CN113117002A - Dizhi rehmannia pills and preparation method thereof - Google Patents

Dizhi rehmannia pills and preparation method thereof Download PDF

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CN113117002A
CN113117002A CN202110598503.3A CN202110598503A CN113117002A CN 113117002 A CN113117002 A CN 113117002A CN 202110598503 A CN202110598503 A CN 202110598503A CN 113117002 A CN113117002 A CN 113117002A
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parts
mixture
box body
water
pill
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朱华
王懋成
唐国庆
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Guilin Xinghao Technology Co ltd
Xing'an Jieshou Orthopedic Hospital Co ltd
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Guilin Xinghao Technology Co ltd
Xing'an Jieshou Orthopedic Hospital Co ltd
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
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    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
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Abstract

The invention discloses a pill of Dizhi Dihuang and a preparation method thereof, wherein the pill of Dizhi Dihuang comprises the following raw materials in parts by weight: 5-13 parts of radix rehmanniae preparata, 5-13 parts of dogwood, 3-8 parts of dioscorea opposita thumb, 1-5 parts of rhizoma alismatis, 1-5 parts of tree peony bark, 2-6 parts of poria cocos, 1-4 parts of glossy privet fruit, 0.5-2 parts of dried orange peel, 1.5-4 parts of eclipta alba and 1-3 parts of eucommia ulmoides; the preparation method of the pill of two to rehmannia comprises the following steps: s1, weighing the raw materials in proper amount; s2 grinding rhizoma Dioscoreae, rhizoma Alismatis, cortex moutan, and Poria into coarse powder, mashing with radix rehmanniae Preparata and fructus Corni, drying, grinding into fine powder, mixing, and sieving with 80-100 mesh sieve; s3, soaking herba Ecliptae and Eucommiae cortex in clear water, decocting for 2-3 hr, squeezing, and filtering to obtain filtrate; mixing the filtrates, heating, and decocting to obtain thick paste; s4, putting the ointment obtained in the step S3 into a lump combining device, adding refined honey, uniformly stirring to obtain moist lump masses, separating lumps, rubbing into strips, and making pills. The invention has better curative effect on early white beard and hair, energy deficiency and the like caused by deficiency of both kidney and spleen through the adjustment of the raw material formula.

Description

Dizhi rehmannia pills and preparation method thereof
Technical Field
The invention belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to a pill of rehmannia glutinosa and a preparation method thereof.
Background
The preparation method of the pill of rehmannia (Xiao' er Yao Zheng Zhi Jue) is as follows: radix rehmanniae Preparata, Corni fructus, dried rhizoma Dioscoreae, Alismatis rhizoma, cortex moutan, and Poria, pulverizing into powder, making honeyed pill, such as Firmiana simplex seed, hollowing, and making into pill with warm water. It is indicated for kidney deficiency, wind, weakness, spirit deficiency, white eyes in eyes, and white face. However, the rehmannia pills are taken for a long time, generally for 1-3 months, when used for treating deficiency of kidney yin, and are not suitable for people with weakness of spleen and stomach.
Disclosure of Invention
The invention provides a Dizhi pill and a preparation method thereof, which aim to solve the technical problems.
In order to solve the technical problems, the invention adopts the following technical scheme:
the pill of two ingredients to rehmannia comprises the following raw materials in parts by weight: 5-13 parts of radix rehmanniae preparata, 5-13 parts of dogwood, 3-8 parts of dioscorea opposita thumb, 1-5 parts of rhizoma alismatis, 1-5 parts of tree peony bark, 2-6 parts of poria cocos, 1-4 parts of glossy privet fruit, 0.5-2 parts of dried orange peel, 1.5-4 parts of eclipta alba and 1-3 parts of eucommia ulmoides.
The traditional Chinese medicine composition comprises 8 parts of radix rehmanniae preparata, 4 parts of dogwood, 4 parts of Chinese yam, 3 parts of rhizoma alismatis, 3 parts of moutan bark, 3 parts of poria cocos, 2 parts of glossy privet fruit, 1 part of dried orange peel, 2 parts of eclipta alba and 2 parts of eucommia ulmoides.
The dogwood is wine-steamed dogwood, and the glossy privet fruit is wine-steamed glossy privet fruit.
