CN113082120A - 防治流行性感冒的精准药膳食疗产品及其制备方法 - Google Patents
防治流行性感冒的精准药膳食疗产品及其制备方法 Download PDFInfo
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Abstract
现有市场上没有针对流感预防的药食同源类产品,所以本发明提出一种防治流行性感冒的精准药膳食疗产品及其制备方法,其产品由以下质量份的各物质组成:藿香1‑10、芫荽1‑10、薄荷1‑10、大茴香1‑10、金银花1‑15、鱼腥草1‑20、余甘子1‑9、绿茶1‑10、北虫草1‑10、低聚甘露糖1‑5。本发明对防治流行性感冒早期预防、中期治疗、后期康复安全有效,保留复方的有效成分,制成适宜的给药形式,包括颗粒剂、粉剂、口服液、片剂等剂型,或者食品形式如压片糖果、餐粉、固体饮料等形式。满足市场对相关产品的需求。
Description
技术领域
本发明属于药膳食疗产品技术领域,尤其涉及防治流行性感冒的精准药膳食疗产品及其制备方法。
背景技术
流感目前已成为影响公共健康的一大危险因素,几乎每年都有不同程度的爆发,具有传染性强、发病率高、流行面广有死亡率高等特点,被列为尚未有效控制的世界性传染病之一。近10年我国多个地区的监测结果显示,南北方每年优势菌株无明显区别,皆以季节性H3、甲型H1N1以及乙型流感多见,其中南方冬春的流感季病毒类型为乙型、甲型共存,夏季的以季节性H3病毒为主。
由于流感病毒的复制无RNA校正酶参与,所以其发生突变的频率远高于其他病毒,且新复制的病毒大都有突变,不同的变异方式又使得流感可反复流行,故流感流行呈现出一定的季节性。流感病毒宿主分布广泛,患者与隐性感染者是主要传染源,飞沫传播与接触传播是其主要传播途径。这些独特的性质导致流感成为近年来干扰人类健康的重大危险因素之一。1889年俄中亚布哈达拉大流行的流感病毒为H2N2;1918年发生人类近代史上最大的流感,病毒为甲型H1N1;1957年首发于我国西南部的流感由H2N2亚型毒株引起。近年来我国多次发生流感,包括2003年的H5N1流感、2009年的新甲型H1N1流感、2013年的人感染H7N9禽流感,给人民带来了沉重的影响。
抗流感的药物有2类,一类针对神经氨酸酶,为神经氨酸酶抑制剂类药物,包括奥司他韦、扎那米韦和帕那米韦,另一类为针对M2蛋白的烷胺类药物,包括金刚烷胺和金刚乙胺,目前烷胺类药物在普通季节性流感中的耐药比例相当高,几乎100%耐药。
流感与中医学中的“时行感冒”相似,属于温病的风瘟、冬瘟、春瘟、暑瘟、秋燥等范畴。发病原因为“非时之气”,亦称为四时不正之气,病机为热毒壅肺、闭肺,肺失宣降,毒瘀互结,肺不主气,化源竭绝,疫毒为本,热咳喘为标,治当清热解毒、除浊解表、化痰利咽。但市场上没有针对流感预防的药食同源类产品。
发明内容
本发明针对现有技术的不足,提出一种防治流行性感冒的精准药膳食疗产品及其制备方法,得到对防治流行性感冒早期预防、中期治疗、后期康复安全有效的、质量可靠、有效成分清晰、作用靶点清楚的精准药膳,具有非常重要的意义和较大市场需求。
本发明提出的防治流行性感冒的精准药膳食疗产品,其由以下质量份的各物质组成:藿香1-10、芫荽1-10、薄荷1-10、大茴香1-10、金银花1-15、鱼腥草1-20、余甘子1-9、绿茶1-10、北虫草1-10、低聚甘露糖1-5。
