CN113181294A - Traditional Chinese medicine formula for treating chronic nasal diseases and preparation method thereof - Google Patents

Traditional Chinese medicine formula for treating chronic nasal diseases and preparation method thereof Download PDF

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CN113181294A
CN113181294A CN202110564848.7A CN202110564848A CN113181294A CN 113181294 A CN113181294 A CN 113181294A CN 202110564848 A CN202110564848 A CN 202110564848A CN 113181294 A CN113181294 A CN 113181294A
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黄磊
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    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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Abstract

The invention discloses a traditional Chinese medicine formula for treating chronic nasal diseases and a preparation method thereof, wherein the traditional Chinese medicine formula comprises the following components in parts by weight: 10-20 parts of centipeda minima, 9-18 parts of bletilla striata, 8-16 parts of angelica dahurica, 8-15 parts of mulberry leaves, 10-15 parts of borneol, 8-22 parts of scutellaria baicalensis, 10-28 parts of liquorice, 6-18 parts of biond magnolia flower, 12-26 parts of cocklebur fruits, 12-24 parts of asarum, 10-25 parts of salvia miltiorrhiza, 32-60 parts of sesame oil, 6-9 parts of mint and 5-10 parts of isatis roots. The traditional Chinese medicine formula for treating the chronic nasal diseases and the preparation method thereof are prepared by scientifically preparing medicines according to a Chinese traditional medicine dictionary, aiming at the disease roots of the focus, and blending multiple traditional Chinese medicines, and the medicine is a pure traditional Chinese medicine formula, has high remission rate, good curative effect, quick response, treatment of both symptoms and root causes, no toxic or side effect, can effectively absorb moisture, reduce the flow of clear nasal discharge, and has the effects of resisting bacteria, diminishing inflammation, inhibiting bacteria, relieving itching, detoxifying and dredging orifices.

