CN113166115A - 单体和多聚体抗hbv药剂 - Google Patents
单体和多聚体抗hbv药剂 Download PDFInfo
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- CN113166115A CN113166115A CN201980081049.5A CN201980081049A CN113166115A CN 113166115 A CN113166115 A CN 113166115A CN 201980081049 A CN201980081049 A CN 201980081049A CN 113166115 A CN113166115 A CN 113166115A
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- independently
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- KJAOHGPJMYCTGL-UHFFFAOYSA-N Cc1c(C(Nc(cc2F)ccc2F)=O)[n](C)c(C)c1C(C(NCc1c[n](CCOCC[n]2nnc(CNC(C(c3c(C)[n](C)c(C(Nc(cc4)cc(F)c4F)=O)c3C)=O)=O)c2)nn1)=O)=O Chemical compound Cc1c(C(Nc(cc2F)ccc2F)=O)[n](C)c(C)c1C(C(NCc1c[n](CCOCC[n]2nnc(CNC(C(c3c(C)[n](C)c(C(Nc(cc4)cc(F)c4F)=O)c3C)=O)=O)c2)nn1)=O)=O KJAOHGPJMYCTGL-UHFFFAOYSA-N 0.000 description 3
- 0 C*(CC(C)(C)C[n]1nnc(CNC(C(c2c(C)[n](C)c(C(Nc(cc3F)ccc3F)=O)c2C)=O)=O)c1)C[n]1nnc(CNC(C(c2c(CCC3)[n]3c(C(Nc(cc3)cc(F)c3F)=O)c2C)=O)=O)c1 Chemical compound C*(CC(C)(C)C[n]1nnc(CNC(C(c2c(C)[n](C)c(C(Nc(cc3F)ccc3F)=O)c2C)=O)=O)c1)C[n]1nnc(CNC(C(c2c(CCC3)[n]3c(C(Nc(cc3)cc(F)c3F)=O)c2C)=O)=O)c1 0.000 description 1
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116120219A (zh) * | 2022-12-27 | 2023-05-16 | 吉斯凯(苏州)制药有限公司 | 一种多取代吡咯类化合物及其制备方法和在制备hbv衣壳蛋白抑制剂中的应用 |
| CN116768776A (zh) * | 2022-03-17 | 2023-09-19 | 成都微芯药业有限公司 | 吡咯酰胺类化合物及其制备方法和用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230056135A1 (en) * | 2018-10-05 | 2023-02-23 | Emory University | Monomer and multimeric anti-hbv agents |
| MX2021012105A (es) * | 2019-04-03 | 2021-11-03 | Aligos Therapeutics Inc | Compuestos de pirrol. |
| GB202105000D0 (en) * | 2021-04-08 | 2021-05-26 | Pathios Therapeutics Ltd | Compounds |
| WO2022156758A1 (zh) * | 2021-01-22 | 2022-07-28 | 广东东阳光药业有限公司 | 新型酰胺吡咯类化合物及其在药物中的用途 |
Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1343205A (zh) * | 1999-03-12 | 2002-04-03 | 百奥塔科学管理有限公司 | 二聚化合物及其作为神经氨酸酶抑制剂 |
| WO2004014374A1 (en) * | 2002-07-25 | 2004-02-19 | Pharmacia Italia S.P.A. | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| WO2012036997A1 (en) * | 2010-09-16 | 2012-03-22 | Schering Corporation | Fused pyrazole derivatives as novel erk inhibitors |
| CN103889953A (zh) * | 2011-07-01 | 2014-06-25 | 肝炎与病毒研究所 | 作为防乙肝病毒感染的抗病毒剂的氨磺酰苯甲酰胺衍生物 |
| CN104812743A (zh) * | 2012-08-28 | 2015-07-29 | 爱尔兰詹森科学公司 | 氨磺酰基-芳基酰胺和其作为药物用于治疗乙型肝炎的用途 |
| CN105051017A (zh) * | 2012-11-09 | 2015-11-11 | 美国印第安纳大学研究和技术公司 | 用于hbv组装效应剂的替代用途 |
| WO2015180631A1 (zh) * | 2014-05-30 | 2015-12-03 | 南京明德新药研发股份有限公司 | 作为hbv抑制剂的二氢嘧啶并环衍生物 |
| CN105209031A (zh) * | 2012-12-27 | 2015-12-30 | 德雷克塞尔大学 | 针对hbv感染的新型抗病毒剂 |
| CN105431413A (zh) * | 2013-07-25 | 2016-03-23 | 爱尔兰詹森科学公司 | 经乙醛酰胺取代的吡咯酰胺衍生物及其作为药物用于治疗乙型肝炎的用途 |
| CN106317055A (zh) * | 2015-07-02 | 2017-01-11 | 中国科学院上海药物研究所 | 一类具有激酶抑制活性的化合物、制备方法和用途 |
| WO2017156255A1 (en) * | 2016-03-09 | 2017-09-14 | Emory University | Elimination of hepatitis b virus with antiviral agents |
| CN107531691A (zh) * | 2014-12-30 | 2018-01-02 | 诺维拉治疗公司 | 治疗乙型肝炎感染的衍生物和方法 |
| WO2018039531A1 (en) * | 2016-08-26 | 2018-03-01 | Gilead Sciences, Inc. | Substituted pyrrolizine compounds and uses thereof |
| CN112469716A (zh) * | 2018-06-28 | 2021-03-09 | 河南天晟泰丰医药科技有限公司 | 二氢嘧啶衍生物及其用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019185016A1 (zh) * | 2018-03-30 | 2019-10-03 | 正大天晴药业集团股份有限公司 | 含有n杂五元环的衣壳蛋白装配抑制剂、其药物组合物和用途 |
| JP2021527638A (ja) * | 2018-06-11 | 2021-10-14 | ベナトルクス ファーマシューティカルズ,インク. | B型肝炎カプシドアセンブリモジュレーター |
| US20230056135A1 (en) * | 2018-10-05 | 2023-02-23 | Emory University | Monomer and multimeric anti-hbv agents |
-
2019
- 2019-10-04 US US17/281,940 patent/US20230056135A1/en active Pending
- 2019-10-04 CA CA3113109A patent/CA3113109A1/en active Pending
- 2019-10-04 WO PCT/US2019/054790 patent/WO2020072955A1/en not_active Ceased
- 2019-10-04 SG SG11202102661UA patent/SG11202102661UA/en unknown
- 2019-10-04 MX MX2021003150A patent/MX2021003150A/es unknown
- 2019-10-04 KR KR1020257021884A patent/KR20250107952A/ko active Pending
- 2019-10-04 BR BR112021006403A patent/BR112021006403A2/pt unknown
- 2019-10-04 AU AU2019355218A patent/AU2019355218B2/en active Active
- 2019-10-04 KR KR1020217012512A patent/KR20210072015A/ko active Pending
- 2019-10-04 JP JP2021544096A patent/JP7648528B2/ja active Active
- 2019-10-04 EP EP19868793.1A patent/EP3860991A4/en active Pending
- 2019-10-04 CN CN201980081049.5A patent/CN113166115A/zh active Pending
-
2021
- 2021-03-19 PH PH12021550632A patent/PH12021550632A1/en unknown
- 2021-03-21 IL IL281698A patent/IL281698A/en unknown
- 2021-04-19 ZA ZA2021/02589A patent/ZA202102589B/en unknown
-
2024
- 2024-10-11 JP JP2024179311A patent/JP2025020149A/ja active Pending
Patent Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1343205A (zh) * | 1999-03-12 | 2002-04-03 | 百奥塔科学管理有限公司 | 二聚化合物及其作为神经氨酸酶抑制剂 |
| WO2004014374A1 (en) * | 2002-07-25 | 2004-02-19 | Pharmacia Italia S.P.A. | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| WO2012036997A1 (en) * | 2010-09-16 | 2012-03-22 | Schering Corporation | Fused pyrazole derivatives as novel erk inhibitors |
