CN203943651U - A kind of biological tissue optoacoustic confocal microscopic image device - Google Patents
A kind of biological tissue optoacoustic confocal microscopic image device Download PDFInfo
- Publication number
- CN203943651U CN203943651U CN201420254726.3U CN201420254726U CN203943651U CN 203943651 U CN203943651 U CN 203943651U CN 201420254726 U CN201420254726 U CN 201420254726U CN 203943651 U CN203943651 U CN 203943651U
- Authority
- CN
- China
- Prior art keywords
- imaging
- biological tissue
- imaging device
- pickup assembly
- signal pickup
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000003384 imaging method Methods 0.000 claims abstract description 42
- 230000003287 optical effect Effects 0.000 claims description 22
- 206010028980 Neoplasm Diseases 0.000 abstract description 5
- 210000003462 vein Anatomy 0.000 abstract description 4
- 210000001557 animal structure Anatomy 0.000 abstract description 3
- 238000002059 diagnostic imaging Methods 0.000 abstract description 3
- 210000001519 tissue Anatomy 0.000 description 12
- 238000010586 diagram Methods 0.000 description 7
- 239000000523 sample Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 206010033675 panniculitis Diseases 0.000 description 2
- 210000004304 subcutaneous tissue Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000931526 Acer campestre Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
Landscapes
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
Abstract
This utility model relates to a kind of biological tissue optoacoustic confocal microscopic image device, belong to medical imaging field, mainly be made up of imaging device, signal pickup assembly and control device, imaging device is all connected control device with signal pickup assembly, and imaging device connects signal pickup assembly.This utility model is simple and reasonable obtains clear 3-D view by improving detectivity and signal noise ratio (snr) of image, solve biological tissue as problems that opto-acoustic microscopic imaging resolution is low in out of focus situation, contrast is low such as veins beneath the skin, tumor, animal organs, be suitable for applying.
Description
Technical field
This utility model belongs to medical imaging field, particularly a kind of optoacoustic confocal microscopic image device that can carry out to veins beneath the skin, tumor, animal organ etc. three-dimensional blur-free imaging.
Background technology
Photoacoustic imaging technology is a development in recent years novel Medical Imaging Technology rapidly, is to adopt the method for " optical excitation acoustic detection image reconstruction " to carry out imaging.Its sharp product carries out imaging with the endogenic optical absorption characteristic of sample, therefore can obtain structural images and the function image of tissue sample, also can obtain the distributed in three dimensions of optical energy deposition simultaneously.As a kind of non-invasive imaging technique, photoacoustic imaging had both possessed the high-resolution of optical image technology, the characteristic of high-contrast, meanwhile, had also possessed the high feature of penetration depth of learning imaging technique.
Existing optical image technology has the feature of high spatial resolution as the means such as fluorescence microscope, optical tomography, but cannot carry out the imaging in biological tissues of the degree of depth.Photoacoustic imaging, by the photon of incident biological tissue is converted into sound wave, keeps high-resolution and the high-penetration degree of depth simultaneously.The image resolution rate variance of existing photoacoustic imaging technology, contrast are low, and this utility model can greatly improve photoacoustic signal receiving efficiency and picture contrast by the method that the focus point of probe microphone and optical focal length point are combined.
Summary of the invention
Goal of the invention
For solving biological tissue as problems that opto-acoustic microscopic imaging resolution is low in out of focus situation, contrast is low such as veins beneath the skin, tumor, animal organs, this utility model provides a kind of smooth harmony the common micro imaging system focusing on, to improve detectivity and signal noise ratio (snr) of image, obtain clear 3-D view.
Technical scheme
A kind of biological tissue optoacoustic confocal microscopic image device, is mainly made up of imaging device, signal pickup assembly and control device, it is characterized in that: imaging device is all connected control device with signal pickup assembly, and imaging device connects signal pickup assembly; Imaging device comprises laser instrument, reflecting mirror, tapered lens, ultrasonic detector, optical concentrator and tank; The corresponding laser emitting direction place, outside of laser instrument is provided with reflecting mirror, and reflecting mirror below is provided with tapered lens, and the tank inner and upper of tapered lens below is provided with ultrasonic detector, and the both sides of ultrasonic detector are equipped with optical concentrator.
Described control device is made up of computer, motor and two-dimensional translation platform, and motor is arranged in the middle of computer and two-dimensional translation platform, and one end connects computer, and the other end connects two-dimensional translation platform; Reflecting mirror, tapered lens, ultrasonic detector and the optical concentrator of imaging device are placed on two-dimensional translation platform.
Signal pickup assembly is amplifier, and the ultrasonic detector of imaging device connects the computer of control device by amplifier.
Advantage and effect
This biological tissue of this utility model optoacoustic confocal microscopic image device tool has the following advantages and beneficial effect:
(1) two-dimensional movement platform simultaneously mobile detector of sound and hot spot scan, each pixel sweep signal comprises depth information, can form a B scanogram along a line multi-point scanning; Repeatedly B scanning can form 3-D view successively;
(2) ring-shaped light through optical focus device cast oblique rays on be mapped on skin skin slightly upper/lower positions focus on, can avoid the photoacoustic signal that skin surface produces and strengthen the signal that the targets such as veins beneath the skin produce;
(3) the mode maximizing coinciding by optical focus and acoustic sounding focus point is surveyed acoustical signal, increases signal to noise ratio and picture contrast.
Brief description of the drawings
Fig. 1 is this utility model agent structure schematic diagram;
Fig. 2 is imaging contrast schematic diagram, and Fig. 2 (a) is common imaging schematic diagram, and Fig. 2 (b) is the imaging schematic diagram of this utility model device.
Description of reference numerals:
1, laser instrument, 2, reflecting mirror, 3, tapered lens, 4, ultrasonic detector, 5, optical concentrator, 6, tank, 7, amplifier, 8, two-dimensional translation platform.
Detailed description of the invention
Below in conjunction with accompanying drawing, this utility model is described further:
The utility model proposes a kind of biological tissue optoacoustic confocal microscopic image device, as shown in fig. 1, mainly formed by imaging device, signal pickup assembly and control device, it is characterized in that: imaging device is all connected control device with signal pickup assembly, imaging device connects signal pickup assembly; Imaging device comprises laser instrument 1, reflecting mirror 2, tapered lens 3, ultrasonic detector 4, optical concentrator 5 and tank 6; The corresponding laser emitting direction place, outside of laser instrument 1 is provided with reflecting mirror 2, and reflecting mirror 2 belows are provided with tapered lens 3, and tank 6 inner and upper of tapered lens 3 belows are provided with ultrasonic detector 4, and the both sides of ultrasonic detector 4 are equipped with optical concentrator 5.
Described control device is made up of computer, motor and two-dimensional translation platform 8, motor is arranged in the middle of computer and two-dimensional translation platform, one end connects computer, and the other end connects two-dimensional translation platform, by the movement of computer-controlled stepper motor and two-dimensional translation platform; Reflecting mirror 2, tapered lens 3, ultrasonic detector 4 and the optical concentrator 5 of imaging device is placed in (i.e. the part of dotted line in figure) on two-dimensional translation platform 8.
Above-mentioned signal pickup assembly is amplifier 7, the ultrasonic detector 4 of imaging device connects the computer of control device by amplifier 7, amplifier 7 is ultrasonic signal amplifier, and its two ends are respectively input and output signal, one end connects ultrasonic detector 4, and the other end connects computer.
The laser that laser instrument 1 sends triggers data collecting card collection the storage data of computer the inside.Ultrasonic detector 4 photoacoustic signal is out exaggerated device and amplifies, and is then transferred in computer and stores.
Optical maser wavelength generally adopts near-infrared wavelength if 700 nm are to reach deep tissues imaging.
