CN113057299A - Composition with antioxidant function and preparation method thereof - Google Patents

Composition with antioxidant function and preparation method thereof Download PDF

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Publication number
CN113057299A
CN113057299A CN202010000840.3A CN202010000840A CN113057299A CN 113057299 A CN113057299 A CN 113057299A CN 202010000840 A CN202010000840 A CN 202010000840A CN 113057299 A CN113057299 A CN 113057299A
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parts
antioxidant
composition
test
antioxidant function
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刘磊
王鹤
任立焕
秦玉霞
侯金才
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Shenwei Pharmaceutical Group Co Ltd
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Shenwei Pharmaceutical Group Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/01—Instant products; Powders; Flakes; Granules
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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Abstract

The invention relates to the technical field of health-care food, and particularly discloses a composition with an antioxidant function, health-care food and a preparation method thereof. The composition comprises the following components in parts by weight: 10-30 parts of blueberry powder; 0.5-15 parts of green tea extract; 0.1-10 parts of saussurea involucrate culture; 5-25 parts of cherry powder; 0.1-10 parts of rosemary extract. The composition provided by the invention is natural in raw materials, safe and reliable, has good antioxidant effect, forms a good antioxidant system with various enzymes and antioxidant substances in a human body, and enhances the antioxidant capacity of an organism through different antioxidant ways.

Description

Composition with antioxidant function and preparation method thereof
Technical Field
The invention relates to the technical field of health-care food, and particularly relates to a composition with an antioxidant function, health-care food and a preparation method thereof.
Background
Antioxidation refers to the abbreviation of antioxidant free radicals. The human body continuously generates free radicals in the human body due to continuous contact with the outside, including respiration (oxidation reaction), external pollution, radiation irradiation and other factors. The human body inevitably generates free radicals and also naturally generates antioxidant substances resisting the free radicals so as to counteract the oxidative attack of the free radicals on human cells. Research proves that the antioxidant system of the human body is a system which is comparable to the immune system and has perfect and complex functions, and the stronger the antioxidant capacity of the body, the healthier the body is, and the longer the life is. However, the body function is declined with the age, or the patient is not cured for a long time, or the unhealthy life style is easy to cause the excessive oxidation of the body to damage the tissues and organs.
More and more studies show that anti-oxidation is an important step in preventing aging, because free radicals or oxidants break down cells and tissues, affect metabolic functions, and cause various health problems. If too many oxidative radicals can be eliminated, aging-related diseases caused by many radicals can be prevented. Such as common cancers, arteriosclerosis, diabetes, cataracts, cardiovascular diseases, senile dementia, arthritis, etc., which are considered to be associated with free radicals.
The antioxidant substances of human body are synthesized by themselves and also supplied by food, so the health food with antioxidant effect has a large market space. However, some existing health-care foods have relatively single anti-oxidation raw materials, and the added additives are easy to have adverse effects on human bodies. Therefore, the development of a health-care nutritional composition with natural raw materials, safe use and antioxidant effect is urgently needed.
Disclosure of Invention
Aiming at the technical problems of the existing antioxidant health food, the invention provides a composition with an antioxidant function, a health food and a preparation method thereof.
In order to achieve the purpose of the invention, the embodiment of the invention adopts the following technical scheme:
the composition with the antioxidant function comprises the following components in parts by weight: 10-30 parts of blueberry powder; 0.5-15 parts of green tea extract; 0.1-10 parts of saussurea involucrate culture; 5-25 parts of cherry powder; 0.1-10 parts of rosemary extract.
Further, the composition with the antioxidant function comprises the following components in parts by weight: 15-25 parts of blueberry powder; 1-10 parts of a green tea extract; 0.5-3 parts of saussurea involucrate culture; 10-20 parts of cherry powder; 0.5-7 parts of rosemary extract.
Further, the composition with the antioxidant function comprises the following components in parts by weight: 20 parts of blueberry powder; 3 parts of green tea extract; 1 part of saussurea involucrate culture; 14 parts of cherry powder; 2 parts of rosemary extract.
The blueberry powder is prepared by using blueberries as raw materials, and crushing freeze-dried powder by adopting a vacuum freeze-drying technology and a low-temperature physical crushing technology. The blueberry is rich in nutritional ingredients such as anthocyanin, the anthocyanin is hydrolyzed to obtain colored aglycon anthocyanin, the anthocyanin contains unpaired electrons, and the anthocyanin has the antioxidant activity of eliminating free radicals, improving the activity of antioxidant enzyme and inhibiting lipid peroxidation, and can effectively prevent oxidative stress injury in vivo.
