CN112986150A - Photoacoustic/ultrasonic imaging device and method based on eccentric wheel reciprocating scanning - Google Patents
Photoacoustic/ultrasonic imaging device and method based on eccentric wheel reciprocating scanning Download PDFInfo
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Abstract
The invention discloses a photoacoustic/ultrasonic imaging device and method based on eccentric wheel reciprocating scanning, wherein the device comprises a light source component, a mechanical scanning component, an optical fiber coupling component, a signal acquisition component and a computer, wherein the computer is electrically connected with the light source component and the signal acquisition component and is used for controlling the light source component to emit pulse laser and storing and processing data acquired by the signal acquisition component; the invention utilizes the eccentric wheel structure of the mechanical scanning component to convert the circular motion of the motor into the reciprocating motion of the transmission rod, wherein the transmission rod drives the integrated imaging probe to perform photoacoustic scanning imaging. The range of photoacoustic scanning can be adjusted by adjusting the eccentric distance of the eccentric wheel, and the speed of photoacoustic imaging can be adjusted by setting the rotating speed of the motor and setting the transmission ratio of the gear. The invention can realize the rapid and wide-range photoacoustic imaging.
Description
Technical Field
The invention belongs to the technical field of photoacoustic microscopic imaging, and particularly relates to a photoacoustic/ultrasonic imaging device and method based on eccentric wheel reciprocating scanning.
Background
The current main scanning modes of photoacoustic imaging are: linear scanning mode based on linear motor, linear scanning mode based on step motor, linear scanning mode based on ultrasonic motor, linear scanning mode based on voice coil motor, fast scanning mode based on vibrating mirror, and scanning mode based on micro electro mechanical system (MEMS mirror).
Based on linear scanning modes of a linear motor, a stepping motor and an ultrasonic motor, the motors need to undergo periodic processes of acceleration, deceleration, static to reverse acceleration, deceleration and static when the motors drive the sliding table to move repeatedly, so that the scanning speed of the motors cannot be kept in a fast moving state, and efficient fast scanning is difficult to realize. Although the photoacoustic imaging system based on the galvanometer and MEMS inertial-free scanning can perform rapid imaging, the scanning range is relatively small due to the limitation of the deflection angle. In addition, the existing galvanometer cannot be waterproof, so that the photoacoustic imaging system based on galvanometer scanning scans a focused light beam by using the galvanometer, and a generated photoacoustic signal is reflected to a flat-field ultrasonic transducer through a light-transmitting and sound-reflecting lens. Since the ultrasonic field of the flat field ultrasonic transducer is unfocused, the resolution of the system is completely determined by the spot size. When the system images a sample or deep tissue layer with large light scattering, the resolution of the system is severely reduced. Although the document reports that coaxial confocal of the light beam and the acoustic beam can be realized by placing the galvanometer in the non-conductive liquid and deflecting the light beam and the acoustic beam by using the galvanometer, the attenuation of the photoacoustic signal in the non-conductive liquid is increased, and the sensitivity of photoacoustic detection is reduced.
Patent No. CN 2012100591089 application discloses an integrated portable confocal photoacoustic microscopic imaging method and device. The invention adopts a microchip laser and a miniature X-Y two-dimensional galvanometer to integrate into a portable confocal photoacoustic microimaging device. The device and the method deflect the light beam through the two-dimensional galvanometer, and the deflected light beam realizes the photoacoustic scanning of the sample through a hollow ultrasonic transducer. Since the deflected light beam needs to pass through the hollow ultrasound transducer, the maximum imaging range of the device is limited by the size of the hollow aperture of the hollow ultrasound transducer. In addition, since the device only deflects the light beam, but the position of the ultrasonic transducer is not moved, it is difficult to ensure the uniformity of the intensity of the ultrasonic sound field in the area scanned by the light beam.
Patent application No. CN 201711122134.0 discloses a miniature optical resolution photoacoustic microscope based on a micro-electromechanical scanning galvanometer. The invention utilizes a micro-electromechanical scanning galvanometer to invent a set of photoacoustic microscope with small volume, light weight, larger scanning range and higher scanning precision. The system adopts a mode of deflecting light beams and fixing the ultrasonic transducer. Although the system can realize fast imaging, the ultrasonic transducer of the system is a flat-field ultrasonic transducer, so the imaging resolution of the system is completely determined by the size of a light spot, and when the system images a sample with large light scattering or a deep layer of tissue, the resolution of the system is reduced.
