿民族传统文化有限责任公司 A kind of rhizoma nardostachyos taste joss stick produced in Xizang and preparation method thereof
CN109395136A (en) * 2018-08-31 2019-03-01 阿坝州慈愿民族传统文化有限责任公司 A kind of dalbergia wood type joss stick produced in Xizang and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1101575A (en) * 1993-10-12 1995-04-19 孙惠民 The Eight Diagrams pillow
CN108968616A (en) * 2018-08-31 2018-12-11 阿坝州慈愿民族传统文化有限责任公司 A kind of santal taste joss stick produced in Xizang and preparation method thereof
CN109105393A (en) * 2018-08-31 2019-01-01 阿坝州慈愿民族传统文化有限责任公司 A kind of rhizoma nardostachyos taste joss stick produced in Xizang and preparation method thereof
CN109395136A (en) * 2018-08-31 2019-03-01 阿坝州慈愿民族传统文化有限责任公司 A kind of dalbergia wood type joss stick produced in Xizang and preparation method thereof

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Application publication date: 20210730