A preparation method of a pill of two ingredients with rehmannia comprises the following steps:
s1, weighing radix rehmanniae Preparata, Corni fructus, rhizoma Dioscoreae, Alismatis rhizoma, cortex moutan, Poria, fructus Ligustri Lucidi, pericarpium Citri Tangerinae, Ecliptae herba, and Eucommiae cortex;
s2, steaming radix rehmanniae Preparata at 100 deg.C for 1 hr, softening, slicing, heating in water at 115-125 deg.C under 2 standard atmospheric pressures for 2-3 hr to obtain mixture A, concentrating at 80 deg.C, and oven drying to humidity of 45-55% to obtain mixture B;
s3, pre-crushing the yam and the tuckahoe into coarse powder, adding water with the weight ratio of 1:5 to the raw materials, heating the mixture for 1 to 2 hours in water with the temperature of 120-125 ℃ under 2 standard atmospheric pressures, and then concentrating the mixture into paste at the temperature of 90 to 105 ℃ to obtain a mixture C;
s4, rolling rhizoma Alismatis and cortex moutan to coarse powder, mashing with fructus Corni, drying, rolling to fine powder, mixing, and sieving with 80-100 mesh sieve to obtain mixture D;
s5, soaking herba Ecliptae and Eucommiae cortex in clear water, decocting for 2-3 hr, squeezing, and filtering to obtain filtrate; adding a proper amount of clear water into filter residues, decocting, squeezing, filtering, taking filtrate, and repeating for three times; mixing the filtrates, heating, and decocting to obtain a thick paste mixture E;
s6, putting the mixture B, the mixture C, the mixture D and the mixture E obtained in the steps S2-S5 into a lump combining device, adding refined honey, uniformly stirring to form moist lumps, dividing the lumps into lumps, rubbing into strips, and making pills.
The loss rate of the medicinal materials in the step S4 is not more than 15%.
The moisture content of the ointment in the step S5 is that a little of the ointment is dripped on moisture absorption paper for inspection, and the moisture content is determined to be that the ointment does not seep the paper.
The refined honey in the step S6 is added for 4 times, and the amount of the refined honey added for each time is 25%, 40%, 25% and 10% of the total amount; the time of adding refined honey for the last time is 2-4 hours apart from the time of adding refined honey for the previous time; the temperature of the refined honey is 90-110 ℃. The refined honey is added in several times to enable the refined honey to be mixed with the ointment more uniformly, and the time interval between the last addition is longer, so that the refined honey can fully soak the ointment for subsequent processing. The temperature of the refined honey is set to ensure the fluidity of the refined honey so as to fully mix the refined honey and the ointment.
The lump combining device comprises a box body, the top of the box body is respectively provided with a first charging opening and a second charging opening, and the bottom of the box body is provided with a discharging opening; the top of the box body is provided with a stirring device, the stirring device is connected with a rotating shaft, a stirring blade is arranged on the rotating shaft, and the bottom of the stirring shaft is provided with a first temperature sensor; the box outside is provided with the control box, the control box with agitating unit links to each other and opens in order to control to open and stop, the control box links to each other in order to show the inside temperature of box with first temperature sensor. Because the pill of two to rehmannia is honeyed pill, the key factors influencing the quality when the refined honey is mixed with the ointment include stirring condition, temperature, moisture and the like, therefore, a lump separating device is used, and the stirring of the stirring leaves is driven by the stirring device to uniformly mix the refined honey and the ointment; and the temperature condition in the box can be detected to the first temperature sensor that sets up, guarantees that the temperature of refining honey is suitable, makes ointment and refining honey misce bene abundant even, guarantees that subsequent processes such as dividing to stick together, rub with the hands, pill normally go on.
The top of the box body is provided with a main water pipe, a water distribution pipe is arranged on the main water pipe, and the bottom of the water distribution pipe is provided with an atomizing nozzle; and a flowmeter is arranged on the main water pipe. The main water pipe, the water distribution pipe and the atomizing nozzle are mainly used for adding water into the box body so that the moisture content of the ointment and refined honey during stirring meets the requirement, and the atomizing nozzle can enable water drops to be finer and to be fully contacted with the ointment and the like so as to avoid the prepared pills from being dry, hard or soft to collapse; the flow meter can control the adding amount of water so as to add according to the use requirement.