The green tea extract is an active ingredient extracted from green tea leaves, wherein the mass content of tea polyphenol is 90-98%, and the green tea extract has strong oxidation resistance. Can effectively remove free radicals and superoxide anions, reduce oxidative damage of cells and inhibit apoptosis. The green tea extract and blueberry powder act together to further improve the antioxidant activity of the composition, thereby protecting cells and tissues.
The saussurea involucrate culture is a substance cultured by culturing isolated plant organs, tissues, cells, embryos or protoplasts of saussurea involucrate on an artificially prepared culture medium in an aseptic condition and adopting an artificial culture mode. The saussurea involucrate culture not only contains flavonoid substances as bioactive components, but also has the effects of resisting inflammation, easing pain, suppressing immunity, resisting oxidation and the like; also contains various vitamins, has close relation with the growth, development and health of human bodies, and is an essential important nutrient element for regulating various metabolic processes of human bodies.
The cherry powder is prepared by using cherry as a raw material, and adopting a vacuum freeze-drying technology and a low-temperature physical crushing technology to crush the freeze-dried powder. The cherry powder contains antioxidant substances such as total phenols, total flavonoids, anthocyanins and the like, has a high inhibition effect on hydroxyl free radicals and superoxide anions, and has a synergistic effect with the blueberry powder and the green tea extract to improve the antioxidant activity of the composition. Meanwhile, the cherry powder contains very rich vitamin C and also contains vitamin A, B1、B2Nicotine and iron and calciumAnd phosphorus, and the like, and the saussurea involucrate culture can fully supplement the nutritional requirements required in the metabolic process under the combined action of the mineral components and the saussurea involucrate culture. In addition, the vitamin C in the cherry powder and the saussurea involucrate culture has good synergistic effect with active substances such as anthocyanin and tea polyphenol, and the antioxidant activity of the composition can be further improved.
The rosemary extract is a volatile oil component extracted from rosemary branches and leaves by a steam distillation method, the rosemary branches and leaves are extracted by the steam distillation method (water distillation), and the volatile oil extract is obtained by separating liquid from distillate and drying, namely the rosemary extract has better free radical scavenging capacity. The composition has excellent antioxidant capacity under the combined action of other components.
Compared with the prior art, the composition with the antioxidant function provided by the invention has natural raw materials, is safe and reliable, and contains active substances such as anthocyanin, tea polyphenol, total phenol, total flavone and vitamin through the combination of different components. The synergistic effect of multiple antioxidant substances can effectively remove free radicals and superoxide anions, improve antioxidant enzyme activity, inhibit lipid peroxidation, and further improve antioxidant effect of the composition by synergistic effect of vitamins with antioxidant substances while promoting metabolism of human body. The composition provided by the invention forms a good antioxidant system with various enzymes and antioxidant substances in a human body, and enhances the antioxidant capacity of the organism through different antioxidant ways, thereby protecting tissues and organs of the human body and ensuring the health of the human body.
The invention also provides a health food with an antioxidant function, which comprises the composition with the antioxidant function. The health food with antioxidant function is in the form of granule, powder or tablet, and has good antioxidant effect.
The invention also provides a granule with an antioxidant function, which comprises the composition with the antioxidant function and 25-45 parts of maltodextrin; 15-35 parts of xylitol; 0.05-1 part of sucralose and 0.1-5 parts of citric acid.
Further, 30-40 parts of maltodextrin; 20-30 parts of xylitol; 0.05-0.2 part of sucralose and 0.5-3 parts of citric acid.
The invention also provides a preparation method of the granules with the antioxidant function, which comprises the following steps:
mixing the composition with the maltodextrin, the xylitol, the sucralose and the citric acid, and preparing the granules according to a conventional method.
According to the preparation method of the granules with the antioxidant function, provided by the invention, the composition consisting of the blueberry powder, the green tea extract, the snow lotus culture, the cherry powder and the rosemary extract is mixed with maltodextrin, xylitol, sucralose and citric acid to prepare the granules, and other additives are not added in the process, so that the active ingredients in the composition are effectively reserved, and the obtained granules have good antioxidant effect.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1
The composition with the antioxidant function comprises the following components in parts by weight: 20 parts of blueberry powder; 3 parts of green tea extract; 1 part of saussurea involucrate culture; 14 parts of cherry powder; 2 parts of rosemary extract.