进一步的,所述防治流行性感冒的精准药膳食疗产品由以下质量份的各物质组成:藿香3-8、芫荽3-8、薄荷3-8、大茴香3-8、金银花7-12、鱼腥草8-15、余甘子5-9、绿茶4-7、北虫草2-5、低聚甘露糖1-3。
进一步的,所述防治流行性感冒的精准药膳食疗产品,其由以下质量份的各物质组成:藿香6、芫荽6、薄荷6、大茴香6、金银花10、鱼腥草10、余甘子9、绿茶5、北虫草3、低聚甘露糖1。
进一步的,所述防治流行性感冒的精准药膳食疗产品包括液体饮料、口服液、固体饮料、颗粒剂、片剂。
本发明还包括上述防治流行性感冒的精准药膳食疗产品的制备方法,包括以下步骤:
S1、按比例取藿香、芫荽、薄荷、大茴香、金银花、鱼腥草、余甘子、绿茶、北虫草中药饮片,加水15倍浸泡30分钟,加热回流提取1小时,200目过滤,药渣加10倍水回流提取1小时,200目过滤;
S2、合并两次滤液,70℃减压浓缩至相对密度约为1.06,离心过滤,加入总质量占比为0.25%的山梨酸钾作为抑菌剂,加入处方规定量的低聚甘露糖和适宜的调味剂,搅拌溶解,加入适量纯净水定容,得到防治流行性感冒的精准药膳食疗液体饮料或口服液。
进一步的,将步骤S1得到的两次滤液合并后减压浓缩至密度约为1.08,得浓缩液,加入麦芽糊精,搅拌均匀,喷雾干燥,喷嘴进风温度为150℃,出风口温度80℃,即得提取物粉末,备用;取上述提取物粉末,加入配方量低聚甘露糖,混合均匀,分装即得到防治流行性感冒的精准药膳食疗固体饮料。
进一步的,将步骤S1得到的的两次滤液合并后减压浓缩至密度约为1.08,得浓缩液,加入麦芽糊精,搅拌均匀,喷雾干燥,喷嘴进风温度为150℃,出风口温度80℃,即得提取物粉末,在所述提取物粉末中加入适宜的食品原料和配方量低聚甘露糖,进行制粒,干燥,分装,得到防治流行性感冒的精准药膳食疗颗粒剂产品。
进一步的,将步骤S1得到的的两次滤液合并后减压浓缩至密度约为1.08,得浓缩液,加入麦芽糊精,搅拌均匀,喷雾干燥,喷嘴进风温度为150℃,出风口温度80℃,即得提取物粉末,在所述提取物粉末中加入适宜的食品原料和配方量低聚甘露糖,进行制粒,干燥,压片,得到防治流行性感冒的精准药膳食疗片剂产品。
进一步的,将步骤S1得到的的两次滤液合并后减压浓缩至密度约为1.08,得浓缩液,加入麦芽糊精,搅拌均匀,喷雾干燥,喷嘴进风温度为150℃,出风口温度80℃,即得提取物粉末,在所述提取物粉末中加入适宜的食品原料和配方量低聚甘露糖,再加入麦芽糊精、玉米淀粉、小麦粉和蛋白粉中的一种或多种,进行粉末直接压片,得到防治流行性感冒的精准药膳食疗片剂产品。
本发明由清热、抗病毒类中药组成,其中藿香芳香化浊、发表解暑,金银花和鱼腥草清热解毒,芫荽发表透疹,薄荷、大茴香温中理气,余甘子清热凉血,可抑制病毒扩增;提高免疫力,增强巨噬细胞吞噬能力,缓解急性肺炎,扩张气管、平喘止咳,扩张血管、渗湿利水,改善肠道功能,治疗泻痢便血。
本发明由藿香、芫荽、薄荷、大茴香、金银花、鱼腥草、余甘子、绿茶、北虫草、低聚甘露糖组成。广藿香醇激活PXR信号、抑制NF-κB信号,从而导致炎症的改善。PXR-NF-κB通路在结肠炎可作为全新的治疗试剂。细胞PI3K/Akt和ERK/MAPK信号通路参与了广藿香醇的抗流感病毒作用。Corilagin可能通过干扰TLR3信号通路,调节HSE的免疫应答,减轻炎症损伤。治疗后,信使rna和蛋白质水平的TLR。鱼腥草hyperin和quercitrin对HCF的疗效起着关键作用,也减少了TLR3/4/7的表达和水平NF-κB p65,通过抑制流感NA活性和TLR信号转导芦丁和金桃丝苷可抑制流感病毒神经氨酸酶NA。虫草腺苷除了作为PKR抑制剂,还能调节ADAR1依赖的基因表达,以对抗抗病毒反应或实现有效的病毒感染。