An outer box body is further arranged on the outer side of the bottom of the box body, a water inlet is formed in the top of the outer box body, a water outlet is formed in the bottom of the outer box body, a heating wire is arranged in the outer box body, and a second temperature sensor is arranged at the bottom in the outer box body; and the second temperature sensor is connected with the control box to display the water temperature in the outer box body. Because the refined honey has certain temperature to guarantee mobility, consequently, the outer box body that sets up is used for adding water, and through the heater strip heating, it is suitable to keep the temperature of box inside through the water bath. The second temperature sensor who sets up is used for the temperature condition of monitoring water bath to in time adjustment avoids the high temperature or crosses lowly.
The raw materials used in the present invention were as follows:
huai Shu Di Huang is sweet in flavor and slightly warm in nature, entering liver and kidney meridians. To nourish yin and enrich blood.
Dogwood, sour and astringent in taste, slightly warm in nature, enters liver and kidney meridians. Tonify liver and kidney, astringe and induce depletion.
Huai Yam, sweet and neutral in flavor, enters spleen, lung and kidney meridians. Nourishing kidney, invigorating stomach, eliminating phlegm, invigorating middle warmer, and invigorating qi.
Mu Dan Pi is bitter, pungent and slightly cold in flavor, and enters heart, liver and kidney meridians. Clear heat and cool blood, activate blood and resolve stasis.
Poria, sweet and bland in flavor, neutral in nature, enters heart, lung, spleen and kidney meridians. Induce diuresis and drain dampness, invigorate spleen and calm heart.
The glossy privet fruit, sweet and bitter in flavor, neutral in nature, enters liver and kidney meridians. Nourishing yin, prolonging life, tonifying liver and kidney, clearing heat, and improving eyesight.
Tangerine peel, pericarpium Citri Reticulatae is bitter and pungent in flavor and warm in nature. It enters lung and spleen meridians. Regulate qi to invigorate spleen, dry dampness and resolve phlegm.
Eclipta alba, sweet and sour in flavor, cool and enters liver and kidney meridians. Cool blood, stop bleeding, tonify kidney and nourish yin.
Du Zhong is sweet, slightly pungent and warm in flavor and enters liver and kidney meridians. Tonify liver and kidney, strengthen tendons and bones.
The invention has the beneficial effects that: the invention solves the problems of long service life, inapplicability to deficiency of both kidney and spleen and the like of the rehmannia pills by adjusting the formula of the raw materials; during preparation, refined honey is added at intervals to be fully contacted with the ointment, so that the infiltration of the ointment is ensured; the device that sticks together that uses makes the temperature that sticks together of condensed honey and ointment be fit for through temperature control, guarantees that ointment and honey misce bene.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
FIG. 1 is a block diagram of the present invention.
FIG. 2 is a partial enlarged view of the present invention at A.
Reference numerals: 1-box body, 11-first feeding port, 12-second feeding port, 13-discharging port, 14-control box, 2-stirring device, 21-rotating shaft, 22-stirring blade, 23-first temperature sensor, 3-main water pipe, 31-water dividing pipe, 32-atomizing nozzle, 33-flowmeter, 4-outer box body, 41-water inlet, 42-water outlet, 43-heating wire and 44-second temperature sensor.
Detailed Description
In order to facilitate a better understanding of the invention, reference is made to the following examples, which are set forth to illustrate, but are not to be construed as the limit of the invention.
Examples
The pill of two ingredients to rehmannia comprises the following raw materials in parts by weight: 5-13 parts of radix rehmanniae preparata, 5-13 parts of dogwood, 3-8 parts of dioscorea opposita thumb, 1-5 parts of rhizoma alismatis, 1-5 parts of tree peony bark, 2-6 parts of poria cocos, 1-4 parts of glossy privet fruit, 0.5-2 parts of dried orange peel, 1.5-4 parts of eclipta alba and 1-3 parts of eucommia ulmoides.
