CN113164473A - 一种维拉佐酮固体分散体及其制备方法 - Google Patents

一种维拉佐酮固体分散体及其制备方法 Download PDF

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Publication number
CN113164473A
CN113164473A CN201980080366.5A CN201980080366A CN113164473A CN 113164473 A CN113164473 A CN 113164473A CN 201980080366 A CN201980080366 A CN 201980080366A CN 113164473 A CN113164473 A CN 113164473A
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vilazodone
solid dispersion
carrier material
surfactant
dispersion according
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CN201980080366.5A
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方代龙
范露露
黄心
游劲松
黄芳芳
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Sunshine Lake Pharma Co Ltd
Guangdong HEC Pharmaceutical
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Sunshine Lake Pharma Co Ltd
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Abstract

本发明涉及一种维拉佐酮固体分散体及其制备方法和用途，所述维拉佐酮固体分散体包含活性成分维拉佐酮、水溶性聚合物载体材料和表面活性剂。所述水溶性聚合物载体材料选自聚维酮、共聚维酮、羟丙基甲基纤维素中的至少一种。所述固体分散体中，维拉佐酮以非结晶态存在于固体分散体中，该固体分散稳定性好，显著提高维拉佐酮的溶解度和体外溶出度，从而显著增加其口服生物利用度。所述维拉佐酮固体分散体可用于制备维拉佐酮相关制剂。

Description

PCT国内申请，说明书已公开。

Claims (30)

  1. PCT国内申请，权利要求书已公开。
CN201980080366.5A 2018-12-13 2019-12-11 一种维拉佐酮固体分散体及其制备方法 Pending CN113164473A (zh)

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CN2018115230432 2018-12-13
CN201811523043 2018-12-13
PCT/CN2019/124429 WO2020119698A1 (zh) 2018-12-13 2019-12-11 一种维拉佐酮固体分散体及其制备方法

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TW202348231A (zh) * 2022-03-25 2023-12-16 大陸商深圳市藥欣生物科技有限公司 非晶形固體分散液及包含其之醫藥組合物
CN115581678B (zh) * 2022-11-04 2023-09-12 北京鑫开元医药科技有限公司 一种瑞派替尼片组合物及其制备方法
CN117257804A (zh) * 2023-10-17 2023-12-22 深圳市新阳唯康科技有限公司 达拉非尼药物组合物及其制备方法和应用

Citations (10)

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WO2013078361A1 (en) * 2011-11-23 2013-05-30 Assia Chemical Industries Ltd. Solid state forms of vilazodone and vilazodone hydrochloride
CN103211751A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 含维拉唑酮的药物组合物及其制备方法
WO2013168126A1 (en) * 2012-05-11 2013-11-14 Dr.Reddys Laboratories Limited Crystalline forms of vilazodone hydrochloride and vilazodone free base
US20130324554A1 (en) * 2012-06-05 2013-12-05 Symed Labs Limited Amorphous form of vilazodone hydrochloride substantially free of crystalline forms
CN104116741A (zh) * 2013-04-24 2014-10-29 江苏先声药物研究有限公司 盐酸维拉佐酮组合物及其制备方法
IN2013MU03458A (zh) * 2013-10-31 2015-07-17 Lupin Ltd
CN106540266A (zh) * 2015-09-18 2017-03-29 天津市汉康医药生物技术有限公司 一种维拉佐酮药物组合物及其制备方法
CN106580914A (zh) * 2017-02-27 2017-04-26 佛山市弘泰药物研发有限公司 一种盐酸维拉佐酮软胶囊及其制备方法
CN106580895A (zh) * 2016-12-07 2017-04-26 万全万特制药（厦门）有限公司 含盐酸维拉佐酮固体分散体的口腔崩解片及其制备方法
WO2018127088A1 (en) * 2017-01-06 2018-07-12 Sunshine Lake Pharma Co., Ltd. Lurasidone solid dispersion and preparation method thereof

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CN104523620A (zh) * 2014-12-14 2015-04-22 天津市康瑞药业有限公司 维拉佐酮滴丸及其制备方法
CN108078934B (zh) * 2017-12-26 2020-08-28 南京工业大学 一种盐酸齐拉西酮固体分散片及其热熔挤出方法

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013078361A1 (en) * 2011-11-23 2013-05-30 Assia Chemical Industries Ltd. Solid state forms of vilazodone and vilazodone hydrochloride
WO2013168126A1 (en) * 2012-05-11 2013-11-14 Dr.Reddys Laboratories Limited Crystalline forms of vilazodone hydrochloride and vilazodone free base
US20130324554A1 (en) * 2012-06-05 2013-12-05 Symed Labs Limited Amorphous form of vilazodone hydrochloride substantially free of crystalline forms
CN103211751A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 含维拉唑酮的药物组合物及其制备方法
CN104116741A (zh) * 2013-04-24 2014-10-29 江苏先声药物研究有限公司 盐酸维拉佐酮组合物及其制备方法
IN2013MU03458A (zh) * 2013-10-31 2015-07-17 Lupin Ltd
CN106540266A (zh) * 2015-09-18 2017-03-29 天津市汉康医药生物技术有限公司 一种维拉佐酮药物组合物及其制备方法
CN106580895A (zh) * 2016-12-07 2017-04-26 万全万特制药（厦门）有限公司 含盐酸维拉佐酮固体分散体的口腔崩解片及其制备方法
WO2018127088A1 (en) * 2017-01-06 2018-07-12 Sunshine Lake Pharma Co., Ltd. Lurasidone solid dispersion and preparation method thereof
CN106580914A (zh) * 2017-02-27 2017-04-26 佛山市弘泰药物研发有限公司 一种盐酸维拉佐酮软胶囊及其制备方法

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Publication number Publication date
CN113164394B (zh) 2023-06-23
US20220071993A1 (en) 2022-03-10
WO2020119698A1 (zh) 2020-06-18
CN113164394A (zh) 2021-07-23
WO2020119701A1 (zh) 2020-06-18

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Address after: 523808 No.1, Gongye North Road, Songshanhu Park, Dongguan City, Guangdong Province

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