Description

Traditional Chinese medicine formula for treating chronic nasal diseases and preparation method thereof
Technical Field
The invention relates to the technical field of Chinese herbal medicine formulas, in particular to a traditional Chinese medicine formula for treating chronic nasal diseases and a preparation method thereof.
Background
The chronic rhinitis is chronic inflammation of nasal mucosa and submucosa, and is mainly characterized in that the inflammation lasts for more than three months or is repeatedly attacked, is not healed after lasting, can not be recovered in an intermittent period, has no definite pathogenic microorganism, is accompanied by obstacles such as nasal obstruction with different degrees, secretion increase, nasal mucosa swelling or thickening and the like, and mainly consists of symptoms such as nasal polyp, nasosinusitis and the like.
The existing main methods for treating rhinitis comprise drug treatment and operative treatment, wherein western medicine treatment not only has long treatment period, large side effect, strong dependence and easy recurrence, so that patients are affected by rhinitis for a long time, but also has long treatment period, unobvious curative effect or frequent recurrence, and under the condition of ineffective drug treatment, rhinitis patients usually adopt operative treatment methods such as laser operation, low-temperature plasma radio frequency operation and the like, so that the operative treatment easily damages tissues and causes a series of complications, and the treatment risk is large.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a traditional Chinese medicine formula for treating chronic nasal diseases and a preparation method thereof, which can effectively promote the treatment of chronic rhinitis, nasal polyp and nasosinusitis by the mutual cooperation and synergy of various components in the formula, and solves the problems in the background art.
In order to achieve the purpose, the invention provides the following technical scheme: a traditional Chinese medicine formula for treating chronic nasal diseases and a preparation method thereof comprise the following components in parts by weight: 10-20 parts of centipeda minima, 9-18 parts of bletilla striata, 8-16 parts of angelica dahurica, 8-15 parts of mulberry leaves, 10-15 parts of borneol, 8-22 parts of scutellaria baicalensis, 10-28 parts of liquorice, 6-18 parts of biond magnolia flower, 12-26 parts of cocklebur fruits, 12-24 parts of asarum, 10-25 parts of salvia miltiorrhiza, 32-60 parts of sesame oil, 6-9 parts of mint and 5-10 parts of isatis roots.
Preferably, the paint comprises the following components in parts by weight: 10 parts of centipeda minima, 9 parts of bletilla striata, 8 parts of angelica dahurica, 8 parts of mulberry leaves, 10 parts of borneol, 8 parts of scutellaria baicalensis, 10 parts of liquorice, 6 parts of biond magnolia flower, 12 parts of cocklebur fruit, 12 parts of asarum, 10 parts of salvia miltiorrhiza, 32 parts of sesame oil, 6 parts of mint and 5 parts of isatis roots.
A preparation method of a traditional Chinese medicine for treating chronic nasal diseases comprises the following steps;
the method comprises the following steps: distilling, crystallizing and crushing the raw material components into powder, and taking out for later use;
step two: soaking the residue in ethanol, heating, concentrating, extracting to obtain paste, and taking out;
step three: mixing the powdery raw materials and the pasty raw materials in the first step and the second step, concentrating to paste, adding sesame oil, and bottling.
Preferably, in the first step, all the raw material medicines are distilled by a steam method to obtain crystals, the crystals are ground into powder by a grinder, and the powder is sieved by a 200-mesh sieve to obtain fine powder.
Preferably, in the second step, the distilled dregs obtained in the first step are added with 5-8 times of 70-90% ethanol for soaking for 1-2 hours, the mixture is heated and extracted for 2 times, the time interval is 1-2 hours each time, supernatant liquid is extracted, the supernatant liquid obtained in the two times is combined, filtered by a 80-120 mesh sieve, ultrafiltered by an ultrafilter column, ultrafiltrate is concentrated into extract under reduced pressure, the extract is heated and concentrated for 30-45 minutes, active ingredients are extracted, the concentrated solution is kept stand to be paste-like extract, and the paste is kept stand for later use.
Preferably, the powder of the crystal extracted by distillation can be put into the extract extracted by ethanol, added with sesame oil and soaked for 5-10 days, and then bottled for use.
This practicality possesses following beneficial effect:
1. the traditional Chinese medicine formula for treating the chronic nasal diseases and the preparation method thereof are prepared according to the Chinese traditional medicine dictionary science, are used for medicine according to the disease root of a focus, and are prepared by blending a plurality of traditional Chinese medicines, the medicine is a pure traditional Chinese medicine formula, has high remission rate, good curative effect, quick response, treatment of both symptoms and root causes, no toxic or side effect, can effectively absorb moisture, reduce the flow of clear nasal discharge, has the effects of resisting bacteria, diminishing inflammation, resisting bacteria, relieving itching, detoxifying and dredging orifices, has soft medicine property and no stimulation when in use, does not cause discomfort when in use by patients, does not cause drug-induced rhinitis, and has good curative effects on chronic rhinitis, nasal polyp and nasosinusitis.
2. The traditional Chinese medicine formula for treating chronic nasal diseases and the preparation method thereof have the advantages that the formula medicine is prepared, the preparation is simple and convenient to obtain, the traditional Chinese medicinal materials with different medicinal properties are adopted and scientifically matched, the ideal treatment effect can be achieved, the traditional Chinese medicine formula is safe, small in toxic and side effects, simple to prepare, short in curing time and not easy to relapse after curing, and the trouble of patients can be solved greatly.
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FIG. 1 is a schematic view of the operation of the present invention.
