CN113143962B - 一种治疗高脂血症的药物组合物及其制备方法 - Google Patents

一种治疗高脂血症的药物组合物及其制备方法 Download PDF

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Publication number
CN113143962B
CN113143962B CN202110509462.6A CN202110509462A CN113143962B CN 113143962 B CN113143962 B CN 113143962B CN 202110509462 A CN202110509462 A CN 202110509462A CN 113143962 B CN113143962 B CN 113143962B
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China
Prior art keywords
pharmaceutical composition
chlorogenic acid
vitamin
treating hyperlipidemia
manganese gluconate
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CN202110509462.6A
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English (en)
Chinese (zh)
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CN113143962A (zh
Inventor
张洁
李文斌
黄望
张飞
张雅
徐敏
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Sichuan Jiuzhang Biotechnology Co Ltd
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Sichuan Jiuzhang Biotechnology Co Ltd
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Priority to CN202110509462.6A priority Critical patent/CN113143962B/zh
Publication of CN113143962A publication Critical patent/CN113143962A/zh
Priority to US18/556,818 priority patent/US20240197665A1/en
Priority to KR1020237031702A priority patent/KR20230145464A/ko
Priority to JP2023568628A priority patent/JP2024518060A/ja
Priority to PCT/CN2022/091766 priority patent/WO2022237731A1/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/32—Manganese; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/34—Copper; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202110509462.6A 2021-05-11 2021-05-11 一种治疗高脂血症的药物组合物及其制备方法 Active CN113143962B (zh)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN202110509462.6A CN113143962B (zh) 2021-05-11 2021-05-11 一种治疗高脂血症的药物组合物及其制备方法
US18/556,818 US20240197665A1 (en) 2021-05-11 2022-05-09 Pharmaceutical Composition For Treating Hyperlipidemia And Preparation Method Therefor
KR1020237031702A KR20230145464A (ko) 2021-05-11 2022-05-09 고지혈증을 치료하는 약물 조성물 및 그 제조 방법
JP2023568628A JP2024518060A (ja) 2021-05-11 2022-05-09 高脂血症を治療するための薬物組成物及びその調製方法
PCT/CN2022/091766 WO2022237731A1 (zh) 2021-05-11 2022-05-09 一种治疗高脂血症的药物组合物及其制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202110509462.6A CN113143962B (zh) 2021-05-11 2021-05-11 一种治疗高脂血症的药物组合物及其制备方法

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CN113143962A CN113143962A (zh) 2021-07-23
CN113143962B true CN113143962B (zh) 2022-08-05

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US (1) US20240197665A1 (https=)
JP (1) JP2024518060A (https=)
KR (1) KR20230145464A (https=)
CN (1) CN113143962B (https=)
WO (1) WO2022237731A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113143962B (zh) * 2021-05-11 2022-08-05 四川九章生物科技有限公司 一种治疗高脂血症的药物组合物及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108208838A (zh) * 2018-03-09 2018-06-29 北京素维生物科技有限公司 一种掩味组合物及其用途

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6041611A (ja) * 1983-08-17 1985-03-05 Sankyo Co Ltd 血中脂質低下剤
WO2000015215A1 (en) * 1998-09-15 2000-03-23 Korea Research Institute Of Bioscience And Biotechnology Composition containing cinnamic acid derivatives for preventing or treating elevated blood lipid level-related diseases
US20020193323A1 (en) * 2000-11-22 2002-12-19 Inna Yegorova Compositions and methods for promoting a healthy cardiovascular system and enhancing blood flow
US6632459B2 (en) * 2000-12-11 2003-10-14 Nutricia N.V. Chlorogenic acid and an analog thereof for immune system stimulation
JP4205870B2 (ja) * 2001-04-13 2009-01-07 花王株式会社 生活習慣病予防・改善剤
JP4179765B2 (ja) * 2001-07-19 2008-11-12 花王株式会社 脂質代謝改善剤
US6592896B2 (en) * 2001-08-06 2003-07-15 The Quigley Corporation Medicinal composition and method of using it
US7332181B1 (en) * 2003-09-05 2008-02-19 Glu-Pro, Inc. Composition for managing diabetes, obesity, and hyperlipidemia and associated methods
JP2006104182A (ja) * 2004-05-14 2006-04-20 Toyo Shinyaku:Kk 体脂肪低減組成物
US20080286254A1 (en) * 2007-05-17 2008-11-20 Kaneka Corporation Composition comprising licorice polyphenol
CN101766274B (zh) * 2010-01-05 2012-10-31 杭州尤美特科技有限公司 含竹叶黄酮的抗氧化功能食品组合物
US8372447B2 (en) * 2010-08-03 2013-02-12 Northern Innovations And Formulations Corp. Compositions and methods for promoting weight loss and increasing energy
EP3040067A4 (en) * 2013-08-21 2017-03-22 Sichuan Jiuzhang Biological Science And Technology Co., Ltd Chlorogenic acid powder-injection and preparation method thereof
DE102014100534A1 (de) * 2014-01-17 2015-07-23 Pm-International Ag Pulverförmige Zusammensetzung zur Herstellung eines Nahrungsmittelersatzes
US20150335604A1 (en) * 2014-05-22 2015-11-26 Boresha International Chromium and Chlorogenic Acid Weight Control Formulations
IL282156B (en) * 2014-07-29 2022-07-01 Shenzhen Hightide Biopharmaceutical Ltd Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof
US20180235917A1 (en) * 2014-09-24 2018-08-23 Nusirt Sciences, Inc. Compositions, methods and kits for treatment of diabetes and/or hyperlipidemia
CN104352457A (zh) * 2014-11-24 2015-02-18 四川九章生物科技有限公司 一种包含绿原酸晶型的制剂及其用途
CN104739818A (zh) * 2015-02-13 2015-07-01 四川九章生物科技有限公司 绿原酸在制备治疗病理性黄疸的药物中的用途
JP2020519688A (ja) * 2017-05-12 2020-07-02 ハウジー ファーマシューティカル リサーチ ラボラトリーズ、エル．エル．シー． 抗糖尿病活性および他の有用な活性を有する植物抽出物
CN107661409A (zh) * 2017-11-25 2018-02-06 衡阳县华盛达农林科技有限公司 一种治疗心脑血管疾病的芦丁口服液及其制备方法
CN110448659A (zh) * 2018-05-07 2019-11-15 新疆吉盛元沙棘生物科技有限公司 沙棘护肝含片制备方法
CN108498497B (zh) * 2018-06-01 2020-05-01 四川九章生物科技有限公司 用于治疗肾癌的药物组合物及其应用
CN110141581A (zh) * 2019-05-29 2019-08-20 山东腾贵医药有限公司 一种辅助治疗三高的维生素矿物质营养组合物及其制备方法
CN111195298B (zh) * 2020-02-17 2021-12-24 集美大学 一种调节肠道菌群和防治食物过敏的组合物及其制备方法
CN112341355B (zh) * 2020-11-09 2022-08-30 中国医学科学院药用植物研究所 一种绿原酸衍生物及其制备方法和应用
CN113143962B (zh) * 2021-05-11 2022-08-05 四川九章生物科技有限公司 一种治疗高脂血症的药物组合物及其制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108208838A (zh) * 2018-03-09 2018-06-29 北京素维生物科技有限公司 一种掩味组合物及其用途

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CN113143962A (zh) 2021-07-23
JP2024518060A (ja) 2024-04-24
US20240197665A1 (en) 2024-06-20
WO2022237731A1 (zh) 2022-11-17
KR20230145464A (ko) 2023-10-17

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