The granules with the antioxidant function comprise the composition with the antioxidant function and 34 parts of maltodextrin; 25 parts of xylitol; 0.1 part of sucralose and 1 part of citric acid.
The preparation method of the granules with the antioxidant function comprises the following steps:
mixing the above herba Saussureae Involueratae culture with sucralose and citric acid, mixing with other components of the above composition, maltodextrin and xylitol, and making into granule by conventional method.
Example 2
The composition with the antioxidant function comprises the following components in parts by weight: 15 parts of blueberry powder; 10 parts of green tea extract; 0.5 part of saussurea involucrate culture; 10 parts of cherry powder; and 7 parts of rosemary extract.
The tablet with the antioxidant function comprises the composition with the antioxidant function and 40 parts of maltodextrin; 20 parts of xylitol; 0.2 part of sucralose and 0.5 part of citric acid.
The preparation method of the tablet with the antioxidant function comprises the following steps:
mixing the above herba Saussureae Involueratae culture with sucralose and citric acid, mixing with other components of the above composition, maltodextrin and xylitol, and making into tablet by conventional method.
Example 3
The composition with the antioxidant function comprises the following components in parts by weight: 25 parts of blueberry powder; 1 part of green tea extract; 3 parts of saussurea involucrate culture; 20 parts of cherry powder; 0.5 part of rosemary extract.
The granules with the antioxidant function comprise the composition with the antioxidant function and 30 parts of maltodextrin; 30 parts of xylitol; 0.05 part of sucralose and 3 parts of citric acid.
The preparation method of the granules with the antioxidant function comprises the following steps:
mixing the green tea extract and rosemary extract with sucralose, mixing with other components of the composition, maltodextrin, xylitol and citric acid, and making into granule by conventional method.
Example 4
The composition with the antioxidant function comprises the following components in parts by weight: 30 parts of blueberry powder; 15 parts of green tea extract; 0.1 part of saussurea involucrate culture; 25 parts of cherry powder; 0.1 part of rosemary extract.
The powder with the antioxidant function comprises the composition with the antioxidant function and 45 parts of maltodextrin; 15 parts of xylitol; 0.05 part of sucralose and 0.1 part of citric acid.
The preparation method of the powder with the antioxidant function comprises the following steps:
mixing the above herba Saussureae Involueratae culture and herba Rosmarini officinalis extract with sucralose and citric acid, mixing with other components of the above composition, maltodextrin and xylitol, and making into powder by conventional method.
Example 5
The composition with the antioxidant function comprises the following components in parts by weight: 10 parts of blueberry powder; 0.5 part of green tea extract; 10 parts of saussurea involucrate culture; 5 parts of cherry powder; 10 parts of rosemary extract.
The granules with the antioxidant function comprise the composition with the antioxidant function and 25 parts of maltodextrin; 35 parts of xylitol; 1 part of sucralose and 5 parts of citric acid.
The preparation method of the granules with the antioxidant function comprises the following steps:
mixing the green tea extract with sucralose, mixing with other components of the composition, maltodextrin, xylitol and citric acid, and making into granule by conventional method.
In order to better illustrate the technical solution of the present invention, further comparison is made below by means of a comparative example and an example of the present invention.
Comparative example 1
The cherry powder in example 1 was replaced with the same amount of red bayberry powder, and the other components were the same as in example to obtain a composition having an antioxidant function, and the composition was prepared into granules having an antioxidant function by the same preparation method as in example 1.
Comparative example 2
The rosemary extract in example 1 was replaced with an equal amount of lavender extract, and the other components were the same as in example to obtain a composition having an antioxidant function, and the composition was prepared into granules having an antioxidant function by the same preparation method as in example 1.
In order to better illustrate the characteristics of the composition having antioxidant function and the corresponding health food provided in the examples of the present invention, the granules prepared in examples 1, 3 and 5 and comparative examples 1 and 2 were subjected to clinical tests.
1. Animal experiments:
1.1 Experimental animals
SPF-grade female Kunming mice weigh 25 g-30 g and are provided by a laboratory of laboratory animal research institute of national institute of human Hospital of Sichuan province, Sichuan academy of medical sciences (license number: SCXK 2013-15). The animals were bred using a barrier-grade animal house (license number: Sichuan Experimental animal management Committee SYXK (Sichuan) 2013-. The feed is provided by Chengdou Shuo biological technology limited, drinking water is pure water, animals freely take food and drink water during the whole experiment, the temperature of an animal room is 20-21 ℃, and the relative humidity is 53-65%.
