CN113056451A - 用于治疗与nlrp活性相关的病症的化合物和组合物 - Google Patents

用于治疗与nlrp活性相关的病症的化合物和组合物 Download PDF

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CN113056451A
CN113056451A CN201980074404.6A CN201980074404A CN113056451A CN 113056451 A CN113056451 A CN 113056451A CN 201980074404 A CN201980074404 A CN 201980074404A CN 113056451 A CN113056451 A CN 113056451A
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W·鲁什
S·文卡特拉曼
S·古什
沈东明
J·卡茨
H·M·塞德尔
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Novartis AG
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    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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CN201980074404.6A 2018-10-24 2019-10-23 用于治疗与nlrp活性相关的病症的化合物和组合物 Pending CN113056451A (zh)

Applications Claiming Priority (25)

Application Number Priority Date Filing Date Title
US201862749730P 2018-10-24 2018-10-24
US201862749712P 2018-10-24 2018-10-24
US201862749725P 2018-10-24 2018-10-24
US62/749,725 2018-10-24
US62/749,712 2018-10-24
US62/749,730 2018-10-24
US201862751301P 2018-10-26 2018-10-26
US201862751380P 2018-10-26 2018-10-26
US201862751386P 2018-10-26 2018-10-26
US62/751,380 2018-10-26
US62/751,301 2018-10-26
US62/751,386 2018-10-26
US201962801930P 2019-02-06 2019-02-06
US62/801,930 2019-02-06
US201962802637P 2019-02-07 2019-02-07
US201962802654P 2019-02-07 2019-02-07
US62/802,654 2019-02-07
US62/802,637 2019-02-07
US201962812794P 2019-03-01 2019-03-01
US201962812813P 2019-03-01 2019-03-01
US201962812517P 2019-03-01 2019-03-01
US62/812,794 2019-03-01
US62/812,813 2019-03-01
US62/812,517 2019-03-01
PCT/US2019/057682 WO2020086732A1 (en) 2018-10-24 2019-10-23 Compounds and compositions for treating conditions associated with nlrp activity

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US (1) US20230011652A1 (https=)
EP (1) EP3870565A1 (https=)
JP (1) JP2022505525A (https=)
CN (1) CN113056451A (https=)
WO (1) WO2020086732A1 (https=)

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WO2023116812A1 (zh) * 2021-12-22 2023-06-29 瑞石生物医药有限公司 一种磺酰脲类化合物
CN116804018A (zh) * 2022-03-25 2023-09-26 成都百裕制药股份有限公司 酰胺衍生物及其制备方法和在医药上的应用

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JP7595642B2 (ja) 2019-07-17 2024-12-06 ズーマゲン バイオサイエンシーズ エルティーディー Ｎｌｒｐ３モジュレーター
AU2020312800B2 (en) * 2019-07-17 2026-04-23 Zomagen Biosciences Ltd N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4,5,6,7-tetrahydrobenzofuran -2-sulfonamide derivatives and related compounds as NLPR3 modulators for the treatment of multiple sclerosis (ms)
KR20220154165A (ko) 2020-03-16 2022-11-21 조마젠 바이오사이언시즈 엘티디 Nlrp3 조절제
CN114516878B (zh) * 2020-11-20 2024-02-02 上海拓界生物医药科技有限公司 三环化合物及其医药用途
CN114539256B (zh) * 2020-11-20 2024-02-02 上海拓界生物医药科技有限公司 三环化合物及其医药用途
JP7825294B2 (ja) * 2021-02-10 2026-03-06 ハンジョウ イノゲート ファーマ カンパニー リミテッド Ｎｌｒｐ３阻害剤としての化合物
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