A formation method for biological tissue as above optoacoustic confocal microscopic image device, the method is specific as follows:
The laser that laser instrument 1 sends, by reflecting mirror 2 directive tapered lens 3, becomes ring-type hot spot through tapered lens 3, and hot spot is irradiated to the edge of optical concentrator 5, focuses on assigned address, on sample through the WATER AS FLOW MEDIUM in tank 6; Meanwhile, the position that the sound focusing point of ultrasonic detector 4 regulates and light focus point (in figure on white mouse) overlaps, thereby focusing-detection photoacoustic signal jointly.
Operation principle of the present utility model is as follows:
Ultrasonic detector has good sensitivity at its focal zone, and by regulating the sound focusing point of ultrasonic detector and the position that laser focusing point overlaps, common focusing-detection photoacoustic signal obtains high s/n ratio signal.
When this biological tissue of this utility model optoacoustic confocal microscopic image device is worked:
The laser that laser light source sends is by reflecting mirror directive tapered lens, become ring-type hot spot through tapered lens, hot spot is irradiated to the edge of optical concentrator, focus on assigned address through WATER AS FLOW MEDIUM, be can produce photoacoustic signal on sample, drive detector point by point scanning just can form a width photoacoustic image by rotation platform.Figure 2 shows that photoacoustic imaging contrast schematic diagram, wherein Fig. 2 (a) is common imaging schematic diagram (patient tumors subcutaneous tissue), Fig. 2 (b) is the imaging schematic diagram (tumor subcutaneous tissue) of this biological tissue of this utility model optoacoustic confocal microscopic image device, as can be seen from Figure 2 the two imaging effect significant difference.
Claims (3)
1. biological tissue's optoacoustic confocal microscopic image device, is mainly made up of imaging device, signal pickup assembly and control device, it is characterized in that: imaging device is all connected control device with signal pickup assembly, and imaging device connects signal pickup assembly; Imaging device comprises laser instrument (1), reflecting mirror (2), tapered lens (3), ultrasonic detector (4), optical concentrator (5) and tank (6); The corresponding laser emitting direction place, outside of laser instrument (1) is provided with reflecting mirror (2), reflecting mirror (2) below is provided with tapered lens (3), tank (6) inner and upper of tapered lens (3) below is provided with ultrasonic detector (4), and the both sides of ultrasonic detector (4) are equipped with optical concentrator (5).
2. biological tissue according to claim 1 optoacoustic confocal microscopic image device, it is characterized in that: described control device is made up of computer, motor and two-dimensional translation platform (8), motor is arranged in the middle of computer and two-dimensional translation platform, one end connects computer, and the other end connects two-dimensional translation platform; Reflecting mirror (2), tapered lens (3), ultrasonic detector (4) and the optical concentrator (5) of imaging device are placed on two-dimensional translation platform.