1.2 grouping
Experimental design model control group, three dose groups of example 1 (three dose groups are administered at 10 times, 20 times and 30 times of the recommended amount of human body (5 g/person/day)), 30 times dose groups of examples 3 and 5 and comparative examples 1 and 2, and each group contains 12 animals.
1.3 Experimental methods
Mice were used for experiments after adaptive feeding. 6.25g, 12.5g and 18.75g of the granule sample of example 1 and 18.75g of the granule sample of examples 3 and 5 and the granule sample of comparative examples 1 and 2 are weighed, respectively added with pure water to 150mL of suspension, and the mixture is orally gazed at 20mL/kg.bw every day, and the model control group mice are gazed with pure water. Continuous gavage for 30 days, after the last gavage, each group fasted for 16 hours (overnight), given 50% ethanol 12mL/kg. bw in one gavage, mice were sacrificed after 6 hours, and the tissue weights were accurately weighed, in terms of weight (g): volume (mL) ═ 1: 9, adding the mixture into 9 times volume of precooled physiological saline, homogenizing under the ice-water bath condition to prepare 10 percent tissue homogenate, centrifuging, and measuring the content of Malondialdehyde (MDA), the content of protein carbonyl, the content of reductive Glutathione (GSH) and the activity of superoxide dismutase (SOD).
1.4 results of the experiment
The effect of administration of the granules on the body weight of mice is shown in table 1, and the difference between the initial body weight, the intermediate body weight and the final body weight of mice between each dose group and the model control group is not statistically significant (P > 0.05). The test substances provided by the embodiment of the invention have no adverse effect on the growth and development of mice.
TABLE 1
Figure BDA0002353320260000071
Figure BDA0002353320260000081
The results of Malondialdehyde (MDA) content, protein carbonyl content, reduced Glutathione (GSH) content, and superoxide dismutase (SOD) activity measurements are shown in table 2.
TABLE 2
Figure BDA0002353320260000082
Note: comparison to model control (p < 005); comparison with model control group (p <0.01)
According to the data, the content of malondialdehyde in liver tissue of mice in the dose group is obviously lower than that in the model control group (P < 0.05); the protein carbonyl content of the liver tissue of mice in dose groups of 1.67g/kg.bw and 2.50g/kg.bw is obviously lower than that of a model control group (P <0.05, P < 0.01); the content of reduced glutathione in liver tissues of mice in a dose group of 2.50g/kg.bw is obviously higher than that in a model control group (P < 0.05). The granules provided by the embodiment of the invention have good antioxidant function. The health food (tablet or powder) provided in examples 2 and 4 of the present invention has the effect equivalent to the granule in examples 1, 3 and 5.
2. Human body test eating test
2.1 samples
The granules of the embodiment 1 of the invention are taken by a test group, the specification is 5 g/bag, and the recommended amount for human body is 1 time per day and 1 bag per time for each person (55-65 kg adult).
2.2 test subjects
According to the principle of informed volunteer, the following standard persons are selected as subjects to participate in human body eating trial.
Subject inclusion criteria: people who are 18-65 years old, have good physical health condition, have no obvious diseases of brain, heart, liver, lung, kidney and blood, have no long-term medicine taking history and are volunteered to ensure matching are selected.
Subject exclusion criteria: pregnant or lactating women who are allergic to health food; patients with serious diseases such as heart, liver, kidney and hematopoietic system; taking articles related to the tested function in a short time to influence the judgment of the result; if the test sample is not in compliance with the inclusion standard, the test sample is not eaten according to the regulation, and the efficacy or the data are not complete and the efficacy or the safety is not judged.
2.3 test methods
Randomly dividing the test group into a test group and a control group according to the MDA, SOD and GSH-Px levels of the subjects, and performing balance test by considering main factors influencing the results such as age, sex, diet and the like as much as possible so as to ensure comparability among the groups. Not less than 50 subjects per group. The test group takes the test sample daily according to the recommended taking method and dosage, and the control group adopts blank control. The subjects maintained their original lifestyle and eating habits during the test period. The sample is taken 1 time a day in 1 bag each time with warm water for 3 months. The control group was blank control, and the other conditions were the same as those of the test group. General condition observation (spirit, sleep, diet, stool and urine, blood pressure, heart rate and the like during trial), safety observation (blood, urine, stool and urine routine, liver and kidney functions and the like) and efficacy observation are carried out on the trial group and the control group.