Detailed Description
All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides a technical scheme that: a traditional Chinese medicine formula for treating chronic nasal diseases and a preparation method thereof comprise the following components in parts by weight: 10-20 parts of centipeda minima, 9-18 parts of bletilla striata, 8-16 parts of angelica dahurica, 8-15 parts of mulberry leaves, 10-15 parts of borneol, 8-22 parts of scutellaria baicalensis, 10-28 parts of liquorice, 6-18 parts of biond magnolia flower, 12-26 parts of cocklebur fruits, 12-24 parts of asarum, 10-25 parts of salvia miltiorrhiza, 32-60 parts of sesame oil, 6-9 parts of mint and 5-10 parts of isatis roots.
The paint comprises the following components in parts by weight: 10 parts of centipeda minima, 9 parts of bletilla striata, 8 parts of angelica dahurica, 8 parts of mulberry leaves, 10 parts of borneol, 8 parts of scutellaria baicalensis, 10 parts of liquorice, 6 parts of biond magnolia flower, 12 parts of cocklebur fruit, 12 parts of asarum, 10 parts of salvia miltiorrhiza, 32 parts of sesame oil, 6 parts of mint and 5 parts of isatis roots.
Wherein, the centipeda minima: has effects in dispelling pathogenic wind and cold, relieving nasal obstruction, relieving cough, and removing toxic substance; bletilla striata: has effects in astringing, stopping bleeding, relieving swelling, and promoting granulation; mulberry leaf: has effects of dispelling pathogenic wind and heat, clearing lung-heat, moistening dryness, removing liver fire, and improving eyesight; borneol: has effects in clearing away heat, relieving pain, improving eyesight, removing nebula, promoting granulation, and healing sore; scutellaria baicalensis: has effects of clearing heat, eliminating dampness, clearing pathogenic fire, and removing toxic substance, and also has strong antiinflammatory effect; licorice root: has the efficacy of delaying the metabolism of cortical hormone, and has no obvious influence on the hypothalamus pituitary adrenal axis; and (3) magnolia flower: has the effects of dispelling pathogenic wind and cold, ascending internal energy, clearing lung and stomach qi, and relieving stuffy nose; fructus xanthil: has effects of dispelling pathogenic wind, relieving pain, dispelling pathogenic wind and cold, relieving nasal obstruction, improving tissue edema, and relieving nasal mucosa congestion; asarum: has effects in dispelling pathogenic wind, relieving pain, relieving cough, and relieving nasal obstruction; red sage root: has effects in nourishing blood, tranquilizing mind, cooling blood, and relieving pain; mint: has effects in dispelling pathogenic wind and heat, refreshing mind, relieving sore throat, promoting eruption, dispersing stagnated liver qi, and promoting qi circulation; radix isatidis: has effects of clearing away heat and toxic materials, cooling blood, relieving sore throat, resisting virus, and enhancing immunity.
The medicine is prepared by blending a plurality of traditional Chinese medicines according to the scientific pharmacy of a Chinese dictionary, is prepared by aiming at the disease root of a focus, has high remission rate, good curative effect and quick response, treats both principal and secondary aspects of diseases, has no toxic or side effect, can effectively absorb moisture, reduces the flow of thin nasal discharge, has the effects of resisting bacteria, diminishing inflammation, inhibiting bacteria, relieving itching, detoxifying and dredging orifices, has soft medicine property and no stimulation when in use, does not cause discomfort when used by a patient, does not cause drug-induced rhinitis, and has good curative effect on chronic rhinitis, nasal polyp and nasosinusitis.
A preparation method of a traditional Chinese medicine for treating chronic nasal diseases comprises the following steps;
the method comprises the following steps: distilling, crystallizing and crushing the raw material components into powder, and taking out for later use;
step two: soaking the residue in ethanol, heating, concentrating, extracting to obtain paste, and taking out;
step three: mixing the powdery raw materials and the pasty raw materials in the first step and the second step, concentrating to paste, adding sesame oil, and bottling.
Wherein, in the first step, all the raw material medicines are distilled by a steam method to obtain crystals, ground into powder by a grinder, and sieved by a 200-mesh sieve to obtain fine powder.
In the second step, the distilled medicine residue in the first step is added with 5-8 times of 70-90% ethanol for soaking for 1-2 hours, the mixture is heated and extracted for 2 times, the interval of 1-2 hours each time, supernatant liquid is extracted, the supernatant liquid obtained in the two times is combined, filtered by a 80-120 mesh sieve, ultrafiltered by an ultrafiltration column for 20-30 minutes, ultrafiltrate is concentrated into extract under reduced pressure, the extract is heated and concentrated for 30-45 minutes, active ingredients are extracted, the concentrated solution is kept stand to be paste-shaped, and the paste-shaped extract is kept stand for 5-10 hours for later use.
Wherein the crystal powder obtained by distillation for 10-20min can be added into the ethanol extract, and mixed and stirred for at least 5min, and 32 g of oleum Sesami can be added into the mixture and soaked for 5-10 days.
The traditional Chinese medicine is prepared simply and conveniently, adopts traditional Chinese medicinal materials with different medicinal properties, is scientifically compatible, can achieve an ideal treatment effect, is safe, has small toxic and side effects, is simple to prepare, can directly reach a focus, is short in curing time, is not easy to relapse after being cured, and greatly helps patients to solve troubles.
In a second embodiment, the traditional Chinese medicine formula for treating chronic nasal diseases comprises the following components in parts by weight: 15 g of centipeda minima, 12 g of bletilla striata, 10 g of angelica dahurica, 9 g of mulberry leaf, 12 g of borneol, 18 g of scutellaria baicalensis, 20 g of liquorice, 9 g of biond magnolia flower, 22 g of cocklebur fruit, 17 g of asarum, 16 g of salvia miltiorrhiza, 40 g of sesame oil, 7 g of mint and 8 g of isatis root.
Drug data comparison reference table
Figure RE-GDA0003110980780000051
Figure RE-GDA0003110980780000061
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (6)