3. biological tissue according to claim 1 and 2 optoacoustic confocal microscopic image device, is characterized in that: signal pickup assembly is amplifier (7), and the ultrasonic detector (4) of imaging device connects the computer of control device by amplifier (7).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420254726.3U CN203943651U (en) | 2014-05-19 | 2014-05-19 | A kind of biological tissue optoacoustic confocal microscopic image device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420254726.3U CN203943651U (en) | 2014-05-19 | 2014-05-19 | A kind of biological tissue optoacoustic confocal microscopic image device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203943651U true CN203943651U (en) | 2014-11-19 |
Family
ID=51885720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420254726.3U Expired - Lifetime CN203943651U (en) | 2014-05-19 | 2014-05-19 | A kind of biological tissue optoacoustic confocal microscopic image device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203943651U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103961065A (en) * | 2014-05-19 | 2014-08-06 | 汇佳生物仪器（上海）有限公司 | Biological tissue opto-acoustic confocal micro-imaging device and method |
| CN105806786A (en) * | 2016-04-11 | 2016-07-27 | 中国科学院声学研究所 | Laser ultrasonic opto-acoustic conversion device and preparation method thereof |
| CN110960198A (en) * | 2019-11-06 | 2020-04-07 | 浙江大学 | Near-infrared two-region confocal microscopic imaging system based on multi-dimensional adjusting frame |
-
2014
- 2014-05-19 CN CN201420254726.3U patent/CN203943651U/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103961065A (en) * | 2014-05-19 | 2014-08-06 | 汇佳生物仪器（上海）有限公司 | Biological tissue opto-acoustic confocal micro-imaging device and method |
| CN105806786A (en) * | 2016-04-11 | 2016-07-27 | 中国科学院声学研究所 | Laser ultrasonic opto-acoustic conversion device and preparation method thereof |
| CN105806786B (en) * | 2016-04-11 | 2019-03-08 | 中国科学院声学研究所 | A kind of laser-ultrasound optoacoustic conversion equipment and preparation method thereof |
| CN110960198A (en) * | 2019-11-06 | 2020-04-07 | 浙江大学 | Near-infrared two-region confocal microscopic imaging system based on multi-dimensional adjusting frame |
| CN110960198B (en) * | 2019-11-06 | 2021-09-24 | 浙江大学 | Near-infrared two-region confocal microscopic imaging system based on multi-dimensional adjusting frame |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103961065A (en) | Biological tissue opto-acoustic confocal micro-imaging device and method | |
| Li et al. | Snapshot photoacoustic topography through an ergodic relay for high-throughput imaging of optical absorption | |
| CN102944521B (en) | Non-contact photoacoustic and optical coherence tomography dual-imaging device and detection method thereof | |
| US9964747B2 (en) | Imaging system and method for imaging an object | |
| Yang et al. | Fast full-view photoacoustic imaging by combined scanning with a linear transducer array | |
| CN104706323B (en) | High-speed large-view-field multi-spectral photoacoustic imaging method and device | |
| CN106333650A (en) | Multi-scale photo-acoustic micro-imaging device and multi-scale photo-acoustic micro-imaging method | |
| US20130190594A1 (en) | Scanning Optoacoustic Imaging System with High Resolution and Improved Signal Collection Efficiency | |
| Kumavor et al. | Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system | |
| CN103054610B (en) | Photoacoustic imaging device free of limitation of ultrasonic transducer frequency bands and detection method of photoacoustic imaging device | |
| CN104825180A (en) | Tri-modal breast imaging system and imaging method thereof | |
| CN104323762A (en) | Photoacoustic microscopy imaging-based quantitative detection device for nevus flammeus blood vessel | |
| CN110251093A (en) | Optoacoustic/ultrasonic probe and scan imaging method are peeped in a kind of sound focusing | |
| CN102488494B (en) | Totally internal reflection type photo-acoustic microscopic imaging system and method | |
| CN100434042C (en) | Method of biological tissue optical and ultrasonic collection and tomographic imaging and its device | |
| Bai et al. | Compact and low-cost handheld quasibright-field linear-array probe design in photoacoustic computed tomography | |
| CN203943651U (en) | A kind of biological tissue optoacoustic confocal microscopic image device | |
| CN107692975A (en) | Three-dimensional optoacoustic laminated imaging device and method | |
| CN114010151B (en) | Photoacoustic ultrasound multi-mode imaging system | |
| CN103018171B (en) | Wide-frequency-band optical-acoustic and fluorescent double-imaging device without energy converter and detection method thereof | |
| CN105249933A (en) | Photo-acoustic molecule three-dimensional image instrument | |
| Sun et al. | 3D photoacoustic tomography system based on full-view illumination and ultrasound detection | |
| CN102579073B (en) | Self-adaptive image reconstruction method for photo-acoustic microscopic imaging | |
| Valluru et al. | Probe design for photoacoustic imaging of prostate | |
| Huang et al. | Review of low-cost light sources and miniaturized designs in photoacoustic microscopy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20141119 |