表1:组合物主要特征成分与流行感冒病毒潜在靶点的作用
本发明主要原则为清热解毒、除浊解表、化痰利咽。本发明具有多系统、多环节的整体调节作用,从分子、细胞、器官、整体的多个层面对机体的结构与功能产生作用,促进机能发生变化,从而发挥疗效。
本发明采用药学、食品、保健品等相关法规可以接受的方法,进行提取、浓缩、干燥或粉碎加入产品,保留复方的有效成分,制成适宜的给药形式(包括颗粒剂、粉剂、口服液、片剂等剂型)或者食品形式如压片糖果、餐粉、固体饮料等形式。满足市场对相关产品的需求。
附图说明
图1是本发明相关中药的网络药理学研究及药理功效分析图。
具体实施方式
实施例1
一种防治流行性感冒的精准药膳食疗产品,其由以下质量份的各物质组成:藿香1、芫荽10、薄荷1、大茴香1、金银花15、鱼腥草1、余甘子9、绿茶1、北虫草10、低聚甘露糖1。
上述防治流行性感冒的精准药膳食疗产品的制备方法,包括以下步骤:
S1、按比例取藿香、芫荽、薄荷、大茴香、金银花、鱼腥草、余甘子、绿茶、北虫草中药饮片,加水15倍浸泡30分钟,加热回流提取1小时,200目过滤,药渣加10倍水回流提取1小时,200目过滤;
S2、合并两次滤液,70℃减压浓缩至相对密度约为1.03,离心过滤,加入处方量的低聚苷露糖,加入总质量占比为0.01%的甜菊糖苷调味,加入总质量占比为0.025%山梨酸钾抑菌,搅拌均匀,纯净水定容至规定量,即得到防治流行性感冒的精准药膳食疗液体饮料。
实施例2
一种防治流行性感冒的精准药膳食疗产品,其由以下质量份的各物质组成:藿香10、芫荽1、薄荷3、大茴香3、金银花1、鱼腥草20、余甘子1、绿茶10、北虫草1、低聚甘露糖5。
上述防治流行性感冒的精准药膳食疗产品的制备方法,包括以下步骤:
S1、按比例取藿香、芫荽、薄荷、大茴香、金银花、鱼腥草、余甘子、绿茶、北虫草中药饮片,加水15倍浸泡30分钟,加热回流提取1小时,200目过滤,药渣加10倍水回流提取1小时,200目过滤;
S2、合并两次滤液,70℃减压浓缩至相对密度约为1.03,离心过滤,加入处方量的低聚苷露糖,加入总质量占比为0.01%的甜味剂阿斯巴甜,加入总质量占比为0.04%的抑菌剂尼泊金乙酯钠,搅拌均匀,纯净水定容,即得到防治流行性感冒的精准药膳食疗口服液。
实施例3
一种防治流行性感冒的精准药膳食疗产品,其由以下质量份的各物质组成:藿香3、芫荽8、薄荷3、大茴香6、金银花12、鱼腥草8、余甘子5、绿茶4、北虫草5、低聚甘露糖1。
上述防治流行性感冒的精准药膳食疗产品的制备方法,包括以下步骤:
S1、按比例取藿香、芫荽、薄荷、大茴香、金银花、鱼腥草、余甘子、绿茶、北虫草中药饮片,加水15倍浸泡30分钟,加热回流提取1小时,200目过滤,药渣加10倍水回流提取1小时,200目过滤;
S2、将步骤S1得到的的两次滤液合并后减压浓缩至密度约为1.08,得浓缩液,加入总质量占比为15%的麦芽糊精,搅拌均匀,喷雾干燥(喷嘴进风温度设为150℃,出风口温度80℃),即得提取物粉末,在所述提取物粉末中加入适宜的食品原料和配方量低聚甘露糖,进行制粒,干燥,分装,得到防治流行性感冒的精准药膳食疗颗粒剂产品。
实施例4
一种防治流行性感冒的精准药膳食疗产品,其由以下质量份的各物质组成:藿香8、芫荽3、薄荷8、大茴香6、金银花7、鱼腥草15、余甘子9、绿茶7、北虫草2、低聚甘露糖3。
上述防治流行性感冒的精准药膳食疗产品的制备方法,包括以下步骤:
S1、按比例取藿香、芫荽、薄荷、大茴香、金银花、鱼腥草、余甘子、绿茶、北虫草中药饮片,加水15倍浸泡30分钟,加热回流提取1小时,200目过滤,药渣加10倍水回流提取1小时,200目过滤;
S2、将步骤S1得到的的两次滤液合并后减压浓缩至密度约为1.08,得浓缩液,加入总质量占比为19%的麦芽糊精,搅拌均匀,喷雾干燥(喷嘴进风温度设为155度,出风口温度83℃),即得提取物粉末,在所述提取物粉末中加入总质量占比为15%的乳糖粉和麦芽糊精作为填充剂,加入配方量的低聚甘露糖,进行制粒,干燥,压片,得到防治流行性感冒的精准药膳食疗片剂产品。
实施例5
一种防治流行性感冒的精准药膳食疗产品,其由以下质量份的各物质组成:藿香6、芫荽6、薄荷6、大茴香6、金银花10、鱼腥草10、余甘子9、绿茶5、北虫草3、低聚甘露糖1。
上述防治流行性感冒的精准药膳食疗产品的制备方法,包括以下步骤:
S1、按比例取藿香、芫荽、薄荷、大茴香、金银花、鱼腥草、余甘子、绿茶、北虫草中药饮片,加水15倍浸泡30分钟,加热回流提取1小时,200目过滤,药渣加10倍水回流提取1小时,200目过滤;
S2、将步骤S1得到的的两次滤液合并后减压浓缩至密度约为1.08,得浓缩液,加入总质量占比为24%的麦芽糊精,搅拌均匀,喷雾干燥(喷嘴进风温度设为160℃,出风口温度84℃),即得提取物粉末,在所述提取物粉末中加入总质量占比为10%的蛋白粉和配方量低聚甘露糖,加入填充剂可溶性淀粉至规定量,进行制粒,干燥,分装,得到防治流行性感冒的精准药膳食疗颗粒剂产品。
实施例6
一种防治流行性感冒的精准药膳食疗产品,其由以下质量份的各物质组成:藿香9、芫荽5、薄荷10、大茴香10、金银花5、鱼腥草13、余甘子6、绿茶3、北虫草10、低聚甘露糖2。
上述防治流行性感冒的精准药膳食疗产品的制备方法,包括以下步骤:
S1、按比例取藿香、芫荽、薄荷、大茴香、金银花、鱼腥草、余甘子、绿茶、北虫草中药饮片,加水15倍浸泡30分钟,加热回流提取1小时,200目过滤,药渣加10倍水回流提取1小时,200目过滤;
S2、将步骤S1得到的的两次滤液合并后减压浓缩至密度约为1.08,得浓缩液,加入总质量占比为30%的麦芽糊精,搅拌均匀,喷雾干燥(喷嘴进风温度设为157℃,出风口温度82℃),即得提取物粉末,在所述提取物粉末中加入配方量低聚甘露糖,再加入总质量占比为5%蛋白粉和总质量占比为8%的乳糖,进行粉末直接压片,得到防治流行性感冒的精准药膳食疗片剂产品。
实施例7
一种防治流行性感冒的精准药膳食疗产品,其由以下质量份的各物质组成:藿香5、芫荽4、薄荷7、大茴香8、金银花8、鱼腥草12、余甘子8、绿茶6、北虫草4、低聚甘露糖2。
上述防治流行性感冒的精准药膳食疗产品的制备方法,包括以下步骤:
S1、按比例取藿香、芫荽、薄荷、大茴香、金银花、鱼腥草、余甘子、绿茶、北虫草中药饮片,加水15倍浸泡30分钟,加热回流提取1小时,200目过滤,药渣加10倍水回流提取1小时,200目过滤;
S2、将步骤S1得到的的两次滤液合并后减压浓缩至密度约为1.08,得浓缩液,加入总质量占比为24%的麦芽糊精,搅拌均匀,喷雾干燥(喷嘴进风温度设为150℃,出风口温度82℃),即得提取物粉末,在所述提取物粉末中加入总质量占比为5%的乳糖,总质量占比为5%的蛋白粉,和配方量低聚甘露糖,以麦芽糊精为稀释剂,加至规定量,进行制粒,干燥,分装,得到防治流行性感冒的精准药膳食疗颗粒剂产品。
实施例8
一种防治流行性感冒的精准药膳食疗产品,其由以下质量份的各物质组成:藿香4、芫荽7、薄荷5、大茴香9、金银花13、鱼腥草5、余甘子4、绿茶8、北虫草6、低聚甘露糖4。
