CN113045654A - 抗ox40抗体及其用途 - Google Patents

抗ox40抗体及其用途 Download PDF

Info

Publication number
CN113045654A
CN113045654A CN201911380303.XA CN201911380303A CN113045654A CN 113045654 A CN113045654 A CN 113045654A CN 201911380303 A CN201911380303 A CN 201911380303A CN 113045654 A CN113045654 A CN 113045654A
Authority
CN
China
Prior art keywords
antibody
cancer
seq
antigen
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201911380303.XA
Other languages
English (en)
Chinese (zh)
Inventor
张宏恺
晋瑞娜
王媛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nankai University
Original Assignee
Nankai University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nankai University filed Critical Nankai University
Priority to CN201911380303.XA priority Critical patent/CN113045654A/zh
Priority to PCT/CN2020/140259 priority patent/WO2021129874A1/fr
Priority to CN202080073615.0A priority patent/CN114630839A/zh
Priority to TW109146417A priority patent/TWI841816B/zh
Publication of CN113045654A publication Critical patent/CN113045654A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39566Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201911380303.XA 2019-12-27 2019-12-27 抗ox40抗体及其用途 Pending CN113045654A (zh)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201911380303.XA CN113045654A (zh) 2019-12-27 2019-12-27 抗ox40抗体及其用途
PCT/CN2020/140259 WO2021129874A1 (fr) 2019-12-27 2020-12-28 Anticorps anti-ox40 et son utilisation
CN202080073615.0A CN114630839A (zh) 2019-12-27 2020-12-28 抗ox40抗体及其用途
TW109146417A TWI841816B (zh) 2019-12-27 2020-12-28 抗ox40抗體及其用途

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201911380303.XA CN113045654A (zh) 2019-12-27 2019-12-27 抗ox40抗体及其用途

Publications (1)

Publication Number Publication Date
CN113045654A true CN113045654A (zh) 2021-06-29

Family

ID=76506637

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201911380303.XA Pending CN113045654A (zh) 2019-12-27 2019-12-27 抗ox40抗体及其用途
CN202080073615.0A Pending CN114630839A (zh) 2019-12-27 2020-12-28 抗ox40抗体及其用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202080073615.0A Pending CN114630839A (zh) 2019-12-27 2020-12-28 抗ox40抗体及其用途

Country Status (2)

Country Link
CN (2) CN113045654A (fr)
WO (1) WO2021129874A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114599680A (zh) * 2019-12-27 2022-06-07 高诚生物医药(香港)有限公司 抗ox40抗体及其用途

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114591988B (zh) * 2022-03-30 2023-01-13 北京贝来生物科技有限公司 一种激活肿瘤免疫的基因修饰干细胞制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018029124A1 (fr) * 2016-08-08 2018-02-15 F. Hoffmann-La Roche Ag Méthodes thérapeutiques et de diagnostic du cancer
CN108623686A (zh) * 2017-03-25 2018-10-09 信达生物制药(苏州)有限公司 抗ox40抗体及其用途
CN110078825A (zh) * 2019-01-23 2019-08-02 北京天广实生物技术股份有限公司 结合ox40的抗体及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101293917B (zh) * 2008-06-16 2010-12-01 南开大学 与pkr激酶结构域特异性结合的多肽及其应用
JP2019526623A (ja) * 2016-08-08 2019-09-19 ソレント・セラピューティクス・インコーポレイテッドSorrento Therapeutics, Inc. 抗ox40結合タンパク質
SG10201914126RA (en) * 2016-12-15 2020-02-27 Abbvie Biotherapeutics Inc Anti-ox40 antibodies and their uses
CN108623685B (zh) * 2017-03-25 2022-07-01 信达生物制药(苏州)有限公司 抗ox40抗体及其用途
US11142579B2 (en) * 2017-12-06 2021-10-12 Sorrento Therapeutics, Inc. Variant antibodies that bind OX40
AU2019264712A1 (en) * 2018-05-11 2021-01-07 Wuxi Biologics (Shanghai) Co., Ltd. Fully human antibodies against OX40, method for preparing same, and use thereof
CN110551216B (zh) * 2018-05-31 2022-11-18 信达生物制药(苏州)有限公司 多价抗ox40抗体及其用途
CN110003338B (zh) * 2019-04-16 2021-04-23 北京免疫方舟医药科技有限公司 抗ox40抗体及其应用
CN110004177A (zh) * 2019-04-22 2019-07-12 中国食品药品检定研究院 一种检测抗ox40抗体的方法及其应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018029124A1 (fr) * 2016-08-08 2018-02-15 F. Hoffmann-La Roche Ag Méthodes thérapeutiques et de diagnostic du cancer
CN108623686A (zh) * 2017-03-25 2018-10-09 信达生物制药(苏州)有限公司 抗ox40抗体及其用途
CN110078825A (zh) * 2019-01-23 2019-08-02 北京天广实生物技术股份有限公司 结合ox40的抗体及其用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WEIYI PENG等: "Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8+ T Cells and Synergizes with PI3Kβ Inhibition in PTEN Loss Melanoma", CLINICAL CANCER RESEARCH, vol. 25, no. 21, 1 August 2019 (2019-08-01), pages 6406 - 6416, XP055823827, DOI: 10.1158/1078-0432.CCR-19-1259 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114599680A (zh) * 2019-12-27 2022-06-07 高诚生物医药(香港)有限公司 抗ox40抗体及其用途
CN114599680B (zh) * 2019-12-27 2023-09-08 高诚生物医药(香港)有限公司 抗ox40抗体及其用途

Also Published As

Publication number Publication date
WO2021129874A1 (fr) 2021-07-01
TW202130661A (zh) 2021-08-16
CN114630839A (zh) 2022-06-14

Similar Documents

Publication Publication Date Title
JP7450592B2 (ja) 癌治療におけるfgfr2阻害剤単独または免疫刺激剤との組み合わせ
TWI824217B (zh) 抗ox40抗體及其用途
KR20210030957A (ko) 항-메소텔린 항체
WO2021129874A1 (fr) Anticorps anti-ox40 et son utilisation
JP7280387B2 (ja) 抗原結合タンパク質
TWI841816B (zh) 抗ox40抗體及其用途
TW202216194A (zh) 包含抗cd137抗體之組合療法
CN114555115A (zh) 用结合lgr5和egfr的抗体与拓扑异构酶i抑制剂的组合治疗癌症
CN113226369A (zh) 给药
WO2023275616A1 (fr) Anticorps monoclonal anti-ox40 et ses procédés d'utilisation
KR20230154315A (ko) 항체의 신규한 조합물 및 이의 용도
WO2021046293A1 (fr) Schéma posologique pour le traitement du cancer avec un anticorps agoniste anti-icos et du trémélimumab

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40053430

Country of ref document: HK

SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination