CN107713993A - A kind of optoacoustic endoscopy microscopic imaging device and its imaging method based on MEMS micromirror - Google Patents
A kind of optoacoustic endoscopy microscopic imaging device and its imaging method based on MEMS micromirror Download PDFInfo
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- CN107713993A CN107713993A CN201711122120.9A CN201711122120A CN107713993A CN 107713993 A CN107713993 A CN 107713993A CN 201711122120 A CN201711122120 A CN 201711122120A CN 107713993 A CN107713993 A CN 107713993A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00172—Optical arrangements with means for scanning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00188—Optical arrangements with focusing or zooming features
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4483—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
Abstract
A kind of optoacoustic endoscopy microscopic imaging device and its imaging method based on MEMS micromirror, belong to opto-acoustic microscopic imaging technical field.Including laser light source module, Single-Mode Fiber Coupling component, endoscope probe component, MEMS micromirror component, data acquisition components and computer, MEMS micromirror component includes MEMS micromirror and PCB drive circuit boards, and PCB drive circuit boards are controlled for driving MEMS micromirror to rotate by computer；Endoscope probe component includes the anti-sound support of printing opacity, and the anti-sound support light-emitting window of printing opacity sets target sample；Computer control laser light source module produces pulse laser, the center of MEMS micromirror is reached after Single-Mode Fiber Coupling component collimation and reflexes to the light inlet of the anti-sound support of printing opacity, photoacoustic signal is produced through the anti-sound support of printing opacity and with the target sample reaction of light-emitting window, photoacoustic signal is gathered by data acquisition components after the anti-sound support of printing opacity and stored by computer and handled.The present invention can realize that more precisely and faster 2D is scanned, and improves image quality.
Description
Technical field
The invention belongs to opto-acoustic microscopic imaging technical field, more particularly to a kind of optoacoustic endoscopy based on MEMS micromirror is micro-
Imaging device and its imaging method.
Background technology
In recent years, optoacoustic endoscopy imaging combines as a kind of Novel noninvasive biomedical imaging method quickly grown
The advantages of high-contrast and ultrasonic imaging strong penetrating power of optical imagery, it is possible to provide high-contrast, high-resolution under the conditions of lossless
Structure and functional imaging, be successfully applied to the fields such as biomedical and clinical diagnosis.
In existing optoacoustic endoscopy imaging technology, in order to obtain high-resolution target object photoacoustic image, main flow
Method is all based on going mechanically to scan whole ultrasonic transducer using micromachine.In this case, if without extra
Motor drag pry head in whole always along target sample, it can only obtain a two-dimentional image, while this scanning
Requirement of the mode to micromachine is higher, and image taking speed is slower, expensive.In addition, during mechanical scanning, micro machine is rotating
During, cross-talk noise can be introduced, and mechanical shaking caused by the acceleration of motor and moderating process and motion can influence
The photoacoustic image quality arrived.
The content of the invention
In consideration of it, being in place of solving above-mentioned the deficiencies in the prior art, present invention offer one kind is high-resolution to be based on MEMS
The optoacoustic endoscopy microscopic imaging device and its imaging method of micro mirror, mechanical movement that both need not be physically, while and can meet
Requirement of the Photoacoustic endoscope to signal to noise ratio, and whole device is simple and compact for structure, cheap, easily operated and application.
The technical scheme is that：
A kind of optoacoustic endoscopy microscopic imaging device based on MEMS micromirror, including laser light source module, Single-Mode Fiber Coupling
Component, endoscope probe component, MEMS micromirror component, data acquisition components and computer 6,
The MEMS micromirror component includes MEMS micromirror 4-1 and PCB drive circuit board 4-2, the PCB drive circuit boards 4-
2 are controlled by the computer 6, for driving the MEMS micromirror 4-1 to rotate；
The endoscope probe component includes printing opacity anti-sound support 3-2, the anti-sound support 3-2 of printing opacity to be internal full of saturating
The closed cavity of bright ultrasonic coupling liquid, including light inlet 3-4 and light-emitting window 3-3, target sample are arranged at the light-emitting window
3-3, the anti-sound support 3-2 of printing opacity are internally provided with the thin slice of the anti-sound of printing opacity；
The computer 6 is electrically connected with the laser light source module and data acquisition components respectively, described for controlling
Laser light source module produces the data of pulse laser and storage and the processing data acquisition components collection；
Described in pulse laser caused by the laser light source module reaches after Single-Mode Fiber Coupling component collimation
MEMS micromirror 4-1 center and the light inlet 3-4 for reflexing to the anti-sound support 3-2 of the printing opacity, through the anti-sound support of the printing opacity
Photoacoustic signal is inspired in 3-2 and the target sample being irradiated at the light-emitting window 3-3, the photoacoustic signal is anti-through the printing opacity
Gathered after the thin slice reflection of the anti-sound of printing opacity in sound support 3-2 by the data acquisition components.
Specifically, the laser light source module includes pulse laser 1, the pulse laser 1 sends high repetition frequency
And pulsewidth is in 1ns to the pulse laser between 2ns.
Specifically, the Single-Mode Fiber Coupling component includes filtering with the spatial light of the 1 coaxial setting of pulse laser
Device 2-1, collimation lens 2-2, object lens 2-3 and single-mode optical-fibre coupler 2-4, the optical fiber of setting coaxial with the MEMS micromirror 4-1
Ceramic head 2-6 and gradient type lens 2-7, and one end are connected with the single-mode optical-fibre coupler 2-4, and the other end passes through the light
The single-mode fiber 2-5 that fine ceramic head 2-6 is connected with the gradient type lens 2-7；The pulse laser that the pulse laser 1 is sent
Enter the single-mode optical-fibre coupler 2-4 after passing sequentially through the space optical filter 2-1, collimation lens 2-2 and object lens 2-3,
Enter the single-mode fiber 2-5 after single-mode optical-fibre coupler 2-4 couplings, the pulse of the single-mode fiber 2-5 outputs swashs
Light is irradiated to the center of the MEMS micromirror 4-1 after gradient type lens 2-7 focusing.
Specifically, the data acquisition components include ultrasonic transducer 5-1, signal amplifier 5-2 and data collecting card 5-
3, the ultrasonic transducer 5-1 are arranged on the anti-sound support 3-2 of the printing opacity and pass through its cavity wall and the ultrasonic coupling
Liquid contacts, and the ultrasonic transducer 5-1 and anti-sound support 3-2 of printing opacity junction is provided with sealing ring, ensures the ultrasonic coupling
Liquid is closed not leak；Photoacoustic signal quilt after the ultrasonic transducer 5-1 is detected and is amplified by the signal amplifier 5-2
The data collecting card 5-3 collections.
Specifically, the anti-sound support 3-3 of printing opacity is rectangular cavities, the thin slice of the anti-sound of printing opacity respectively with the light extraction
Side wall where mouth 3-3 and the side wall angle at 45 ° where the ultrasonic transducer 5-1 so that set at the light-emitting window 3-3
Target sample caused by photoacoustic signal through the anti-sound of the printing opacity thin slice reflection after can be detected by the ultrasonic transducer 5-1.
Specifically, the optoacoustic endoscopy microscopic imaging device also includes rigid base 3-1, the optical fiber ceramic head 2-6, ladder
Degree type lens 2-7 and the anti-sound support 3-2 of printing opacity are fixed on the rigid base 3-1 by glue.
A kind of optoacoustic endoscopy micro imaging method based on MEMS micromirror, comprises the following steps：
Step 1: photo-acoustic excitation
Pulse laser is produced using pulse laser, is focused on after the pulse laser is collimated in the MEMS micromirror
The heart is simultaneously got to by the anti-sound support of printing opacity photoacoustic signal is inspired in target sample along after 90 ° of reflections；The anti-sound support of printing opacity
For enclosed cavity, inside is full of ultrasonic coupling liquid, the thin slice of the anti-sound of printing opacity is additionally provided with the anti-sound support of printing opacity；
Step 2: optoacoustic gathers
Using the ultrasonic transducer photoacoustic signal that sends of detection target sample by the anti-sound support of the printing opacity and described
The signal after thin slice reflection in the anti-sound support of printing opacity, the signal that the ultrasonic transducer is detected are stored after amplification and arrived
In computer；
Step 3: interior peep inner scanning
After completing step 2 every time, control the MEMS micromirror to deflect an angle by computer and repeat step 2,
Scanning until completing whole target sample；
Step 4: image reconstruction and display
All photoacoustic signals obtained using computer disposal step 2 and step 3, so as to obtain the optoacoustic of target sample
Image.
Beneficial effects of the present invention are：Optoacoustic endoscopy microscopic imaging device provided by the invention based on MEMS micromirror and its
Imaging method, very high resolution ratio can be reached, compared to the existing based endoscopic imaging device based on electromechanics scanning, MEMS
Micro mirror scanning can realize that precision is higher and the faster 2D scannings of speed, so as to the time required to greatly shortening experiment；And can
To be completely free of in experimentation the image quality for because of the external noise that motor rotates and introduces, improving experimental result；This hair
It is bright compact-sized, it is cheap, it is easily operated.
Brief description of the drawings
In order to illustrate the technical solution of the embodiments of the present invention more clearly, required use in being described below to embodiment
Accompanying drawing be briefly described.
Fig. 1 is the structural representation of the optoacoustic endoscopy microscopic imaging device provided by the invention based on MEMS micromirror.
Wherein reference is described as follows：Pulse laser 1, space optical filter 2-1, collimation lens 2-2, thing
Mirror 2-3, single-mode optical-fibre coupler 2-4, single-mode fiber 2-5, optical fiber ceramic head 2-6, gradient type lens 2-7, rigid base 3-1,
Printing opacity anti-sound support 3-2, MEMS micromirror 4-1, PCB drive circuit board 4-2, ultrasonic transducer 5-1, signal amplifier 5-2, data
Capture card 5-3, computer 6.
Fig. 2 is to apply optoacoustic endoscopy microscopic imaging device and its imaging method pair provided by the invention based on MEMS micromirror
Analog sample carbon fiber wire carries out the photoacoustic image that photoacoustic imaging obtains.
Fig. 3 is to apply optoacoustic endoscopy microscopic imaging device and its imaging method pair provided by the invention based on MEMS micromirror
Mouse rectum carries out the photoacoustic image that photoacoustic imaging obtains.
Embodiment
The invention will be further described with reference to the accompanying drawings and examples.
Fig. 1 be the optoacoustic endoscopy microscopic imaging device provided by the invention based on MEMS micromirror structure chart, the device bag
Include laser light source module, Single-Mode Fiber Coupling component, endoscope probe component, MEMS micromirror component, data acquisition components and meter
Calculation machine.
In some embodiments, laser light source module is made up of high repeat frequency pulsed laser device 1, and electric with computer 6
Connection.
In some embodiments, Single-Mode Fiber Coupling component includes space optical filter 2-1, collimation lens 2-2, object lens 2-3,
Single-mode optical-fibre coupler 2-4, single-mode fiber 2-5, optical fiber ceramic head 2-6 and gradient type lens 2-7, space optical filter 2-1 are accurate
Straight lens 2-2, object lens 2-3, single-mode optical-fibre coupler 2-4 installation composition coaxial with pulse laser 1, and pass through single-mode optics successively
Fine 2-5 and optical fiber ceramic head 2-6 is connected with gradient type lens 2-7.Wherein, optical fiber ceramic head 2-6 external diameters are 1.25mm, for protecting
Protect single-mode fiber 2-5.Gradient type lens 2-7 external diameters are 0.7mm, operating distance 10mm；MEMS micromirror 4-1 and optical fiber ceramic head
2-6, the coaxial placements of gradient type lens 2-7, make the laser beam through gradient type lens 2-7 outgoing along 90 ° of reflections, wherein, MEMS is micro-
Mirror 4-1 minute surfaces size is 1mm, and mechanical corner is up to 5 °
Data acquisition components include ultrasonic transducer 5-1, signal amplifier 5-2 and data collecting card 5- in some embodiments
3, data collecting card 5-3 is electrically connected with computer 6；Ultrasonic transducer 5-1 and the anti-sound support 3-1 of printing opacity are fixed on rigid base
On 3-2, transparent ultrasonic coupling liquid is full of inside reflective support 3-2, and the thin slice of the anti-sound of printing opacity is installed；Ultrasonic transducer
5-1 is by the photoacoustic signal detected by being transferred to computer 6 by data collecting card 5-3 after signal amplifier 5-2 amplifications.
Wherein high repeat frequency pulsed laser device 1 can produce wavelength from the FDSS-Q3-532 lasers of CryLas companies
532nm, pulse width<2ns, highest repetition 2500Hz laser pulse, and send synchronous arteries and veins while pulse laser is exported
Rush signal；The energy of pulse laser enters endoscope by Single-Mode Fiber Coupling component, and after being focused on by gradient type lens 2-7,
Target sample surface is reflexed to through MEMS micromirror 4-1, produces photoacoustic signal；After photoacoustic signal produces, by ultrasonic transducer 5-1
Detected, data collecting card 5-3 is transferred to after amplifier 5-2 amplifications, and in the triggering of pulse laser lock-out pulse
It is lower by data record and to be saved in computer 6, complete the signal acquisition to a scanning element.
That MEMS micromirror 4-1 is selected is WIO WM-S3.1, under the control of computer 6, focuses on laser beam along imaging
Raster scanning is done in region, and excites photoacoustic signal at each scanning element on scanning track, and ultrasonic transducer 5-1 is detected
Photoacoustic signal by data collecting card 5-3 recorded and be transferred in computer 6 by computer after signal amplifier 5-2 amplifications
Preserve, computer 6 is handled photoacoustic signal data by data processing software and obtains the image of target object.
The method for obtaining target sample photoacoustic image using the above-mentioned optoacoustic endoscopy microscopic imaging device based on MEMS micromirror
Comprise the following steps：
1st, photo-acoustic excitation：Pulse laser sends pulse laser through space optical filter 2-1, collimation lens 2-2 and object lens
After 2-3, single-mode fiber 2-5 is coupled into by single-mode optical-fibre coupler 2-4, the pulsed light exported from single-mode fiber 2-5 is through ladder
By MEMS micromirror 4-1 center after degree type lens 2-7 focusing, and to pass through the anti-sound support 3-1 of printing opacity after 90 ° of angle reflection
Get to and photoacoustic signal is inspired in target sample.
2nd, optoacoustic gathers：The photoacoustic signal sent in target sample, by ultrasonic transducer institute after the anti-sound support 3-1 of printing opacity
Detection, gathered after then amplifying through signal amplifier 5-2 by data collecting card 5-3, be then stored in computer 6 and wait number
According to processing.
3rd, it is interior to peep inner scanning：Gather in target sample after the photoacoustic signal of some position, computer 6 controls MEMS
Micro mirror 4-1 deflects an angle, in MEMS micromirror 4-1 deflections, excites optical focus same relative to the position of target sample
When deflect, to the next position carry out photoacoustic signal collection, until complete target sample scanning.
4th, image reconstruction and display：The photoacoustic signal on computer 6 is recorded in after data software is handled, obtains target
The photoacoustic image of sample.
It is to apply optoacoustic endoscopy microscopic imaging device and its imaging method provided by the invention based on MEMS micromirror below
Two specific embodiments.
The application apparatus of the present invention of embodiment 1 and method are imaged to being embedded in the carbon fiber wire inside agar
It is imaged using the device of embodiment 1 to being embedded in the carbon fiber wire inside agar, wherein pulse laser exports
Wavelength be 532nm, pulsewidth 2ns, repetition rate 2000Hz, MEMS micromirror 4-1 carries out raster scanning, scanning along imaging region
Scope is 400X400 μm2, scanning step is 1 μm, gathers 400 groups of signals altogether, obtains image as shown in Figure 2, can be with by image
Find out, what the carbon fiber wire in agar can be apparent from is observed, and illustrates the device of the present invention and can obtain to imaging region
Interior target object is clearly imaged.
The device and method of the application present invention of embodiment 2 is imaged to mouse rectum vein
Isolated mouse rectum vein is imaged using the device of embodiment 1, wherein the wavelength of pulse laser output
It is scanned, scans along the diameter of imaging region for 532nm, pulsewidth 2ns, repetition rate 2500Hz, two-dimensional scanning mirrors system
Scope is 400X400um2, scanning step is 1 μm, gathers 400 groups of signals altogether, obtains image as shown in Figure 3, can be with by image
Find out, the capillary in mouse rectum is clearly showed, and illustrates that the device of the present invention can be with very high resolution ratio
Target object is imaged.
One of ordinary skill in the art can make various do not depart from originally according to these technical inspirations disclosed by the invention
The other various specific deformations and combination, these deformations and combination of invention essence are still within the scope of the present invention.
Claims (7)
1. a kind of optoacoustic endoscopy microscopic imaging device based on MEMS micromirror, it is characterised in that including laser light source module, single mode
Fiber coupling component, endoscope probe component, MEMS micromirror component, data acquisition components and computer (6),
The MEMS micromirror component includes MEMS micromirror (4-1) and PCB drive circuit boards (4-2), the PCB drive circuit boards
(4-2) is controlled by the computer (6), for driving the MEMS micromirror (4-1) to rotate；
The endoscope probe component includes the anti-sound support (3-2) of printing opacity, and the anti-sound support (3-2) of printing opacity is to be internal full of saturating
The closed cavity of bright ultrasonic coupling liquid, including light inlet (3-4) and light-emitting window (3-3), target sample are arranged on the light extraction
At mouthful (3-3), the anti-sound support (3-2) of printing opacity is internally provided with the thin slice of the anti-sound of printing opacity；
The computer (6) is electrically connected with the laser light source module and data acquisition components respectively, described sharp for controlling
Radiant component produces the data of pulse laser and storage and the processing data acquisition components collection；
It is micro- that pulse laser caused by the laser light source module reaches the MEMS after Single-Mode Fiber Coupling component collimation
The center of mirror (4-1) and the light inlet (3-4) for reflexing to the anti-sound support (3-2) of the printing opacity, through the anti-sound support of the printing opacity
(3-2) and it is irradiated in the target sample at the light-emitting window (3-3) place and inspires photoacoustic signal, the photoacoustic signal is through described
Gathered after the thin slice reflection of the anti-sound of printing opacity in the anti-sound support (3-2) of light by the data acquisition components.
2. the optoacoustic endoscopy microscopic imaging device according to claim 1 based on MEMS micromirror, it is characterised in that described to swash
Radiant component includes pulse laser (1), the pulse laser (1) send high repetition frequency and pulsewidth 1ns to 2ns it
Between pulse laser.
3. the optoacoustic endoscopy microscopic imaging device according to claim 2 based on MEMS micromirror, it is characterised in that the list
Mode fiber coupling assembly includes space optical filter (2-1), the collimation lens (2- of setting coaxial with the pulse laser (1)
2), object lens (2-3) and single-mode optical-fibre coupler (2-4), the optical fiber ceramic head (2- of setting coaxial with the MEMS micromirror (4-1)
6) it is connected with gradient type lens (2-7), and one end with the single-mode optical-fibre coupler (2-4), the other end passes through the optical fiber
The single-mode fiber (2-5) that ceramic head (2-6) is connected with the gradient type lens (2-7)；The arteries and veins that the pulse laser (1) sends
Impulse light passes sequentially through the space optical filter (2-1), collimation lens (2-2) and object lens (2-3) and enters the single-mode optics afterwards
Fine coupler (2-4), enter the single-mode fiber (2-5), the single-mode optics after the single-mode optical-fibre coupler (2-4) coupling
The pulse laser of fine (2-5) output is irradiated in the MEMS micromirror (4-1) after the gradient type lens (2-7) focus on
The heart.
4. the optoacoustic endoscopy microscopic imaging device according to claim 1 based on MEMS micromirror, it is characterised in that the number
Include ultrasonic transducer (5-1), signal amplifier (5-2) and data collecting card (5-3), the ultrasonic transducer according to acquisition component
(5-1) is arranged on the anti-sound support (3-2) of the printing opacity and contacted through its cavity wall with the ultrasonic coupling liquid, described super
Sonic transducer (5-1) and the junction of the anti-sound support (3-2) of printing opacity are provided with sealing ring, ensure that the ultrasonic coupling liquid is not let out
Leakage；The photoacoustic signal is described after the ultrasonic transducer (5-1) detects and is amplified by the signal amplifier (5-2)
Data collecting card (5-3) gathers.
5. the optoacoustic endoscopy microscopic imaging device according to claim 4 based on MEMS micromirror, it is characterised in that described
The anti-sound support (3-3) of light is rectangular cavities, the thin slice of the anti-sound of printing opacity respectively with the side wall where the light-emitting window (3-3) and
Side wall angle at 45 ° where the ultrasonic transducer (5-1) so that the target sample production set from the light-emitting window (3-3)
Raw photoacoustic signal can be detected after the thin slice reflection of the anti-sound of the printing opacity by the ultrasonic transducer (5-1).
6. the optoacoustic endoscopy microscopic imaging device based on MEMS micromirror according to claim 3 or 4, it is characterised in that institute
Stating optoacoustic endoscopy microscopic imaging device also includes rigid base (3-1), the optical fiber ceramic head (2-6), gradient type lens (2-7)
Sound support (3-2) anti-with printing opacity is fixed on the rigid base (3-1) by glue.
7. a kind of optoacoustic endoscopy micro imaging method based on MEMS micromirror, it is characterised in that comprise the following steps：
Step 1: photo-acoustic excitation
Pulse laser is produced using pulse laser, the center of the MEMS micromirror is focused on simultaneously after the pulse laser is collimated
Got to along after 90 ° of reflections by the anti-sound support of printing opacity and photoacoustic signal is inspired in target sample；The anti-sound support of printing opacity is envelope
The cavity of enclosed, inside are full of ultrasonic coupling liquid, the thin slice of the anti-sound of printing opacity are additionally provided with the anti-sound support of printing opacity；
Step 2: optoacoustic gathers
The photoacoustic signal sent using ultrasonic transducer detection target sample is by the anti-sound support of the printing opacity and by the printing opacity
The signal after thin slice reflection in anti-sound support, the signal that the ultrasonic transducer is detected are stored after amplification to calculating
In machine；
Step 3: interior peep inner scanning
After completing step 2 every time, control the MEMS micromirror to deflect an angle by computer and repeat step 2, until
Complete the scanning of whole target sample；
Step 4: image reconstruction and display
All photoacoustic signals obtained using computer disposal step 2 and step 3, so as to obtain the optoacoustic figure of target sample
Picture.
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| CN109077698A (en) * | 2018-06-29 | 2018-12-25 | 华南师范大学 | A kind of reversible preposition scanning optoacoustic microlaparoscopy |
| CN110584615A (en) * | 2019-10-15 | 2019-12-20 | 南方科技大学 | Bimodal endoscopic imaging system |
| CN111134591A (en) * | 2019-12-27 | 2020-05-12 | 华南师范大学 | Photoacoustic microscopic imaging pen and imaging method |
| CN112986150A (en) * | 2021-01-28 | 2021-06-18 | 华南师范大学 | Photoacoustic/ultrasonic imaging device and method based on eccentric wheel reciprocating scanning |
| CN114010151A (en) * | 2021-09-16 | 2022-02-08 | 南方科技大学 | Photoacoustic ultrasonic multi-mode imaging system |
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