上述防治流行性感冒的精准药膳食疗产品的制备方法,包括以下步骤:
S1、按比例取藿香、芫荽、薄荷、大茴香、金银花、鱼腥草、余甘子、绿茶、北虫草中药饮片,加水15倍浸泡30分钟,加热回流提取1小时,200目过滤,药渣加10倍水回流提取1小时,200目过滤;
S2、将步骤S1得到的的两次滤液合并后减压浓缩至密度约为1.08,得浓缩液,加入总质量占比为23%的麦芽糊精,搅拌均匀,喷雾干燥(喷嘴进风温度设为160℃,出风口温度86℃),即得提取物粉末,在所述提取物粉末中加入总质量占比为9%的乳糖和配方量低聚甘露糖,以麦芽糊精为稀释剂加至规定的量,进行制粒,干燥,分装,得到防治流行性感冒的精准药膳食疗颗粒剂产品。
本发明的液体饮料建议口服2-3次/天,每次100-200ml;固体饮料建议每天2-3次,每次取本品10g,加入100-200毫升热水冲调搅至溶解后,即可食用;颗粒剂建议每天2-3次,每次取本品10-15g,加入100-200毫升热水冲调搅至溶解后,即可食用;片剂建议每天2-3次,每次取本品15-20g直接食用。
本发明防治流行性感冒的精准药膳食疗产品的治疗效果可以通过下述临床病例的观察得到进一步证实。
1、病人概况:流行性感冒患者360例,随机分为9组,每组40人,其中1-8组为观察组,分别服用实施例1-8的产品;第9组为对照组。观察组平均每组男性19例,女性21例,平均年龄36.3岁,病程16-39h,平均32.3h;对照组男性20例,女性20例,平均年龄35.8岁,病程15-36h,平均30.6h。观察组和对照组患者性别、年龄、病程等方面比较无统计学差异(P>0.05)。
2、入选标准
①年龄:18-70岁;
②临床表现:通常表现为高热(腋下体温≥37.5℃),出现畏寒、头疼、头晕、全身酸疼、无力等症状;
③诊断原则:在流感高发期,本地区出现大量呼吸道感染患者或者门诊、急诊上呼吸道感染患者明显增加,具有相应的临床表现可以作为流感诊断的病例。
3、排除标准
①具有严重心、肺、胃、肝等疾病,以及孕期及哺乳期妇女;
②一年内接种过流行性感冒疫苗的患者。
4、治疗方法
对照组给予999感冒灵颗粒(华润三九医药股份有限公司),口服,一次一袋,一日3次;
观察组给予本发明实施例1-8的产品,液体饮料口服3次/天,每次100ml;固体饮料每天3次,每次取本品10g,加入100毫升热水冲调搅至溶解后食用;颗粒剂每天3次,每次取本品10g,加入100热水冲调搅至溶解后食用;片剂每天3次,每次取本品15g直接食用。
5、疗效标准
显效:治疗后1天体温正常,全身的症状消失;
有效:治疗后1-2天体温正常,全身的症状消失;
无效:治疗2天后体温变化不明显,全身的症状无好转或者恶化。
总有效率=显效率+有效率
6、结果
7、结果分析:本发明防治流行性感冒的精准药膳食疗产品能够较为有效地治疗流行性感冒。在临床观察过程中,未发现本产品有任何不良毒副反应。
本发明产品的最终形式可以是多种,包括粉剂、颗粒、片剂、蜜丸、膏滋、口服液、糖浆剂等。制备工艺中,干燥方式可以是喷雾干燥、真空干燥、冷冻干燥等;制粒方法可以是干法制粒、湿法制粒、一步制粒等。
以上所述仅为本发明的优选实施例而已,并不用于限制本发明,对于本领域的技术人员来说,凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (9)
