CN112913853A - Multipurpose new coronavirus sterilizing disinfectant and preparation method thereof - Google Patents
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Abstract
The invention provides a multi-purpose novel coronavirus sterilization disinfectant. The raw materials comprise: 48-58 parts of sodium chlorite, 0-5 parts of effervescent agent, 3-7 parts of organic acid, 30-40 parts of stabilizer, 3-7 parts of lubricant, 1-2 parts of activator, 0.1-0.5 part of essence, 0.5-1 part of surfactant and 0.5-1 part of mineral substance. The multi-purpose sterilizing disinfectant for the new coronavirus can effectively and durably sterilize and disinfect, purify air, protect human bodies from being invaded by the new coronavirus, is convenient to store, and has high stability and wide application.
Description
Technical Field
The invention relates to the field of disinfection, in particular to a multipurpose new coronavirus sterilization disinfectant and a preparation method thereof.
Background
With the economic development and the improvement of living standard, the requirements of people on the environment around the body are higher and higher. Especially, the outbreak of new crown epidemic situation, the sterilization and disinfection in daily life and the like become common affairs. Chlorine dioxide as a disinfectant has the advantages of high efficiency, broad spectrum, no residue and the like, and has been widely researched and applied. However, chlorine dioxide is unstable and inconvenient to transport and store. Therefore, the solid preparation of chlorine dioxide is produced as a disinfection product with high stability and convenient use. The chlorine dioxide solid preparation generally takes chlorite or stable chlorine dioxide solution as a generating agent, particularly the chlorite is taken as a raw material to produce the chlorine dioxide, the production process is simple, the equipment is easy to operate and maintain, effective substances can be stably and rapidly released, and the purity of the produced chlorine dioxide is high, so the chlorine dioxide solid preparation becomes a current research hotspot.
However, the disinfectant used for disinfection and sterilization in the current market generally has poor stability and short storage period; the release speed of chlorine dioxide is difficult to control, the concentration of the generated chlorine dioxide is not high, the use requirement cannot be met, and the like, and the requirements of people on daily life or disinfection and epidemic prevention after serious epidemic situations cannot be met, so that the improvement is urgently needed.
Disclosure of Invention
In order to solve the technical problems, the invention provides a multipurpose novel coronavirus sterilization disinfectant, which comprises the following raw materials in parts by weight: 48-58 parts of sodium chlorite, 0-5 parts of effervescent agent, 3-7 parts of organic acid, 30-40 parts of stabilizer, 3-7 parts of lubricant, 1-2 parts of activator, 0.1-0.5 part of essence, 0.5-1 part of surfactant and 0.5-1 part of mineral substance. As a preferred technical scheme, the effervescent agent comprises one or more of sodium bicarbonate, sodium carbonate, calcium carbonate and potassium carbonate.
As a further preferred embodiment, the effervescent agent is sodium bicarbonate.
As a preferred technical scheme, the organic acid comprises one or more of lactic acid, malic acid, citric acid and tartaric acid.
As a further preferable technical solution, the organic acid is citric acid.
As a preferred technical scheme, the stabilizing agent comprises one or more of magnesium sulfate, sodium sulfate, magnesium chloride, potassium sulfate, calcium sulfate and calcium chloride.
As a further preferable technical scheme, the stabilizing agent is compounded by magnesium sulfate, sodium sulfate and calcium chloride.
As a further preferable technical scheme, the compound mass ratio of the magnesium sulfate, the sodium sulfate and the calcium chloride is 23-27: 8-12: 1-2.
As a preferred technical scheme, the lubricant comprises one or more of polyethylene glycol and magnesium stearate.
As a further preferred embodiment, the lubricant is polyethylene glycol.
As a preferable technical scheme, the activating agent comprises one or more of sodium bisulfate, glucose and sulfur.
As a further preferable technical scheme, the activating agent is compounded by sodium bisulfate and glucose.
As a preferable technical scheme, the mass ratio of the sodium bisulfate to the glucose is 10-15: 15-20.
As a further preferable technical scheme, the mass ratio of the sodium bisulfate to the glucose is 12: 17.
as a preferred technical scheme, the essence comprises one or more of green tea essence, evening primrose essence and rose essence.
As a preferred technical scheme, the surfactant is a fluorine-containing surfactant.
As a further preferable technical scheme, the fluorine-containing surfactant is sodium perfluorononenoxybenzene sulfonate.
As a preferable technical scheme, the mineral comprises one or more of nano attapulgite, medical stone, sepiolite and tourmaline.
As a further preferable technical proposal, the mineral is one or more of nano attapulgite and medical stone.
A preparation method of a multi-purpose sterilizing disinfectant for new coronavirus comprises the following steps: weighing the components according to the formula, preparing the components into powder, respectively drying the powder in a drying oven, mixing sodium chlorite, a surfactant, a stabilizer, a lubricant, an effervescent agent, an organic acid, an activator, essence and mineral substances, mixing and stirring the mixture to obtain powder, and performing aftertreatment to obtain the disinfectant.
As a preferred technical scheme, the multipurpose new coronavirus sterilization disinfectant can be in various shapes. The various shapes include tablet-column type, original tablet, granule, powder, pill.
The sodium chlorite reacts to release chlorine dioxide gas, and the chlorine dioxide gas can be adsorbed on cell walls of viruses, bacteria and microorganisms, penetrates the cell walls, enters cells and directly oxidizes substances containing cysteine, tryptophan, tyrosine and the like in the cells, so that the bacteria are killed.
The effervescent agent can release carbon dioxide, and effectively adjusts the release rate of chlorine dioxide in a system.
The organic acid can activate sodium chlorite to release chlorine dioxide; on the other hand, the organic acid can also chelate metal ions, and the auxiliary surfactant can better play a role.
On one hand, the stabilizer can coat sodium chlorite, so that the stability of the disinfectant is improved; on the other hand, the stabilizer can absorb moisture in the air. The release speed of the chlorine dioxide is weakened along with the reaction, but the chlorine dioxide is easy to react with water, so that the chlorine dioxide can still maintain a certain release speed in the later reaction period, and the aim of inhibiting bacteria for a long time is fulfilled. Meanwhile, the material can also be used as a filling material, so that the material performance is improved, and the cost is reduced.
The lubricant is used for reducing friction resistance, improving dispersibility, enabling all substances in the disinfectant to be uniformly mixed and preventing pollution. The polyethylene glycol has good adhesiveness in addition to lubricity. The polyethylene glycol has thickening effect on the system, so that the speed of generating active chlorine dioxide by hydrogen ions and chlorous acid ions is reduced, and the diffusion speed of the chlorine dioxide is reduced.
Said activationThe agent can react with sodium chlorite to make sodium chlorite generate chlorine dioxide quickly and raise conversion rate. Sodium chlorite is able to disproportionate with sodium bisulfate: NaClO2+NaHSO4＝HClO2+Na2SO4,HClO2Can be decomposed into chlorine dioxide. The glucose is added into the system to stimulate and promote the reaction, the reaction is less influenced by temperature and time, and higher conversion rate can be obtained at lower temperature in shorter time.
The essence can freshen smell, air-purifying promotes the environment comfort level.
The surfactant has hydrophilic and lipophilic characteristics, amphiphilic molecules of the surfactant are adsorbed on the solid surface to form an adsorption layer in directional arrangement, the hydrophilic group faces the solid surface, and the lipophilic group faces outwards, so that the water absorption of the disinfectant is reduced, and the stability is improved. The fluorine-containing surfactant is a surfactant with fluorocarbon chains as nonpolar groups, and is good in stability.
The mineral has adsorption effect, and helps to improve disinfectant and antibacterial effects of disinfectant. The mineral substance has a developed hollow structure and strong adsorption performance, can adsorb moisture in a system to keep the system in a certain dry state, and can adsorb a certain amount of chlorine dioxide, so that the release rate of the chlorine dioxide is controlled. The addition of medical stone can obviously reduce the peak value of the release rate, eliminate the burst release phenomenon and increase the later release rate.
Has the advantages that: the multi-purpose sterilizing disinfectant for the new coronavirus can effectively and durably sterilize and disinfect, purify air, protect human bodies from being invaded by the new coronavirus, is convenient to store, and has high stability and wide application.
1) The multi-purpose sterilizing disinfectant for the new coronavirus can be prepared into effervescent tablets and sustained-release tablets. When the effervescent tablet is prepared, the disintegration is fast, and the chlorine dioxide can be released rapidly; the sustained-release tablet can stably and continuously release chlorine dioxide and has lasting effect.
2) The multi-purpose sterilizing disinfectant for the new coronavirus can release chlorine dioxide, sterilize and effectively kill various germs such as escherichia coli, staphylococcus aureus, new coronavirus and the like, and the elimination rate is as high as 99.9%. Can also prevent and treat influenza, and protect human body from being invaded by new coronavirus.
3) The multi-purpose new coronavirus sterilization disinfectant prepared by the invention has wide application, can be used for air purification besides sterilization and disinfection, and can absorb toxic gas and peculiar smell, remove formaldehyde and prevent haze.
4) The multipurpose new coronavirus sterilization disinfectant prepared by the invention has high chlorine dioxide conversion rate, can continuously and slowly release chlorine dioxide, and has lasting effect and long service life.
5) The multi-purpose new coronavirus sterilization disinfectant prepared by the invention is safe and nontoxic, is convenient to store and carry, has high product stability, and can be widely applied to the aspects of disinfection of medical instruments, water bodies, air environments and the like.
Detailed Description
In order to solve the problems, the invention provides a multipurpose novel coronavirus sterilization disinfectant, which comprises the following raw materials in parts by weight: 48-58 parts of sodium chlorite, 0-5 parts of effervescent agent, 3-7 parts of organic acid, 30-40 parts of stabilizer, 3-7 parts of lubricant, 1-2 parts of activator, 0.1-0.5 part of essence, 0.5-1 part of surfactant and 0.5-1 part of mineral substance.
As a preferred technical scheme, the effervescent agent comprises one or more of sodium bicarbonate, sodium carbonate, calcium carbonate and potassium carbonate.
As a further preferred embodiment, the effervescent agent is sodium bicarbonate.
As a preferred technical scheme, the organic acid comprises one or more of lactic acid, malic acid, citric acid and tartaric acid.
As a further preferable technical solution, the organic acid is citric acid.
As a preferred technical scheme, the stabilizing agent comprises one or more of magnesium sulfate, sodium sulfate, magnesium chloride, potassium sulfate, calcium sulfate and calcium chloride.
As a further preferable technical scheme, the stabilizing agent is compounded by magnesium sulfate, sodium sulfate and calcium chloride.
As a further preferable technical scheme, the compound mass ratio of the magnesium sulfate, the sodium sulfate and the calcium chloride is 23-27: 8-12: 1-2.
As a preferred technical scheme, the lubricant comprises one or more of polyethylene glycol and magnesium stearate.
As a further preferred embodiment, the lubricant is polyethylene glycol.
As a preferable technical scheme, the activating agent comprises one or more of sodium bisulfate, glucose and sulfur.
As a further preferable technical scheme, the activating agent is compounded by sodium bisulfate and glucose.
As a preferable technical scheme, the mass ratio of the sodium bisulfate to the glucose is 10-15: 15-20.
As a further preferable technical scheme, the mass ratio of the sodium bisulfate to the glucose is 12: 17.
as a preferred technical scheme, the essence comprises one or more of green tea essence, evening primrose essence and rose essence.
As a preferred technical scheme, the surfactant is a fluorine-containing surfactant.
As a further preferable technical scheme, the fluorine-containing surfactant is sodium perfluorononenoxybenzene sulfonate.
As a preferable technical scheme, the mineral comprises one or more of nano attapulgite, medical stone, sepiolite and tourmaline.
As a further preferable technical proposal, the mineral is one or more of nano attapulgite and medical stone.
A preparation method of a multi-purpose sterilizing disinfectant for new coronavirus comprises the following steps: weighing the components according to the formula, preparing the components into powder, respectively drying the powder in a drying oven, mixing sodium chlorite, a surfactant, a stabilizer, a lubricant, an effervescent agent, an organic acid, an activator, essence and mineral substances, mixing and stirring the mixture to obtain powder, and performing aftertreatment to obtain the disinfectant.
As a preferred technical scheme, the multipurpose new coronavirus sterilization disinfectant can be in various shapes.
As a further preferred embodiment, the plurality of shapes include dosage-column form, tablet, granule, powder, pill.
As a preferred technical scheme, the powder is sieved, and powder with the particle size of 150 +/-10 um is selected to prepare the disinfection powder.
As a preferable technical scheme, the powder is made into granules by a granulator, sieved and selected into granules with the particle size of 2000-.
As a preferable technical scheme, the powder is prepared into tablets, namely columnar tablets and original tablets by a tablet machine to prepare the disinfection tablets.
The present invention will be specifically described below by way of examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.
In addition, the starting materials used are all commercially available, unless otherwise specified.
Examples
Example 1
A multipurpose new coronavirus degerming disinfectant comprises the following raw materials in parts by weight: 50 parts of sodium chlorite, 5 parts of effervescent agent, 5 parts of organic acid, 36 parts of stabilizing agent, 5 parts of lubricating agent, 2 parts of activating agent, 0.3 part of essence, 0.5 part of surfactant and 1 part of mineral substance.
The effervescent agent is sodium bicarbonate.
The organic acid is citric acid.
The stabilizer is compounded by magnesium sulfate, sodium sulfate and calcium chloride. The compounding mass ratio of the magnesium sulfate, the sodium sulfate and the calcium chloride is 25: 10: 1.
the lubricant is polyethylene glycol. The polyethylene glycol has a relative molecular weight of 4000. The polyethylene glycol was purchased from Effield chemical technology, Inc. of Jiangsu.
The activating agent is compounded by sodium bisulfate and glucose. The compounding mass ratio of the sodium bisulfate to the glucose is 12: 17. the glucose was purchased from suzhou merchantability chemical ltd.
The essence is green tea essence. The green tea essence is purchased from Yunya spices Co Ltd of Jiangmen city flower.
The surfactant is perfluorononenoxybenzene sodium sulfonate.
The mineral is Maifanitum. The medical stone is purchased from Changsha Jianglong chemical technology Co.
A preparation method of a multi-purpose sterilizing disinfectant for new coronavirus comprises the following steps: weighing the components according to the formula, preparing the materials into powder, respectively drying the powder in a drying box, mixing sodium chlorite, a surfactant and a stabilizer, adding a lubricant, an effervescent agent, an organic acid, an activating agent, essence and mineral substances, mixing and stirring the mixture to form powder, sieving the powder, selecting particles with the particle size of 150-2000 mu m, and pressing the particles into tablets by using a tabletting machine.
Example 2
A multipurpose new coronavirus degerming disinfectant comprises the following raw materials in parts by weight: 55 parts of sodium chlorite, 5 parts of organic acid, 36 parts of stabilizer, 5 parts of lubricant, 2 parts of activator, 0.3 part of essence, 0.5 part of surfactant and 1 part of mineral substance.
The organic acid is citric acid.
The stabilizer is compounded by magnesium sulfate, sodium sulfate and calcium chloride. The compounding mass ratio of the magnesium sulfate, the sodium sulfate and the calcium chloride is 25: 10: 1.
the lubricant is polyethylene glycol. The molecular weight of the polyethylene glycol is 4000. The polyethylene glycol was purchased from Effield chemical technology, Inc. of Jiangsu.
The activating agent is compounded by sodium bisulfate and glucose. The compounding mass ratio of the sodium bisulfate to the glucose is 12: 17. the glucose was purchased from suzhou merchantability chemical ltd.
The essence is green tea essence. The green tea essence is purchased from Yunya spices Co Ltd of Jiangmen city flower.
The surfactant is perfluorononenoxybenzene sodium sulfonate (CAS number: 77061-68-8). The sodium perfluorononenoxybenzenesulfonate was purchased from fluorinating technology.
The mineral is Maifanitum. The medical stone is purchased from Changsha Jianglong chemical technology Co.
A preparation method of a multi-purpose sterilizing disinfectant for new coronavirus comprises the following steps: weighing the components according to the formula, preparing the materials into powder, respectively drying the powder in a drying box, mixing sodium chlorite, a surfactant and a stabilizer, adding a lubricant, an effervescent agent, an organic acid, an activating agent, essence and mineral substances, mixing and stirring the mixture to form powder, sieving the powder, selecting particles with the particle size of 150-2000 mu m, and pressing the particles into tablets by using a tabletting machine.
Example 3
A multi-purpose disinfectant for sterilizing new coronavirus is disclosed in the same manner as in example 1, except that the lubricant is magnesium stearate.
Example 4
A multi-purpose disinfectant for sterilizing new coronavirus is disclosed in the following embodiment with the difference that the activating agent is sodium bisulfate.
Example 5
A multi-purpose disinfectant for sterilizing new coronavirus is disclosed, which is prepared in the same manner as in example 1, except that the mineral is sepiolite.
Performance testing
1. Test of bactericidal and bacteriostatic effects
The test basis is as follows: according to the sterilization performance test of the product in appendix C of GB 15979-2002 hygienic Standard for Disposable sanitary articles, the sample of the example is used, the action time is 1 minute, the test is repeated for 3 times, and the test result is averaged.
Test strains: escherichia coli, Staphylococcus aureus, Candida albicans, and Pseudomonas aeruginosa
Preparing bacterial liquid: according to GB1579-2002C recording product sterilization performance test method, selecting bacteria content 1 x 107cfu/mL-9*107cfu/mL of bacterial suspension were tested.
And (3) testing conditions: the temperature is 24.0 ℃, and the relative humidity is 67 percent
The test results are detailed in Table 1
TABLE 1
| Escherichia coli | Staphylococcus aureus | Candida albicans | Pseudomonas aeruginosa | |
| Example 1 | 99.9％ | 99.9％ | 99.9％ | 99.9％ |
| Example 2 | 99.9％ | 99.9％ | 99.9％ | 99.9％ |
| Example 3 | 98％ | 98％ | 98％ | 98％ |
| Example 4 | 95％ | 95％ | 95％ | 95％ |
| Example 5 | 93％ | 93％ | 93％ | 93％ |
2. Disinfection test
The inspection and evaluation basis is as follows: reference to Disinfection technical Specification (2002 year edition)
1) Air laboratory test
A test chamber: 3m2
Test strains: staphylococcus albus 8032. Culture medium: common nutrient agar medium
Detecting the environment: temperature: (20-25 ℃), humidity: (50-70)% RH
The disinfection method comprises the following steps: during testing, a sample machine to be tested is arranged in a test chamber, the sample machine is started to a set gear position for disinfection for 120min and then is sampled, the test is repeated for 3 times, and the test result is averaged.
2) On-site sterilization test
The test site comprises: about 30m3Unmanned closed space culture medium: common nutrient agar medium
Detecting the environment: temperature: (26-28 ℃ C.), humidity: (70-80)% RH
The disinfection method comprises the following steps: during the test, the sample to be tested is placed in an unmanned closed space, sampling is carried out after disinfection is carried out for 60min, the test is repeated for 3 times, and the average value of the test results is obtained.
The test results are detailed in Table 2
TABLE 2
3. Experiment against New coronavirus
The test basis is as follows: refer to the Disinfection Specification (2002 edition). Using the samples of the examples as test groups, a blank control group was set at the same time, the antiviral activity was measured every other hour for 3 hours, the experiment was repeated 3 times, and the test results were averaged.
Experimental strains: coronavirus SARS-COV-2Vero-E6 cell
TABLE 2
| Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | |
| Rate of antiviral activity | >99.9％ | >99.9％ | >95％ | >92.5％ | >90％ |
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in other forms, and any person skilled in the art may modify or change the technical content of the above disclosure into equivalent embodiments with equivalent changes, but all those simple modifications, equivalent changes and modifications made to the above embodiments according to the technical spirit of the present invention still belong to the protection scope of the present invention.
Claims (10)
1. A multipurpose new coronavirus sterilization disinfectant is characterized by comprising the following raw materials in parts by weight: 48-58 parts of sodium chlorite, 0-5 parts of effervescent agent, 3-7 parts of organic acid, 30-40 parts of stabilizer, 3-7 parts of lubricant, 1-2 parts of activator, 0.1-0.5 part of essence, 0.5-1 part of surfactant and 0.5-1 part of mineral substance.
2. The multipurpose degerming disinfectant for new coronaviruses, as claimed in claim 1, wherein said effervescent agent comprises one or more of sodium bicarbonate, sodium carbonate, calcium carbonate and potassium carbonate.
3. The multipurpose degerming disinfectant for new coronaviruses, as claimed in claim 1, wherein said organic acid comprises one or more of lactic acid, malic acid, citric acid, and tartaric acid.
4. The multipurpose disinfectant for sterilizing new coronavirus according to claim 1, wherein the stabilizer comprises one or more of magnesium sulfate, sodium sulfate, magnesium chloride, potassium sulfate, calcium sulfate and calcium chloride.
5. The multipurpose disinfectant for sterilizing new coronavirus according to claim 1, wherein the lubricant comprises one or more of polyethylene glycol and magnesium stearate.
6. The multipurpose disinfectant for sterilizing new coronavirus according to claim 1, wherein the activator comprises one or more of sodium bisulfate, glucose and sulfur.
7. The multipurpose disinfectant for sterilizing new coronavirus according to claim 6, wherein the activator is a combination of sodium bisulfate and glucose.
8. The multipurpose disinfectant for sterilizing new coronavirus according to claim 1, wherein said surfactant is a fluorine-containing surfactant.
9. The multipurpose degerming disinfectant for new coronaviruses as claimed in claim 1, wherein said minerals comprise one or more of nano attapulgite, medical stone, sepiolite and tourmaline.
10. A method for preparing the multipurpose sterilizing disinfectant for new coronavirus according to claim 1, which comprises the following steps: weighing the components according to the formula, preparing the components into powder, respectively drying the powder in a drying oven, mixing sodium chlorite, a surfactant and a stabilizer, adding a lubricant, an effervescent agent, an organic acid, an activating agent, essence and mineral substances, mixing and stirring the mixture to obtain powder, and performing aftertreatment to obtain the disinfectant.
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