2.4 efficacy index
The change and decrease percentage of lipid peroxide (MDA), the change and increase percentage of superoxide dismutase (SOD), and the change and increase percentage of glutathione peroxidase (GSH-Px) before and after the test.
The comparison between the indexes before and after the test and the comparison between the groups after the test have statistical significance, so that the positive index can be judged. The results of any two experiments of the lipid peroxide content, superoxide dismutase and glutathione peroxidase are positive, and the tested sample can be judged to have the function of antioxidation.
2.5 results
The balance comparison of the test food group and the control group is carried out, 119 cases of subjects are included, 3 cases of test food group loss and 2 cases of control group loss in the test process are removed, and the effective subjects are 114 cases, 15 cases of males and 99 cases of females. The results of comparing the MDA content, SOD, GSH-Px activity, age and sex of the test group with those of the control group before test feeding are shown in Table 3, and the difference is not significant (P is more than 0.05). Indicating that the test group and the control group have balanced comparability.
TABLE 3
Item Test food group (n ═ 56) Control group (n ═ 58)
Age (year) 59.39±4.48 57.67±5.20
Sex (male/female) 7/49 8/50
MDA(mmol/mL) 7.92±0.47 7.89±0.66
SOD(U/mL) 72.83±6.06 71.51±9.50
GSH-Px(U/mL) 136.23±19.00 142.02±30.66
Comparing the general conditions of the test group and the control group, inquiring and investigating the mental, sleep, diet and defecation conditions of the test person, carrying out statistics according to good, general and difference levels, and measuring the blood pressure and the heart rate, wherein no abnormality exists before and after the test. Abdomen B-ultrasound, electrocardiogram, chest X-ray, the test group and the control group were all in the normal range. The results are shown in table 4, most of the test subjects are in good general conditions, the mental states and the dietary conditions of the test groups are normal, and the differences of all indexes are not significant (P is more than 0.05) compared with the original conditions before and after the test of the two groups, which indicates that the test subjects have no adverse effect on the general conditions of the human body.
TABLE 4
Figure BDA0002353320260000101
The results of the tests on the blood routine, the urine routine, the stool routine and the blood biochemical indexes of the test group and the control group before and after the test are shown in table 5, the blood routine and the blood biochemical indexes of two groups of subjects are basically in a normal range, and the blood routine and the blood biochemical indexes of the two groups of subjects have no significant change (P is more than 0.05) before and after the test. The routine urine and routine stool are normal before and after the two groups of test meals.
TABLE 5
Figure BDA0002353320260000111
The results of the MDA content before and after the test are shown in the table 6, and the MDA content difference of the test group and the control group which are matched and compared with each other before and after the test has no inferiority (P is more than 0.05); compared with a control group, the difference of the MDA content of the test group before and after the test is not significant (P is more than 0.05).
TABLE 6
Grouping Before tasting After eating trial Increase value The rate of increase%
Test food group 7.92±0.47 7.92±0.44 -0.00±0.56 -0.30±7.12
Control group 7.89±0.66 7.77±0.61 0.12±0.49 1.27±6.13
As shown in table 7, the activity difference of GSH-Px by self-pairing comparison before and after the test feeding of the test feeding group is significant (P <0.001), and the activity difference after the test feeding is higher than that before the test feeding; the activity difference of GSH-Px is not significant by self-pairing comparison before and after the test feeding of a control group (P is more than 0.05); the difference of GSH-Px activity between the pre-test group and the control group is not significant (P is more than 0.05); after the test diet, the GSH-Px activity of the test diet group is obviously higher than that of a control group (P < 0.001).
TABLE 7
Grouping Before tasting After eating trial Increase value The rate of increase%
Test food group 136.23±19.00 163.98±19.98***### 27.75±23.91### 22.25±21.29###
Control group 142.02±30.66 143.09±28.58 1.07±14.55 1.49±10.04
Self-comparison p < 0.001; comparison between groups # # # P <0.001
As shown in table 8, the comparison of the SOD activity difference between the pre-test and the post-test of the test group by self-pairing is significant (P is less than 0.01), and the ratio after the test is higher than that before the test; the SOD activity difference of the control group is not significant by self pairing comparison before and after test eating (P is more than 0.05); compared with a control group, the SOD activity difference of the test group and the control group before the test feeding is not significant (P is more than 0.05); after the test feeding, the SOD activity of the test feeding group is obviously higher than that of the control group (P < 0.001).
TABLE 8
Grouping Before tasting After eating trial Increase value The rate of increase%
Test food group 72.83±6.06 75.47±6.02**### 2.64±6.60## 4.04±9.38#
Control group 71.51±9.50 70.69±6.50 -0.82±6.50 -0.35±8.65
Self-comparison P < 0.01; comparison between groups # P <0.05# # P <0.01# # P <0.001
From the above data, no allergic or other adverse reactions were observed after taking the granules provided in the examples of the present invention. Compared with the test group before and after the test, the average increase of GSH-Px (27.75 +/-23.91) U/mL (P <0.001) is 22.25 percent; the SOD average increased (2.64 +/-6.60) U/mL (P <0.01), and the increase percentage was 4.04%. After the test feeding, compared with the control group, the GSH-Px activity is increased (P <0.001) and the SOD activity is increased (P < 0.001). According to the judgment standard of the human body food trial test with the antioxidant function in the attachment 1 of the State food and drug administration (State food and drug administration [2012] 107), the result shows that the granules provided by the embodiment of the invention have the antioxidant function.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents or improvements made within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims (7)

1. The composition with the antioxidant function is characterized by comprising the following components in parts by weight: 10-30 parts of blueberry powder; 0.5-15 parts of green tea extract; 0.1-10 parts of saussurea involucrate culture; 5-25 parts of cherry powder; 0.1-10 parts of rosemary extract.
2. The composition with antioxidant function as claimed in claim 1, characterized by comprising the following components in parts by weight: 15-25 parts of blueberry powder; 1-10 parts of a green tea extract; 0.5-3 parts of saussurea involucrate culture; 10-20 parts of cherry powder; 0.5-7 parts of rosemary extract.
3. The composition with antioxidant function as claimed in claim 1, characterized by comprising the following components in parts by weight: 20 parts of blueberry powder; 3 parts of green tea extract; 1 part of saussurea involucrate culture; 14 parts of cherry powder; 2 parts of rosemary extract.
4. A health food having an antioxidant function, characterized by comprising the composition having an antioxidant function as claimed in any one of claims 1 to 3.
5. The health food having an antioxidant function as claimed in claim 4, wherein: the dosage form is granule, powder or tablet.
6. A granule having an antioxidant function, characterized by comprising the composition having an antioxidant function according to any one of claims 1 to 3, and further comprising 25 to 45 parts of maltodextrin; 15-35 parts of xylitol; 0.05-1 part of sucralose and 0.1-5 parts of citric acid.
7. The method for preparing granules having an antioxidant function according to claim 6, characterized by comprising the steps of:
mixing the composition with the maltodextrin, the xylitol, the sucralose and the citric acid, and preparing the granules according to a conventional method.
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103005260A (en) * 2012-12-21 2013-04-03 北京康比特体育科技股份有限公司 Antioxidant nutritional composition and manufacturing method thereof
CN103918966A (en) * 2013-01-15 2014-07-16 北京同仁堂健康药业股份有限公司 Composition containing Haematococcus pluvialis
CN104432037A (en) * 2014-11-24 2015-03-25 广州市香雪制药股份有限公司 Antioxidative health care nutrition composition, as well as preparation method and application thereof
CN105520149A (en) * 2015-12-04 2016-04-27 南京泛成生物化工有限公司 Natural antioxidation composition, as well as preparation method and application thereof
CN108741014A (en) * 2018-04-24 2018-11-06 北京中和鸿业医药科技有限公司 A kind of antioxidant composition, health food, preparation method and applications

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103005260A (en) * 2012-12-21 2013-04-03 北京康比特体育科技股份有限公司 Antioxidant nutritional composition and manufacturing method thereof
CN103918966A (en) * 2013-01-15 2014-07-16 北京同仁堂健康药业股份有限公司 Composition containing Haematococcus pluvialis
CN104432037A (en) * 2014-11-24 2015-03-25 广州市香雪制药股份有限公司 Antioxidative health care nutrition composition, as well as preparation method and application thereof
CN105520149A (en) * 2015-12-04 2016-04-27 南京泛成生物化工有限公司 Natural antioxidation composition, as well as preparation method and application thereof
CN108741014A (en) * 2018-04-24 2018-11-06 北京中和鸿业医药科技有限公司 A kind of antioxidant composition, health food, preparation method and applications

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Application publication date: 20210702