A preparation method of a pill of two ingredients with rehmannia comprises the following steps:
s1, weighing radix rehmanniae Preparata, Corni fructus, rhizoma Dioscoreae, Alismatis rhizoma, cortex moutan, Poria, fructus Ligustri Lucidi, pericarpium Citri Tangerinae, Ecliptae herba, and Eucommiae cortex;
s2, steaming radix rehmanniae Preparata at 100 deg.C for 1 hr, softening, slicing, heating in water at 115-125 deg.C under 2 standard atmospheric pressures for 2-3 hr to obtain mixture A, concentrating at 80 deg.C, and oven drying to humidity of 45-55% to obtain mixture B;
s3, pre-crushing the yam and the tuckahoe into coarse powder, adding water with the weight ratio of 1:5 to the raw materials, heating the mixture for 1 to 2 hours in water with the temperature of 120-125 ℃ under 2 standard atmospheric pressures, and then concentrating the mixture into paste at the temperature of 90 to 105 ℃ to obtain a mixture C;
s4, rolling rhizoma Alismatis and cortex moutan to coarse powder, mashing with fructus Corni, drying, rolling to fine powder, mixing, and sieving with 80-100 mesh sieve to obtain mixture D;
s5, soaking herba Ecliptae and Eucommiae cortex in clear water, decocting for 2-3 hr, squeezing, and filtering to obtain filtrate; adding a proper amount of clear water into filter residues, decocting, squeezing, filtering, taking filtrate, and repeating for three times; mixing the filtrates, heating, and decocting to obtain a thick paste mixture E;
s6, putting the mixture B, the mixture C, the mixture D and the mixture E obtained in the steps S2-S5 into a lump combining device, adding refined honey, uniformly stirring to form moist lumps, dividing the lumps into lumps, rubbing into strips, and making pills.
And step S4, the loss rate of the medicinal materials is not more than 15%.
The moisture content of the ointment in the step S5 is that a little of the ointment is dripped on moisture absorption paper for inspection, and the moisture content is not penetrated.
The refined honey of the step S6 is added for 4 times, and the amount of the refined honey added for each time is 25%, 40%, 25% and 10% of the total amount; the time of adding refined honey for the last time is 2-4 hours apart from the time of adding refined honey for the previous time; the temperature for refining honey is 90-110 deg.C.
The lump combining device comprises a box body 1, wherein the top of the box body 1 is respectively provided with a first charging hole 11 and a second charging hole 12, and the bottom of the box body 1 is provided with a discharging hole 13; the top of the box body 1 is provided with a stirring device 2, the stirring device 2 is connected with a rotating shaft 21, a stirring blade 22 is arranged on the rotating shaft 21, and the bottom of the stirring shaft 21 is provided with a first temperature sensor 23; the outer side of the box body 1 is provided with a control box 14, the control box 14 is connected with the stirring device 2 to control starting and stopping, and the control box 14 is connected with a first temperature sensor 23 to display the temperature inside the box body 1.
The top of the box body 1 is provided with a water pipe 3, a water diversion pipe 31 is arranged on the main water pipe 3, and the bottom of the water diversion pipe 31 is provided with an atomizing nozzle 32; a flowmeter 33 is provided in the main water pipe 3.
The outer side of the bottom of the box body 1 is also provided with an outer box body 4, the top of the outer box body 4 is provided with a water inlet 41, the bottom of the outer box body 4 is provided with a water outlet 42, a heating wire 43 is arranged inside the outer box body 4, and the bottom inside the outer box body 4 is provided with a second temperature sensor 44; the second temperature sensor 44 is connected to the control box 14 to display the temperature of the water in the outer case 4.
In the device of the present invention, the specific types of the stirring device, the first temperature sensor, the second temperature sensor, the flow meter, and the like are not improvement points of the present invention, and are not described herein again.
Example 1
The pill of two ingredients to rehmannia comprises the following raw materials in parts by weight: 5 parts of radix rehmanniae preparata, 5 parts of dogwood, 3 parts of Chinese yam, 1 part of rhizoma alismatis, 1 part of tree peony bark, 2 parts of poria cocos, 1 part of glossy privet fruit, 0.5 part of dried orange peel, 1.5 parts of eclipta alba and 1 part of eucommia bark.
The preparation method of the pill of two to rehmannia comprises the following steps:
s1, weighing radix rehmanniae Preparata, Corni fructus, rhizoma Dioscoreae, Alismatis rhizoma, cortex moutan, Poria, fructus Ligustri Lucidi, pericarpium Citri Tangerinae, Ecliptae herba, and Eucommiae cortex;
s2, steaming radix rehmanniae Preparata at 100 deg.C for 1 hr, softening, slicing, heating in 120 deg.C water with 2 standard atmospheric pressures for 2 hr to obtain mixture A, concentrating at 80 deg.C, and oven drying to humidity of 50% to obtain mixture B;
s3, pre-crushing the Chinese yam and the tuckahoe into coarse powder, adding water with the weight ratio of 1:5 to the raw materials, heating the mixture in 120 ℃ water with 2 standard atmospheric pressures for 1 hour, and then concentrating the mixture into paste at 100 ℃ to obtain a mixture C;
s4, rolling rhizoma Alismatis and cortex moutan to coarse powder, mashing with fructus Corni, drying, rolling to fine powder, mixing, and sieving with 100 mesh sieve to obtain mixture D;
s5, adding clear water into the eclipta alba and the eucommia ulmoides, decocting for 3 hours, squeezing and filtering to obtain filtrate; adding a proper amount of clear water into filter residues, decocting, squeezing, filtering, taking filtrate, and repeating for three times; mixing the filtrates, heating, and decocting to obtain a thick paste mixture E;
s6, putting the mixture B, the mixture C, the mixture D and the mixture E obtained in the steps S2-S5 into a lump combining device, adding refined honey, uniformly stirring to form moist lumps, dividing the lumps into lumps, rubbing into strips, and making pills.