Disclosure of Invention
The invention mainly aims to overcome the defects of the prior art and provide a photoacoustic/ultrasonic imaging device and method based on eccentric wheel reciprocating scanning, which can perform photoacoustic imaging with high speed, large range and high resolution.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention provides a photoacoustic/ultrasonic imaging device based on eccentric wheel reciprocating scanning, which comprises a light source component, a mechanical scanning component, an optical fiber coupling component, a signal acquisition component and a computer, wherein the computer is electrically connected with the light source component and the signal acquisition component and is used for controlling the light source component to emit pulse laser and storing and processing data acquired by the signal acquisition component;
the mechanical scanning assembly comprises a servo motor, a motor control circuit, a speed change gear assembly, an eccentric wheel, a connecting rod, a horizontal transmission rod, a fixed base, a position sensor and a photoacoustic/ultrasonic integrated imaging probe, wherein the servo motor, the speed change gear assembly and the horizontal transmission rod are all arranged on the fixed base;
the speed change gear assembly comprises a driving wheel and a driven wheel, a rotating shaft of the servo motor is coaxially and rigidly connected with the driving wheel of the speed change gear assembly, the driving wheel of the speed change gear assembly drives the driven wheel to rotate, the driven wheel is coaxially and rigidly connected with the axis of an eccentric wheel, an outer edge rotating shaft of the eccentric wheel is connected with a connecting rod through a bearing, the other end of the connecting rod is connected with a horizontal transmission rod through a bearing, the other end of the horizontal transmission rod is rigidly connected with the photoacoustic/ultrasonic integrated imaging probe, and finally the uniform motion of the servo motor is converted into the rapid horizontal reciprocating motion of the;
the photoacoustic/ultrasonic integrated imaging probe comprises an optical fiber collimator, a focusing lens and a hollow focusing ultrasonic transducer which are coaxially connected in sequence, wherein a light focus and a sound focus are superposed; the hollow focusing ultrasonic transducer is electrically connected with the signal acquisition assembly.
Preferably, the light source assembly pulse laser and the pulse control circuit thereof are used for synchronizing the collection of light-emitting and photoacoustic signals of the laser; the wavelength of the pulse laser is 532nm, the repetition frequency is 100kHz, and the pulse width is 10 ns.
Preferably, the hollow focusing ultrasonic transducer is electrically connected with a signal acquisition assembly, and the signal acquisition assembly comprises a small signal amplifier and a data acquisition card.
Preferably, the pulse laser generates pulse laser with pulse width of 1ns-10ns, repetition frequency of 1kHz-100kHz and wavelength determined according to the imaging target.
Preferably, the optical fiber coupling component includes an optical fiber coupler and a single-mode optical fiber, one end of the single-mode optical fiber is connected to the optical fiber coupler, and the other end of the single-mode optical fiber is connected to the mechanical scanning component.
Preferably, the speed change gear assembly is used for amplifying and reducing the rotating speed generated by the servo motor, the reciprocating speed of the transmission rod is adjusted by adjusting the rotating speed of the motor and the gear transmission ratio, the eccentric distance of the eccentric wheel is adjustable, and the moving range of the transmission rod is adjusted by adjusting the eccentric distance of the eccentric wheel.
Preferably, the hollow focusing ultrasonic transducer is made of an annular PVDF membrane with the outer diameter of 7mm and the inner diameter of 3mm, the center frequency is 45MHz, the bandwidth is 100%, the focal length is 8mm, and the central hole is filled with an optical glass column.
Preferably, the rotating speed of the servo motor is set to be 20 revolutions per second;
the gear rotation speed ratio of the speed change gear assembly is 1: 2;
the eccentric distance of the eccentric wheel is 10mm, and the transmission distance of the corresponding horizontal transmission rod is 20 mm.
Preferably, the fixed base is fixed on a one-dimensional scanning platform to realize two-dimensional photoacoustic/ultrasonic scanning imaging, wherein the moving direction of the one-dimensional scanning platform is perpendicular to the moving direction of the photoacoustic/ultrasonic integrated imaging probe.
The invention also provides an imaging method of the photoacoustic/ultrasonic imaging device based on eccentric wheel reciprocating scanning, which comprises the following steps:
fixing a mechanical scanning assembly on a one-dimensional scanning platform, wherein the motion direction of the one-dimensional scanning platform is vertical to the scanning direction of the mechanical scanning assembly;
the lower end of a hollow focusing ultrasonic transducer of a photoacoustic/ultrasonic integrated imaging probe of the mechanical scanning assembly enters coupling liquid, and a coupling groove for containing the coupling liquid is arranged right above a sample;
the computer controls the pulse controller to control the pulse laser to generate pulse laser, the pulse laser beam is coupled into a single-mode fiber through a light coupler, the other end of the single-mode fiber is connected with the photoacoustic/ultrasonic integrated imaging probe, the pulse laser beam sequentially passes through the fiber collimator, the focusing lens and the hollow focusing ultrasonic transducer and then irradiates the surface of the sample, and the generated photoacoustic signal is received by the hollow focusing ultrasonic transducer right above the sample through coupling liquid to realize the acquisition of a one-dimensional A-line signal;
the computer controls the motor to rotate circumferentially at a constant speed through the motor control circuit, an eccentric wheel in the mechanical scanning assembly converts the circumferential motion into the motion of a horizontal transmission rod in the horizontal direction, and the horizontal transmission rod drives the photoacoustic/ultrasonic integrated imaging probe to move in the horizontal direction, so that the acquisition of two-dimensional photoacoustic signals, namely two-dimensional B-scan data, is realized;
the one-dimensional scanning platform drives the mechanical scanning assembly to move, the three-dimensional photoacoustic signals are acquired, and the acquired three-dimensional photoacoustic data are subjected to image reconstruction to obtain three-dimensional photoacoustic images.
Compared with the prior art, the invention has the following advantages and beneficial effects:
the invention uses the reciprocating motion of the eccentric wheel to drive the integrated imaging probe to perform photoacoustic imaging and has the following advantages:
1. the sensitivity of photoacoustic detection is high: because the scanning mode can carry out scanning on the sample by the optical/acoustic coaxial confocal integrated imaging probe, the high detection sensitivity can be achieved;
2. the scanning range is large and adjustable: the scanning range (from a few millimeters to a few tens of centimeters) can be adjusted by setting the eccentricity;
3. the scanning frequency is fast: the eccentric wheel is driven by a motor, and the driving motor performs unidirectional circular motion to realize continuous scanning without speed reduction. Therefore, rapid reciprocating scanning can be achieved. In addition, the frequency of photoacoustic scanning can be further increased by adding a transmission device with a large gear ratio between the driving motor and the eccentric wheel;
4. the cost is low: compared with other systems, the system based on the eccentric wheel transmission is simpler in structure and lower in cost.
Drawings
FIG. 1 is a schematic structural diagram of a photoacoustic/ultrasonic imaging device based on eccentric wheel reciprocating scanning according to the present invention;
FIG. 2 is a schematic structural diagram of a mechanical scanning assembly according to the present invention;
fig. 3 is a schematic structural diagram of the photoacoustic/ultrasound integrated imaging probe of the present invention.
The reference numbers illustrate:
the device comprises a computer 1, a pulse control circuit 2, a pulse laser 3, a pulse laser beam 4, an optical fiber coupler 5, a single-mode optical fiber 6, a mechanical scanning assembly 7, a focused light beam 8, a detected sample 9, an amplifier 10, a data acquisition circuit 11 and a motor control circuit 12, wherein the single-mode optical fiber is a single-mode optical fiber;
7-1 is a servo motor, 7-2 is a speed change gear assembly, 7-3 is an eccentric wheel, 7-4 is a connecting rod, 7-5 is a horizontal transmission rod, 7-6 is a fixed base, 7-7 is a position sensor, and 7-8 is a photoacoustic/ultrasonic integrated imaging probe;
7-8-1 is a fixed shell, 7-8-2 is an optical fiber collimator, 7-8-3 is a focusing lens, 7-8-4 is a hollow focusing ultrasonic transducer, 7-8-5 is a coaxial signal line, and 7-8-6 is a focused laser beam.
Detailed Description
In order to make the technical solutions better understood by those skilled in the art, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. It is to be understood that the embodiments described are only a few embodiments of the present application and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
As shown in fig. 1, the photoacoustic/ultrasonic imaging apparatus based on eccentric reciprocating scanning in this embodiment includes a computer 1, a pulse control circuit 2, a pulse laser 3, a fiber coupler 5, a single-mode fiber 6, a mechanical scanning assembly 7, a focused beam 8, an amplifier 10, a data acquisition circuit 11, and a motor control circuit 12; the computer 1 is communicated with a pulse control circuit 2 and a motor control circuit 12, the pulse control circuit 2 sends out a pulse signal to control a pulse laser 3 to generate pulse laser 4, the pulse laser 4 is coupled into a single-mode optical fiber 6 through a light coupler 5, the other end of the single-mode optical fiber 6 is connected to a mechanical scanning assembly 7, focused light focused by the mechanical scanning assembly 7 irradiates the surface of a detected sample 9, and a generated photoacoustic signal is amplified by an amplifier 10 and then collected by a data collecting circuit 11; the computer is electrically connected with the light source assembly and the signal acquisition assembly and controls the light source assembly to emit pulse laser and store and process data acquired by the signal acquisition assembly.
As shown in fig. 2, the structural schematic diagram of the mechanical scanning assembly is shown, the mechanical scanning assembly includes a servo motor 7-1, a motor control circuit, a speed change gear assembly 7-2, an eccentric wheel 7-3, a connecting rod 7-4, a horizontal transmission rod 7-5, a fixed base 7-6, a position sensor 7-7 and a photoacoustic/ultrasonic integrated imaging probe 7-8, the servo motor, the speed change gear assembly and the horizontal transmission rod are all arranged on the fixed base, the computer is connected with the motor control circuit, the computer controls the servo motor to move at a constant speed through the motor control circuit, and the position information of the transmission rod is recorded in real time by the position sensor. The speed change gear set is used for amplifying and reducing the rotating speed generated by the servo motor, the reciprocating speed of the transmission rod can be adjusted by adjusting the rotating speed of the motor and the gear transmission ratio, the eccentric distance of the eccentric wheel can be adjusted, and the moving range of the transmission rod can be adjusted by adjusting the eccentric distance of the eccentric wheel.
Further, in the embodiment, the motor control circuit 12 is configured to control the servo motor 7-1 to rotate at a constant speed, after the motor rotates, the variable speed gear assembly 7-2 drives the eccentric wheel 7-3 to rotate, the eccentric wheel 7-3 drives the horizontal transmission rod 7-5 to reciprocate in the horizontal direction through the connection rod 7-4, the photoacoustic/ultrasonic integrated imaging probe 7-8 is fixed at one end of the horizontal transmission rod 7-5, and the horizontal transmission rod 7-5 drives the photoacoustic/ultrasonic integrated imaging probe 7-8 to perform rapid photoacoustic scanning imaging.
Furthermore, the position information of the horizontal transmission rod 7-5 is recorded by a position sensor in real time, and the pulse control circuit 2 synchronizes the light output of the pulse laser 3 and the data acquisition circuit 11 to acquire photoacoustic signals according to the recorded position signals of the photoacoustic/ultrasonic integrated imaging probe 7-8.
In the embodiment, the frequency of the reciprocating scanning of the integrated imaging probe 7-8 can be adjusted by adjusting the gear transmission ratio of the speed change gear assembly 7-2; the reciprocating scanning range of the integrated imaging probe 7-8 can be adjusted by adjusting the eccentric distance of the eccentric wheel 7-3.
Furthermore, the speed change gear assembly 7-2 comprises a driving wheel and a driven wheel, wherein a rotating shaft of the servo motor is coaxially and rigidly connected with the driving wheel of the speed change gear assembly, the driving wheel of the speed change gear assembly drives the driven wheel to rotate, the driven wheel is coaxially and rigidly connected with an axis of the eccentric wheel, an outer edge rotating shaft of the eccentric wheel is connected with the connecting rod through a bearing, the other end of the connecting rod is connected with the horizontal transmission rod through a bearing, the other end of the horizontal transmission rod is rigidly connected with the photoacoustic/ultrasonic integrated imaging probe, and finally the uniform motion of the servo motor is converted into the rapid horizontal reciprocating motion of the photoacoustic/ultrasonic.
As shown in fig. 3, in this embodiment, the photoacoustic/ultrasound integrated imaging probe 7-8 includes a fiber collimator 7-8-2, a focusing lens 7-8-3, and a hollow focusing ultrasonic transducer 7-8-4, which are coaxially connected in sequence by a coaxial signal line 7-8-5, where the fiber collimator 7-8-2, the focusing lens 7-8-3, and the hollow focusing ultrasonic transducer 7-8-4 are disposed on a fixed housing 7-8-1, where the focal points of the optical focuses coincide, and the focused laser beam 7 and the acoustic beam 8-6 are emitted; the hollow focusing ultrasonic transducer is electrically connected with the signal acquisition assembly.
Furthermore, in this embodiment, the wavelength of the pulse laser is 532nm, the repetition frequency is 100kHz, the pulse width is 10ns, the pulse light is coupled into the single-mode fiber 6 through the fiber coupler 5, the light outlet of the single-mode fiber 6 is connected with the fiber collimator 7-8-2, the collimated pulse laser beam is focused into the focused light beam 8 through the focusing lens 7-8-3, and the focused light beam 8 is irradiated onto the surface of the detected sample through the hollow focusing ultrasonic transducer 7-8-4. Wherein, the optical fiber collimator 7-8-2, the focusing lens 7-8-3 and the hollow focusing ultrasonic transducer 7-8-4 are rigidly and coaxially connected through a fixed shell 7-8-1; the generated photoacoustic signal is collected by the data collecting circuit 11 through the amplifier 10, and the data is transmitted to a computer for image reconstruction and display.
Furthermore, the hollow focusing ultrasonic transducer is made of an annular PVDF membrane with the outer diameter of 7mm and the inner diameter of 3mm, the center frequency is 45MHz, the bandwidth is 100%, the focal length is 8mm, and the center hole is filled with an optical glass column.
Further, the amplifier 10 has 2 stages: the pre-amplifier and the main amplifier have the pre-amplification factor of 20dB and the post-amplifier has the amplification circuit of 30 dB.
Furthermore, the pulse control circuit is mainly used for collecting light-emitting and photoacoustic signals of a synchronous laser as a preferable technical scheme, the wavelength of the pulse laser is 532nm, the repetition frequency of the laser is 100kHz, and the pulse width is 10 ns.
In another embodiment of the present application, the rotation speed of the servo motor is set to 20 rpm; the gear speed ratio of the speed change gear set is 1: 2; the eccentric distance of the eccentric wheel is 10mm, and the transmission distance of the corresponding horizontal transmission rod is 20 mm; the data acquisition circuit is used for single-channel acquisition, the sampling rate is 200MPs, and the acquisition precision is 16 bits;
furthermore, the fixed base can be fixed on a one-dimensional scanning platform to realize 2-dimensional photoacoustic/ultrasonic scanning imaging, wherein the moving direction of the one-dimensional scanning platform is perpendicular to the moving direction of the photoacoustic/ultrasonic integrated imaging probe
In another embodiment of the present application, there is provided a photoacoustic/ultrasonic imaging apparatus method based on eccentric wheel reciprocating scan, including the steps of:
(1) fixing a mechanical scanning assembly on a one-dimensional scanning platform, wherein the motion direction of the one-dimensional scanning platform is vertical to the scanning direction of the mechanical scanning assembly;
(2) the depth of the lower end of a hollow focusing ultrasonic transducer of a photoacoustic/ultrasonic integrated imaging probe of the mechanical scanning assembly entering coupling liquid is about 5mm, a coupling groove for containing the coupling liquid is arranged right above a sample, as an optimal technical scheme, the coupling liquid is distilled water, and the coupling liquid is connected with the sample through a transparent PE preservative film;
(3) the computer controls the pulse controller to control the pulse laser to generate pulse laser, the pulse laser beam is coupled into a single-mode fiber through a light coupler, the other end of the single-mode fiber is connected with the photoacoustic/ultrasonic integrated imaging probe, the pulse laser beam sequentially passes through the fiber collimator, the focusing lens and the hollow focusing ultrasonic transducer and then irradiates the surface of the sample, and the generated photoacoustic signal is received by the hollow focusing ultrasonic transducer right above the sample through coupling liquid to realize the acquisition of a one-dimensional A-line signal;
(4) the computer controls the motor to rotate circumferentially at a constant speed through the motor control circuit, an eccentric wheel in the mechanical scanning assembly converts the circumferential motion into the motion of a horizontal transmission rod in the horizontal direction, and the horizontal transmission rod drives the photoacoustic/ultrasonic integrated imaging probe to move in the horizontal direction, so that the acquisition of two-dimensional photoacoustic signals, namely two-dimensional B-scan data, is realized;
(5) the one-dimensional scanning platform drives the mechanical scanning assembly to move, the three-dimensional photoacoustic signals are acquired, and the acquired three-dimensional photoacoustic data are subjected to image reconstruction to obtain three-dimensional photoacoustic images.
In this application, unless expressly stated or limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can include, for example, fixed connections, removable connections, or integral parts; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art as appropriate.
In this application, unless expressly stated or limited otherwise, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through intervening media. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.
In the description herein, reference to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the application. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples and features of different embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction.
Claims (10)
1. The photoacoustic/ultrasonic imaging device based on eccentric wheel reciprocating scanning is characterized by comprising a light source component, a mechanical scanning component, an optical fiber coupling component, a signal acquisition component and a computer, wherein the computer is electrically connected with the light source component and the signal acquisition component and is used for controlling the light source component to emit pulsed laser and storing and processing data acquired by the signal acquisition component;
the mechanical scanning assembly comprises a servo motor, a motor control circuit, a speed change gear assembly, an eccentric wheel, a connecting rod, a horizontal transmission rod, a fixed base, a position sensor and a photoacoustic/ultrasonic integrated imaging probe, wherein the servo motor, the speed change gear assembly and the horizontal transmission rod are all arranged on the fixed base;
the speed change gear assembly comprises a driving wheel and a driven wheel, a rotating shaft of the servo motor is coaxially and rigidly connected with the driving wheel of the speed change gear assembly, the driving wheel of the speed change gear assembly drives the driven wheel to rotate, the driven wheel is coaxially and rigidly connected with the axis of an eccentric wheel, an outer edge rotating shaft of the eccentric wheel is connected with a connecting rod through a bearing, the other end of the connecting rod is connected with a horizontal transmission rod through a bearing, the other end of the horizontal transmission rod is rigidly connected with the photoacoustic/ultrasonic integrated imaging probe, and finally the uniform motion of the servo motor is converted into the rapid horizontal reciprocating motion of the;
the photoacoustic/ultrasonic integrated imaging probe comprises an optical fiber collimator, a focusing lens and a hollow focusing ultrasonic transducer which are coaxially connected in sequence, wherein a light focus and a sound focus are superposed; the hollow focusing ultrasonic transducer is electrically connected with the signal acquisition assembly.
2. The photoacoustic/ultrasonic imaging device based on eccentric wheel reciprocating scanning of claim 1, wherein the light source assembly is a pulse laser and a pulse control circuit thereof, and the pulse control circuit is used for synchronizing the light emission of the laser and the collection of photoacoustic signals; the wavelength of the pulse laser is 532nm, the repetition frequency is 100kHz, and the pulse width is 10 ns.
3. The photoacoustic/ultrasound imaging apparatus based on eccentric reciprocating scanning according to claim 1, wherein the hollow focused ultrasound transducer is electrically connected to a signal acquisition module, and the signal acquisition module comprises a small signal amplifier and a data acquisition card.
4. The photoacoustic/ultrasonic imaging apparatus based on eccentric reciprocating scanning according to claim 1, wherein the pulsed laser generates pulsed laser with pulse width of 1ns-10ns, repetition frequency of 1kHz-100kHz, and wavelength determined according to the imaging target.
5. The photoacoustic/ultrasonic imaging apparatus based on eccentric reciprocating scanning according to claim 1, wherein the optical fiber coupling assembly comprises an optical fiber coupler and a single mode optical fiber, one end of the single mode optical fiber is connected with the optical fiber coupler, and the other end of the single mode optical fiber is connected with the mechanical scanning assembly.
6. The photoacoustic/ultrasonic imaging apparatus based on eccentric reciprocating scanning according to claim 1, wherein the speed change gear assembly is used to increase and decrease the rotation speed generated by the servo motor, the reciprocating speed of the transmission rod is adjusted by adjusting the rotation speed of the motor and the gear transmission ratio, the eccentric distance of the eccentric is adjustable, and the range of the transmission rod is adjusted by adjusting the eccentric distance of the eccentric.
7. The photoacoustic/ultrasonic imaging device based on eccentric reciprocating scanning of claim 1, wherein the hollow focused ultrasonic transducer is made of an annular PVDF film with 7mm outer diameter and 3mm inner diameter, the center frequency is 45MHz, the bandwidth is 100%, the focal length is 8mm, and the center hole is filled with an optical glass column.
8. The photoacoustic/ultrasonic imaging apparatus based on eccentric reciprocating scanning according to claim 1, wherein the rotation speed of the servo motor is set to 20 rpm;
the gear rotation speed ratio of the speed change gear assembly is 1: 2;
the eccentric distance of the eccentric wheel is 10mm, and the transmission distance of the corresponding horizontal transmission rod is 20 mm.
9. The photoacoustic/ultrasonic imaging apparatus based on eccentric reciprocating scanning according to claim 1, wherein the fixed base is fixed on a one-dimensional scanning platform to realize two-dimensional photoacoustic/ultrasonic scanning imaging, and the moving direction of the one-dimensional scanning platform is perpendicular to the moving direction of the photoacoustic/ultrasonic integrated imaging probe.
10. The imaging method of the photoacoustic/ultrasonic imaging apparatus based on eccentric reciprocating scanning according to any one of claims 1 to 9, comprising the following steps:
fixing a mechanical scanning assembly on a one-dimensional scanning platform, wherein the motion direction of the one-dimensional scanning platform is vertical to the scanning direction of the mechanical scanning assembly;
the lower end of a hollow focusing ultrasonic transducer of a photoacoustic/ultrasonic integrated imaging probe of the mechanical scanning assembly enters coupling liquid, and a coupling groove for containing the coupling liquid is arranged right above a sample;
the computer controls the pulse controller to control the pulse laser to generate pulse laser, the pulse laser beam is coupled into a single-mode fiber through a light coupler, the other end of the single-mode fiber is connected with the photoacoustic/ultrasonic integrated imaging probe, the pulse laser beam sequentially passes through the fiber collimator, the focusing lens and the hollow focusing ultrasonic transducer and then irradiates the surface of the sample, and the generated photoacoustic signal is received by the hollow focusing ultrasonic transducer right above the sample through coupling liquid to realize the acquisition of a one-dimensional A-line signal;
the computer controls the motor to rotate circumferentially at a constant speed through the motor control circuit, an eccentric wheel in the mechanical scanning assembly converts the circumferential motion into the motion of a horizontal transmission rod in the horizontal direction, and the horizontal transmission rod drives the photoacoustic/ultrasonic integrated imaging probe to move in the horizontal direction, so that the acquisition of two-dimensional photoacoustic signals, namely two-dimensional B-scan data, is realized;
the one-dimensional scanning platform drives the mechanical scanning assembly to move, the three-dimensional photoacoustic signals are acquired, and the acquired three-dimensional photoacoustic data are subjected to image reconstruction to obtain three-dimensional photoacoustic images.
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| CN106419839A (en) * | 2016-08-31 | 2017-02-22 | 华南师范大学 | Rapid opto-acoustic/ultrasonic sector-scanning imaging device with large view field and high resolution and method for same |
| CN107271554A (en) * | 2017-07-28 | 2017-10-20 | 上海和伍精密仪器股份有限公司 | A kind of Non-Destructive Testing synchronous scanning devices, systems, and methods |
| CN107713993A (en) * | 2017-11-14 | 2018-02-23 | 电子科技大学 | A kind of optoacoustic endoscopy microscopic imaging device and its imaging method based on MEMS micromirror |
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