1.防治流行性感冒的精准药膳食疗产品,其特征在于,所述防治流行性感冒的精准药膳食疗产品由以下质量份的各物质组成:藿香1-10、芫荽1-10、薄荷1-10、大茴香1-10、金银花1-15、鱼腥草1-20、余甘子1-9、绿茶1-10、北虫草1-10、低聚甘露糖1-5。
2.根据权利要求1所述的防治流行性感冒的精准药膳食疗产品,其特征在于,所述防治流行性感冒的精准药膳食疗产品由以下质量份的各物质组成:藿香3-8、芫荽3-8、薄荷3-8、大茴香3-8、金银花7-12、鱼腥草8-15、余甘子5-9、绿茶4-7、北虫草2-5、低聚甘露糖1-3。
3.根据权利要求1所述的防治流行性感冒的精准药膳食疗产品,其特征在于,所述防治流行性感冒的精准药膳食疗产品,其由以下质量份的各物质组成:藿香6、芫荽6、薄荷6、大茴香6、金银花10、鱼腥草10、余甘子9、绿茶5、北虫草3、低聚甘露糖1。
4.根据权利要求1所述的防治流行性感冒的精准药膳食疗产品,其特征在于,所述防治流行性感冒的精准药膳食疗产品包括液体饮料、口服液、固体饮料、颗粒剂、片剂。
5.根据权利要求1至4中任一项所述的防治流行性感冒的精准药膳食疗产品的制备方法,其特征在于,所述制备方法包括以下步骤:
S1、按比例取藿香、芫荽、薄荷、大茴香、金银花、鱼腥草、余甘子、绿茶、北虫草中药饮片,加水15倍浸泡30分钟,加热回流提取1小时,200目过滤,药渣加10倍水回流提取1小时,200目过滤;
S2、合并两次滤液,70℃减压浓缩至相对密度约为1.06,离心过滤,加入总质量占比为0.25%的山梨酸钾作为抑菌剂,加入处方规定量的低聚甘露糖和适宜的调味剂,搅拌溶解,加入适量纯净水定容,得到防治流行性感冒的精准药膳食疗液体饮料或口服液。
6.根据权利要求5所述的防治流行性感冒的精准药膳食疗产品的制备方法,其特征在于,将步骤S1得到的两次滤液合并后减压浓缩至密度约为1.08,得浓缩液,加入麦芽糊精,搅拌均匀,喷雾干燥,喷嘴进风温度为150℃,出风口温度80℃,即得提取物粉末,备用;取上述提取物粉末,加入配方量低聚甘露糖,混合均匀,分装即得到防治流行性感冒的精准药膳食疗固体饮料。
7.根据权利要求6所述的防治流行性感冒的精准药膳食疗产品的制备方法,其特征在于,将步骤S1得到的的两次滤液合并后减压浓缩至密度约为1.08,得浓缩液,加入麦芽糊精,搅拌均匀,喷雾干燥,喷嘴进风温度为150℃,出风口温度80℃,即得提取物粉末,在所述提取物粉末中加入适宜的食品原料和配方量低聚甘露糖,进行制粒,干燥,分装,得到防治流行性感冒的精准药膳食疗颗粒剂产品。
8.根据权利要求6所述的防治流行性感冒的精准药膳食疗产品的制备方法,其特征在于,将步骤S1得到的的两次滤液合并后减压浓缩至密度约为1.08,得浓缩液,加入麦芽糊精,搅拌均匀,喷雾干燥,喷嘴进风温度为150℃,出风口温度80℃,即得提取物粉末,在所述提取物粉末中加入适宜的食品原料和配方量低聚甘露糖,进行制粒,干燥,压片,得到防治流行性感冒的精准药膳食疗片剂产品。
9.根据权利要6所述的防治流行性感冒的精准药膳食疗产品的制备方法,其特征在于,将步骤S1得到的的两次滤液合并后减压浓缩至密度约为1.08,得浓缩液,加入麦芽糊精,搅拌均匀,喷雾干燥,喷嘴进风温度为150℃,出风口温度80℃,即得提取物粉末,在所述提取物粉末中加入适宜的食品原料和配方量低聚甘露糖,再加入麦芽糊精、玉米淀粉、小麦粉和蛋白粉中的一种或多种,进行粉末直接压片,得到防治流行性感冒的精准药膳食疗片剂产品。
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