CN115768797A - 抗b7-h3抗体及其制备和应用 - Google Patents

抗b7-h3抗体及其制备和应用 Download PDF

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CN115768797A
CN115768797A CN202180039871.2A CN202180039871A CN115768797A CN 115768797 A CN115768797 A CN 115768797A CN 202180039871 A CN202180039871 A CN 202180039871A CN 115768797 A CN115768797 A CN 115768797A
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China
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seq
antibody
variable region
chain variable
heavy chain
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朱丽媛
王文义
郎国竣
邓敏
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Minghui Pharmaceutical Hangzhou Co ltd
Minghui Pharmaceutical Shanghai Co ltd
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Minghui Pharmaceutical Hangzhou Co ltd
Minghui Pharmaceutical Shanghai Co ltd
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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Abstract

提供了一种抗B7‑H3抗体及其制备和应用，还提供了包含该抗体的药物偶联物和重组蛋白。本发明的抗体能够有效地被细胞内吞，利用本发明的抗体制备的抗体偶联药物表现出肿瘤抑制效果。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN202180039871.2A 2020-06-02 2021-06-02 抗b7-h3抗体及其制备和应用 Pending CN115768797A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2020104914483 2020-06-02
CN202010491448.3A CN113754766A (zh) 2020-06-02 2020-06-02 抗b7-h3抗体及其制备和应用
PCT/CN2021/098018 WO2021244590A1 (zh) 2020-06-02 2021-06-02 抗b7-h3抗体及其制备和应用

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CN115768797A true CN115768797A (zh) 2023-03-07

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CN202010491448.3A Pending CN113754766A (zh) 2020-06-02 2020-06-02 抗b7-h3抗体及其制备和应用
CN202180039871.2A Pending CN115768797A (zh) 2020-06-02 2021-06-02 抗b7-h3抗体及其制备和应用

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EP (1) EP4159759A1 (zh)
JP (1) JP7568238B2 (zh)
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AU (1) AU2021284765A1 (zh)
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Publication number Priority date Publication date Assignee Title
CN114773477B (zh) * 2022-06-23 2022-09-09 上海优替济生生物医药有限公司 抗b7-h3抗体及其用途
WO2024022372A1 (zh) * 2022-07-27 2024-02-01 明慧医药（杭州）有限公司 抗体药物偶联物及其应用
CN118515764A (zh) * 2023-01-12 2024-08-20 迈博斯（香港）科技有限公司 免疫调节蛋白分子b7-h3的结合蛋白及其应用

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
SG194620A1 (en) * 2011-04-25 2013-12-30 Daiichi Sankyo Co Ltd Anti-b7-h3 antibody
WO2014160627A1 (en) 2013-03-25 2014-10-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-cd276 polypeptides, proteins, and chimeric antigen receptors
AU2015265976B2 (en) 2014-05-29 2019-08-01 Ventana Medical Systems, Inc. Anti-B7-H3 antibodies and diagnostic uses thereof
WO2018161872A1 (zh) * 2017-03-06 2018-09-13 江苏恒瑞医药股份有限公司 抗b7-h3抗体、其抗原结合片段及其医药用途
CN114957475B (zh) * 2018-09-26 2023-06-20 福州拓新天成生物科技有限公司 抗b7-h3的单克隆抗体及其在细胞治疗中的应用
CN110305213B (zh) * 2018-11-09 2023-03-10 泰州复旦张江药业有限公司 一种抗b7-h3抗体及其制备方法、其偶联物和应用
CN110914296B (zh) 2019-02-22 2021-02-19 武汉友芝友生物制药有限公司 改造的Fc片段，包含其的抗体及其应用

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CA3181013A1 (en) 2021-12-09
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