And step S4, the loss rate of the medicinal materials is not more than 15%.
The moisture content of the ointment in the step S5 is that a little of the ointment is dripped on moisture absorption paper for inspection, and the moisture content is not penetrated.
The refined honey of the step S6 is added for 4 times, and the amount of the refined honey added for each time is 25%, 40%, 25% and 10% of the total amount; the time of adding refined honey for the last time is 2 hours away from the time of adding refined honey for the previous time; the temperature for refining honey is 90 ℃.
Example 2
The pill of two ingredients to rehmannia comprises the following raw materials in parts by weight: 8 parts of radix rehmanniae preparata, 4 parts of dogwood, 4 parts of Chinese yam, 3 parts of rhizoma alismatis, 3 parts of tree peony bark, 3 parts of poria cocos, 2 parts of glossy privet fruit, 1 part of dried orange peel, 2 parts of eclipta alba and 2 parts of eucommia ulmoides.
The preparation method was the same as that of example 1.
Example 3
The pill of two ingredients to rehmannia comprises the following raw materials in parts by weight: 5-13 parts of radix rehmanniae preparata, 5-13 parts of dogwood, 3-8 parts of dioscorea opposita thumb, 1-5 parts of rhizoma alismatis, 1-5 parts of tree peony bark, 2-6 parts of poria cocos, 1-4 parts of glossy privet fruit, 0.5-2 parts of dried orange peel, 1.5-4 parts of eclipta alba and 1-3 parts of eucommia ulmoides.
The preparation method was the same as that of example 1.
Comparative example 1
The procedure was as in example 2 except that the raw material lacked the tangerine peel.
Comparative example 2
The procedure of example 2 was repeated except that eucommia ulmoides was not included in the starting material.
Comparative example 3
The same as example 2 except that the raw materials lack fructus ligustri lucidi, pericarpium citri reticulatae, eclipta alba and eucommia ulmoides.
For 60 patients with spleen deficiency and kidney deficiency, the pills prepared in the examples 1-3 and the comparative examples 1-3 are taken one pill each time and twice a day, and are taken with warm boiled water or light salt soup for 20 days continuously. The number of people with remarkable, common and unchanged effects after the medicine is taken is counted.
Numbering Is remarkable in that In general Without change
Example 1 8 1 1
Example 2 9 1 0
Example 3 9 0 1
Comparative example 1 5 2 3
Comparative example 2 6 1 2
Comparative example 3 4 3 3
As can be seen from the data of examples 1 to 3 and comparative example 3, the number of persons who showed the effect of the present invention (the effect was significant and general) was large, indicating that the conditioning effect of the present invention was better; in example 2 and comparative examples 1-2, it can be seen that the added pericarpium citri reticulatae and eucommia ulmoides can improve the spleen tonifying and qi benefiting effects of the prescription by adjusting the formula of the raw materials, so that the prescription has better treatment and conditioning effects on patients within the same using time.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions and improvements made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (10)

1. The pill of two ingredients to rehmannia is characterized by comprising the following raw materials in parts by weight: 5-13 parts of radix rehmanniae preparata, 5-13 parts of dogwood, 3-8 parts of dioscorea opposita thumb, 1-5 parts of rhizoma alismatis, 1-5 parts of tree peony bark, 2-6 parts of poria cocos, 1-4 parts of glossy privet fruit, 0.5-2 parts of dried orange peel, 1.5-4 parts of eclipta alba and 1-3 parts of eucommia ulmoides.