1. A traditional Chinese medicine formula for treating chronic nasal diseases, which is characterized in that: the paint comprises the following components in parts by weight: 10-20 parts of centipeda minima, 9-18 parts of bletilla striata, 8-16 parts of angelica dahurica, 8-15 parts of mulberry leaves, 10-15 parts of borneol, 8-22 parts of scutellaria baicalensis, 10-28 parts of liquorice, 6-18 parts of biond magnolia flower, 12-26 parts of cocklebur fruits, 12-24 parts of asarum, 10-25 parts of salvia miltiorrhiza, 32-60 parts of sesame oil, 6-9 parts of mint and 5-10 parts of isatis roots.
2. The traditional Chinese medicine formula for treating chronic nasal diseases according to claim 1, wherein the formula comprises: the paint comprises the following components in parts by weight: 10 parts of centipeda minima, 9 parts of bletilla striata, 8 parts of angelica dahurica, 8 parts of mulberry leaves, 10 parts of borneol, 8 parts of scutellaria baicalensis, 10 parts of liquorice, 6 parts of biond magnolia flower, 12 parts of cocklebur fruit, 12 parts of asarum, 10 parts of salvia miltiorrhiza, 32 parts of sesame oil, 6 parts of mint and 5 parts of isatis roots.
3. A preparation method of a traditional Chinese medicine for treating chronic nasal diseases is characterized by comprising the following steps: comprises the following steps;
the method comprises the following steps: distilling, crystallizing and crushing the raw material components into powder, and taking out for later use;
step two: soaking the residue in ethanol, heating, concentrating, extracting to obtain paste, and taking out;
step three: mixing the powdery raw materials and the pasty raw materials in the first step and the second step, concentrating to paste, adding sesame oil, and bottling.
4. The preparation method of the traditional Chinese medicine for treating chronic nasal diseases according to claim 3, characterized in that: in the first step, all raw material medicines are distilled by a steam method to obtain crystals, the crystals are ground into powder by a grinder, and the powder is sieved by a 200-mesh sieve to obtain fine powder.
5. The preparation method of the traditional Chinese medicine for treating chronic nasal diseases according to claim 3, characterized in that: and in the second step, the distilled medicine residue in the first step is extracted, 5-8 times of 70-90% ethanol is added for soaking for 1-2 hours, the mixture is heated and extracted for 2 times, the supernatant is extracted at an interval of 1-2 hours each time, the supernatants obtained in the two steps are combined, filtered by a 80-120 mesh sieve, ultrafiltered by an ultrafiltration column, ultrafiltrate is concentrated under reduced pressure into extract, the extract is heated and concentrated for 30-45 minutes to extract active ingredients, the concentrated solution is kept stand to be paste-like extract, and the paste-like extract is kept stand for later use.
6. The preparation method of the traditional Chinese medicine for treating chronic nasal diseases according to claim 3, characterized in that: the crystal powder obtained by distillation can be added into the extract obtained by ethanol extraction, and then the extract is added with sesame oil to be soaked for 5-10 days and then can be bottled for use.
CN202110564848.7A 2021-05-24 2021-05-24 Traditional Chinese medicine formula for treating chronic nasal diseases and preparation method thereof Pending CN113181294A (en)

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* Cited by examiner, † Cited by third party
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