| CN103889953A (zh) * | 2011-07-01 | 2014-06-25 | 肝炎与病毒研究所 | 作为防乙肝病毒感染的抗病毒剂的氨磺酰苯甲酰胺衍生物 |
| CN104812743A (zh) * | 2012-08-28 | 2015-07-29 | 爱尔兰詹森科学公司 | 氨磺酰基-芳基酰胺和其作为药物用于治疗乙型肝炎的用途 |
| CN105051017A (zh) * | 2012-11-09 | 2015-11-11 | 美国印第安纳大学研究和技术公司 | 用于hbv组装效应剂的替代用途 |
| CN105209031A (zh) * | 2012-12-27 | 2015-12-30 | 德雷克塞尔大学 | 针对hbv感染的新型抗病毒剂 |
| CN105431413A (zh) * | 2013-07-25 | 2016-03-23 | 爱尔兰詹森科学公司 | 经乙醛酰胺取代的吡咯酰胺衍生物及其作为药物用于治疗乙型肝炎的用途 |
| WO2015180631A1 (zh) * | 2014-05-30 | 2015-12-03 | 南京明德新药研发股份有限公司 | 作为hbv抑制剂的二氢嘧啶并环衍生物 |
| CN107531691A (zh) * | 2014-12-30 | 2018-01-02 | 诺维拉治疗公司 | 治疗乙型肝炎感染的衍生物和方法 |
| CN106317055A (zh) * | 2015-07-02 | 2017-01-11 | 中国科学院上海药物研究所 | 一类具有激酶抑制活性的化合物、制备方法和用途 |
| WO2017156255A1 (en) * | 2016-03-09 | 2017-09-14 | Emory University | Elimination of hepatitis b virus with antiviral agents |
| WO2018039531A1 (en) * | 2016-08-26 | 2018-03-01 | Gilead Sciences, Inc. | Substituted pyrrolizine compounds and uses thereof |
| CN112469716A (zh) * | 2018-06-28 | 2021-03-09 | 河南天晟泰丰医药科技有限公司 | 二氢嘧啶衍生物及其用途 |
Non-Patent Citations (1)
| Title |
|---|
| SEBASTIEN BOUCLE等: "Bioorganic & Medicinal Chemistry Letters", SYNTHESIS AND ANTIVIRAL EVALUATION OF NOVEL HETEROARYLPYRIMIDINES ANALOGS AS HBV CAPSID EFFECTORS, vol. 27, pages 904 - 910 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116768776A (zh) * | 2022-03-17 | 2023-09-19 | 成都微芯药业有限公司 | 吡咯酰胺类化合物及其制备方法和用途 |
| CN116120219A (zh) * | 2022-12-27 | 2023-05-16 | 吉斯凯(苏州)制药有限公司 | 一种多取代吡咯类化合物及其制备方法和在制备hbv衣壳蛋白抑制剂中的应用 |
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| Publication number | Publication date |
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| JP7648528B2 (ja) | 2025-03-18 |
| EP3860991A4 (en) | 2022-11-16 |
| IL281698A (en) | 2021-05-31 |
| KR20250107952A (ko) | 2025-07-14 |
| EP3860991A1 (en) | 2021-08-11 |
| PH12021550632A1 (en) | 2022-02-14 |
| WO2020072955A1 (en) | 2020-04-09 |
| ZA202102589B (en) | 2022-04-28 |
| CA3113109A1 (en) | 2020-04-09 |
| JP2022508642A (ja) | 2022-01-19 |
| JP2025020149A (ja) | 2025-02-12 |
| BR112021006403A2 (pt) | 2021-07-06 |
| KR20210072015A (ko) | 2021-06-16 |
| AU2019355218A1 (en) | 2021-05-13 |
| SG11202102661UA (en) | 2021-04-29 |
| MX2021003150A (es) | 2021-07-06 |
| AU2019355218B2 (en) | 2023-11-30 |
| US20230056135A1 (en) | 2023-02-23 |
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