CN113166257A - Cd47抗体及其制备方法和应用 - Google Patents
Cd47抗体及其制备方法和应用 Download PDFInfo
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- CN113166257A CN113166257A CN201980079889.8A CN201980079889A CN113166257A CN 113166257 A CN113166257 A CN 113166257A CN 201980079889 A CN201980079889 A CN 201980079889A CN 113166257 A CN113166257 A CN 113166257A
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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Abstract
一种靶向CD47的抗体、其制备方法和用途。一种新的靶向CD47的鼠源或人鼠嵌合抗体。制备该单克隆抗体的方法。该单克隆抗体能够高特异性地结合CD47抗原，具有很高的亲和力并且具有显著抗肿瘤等活性。
Description
PCT国内申请，说明书已公开。
Claims (17)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018114676376 | 2018-12-03 | ||
| CN201811467637 | 2018-12-03 | ||
| PCT/CN2019/122777 WO2020114399A1 (zh) | 2018-12-03 | 2019-12-03 | Cd47抗体及其制备方法和应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113166257A true CN113166257A (zh) | 2021-07-23 |
| CN113166257B CN113166257B (zh) | 2023-05-30 |
Family
ID=70954168
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911223386.1A Pending CN111253488A (zh) | 2018-12-03 | 2019-12-03 | Cd47抗体及其制备方法和应用 |
| CN201980079889.8A Active CN113166257B (zh) | 2018-12-03 | 2019-12-03 | Cd47抗体及其制备方法和应用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911223386.1A Pending CN111253488A (zh) | 2018-12-03 | 2019-12-03 | Cd47抗体及其制备方法和应用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20220017615A1 (zh) |
| EP (1) | EP3892637A1 (zh) |
| CN (2) | CN111253488A (zh) |
| WO (1) | WO2020114399A1 (zh) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020114399A1 (zh) * | 2018-12-03 | 2020-06-11 | 上海开拓者生物医药有限公司 | Cd47抗体及其制备方法和应用 |
| JP2023536737A (ja) | 2020-08-04 | 2023-08-29 | アボット・ラピッド・ダイアグノスティクス・インターナショナル・アンリミテッド・カンパニー | Ｓａｒｓ－ｃｏｖ－２を検出するためのアッセイ |
| WO2022037672A1 (en) * | 2020-08-21 | 2022-02-24 | Doma Biopharmaceutical (Suzhou) Co., Ltd | Anti-cd47 antibodies and uses thereof |
| MX2023007667A (es) * | 2020-12-23 | 2023-10-30 | Guangdong Fapon Biopharma Inc | Anticuerpo dirigido contra cd47 y su aplicacion. |
| WO2022140659A2 (en) * | 2020-12-23 | 2022-06-30 | D-10 Therapeutics, Inc. | Anti-cd47 antibodies and uses thereof |
| CN113156130B (zh) * | 2021-02-19 | 2024-04-02 | 山东省大健康精准医疗产业技术研究院 | 一种检测cd47的酶联免疫试剂盒及其制备方法与应用 |
| CN113501874B (zh) * | 2021-08-09 | 2022-03-11 | 生工生物工程（上海）股份有限公司 | 一种抗人cd47蛋白的抗体、检测试剂盒及其应用 |
| CN116813774B (zh) * | 2023-06-02 | 2024-04-30 | 生工生物工程（上海）股份有限公司 | 一种抗人cd47蛋白的抗体、核酸分子及其应用 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101133083A (zh) * | 2003-11-11 | 2008-02-27 | 中外制药株式会社 | 人源化的抗cd47抗体 |
| CN104271757A (zh) * | 2012-02-06 | 2015-01-07 | 印希彼有限责任公司 | Cd47抗体及其使用方法 |
| CN105102479A (zh) * | 2012-12-12 | 2015-11-25 | 瓦斯库劳克斯有限公司 | 治疗性cd47抗体 |
| CN108503708A (zh) * | 2017-09-01 | 2018-09-07 | 北京智仁美博生物科技有限公司 | 抗人cd47抗体及其用途 |
| WO2018175790A1 (en) * | 2017-03-22 | 2018-09-27 | Arch Oncology, Inc. | Combination therapy for the treatment of solid and hematological cancers |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| PT2569013T (pt) | 2010-05-14 | 2017-02-08 | Univ Leland Stanford Junior | Anticorpos monoclonais humanizados e quiméricos para cd47 |
| CN110305214A (zh) * | 2018-03-20 | 2019-10-08 | 上海药明生物技术有限公司 | 新型抗cd47抗体 |
| WO2020114399A1 (zh) * | 2018-12-03 | 2020-06-11 | 上海开拓者生物医药有限公司 | Cd47抗体及其制备方法和应用 |
-
2019
- 2019-12-03 WO PCT/CN2019/122777 patent/WO2020114399A1/zh unknown
- 2019-12-03 EP EP19894109.8A patent/EP3892637A1/en not_active Withdrawn
- 2019-12-03 US US17/299,368 patent/US20220017615A1/en active Pending
- 2019-12-03 CN CN201911223386.1A patent/CN111253488A/zh active Pending
- 2019-12-03 CN CN201980079889.8A patent/CN113166257B/zh active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101133083A (zh) * | 2003-11-11 | 2008-02-27 | 中外制药株式会社 | 人源化的抗cd47抗体 |
| CN104271757A (zh) * | 2012-02-06 | 2015-01-07 | 印希彼有限责任公司 | Cd47抗体及其使用方法 |
| CN105102479A (zh) * | 2012-12-12 | 2015-11-25 | 瓦斯库劳克斯有限公司 | 治疗性cd47抗体 |
| WO2018175790A1 (en) * | 2017-03-22 | 2018-09-27 | Arch Oncology, Inc. | Combination therapy for the treatment of solid and hematological cancers |
| CN108503708A (zh) * | 2017-09-01 | 2018-09-07 | 北京智仁美博生物科技有限公司 | 抗人cd47抗体及其用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20220017615A1 (en) | 2022-01-20 |
| CN111253488A (zh) | 2020-06-09 |
| WO2020114399A1 (zh) | 2020-06-11 |
| CN113166257B (zh) | 2023-05-30 |
| EP3892637A1 (en) | 2021-10-13 |
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