2. The pill of two to rehmannia according to claim 1, wherein the prepared rehmannia root 8 parts, cornus officinalis 4 parts, dioscorea opposita 4 parts, alisma orientale 3 parts, moutan bark 3 parts, poria cocos wolf 3 parts, ligustrum lucidum 2 parts, dried orange peel 1 part, eclipta alba 2 parts, and eucommia ulmoides 2 parts.
3. The pill of claim 1, wherein the fructus Corni is wine-steamed fructus Corni, and the fructus Ligustri Lucidi is wine-steamed fructus Ligustri Lucidi.
4. A method for preparing a pill of two to rehmannia according to claims 1 to 3, comprising the steps of:
s1, weighing radix rehmanniae Preparata, Corni fructus, rhizoma Dioscoreae, Alismatis rhizoma, cortex moutan, Poria, fructus Ligustri Lucidi, pericarpium Citri Tangerinae, Ecliptae herba, and Eucommiae cortex;
s2, steaming radix rehmanniae Preparata at 100 deg.C for 1 hr, softening, slicing, heating in water at 115-125 deg.C under 2 standard atmospheric pressures for 2-3 hr to obtain mixture A, concentrating at 80 deg.C, and oven drying to humidity of 45-55% to obtain mixture B;
s3, pre-crushing the yam and the tuckahoe into coarse powder, adding water with the weight ratio of 1:5 to the raw materials, heating the mixture for 1 to 2 hours in water with the temperature of 120-125 ℃ under 2 standard atmospheric pressures, and then concentrating the mixture into paste at the temperature of 90 to 105 ℃ to obtain a mixture C;
s4, rolling rhizoma Alismatis and cortex moutan to coarse powder, mashing with fructus Corni, drying, rolling to fine powder, mixing, and sieving with 80-100 mesh sieve to obtain mixture D;
s5, soaking herba Ecliptae and Eucommiae cortex in clear water, decocting for 2-3 hr, squeezing, and filtering to obtain filtrate; adding a proper amount of clear water into filter residues, decocting, squeezing, filtering, taking filtrate, and repeating for three times; mixing the filtrates, heating, and decocting to obtain a thick paste mixture E;
s6, putting the mixture B, the mixture C, the mixture D and the mixture E obtained in the steps S2-S5 into a lump combining device, adding refined honey, uniformly stirring to form moist lumps, dividing the lumps into lumps, rubbing into strips, and making pills.
5. The method for preparing the Dizhi Dihuang Wan as claimed in claim 4, wherein the loss rate of the herbs in step S4 is not more than 15%.
6. The method for preparing a pill of two to rehmannia according to claim 4, wherein the moisture content of the ointment obtained in step S5 is measured by dropping a little on moisture absorption paper to be inspected, and the moisture content is measured by not permeating the paper.
7. The method for preparing a di-zhi huang wan as claimed in claim 4, wherein the refined honey of step S6 is added in 4 times, and the amount of the refined honey added in each time is 25%, 40%, 25%, 10% of the total amount; the time of adding refined honey for the last time is 2-4 hours apart from the time of adding refined honey for the previous time; the temperature of the refined honey is 90-110 ℃.
8. The preparation method of the di-to-rehmannia pills according to claim 4, wherein the lump combining device comprises a box body (1), a first feeding port (11) and a second feeding port (12) are respectively arranged at the top of the box body (1), and a discharge port (13) is arranged at the bottom of the box body (1); the stirring device (2) is arranged at the top of the box body (1), the stirring device (2) is connected with a rotating shaft (21), a stirring blade (22) is arranged on the rotating shaft (21), and a first temperature sensor (23) is arranged at the bottom of the stirring shaft (21); the outer side of the box body (1) is provided with a control box (14), the control box (14) is connected with the stirring device (2) to control starting and stopping, and the control box (14) is connected with a first temperature sensor (23) to display the internal temperature of the box body (1).
9. The preparation method of the pills of two or four roots according to claim 8, wherein a main water pipe (3) is arranged at the top of the box body (1), a water diversion pipe (31) is arranged on the main water pipe (3), and an atomizing spray head (32) is arranged at the bottom of the water diversion pipe (31); and a flowmeter (33) is arranged on the main water pipe (3).
10. The method for preparing pills of two to rehmannia according to claim 9, wherein an outer box (4) is further arranged on the outer side of the bottom of the box body (1), a water inlet (41) is arranged at the top of the outer box (4), a water outlet (42) is arranged at the bottom of the outer box (4), a heating wire (43) is arranged inside the outer box (4), and a second temperature sensor (44) is arranged at the bottom inside the outer box (4); the second temperature sensor (44) is connected with the control box (14) to display the temperature of the water in the outer box body (4).
CN202110598503.3A 2021-05-31 2021-05-31 Dizhi rehmannia pills and preparation method thereof Pending CN113117002A (en)

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Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105641314A (en) * 2014-11-10 2016-06-08 顾立新 Traditional Chinese medicine formula for treating depression with syndrome of insufficiency of both the spleen and the kidney
CN106728667A (en) * 2016-12-05 2017-05-31 通渭县中医医院 A kind of Chinese medicine composition for treating Chong and Ren channel disorder type mastoproliferation
CN206443928U (en) * 2016-07-18 2017-08-29 青岛食安生物工程有限公司 A kind of production equipment of Llaemorrhoids pills/powder one
CN207838969U (en) * 2017-12-13 2018-09-11 江西神田生物科技有限公司 A kind of reaction kettle
CN208130882U (en) * 2018-02-09 2018-11-23 北方民族大学 A kind of temperature controllable blender
CN109010063A (en) * 2018-10-10 2018-12-18 南京正宽医药科技有限公司 A kind of Chinese medicinal pills preparing machine
CN209677274U (en) * 2019-03-06 2019-11-26 江西花圣食品有限公司 A kind of heating device for honey production
CN210186058U (en) * 2019-03-21 2020-03-27 嘉兴欣贝莱生物科技有限公司 Preparation facilities of scutellarin aglycone liposome
CN111110559A (en) * 2019-11-26 2020-05-08 安徽七方中药饮片有限公司 Traditional Chinese medicine decoction piece processing equipment
CN211326916U (en) * 2019-09-12 2020-08-25 山东中医药高等专科学校 Device for processing traditional Chinese medicine and roasting with honey
CN211512692U (en) * 2019-10-21 2020-09-18 亳州市中泰药业有限公司 A fry medicine machine for traditional chinese medicine preparation
CN211886447U (en) * 2020-01-31 2020-11-10 乐比(广州)健康产业有限公司 Mixing arrangement is used in production of surgery ointment

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105641314A (en) * 2014-11-10 2016-06-08 顾立新 Traditional Chinese medicine formula for treating depression with syndrome of insufficiency of both the spleen and the kidney
CN206443928U (en) * 2016-07-18 2017-08-29 青岛食安生物工程有限公司 A kind of production equipment of Llaemorrhoids pills/powder one
CN106728667A (en) * 2016-12-05 2017-05-31 通渭县中医医院 A kind of Chinese medicine composition for treating Chong and Ren channel disorder type mastoproliferation
CN207838969U (en) * 2017-12-13 2018-09-11 江西神田生物科技有限公司 A kind of reaction kettle
CN208130882U (en) * 2018-02-09 2018-11-23 北方民族大学 A kind of temperature controllable blender
CN109010063A (en) * 2018-10-10 2018-12-18 南京正宽医药科技有限公司 A kind of Chinese medicinal pills preparing machine
CN209677274U (en) * 2019-03-06 2019-11-26 江西花圣食品有限公司 A kind of heating device for honey production
CN210186058U (en) * 2019-03-21 2020-03-27 嘉兴欣贝莱生物科技有限公司 Preparation facilities of scutellarin aglycone liposome
CN211326916U (en) * 2019-09-12 2020-08-25 山东中医药高等专科学校 Device for processing traditional Chinese medicine and roasting with honey
CN211512692U (en) * 2019-10-21 2020-09-18 亳州市中泰药业有限公司 A fry medicine machine for traditional chinese medicine preparation
CN111110559A (en) * 2019-11-26 2020-05-08 安徽七方中药饮片有限公司 Traditional Chinese medicine decoction piece processing equipment
CN211886447U (en) * 2020-01-31 2020-11-10 乐比(广州)健康产业有限公司 Mixing arrangement is used in production of surgery ointment

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
刘朝霞 等: "《谢晶日教授‘肝脾论’学术思想及临床经验辑选》", 30 September 2017, 中国中医药出版社 *
李前龙 等: "六味地黄汤治疗老年性骨质疏松症38例", 《长春中医药大学学报》 *
王高丹: "浅析以补肾疏肝法论治乳腺癌类围绝经期综合征", 《江西中医药》 *
董海: "中药内外结合穴位埋线治疗黄褐斑67例", 《辽宁中医药大学学报》 *

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